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Volumn 46, Issue 12, 2003, Pages 1594-1603

Regulation of adipocytokines and insulin resistance

Author keywords

Adipocytokine; Adiponectin; Adrenergic; Glucocorticoid; Growth hormone; Insulin; Insulin resistance; Interleukin 6; Leptin; Obesity; Resistin; Tumour necrosis factor

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPONECTIN; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYTOKINE; GLUCOCORTICOID; GROWTH HORMONE; INSULIN; INTERLEUKIN 6; RESISTIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 0348107406     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1228-z     Document Type: Review
Times cited : (471)

References (128)
  • 1
    • 0034496387 scopus 로고    scopus 로고
    • Pathophysiology and pharmacological treatment of insulin resistance
    • Matthaei S, Stumvoll M, Kellerer M, Haring HU (2000) Pathophysiology and pharmacological treatment of insulin resistance. Endocr Rev 21:585-618
    • (2000) Endocr Rev , vol.21 , pp. 585-618
    • Matthaei, S.1    Stumvoll, M.2    Kellerer, M.3    Haring, H.U.4
  • 2
    • 0034221270 scopus 로고    scopus 로고
    • The molecular and physiological basis of insulin resistance: Emerging implications for metabolic and cardiovascular diseases
    • Saltiel AR (2000) The molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases. J Clin Invest 106:163-164
    • (2000) J Clin Invest , vol.106 , pp. 163-164
    • Saltiel, A.R.1
  • 3
    • 0036255529 scopus 로고    scopus 로고
    • The mode of action of thiazolidinediones
    • Hauner H (2002) The mode of action of thiazolidinediones. Diabetes Metab Res Rev 18 [Suppl 2]:S10-S15
    • (2002) Diabetes Metab Res Rev , vol.18 , Issue.2 SUPPL.
    • Hauner, H.1
  • 4
    • 0035992811 scopus 로고    scopus 로고
    • Glitazones: Clinical effects and molecular mechanisms
    • Stumvoll M, Haring HU (2002) Glitazones: clinical effects and molecular mechanisms. Ann Med 34:217-224
    • (2002) Ann Med , vol.34 , pp. 217-224
    • Stumvoll, M.1    Haring, H.U.2
  • 5
    • 0030025673 scopus 로고    scopus 로고
    • Hypertension and associated metabolic abnormalities - The role of insulin resistance and the sympathoadrenal system
    • Reaven GM, Lithell H, Landsberg L (1996) Hypertension and associated metabolic abnormalities - the role of insulin resistance and the sympathoadrenal system. N Engl J Med 334:374-381
    • (1996) N Engl J Med , vol.334 , pp. 374-381
    • Reaven, G.M.1    Lithell, H.2    Landsberg, L.3
  • 6
    • 0033521022 scopus 로고    scopus 로고
    • Beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes
    • Klein J, Fasshauer M, Ito M, Lowell BB, Benito M, Kahn CR (1999) beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes. J Biol Chem 274:34795-34802
    • (1999) J Biol Chem , vol.274 , pp. 34795-34802
    • Klein, J.1    Fasshauer, M.2    Ito, M.3    Lowell, B.B.4    Benito, M.5    Kahn, C.R.6
  • 8
    • 0034682780 scopus 로고    scopus 로고
    • Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes
    • Fasshauer M, Klein J, Ueki K et al. (2000) Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes. J Biol Chem 275:25494-25501
    • (2000) J Biol Chem , vol.275 , pp. 25494-25501
    • Fasshauer, M.1    Klein, J.2    Ueki, K.3
  • 9
    • 0032804629 scopus 로고    scopus 로고
    • Nutrient modulation of cellular insulin action
    • Patti ME (1999) Nutrient modulation of cellular insulin action. Ann NY Acad Sci 892:187-203
    • (1999) Ann NY Acad Sci , vol.892 , pp. 187-203
    • Patti, M.E.1
  • 10
    • 0033849777 scopus 로고    scopus 로고
    • Obesity and insulin resistance
    • Kahn BB, Flier JS (2000) Obesity and insulin resistance. J Clin Invest 106:473-481
