The positive charge of the imidazole side chain of histidine7 is crucial for GLP-1 action

Endocrine Journal

Volumn 44, Issue 5, 1997, Pages 701-705

  Hareter, Alexandra ^a   Hoffmann, Eike ^a   Bode, Hans Peter ^a   Göke, Burkhard ^a   Göke, Rüdiger ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Glucagon like peptide 1; Histidine; Structure activity relationship

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; HISTIDINE; IMIDAZOLE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; DIABETES MELLITUS; GLUCAGON RELEASE; GLUCOSE METABOLISM; HAMSTER; INSULIN SYNTHESIS; NONHUMAN; POSTPRANDIAL STATE; STRUCTURE ACTIVITY RELATION;

EID: 0031465992     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.44.701     Document Type: Article

References (12)

1. Conlon JM (1988) Proglucagon-derived peptides: Nomenclature, biosynthetic relationships and physiological roles. Diabetologia 31: 563-568.
2. Fehmann HC, Göke R, Göke B (1995) Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide. Endocr Rev 16: 390-410.
3. Göke R, Conlon JM (1988) Receptors for glucagon-like peptide-1 (7-36) amid e on rat insulinoma-derived cells. J Endocrinol 116: 357-362.
4. Fehmann HC, Habener JF (1991) Homologues desensitization of the insulinotropic glucagon-like peptide-I (7-37) receptor on insulinoma (HIT-T15) cells. Endocrinology 128: 2880-2888.
5. Fehmann HC, Habener JF (1992) Insulinotropic hormone glucagon-like peptide-I (7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma βTC-I cells. Endocrinology 130: 159-166.
6. Unson C, MacDonald D, Merrifield RB (1993) The role of histidine-1 in glucagon action. Arch Biochem Biophys 300: 747-750.
7. Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB (1992) Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130: 167-178.
8. Sekine N, Cirulli V, Regazzi R, Brown LJ, Gine E, Tamarit Rodriguez J, Girotti M, Marie S, MacDonald MJ, Wollheim CB (1994) Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing. J Biol Chem 269: 4895-4902.
9. Bode HP, Göke B (1994) Protein kinase C activates the capacitative calcium entry in the insulin secreting cell line RINm5F. FEBS Lett 339: 307-311.
10. Bode HP, Yule D, Fehmann HC, Göke B, Williams JA (1994) Spontaneous and agonist induced calcium oscillations in clonal endocrine pancreatic glucagon secreting cells (INR1 G9). Biochem Biophys Res Commun 205: 435-440.
11. Hruby VJ, Krstenansky J, Gysin B, Pelton JT, Trevedi D, McKee RL (1986) Conformational considerations in the design of glucagon antagonists and antagonists: Examination using synthetic analogues. Biopolymers (Suppl) 25: 135-155.
12. Unson C, MacDonald D, Ray K, Durrah TL, Merrifield RB (1991) Position 9 replacement analogues of glucagon uncouple biological activity and receptor binding. J Biol Chem 266: 2763-2766.