[Ser2]- and [Ser(P)2]incretin analogs. Comparison of dipeptidyl peptidase IV resistance and biological activities in vitro and in vivo

Journal of Biological Chemistry

Volumn 279, Issue 6, 2004, Pages 3998-4006

  Hinke, Simon A ^a,c   Manhart, Susanne ^b   Kühn Wache, Kerstin ^b   Nian, Cuilan ^a   Demuth, Hans Ulrich ^b   Pederson, Raymond A ^a   McIntosh, Christopher H S ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b PROBIODRUG AG   (Germany)

^c DIABETES RESEARCH CENTER   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL ACTIVATION; CHEMICAL MODIFICATION; CLONING; ENZYMES; GLUCOSE; INSULIN; METABOLISM; POLYPEPTIDES; SUBSTITUTION REACTIONS;

DIPEPTIDYL PEPTIDASE (DP); RECEPTOR BINDING;

BIOCHEMISTRY;

CYCLIC AMP; DIPEPTIDYL PEPTIDASE; GASTROINTESTINAL HORMONE; GLUCAGON LIKE PEPTIDE 1; INCRETIN; POLYPEPTIDE; SERINE; UNCLASSIFIED DRUG; DIPEPTIDYL PEPTIDASE IV; GASTRIC INHIBITORY POLYPEPTIDE; GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR; GLUCAGON; GLUCAGON LIKE PEPTIDE RECEPTOR; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE RECEPTOR; HORMONE RECEPTOR; PEPTIDE FRAGMENT; PHOSPHOSERINE; PROTEIN PRECURSOR;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CHO CELL; CONCENTRATION RESPONSE; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME MODIFICATION; GLUCOSE BLOOD LEVEL; HORMONE RELEASE; INSULIN RELEASE; MALE; METABOLIC ACTIVATION; MOLECULAR CLONING; NONHUMAN; PANCREAS ISLET BETA CELL; POSTPRANDIAL STATE; PRIORITY JOURNAL; RAT; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; DRUG STABILITY; HAMSTER; IN VITRO STUDY; MASS SPECTROMETRY; METABOLISM; SYNTHESIS; WISTAR RAT;

ANIMALIA; RATTUS NORVEGICUS;

ANIMALS; ANTIGENS, CD26; BLOOD GLUCOSE; CHO CELLS; CRICETINAE; CYCLIC AMP; DRUG STABILITY; GASTRIC INHIBITORY POLYPEPTIDE; GASTROINTESTINAL HORMONES; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; MALE; PEPTIDE FRAGMENTS; PHOSPHOSERINE; PROTEIN PRECURSORS; RATS; RATS, WISTAR; RECEPTORS, GASTROINTESTINAL HORMONE; RECEPTORS, GLUCAGON; SERINE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 1042301414     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M311304200     Document Type: Article

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