    • (2000) J Clin Invest , vol.106 , pp. 473-481
    • Kahn, B.B.1    Flier, J.S.2
  • 11
    • 0035145487 scopus 로고    scopus 로고
    • Plasma levels of tumor necrosis factor-alpha, angiotensin II, growth hormone, and IGF-I are not elevated in insulin-resistant obese individuals with impaired glucose tolerance
    • Bluher M, Kratzsch J, Paschke R (2001) Plasma levels of tumor necrosis factor-alpha, angiotensin II, growth hormone, and IGF-I are not elevated in insulin-resistant obese individuals with impaired glucose tolerance. Diabetes Care 24:328-334
    • (2001) Diabetes Care , vol.24 , pp. 328-334
    • Bluher, M.1    Kratzsch, J.2    Paschke, R.3
  • 12
    • 0032449219 scopus 로고    scopus 로고
    • The genetic basis of type 2 diabetes mellitus: Impaired insulin secretion versus impaired insulin sensitivity
    • Gerich JE (1998) The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr Rev 19:491-503
    • (1998) Endocr Rev , vol.19 , pp. 491-503
    • Gerich, J.E.1
  • 13
    • 0037380214 scopus 로고    scopus 로고
    • Cortisol and the metabolic syndrome in South Asians
    • Ward AM, Fall CH, Stein CE et al. (2003) Cortisol and the metabolic syndrome in South Asians. Clin Endocrinol 58:500-505
    • (2003) Clin Endocrinol , vol.58 , pp. 500-505
    • Ward, A.M.1    Fall, C.H.2    Stein, C.E.3
  • 14
    • 0019970112 scopus 로고
    • Effects of growth hormone on insulin action in man. Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization
    • Rizza RA, Mandarino LJ, Gerich JE (1982) Effects of growth hormone on insulin action in man. Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization. Diabetes 31:663-669
    • (1982) Diabetes , vol.31 , pp. 663-669
    • Rizza, R.A.1    Mandarino, L.J.2    Gerich, J.E.3
  • 15
    • 0022477133 scopus 로고
    • Insulin resistance in acromegaly: Defects in both hepatic and extrahepatic insulin action
    • Hansen I, Tsalikian E, Beaufrere B, Gerich J, Haymond M, Rizza R (1986) Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action. Am J Physiol 250:E269-E273
    • (1986) Am J Physiol , vol.250
    • Hansen, I.1    Tsalikian, E.2    Beaufrere, B.3    Gerich, J.4    Haymond, M.5    Rizza, R.6
  • 16
    • 0030740995 scopus 로고    scopus 로고
    • Growth hormone-induced insulin resistance: Role of the insulin receptor, IRS-1, GLUT-1, and GLUT-4
    • Smith TR, Elmendorf JS, David TS, Turinsky J (1997) Growth hormone-induced insulin resistance: role of the insulin receptor, IRS-1, GLUT-1, and GLUT-4. Am J Physiol 272:E1071-E1079
    • (1997) Am J Physiol , vol.272
    • Smith, T.R.1    Elmendorf, J.S.2    David, T.S.3    Turinsky, J.4
  • 18
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87-91
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 19
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM (1996) IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance. Science 271:665-668
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 20
    • 0031022434 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction
    • Stephens JM, Lee J, Pilch PF (1997) Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction. J Biol Chem 272:971-976
    • (1997) J Biol Chem , vol.272 , pp. 971-976
    • Stephens, J.M.1    Lee, J.2    Pilch, P.F.3
  • 21
    • 0036266125 scopus 로고    scopus 로고
    • Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity
    • Xu H, Uysal KT, Becherer JD, Arner P, Hotamisligil GS (2002) Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity. Diabetes 51:1876-1883
    • (2002) Diabetes , vol.51 , pp. 1876-1883
    • Xu, H.1    Uysal, K.T.2    Becherer, J.D.3    Arner, P.4    Hotamisligil, G.S.5
  • 22
    • 0036212593 scopus 로고    scopus 로고
    • Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance
    • Xu H, Hirosumi J, Uysal KT, Guler AD, Hotamisligil GS (2002) Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance. Endocrinology 143:1502-1511
    • (2002) Endocrinology , vol.143 , pp. 1502-1511
    • Xu, H.1    Hirosumi, J.2    Uysal, K.T.3    Guler, A.D.4    Hotamisligil, G.S.5
  • 23
    • 0031756640 scopus 로고    scopus 로고
    • An in vivo model for elucidation of the mechanism of tumor necrosis factor-alpha (TNF-alpha)-induced insulin resistance: Evidence for differential regulation of insulin signaling by TNF-alpha
    • Cheung AT, Ree D, Kolls JK, Fuselier J, Coy DH, Bryer-Ash M (1998) An in vivo model for elucidation of the mechanism of tumor necrosis factor-alpha (TNF-alpha)-induced insulin resistance: evidence for differential regulation of insulin signaling by TNF-alpha. Endocrinology 139:4928-4935
    • (1998) Endocrinology , vol.139 , pp. 4928-4935
    • Cheung, A.T.1    Ree, D.2    Kolls, J.K.3    Fuselier, J.4    Coy, D.H.5    Bryer-Ash, M.6
  • 24
    • 0029906375 scopus 로고    scopus 로고
    • Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM
    • Ofei F, Hurel S, Newkirk J, Sopwith M, Taylor R (1996) Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes 45:881-885
    • (1996) Diabetes , vol.45 , pp. 881-885
    • Ofei, F.1    Hurel, S.2    Newkirk, J.3    Sopwith, M.4    Taylor, R.5
  • 25
    • 0033867178 scopus 로고    scopus 로고
    • Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes
    • Moller DE (2000) Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol Metab 11:212-217
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 212-217
    • Moller, D.E.1
  • 26
    • 0035023128 scopus 로고    scopus 로고
    • Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
    • Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G (2001) Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 280:E745-E751
    • (2001) Am J Physiol Endocrinol Metab , vol.280
    • Kern, P.A.1    Ranganathan, S.2    Li, C.3    Wood, L.4    Ranganathan, G.5
  • 27
    • 0028968879 scopus 로고
    • The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
    • Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB (1995) The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 95:2111-2119
    • (1995) J Clin Invest , vol.95 , pp. 2111-2119
    • Kern, P.A.1    Saghizadeh, M.2    Ong, J.M.3    Bosch, R.J.4    Deem, R.5    Simsolo, R.B.6
  • 28
    • 0032520921 scopus 로고    scopus 로고
    • Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats
    • Okuno A, Tamemoto H, Tobe K et al. (1998) Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest 101:1354-1361
    • (1998) J Clin Invest , vol.101 , pp. 1354-1361
    • Okuno, A.1    Tamemoto, H.2    Tobe, K.3
  • 29
    • 0032887992 scopus 로고    scopus 로고
    • Regulation of tumour necrosis factor-alpha release from human adipose tissue in vitro
    • Sewter CP, Digby JE, Blows F, Prins J, O'Rahilly S (1999) Regulation of tumour necrosis factor-alpha release from human adipose tissue in vitro. J Endocrinol 163:33-38
    • (1999) J Endocrinol , vol.163 , pp. 33-38
    • Sewter, C.P.1    Digby, J.E.2    Blows, F.3    Prins, J.4    O'Rahilly, S.5
  • 30
    • 0033304608 scopus 로고    scopus 로고
    • The differential effect of food intake and beta-adrenergic stimulation on adipose-derived hormones and cytokines in man
    • Orban Z, Remaley AT, Sampson M, Trajanoski Z, Chrousos GP (1999) The differential effect of food intake and beta-adrenergic stimulation on adipose-derived hormones and cytokines in man. J Clin Endocrinol Metab 84:2126-2133
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 2126-2133
    • Orban, Z.1    Remaley, A.T.2    Sampson, M.3    Trajanoski, Z.4    Chrousos, G.P.5
  • 31
    • 0029847504 scopus 로고    scopus 로고
    • Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
    • Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM (1996) Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274:1377-1379
    • (1996) Science , vol.274 , pp. 1377-1379
    • Hotamisligil, G.S.1    Johnson, R.S.2    Distel, R.J.3    Ellis, R.4    Papaioannou, V.E.5    Spiegelman, B.M.6
  • 32
    • 0035076381 scopus 로고    scopus 로고
    • Effect of dexamethasone on adipocyte differentiation markers and tumour necrosis factor-alpha expression in human PAZ6 cells
    • Zilberfarb V, Siquier K, Strosberg AD, Issad T (2001) Effect of dexamethasone on adipocyte differentiation markers and tumour necrosis factor-alpha expression in human PAZ6 cells. Diabetologia 44:377-386
    • (2001) Diabetologia , vol.44 , pp. 377-386
    • Zilberfarb, V.1    Siquier, K.2    Strosberg, A.D.3    Issad, T.4
  • 33
    • 0034804373 scopus 로고    scopus 로고
    • Adipocyte insensitivity to insulin in growth hormone-transgenic mice
    • Chen XL, Lee K, Hartzell DL et al. (2001) Adipocyte insensitivity to insulin in growth hormone-transgenic mice. Biochem Biophys Res Commun 283:933-937
    • (2001) Biochem Biophys Res Commun , vol.283 , pp. 933-937
    • Chen, X.L.1    Lee, K.2    Hartzell, D.L.3
  • 34
    • 0031788315 scopus 로고    scopus 로고
    • Obesity and insulin resistance in human growth hormone transgenic rats
    • Ikeda A, Chang KT, Matsumoto Y et al. (1998) Obesity and insulin resistance in human growth hormone transgenic rats. Endocrinology 139:3057-3063
    • (1998) Endocrinology , vol.139 , pp. 3057-3063
    • Ikeda, A.1    Chang, K.T.2    Matsumoto, Y.3
  • 35
    • 0035213925 scopus 로고    scopus 로고
    • Increased leptin and tumour necrosis factor alpha per unit fat mass in hypopituitary women without growth hormone treatment
    • Bulow B, Ahren B, Erfurth EM (2001) Increased leptin and tumour necrosis factor alpha per unit fat mass in hypopituitary women without growth hormone treatment. Eur J Endocrinol 145:737-742
    • (2001) Eur J Endocrinol , vol.145 , pp. 737-742
    • Bulow, B.1    Ahren, B.2    Erfurth, E.M.3
  • 36
    • 0030735542 scopus 로고    scopus 로고
    • Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo
    • Mohamed-Ali V, Goodrick S, Rawesh A et al. (1997) Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab 82:4196-4200
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 4196-4200
    • Mohamed-Ali, V.1    Goodrick, S.2    Rawesh, A.3
  • 37
    • 0028929156 scopus 로고
    • Interleukin-6 stimulates hepatic triglyceride secretion in rats
    • Nonogaki K, Fuller GM, Fuentes NL et al. (1995) Interleukin-6 stimulates hepatic triglyceride secretion in rats. Endocrinology 136:2143-2149
    • (1995) Endocrinology , vol.136 , pp. 2143-2149
    • Nonogaki, K.1    Fuller, G.M.2    Fuentes, N.L.3
  • 38
    • 0036894360 scopus 로고    scopus 로고
    • Interleukin-6 induces cellular insulin resistance in hepatocytes
    • Senn JJ, Klover PJ, Nowak IA, Mooney RA (2002) Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 51:3391-3399
    • (2002) Diabetes , vol.51 , pp. 3391-3399
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Mooney, R.A.4
  • 39
    • 0013461697 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) reduces gene and protein expression of IRS-1 and GLUT4 and is overexpressed in human fat cells from insulin-resistant subjects
    • Abstract
    • Rotter V, Nagaev I, Smith U (2002) Interleukin-6 (IL-6) reduces gene and protein expression of IRS-1 and GLUT4 and is overexpressed in human fat cells from insulin-resistant subjects. Diabetes 51 [Suppl 2]: A303 (Abstract)
    • (2002) Diabetes , vol.51 , Issue.2 SUPPL.
    • Rotter, V.1    Nagaev, I.2    Smith, U.3
  • 40
    • 0028674174 scopus 로고
    • Endocrine and carbohydrate responses to interleukin-6 in vivo
    • Stith RD, Luo J (1994) Endocrine and carbohydrate responses to interleukin-6 in vivo. Circ Shock 44:210-215
    • (1994) Circ Shock , vol.44 , pp. 210-215
    • Stith, R.D.1    Luo, J.2
  • 42
    • 0035403205 scopus 로고    scopus 로고
    • Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion
    • Vozarova B, Weyer C, Hanson K, Tataranni PA, Bogardus C, Pratley RE (2001) Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes Res 9:414-417
    • (2001) Obes Res , vol.9 , pp. 414-417
    • Vozarova, B.1    Weyer, C.2    Hanson, K.3    Tataranni, P.A.4    Bogardus, C.5    Pratley, R.E.6
  • 43
    • 0030731621 scopus 로고    scopus 로고
    • NIDDM as a disease of the innate immune system: Association of acute-phase reactants and interleukin-6 with metabolic syndrome X
    • Pickup JC, Mattock MB, Chusney GD, Burt D (1997) NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 40:1286-1292
    • (1997) Diabetologia , vol.40 , pp. 1286-1292
    • Pickup, J.C.1    Mattock, M.B.2    Chusney, G.D.3    Burt, D.4
  • 44
    • 0035908632 scopus 로고    scopus 로고
    • C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
    • Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM (2001) C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286:327-334
    • (2001) JAMA , vol.286 , pp. 327-334
    • Pradhan, A.D.1    Manson, J.E.2    Rifai, N.3    Buring, J.E.4    Ridker, P.M.5
  • 45
    • 0037031267 scopus 로고    scopus 로고
    • Effect of rosiglitazone treatment on non-traditional markers of cardiovascular disease in patients with type 2 diabetes mellitus
    • Haffner SM, Greenberg AS, Weston WM, Chen H, Williams K, Freed MI (2002) Effect of rosiglitazone treatment on non-traditional markers of cardiovascular disease in patients with type 2 diabetes mellitus. Circulation 106:679-684
    • (2002) Circulation , vol.106 , pp. 679-684
    • Haffner, S.M.1    Greenberg, A.S.2    Weston, W.M.3    Chen, H.4    Williams, K.5    Freed, M.I.6
  • 46
    • 0037617454 scopus 로고    scopus 로고
    • Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes
    • Fasshauer M, Klein J, Lossner U, Paschke R (2003) Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes. Horm Metab Res 35:147-152
    • (2003) Horm Metab Res , vol.35 , pp. 147-152
    • Fasshauer, M.1    Klein, J.2    Lossner, U.3    Paschke, R.4
  • 47
    • 0035217644 scopus 로고    scopus 로고
    • Adrenergic regulation of IL-6 release from adipose tissue: In vivo and in vitro studies
    • Mohamed-Ali V, Flower L, Sethi J et al. (2001) beta-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies. J Clin Endocrinol Metab 86:5864-5869
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5864-5869
    • Mohamed-Ali, V.1    Flower, L.2    Sethi, J.3
  • 48
    • 0035016791 scopus 로고    scopus 로고
    • Human breast adipocytes express interleukin-6 (IL-6) and its receptor system: Increased IL-6 production by beta-adrenergic activation and effects of IL-6 on adipocyte function
    • Path G, Bornstein SR, Gurniak M, Chrousos GP, Scherbaum WA, Hauner H (2001) Human breast adipocytes express interleukin-6 (IL-6) and its receptor system: increased IL-6 production by beta-adrenergic activation and effects of IL-6 on adipocyte function. J Clin Endocrinol Metab 86:2281-2288
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2281-2288
    • Path, G.1    Bornstein, S.R.2    Gurniak, M.3    Chrousos, G.P.4    Scherbaum, W.A.5    Hauner, H.6
  • 50
    • 0031762908 scopus 로고    scopus 로고
    • Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: Depot difference and regulation by glucocorticoid
    • Fried SK, Bunkin DA, Greenberg AS (1998) Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 83:847-850
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 847-850
    • Fried, S.K.1    Bunkin, D.A.2    Greenberg, A.S.3
  • 51
    • 0029820502 scopus 로고    scopus 로고
    • Exercise stimulates interleukin-6 secretion: Inhibition by glucocorticoids and correlation with catecholamines
    • Papanicolaou DA, Petrides JS, Tsigos C et al. (1996) Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines. Am J Physiol 271:E601-E605
    • (1996) Am J Physiol , vol.271
    • Papanicolaou, D.A.1    Petrides, J.S.2    Tsigos, C.3
  • 52
    • 0032936343 scopus 로고    scopus 로고
    • Glucocorticoids and insulin resistance: Old hormones, new targets
    • Colch
    • Andrews RC, Walker BR (1999) Glucocorticoids and insulin resistance: old hormones, new targets. Clin Sci (Colch) 96:513-523
    • (1999) Clin Sci , vol.96 , pp. 513-523
    • Andrews, R.C.1    Walker, B.R.2
  • 53
    • 0034682622 scopus 로고    scopus 로고
    • Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial
    • Sesmilo G, Biller BM, Llevadot J et al. (2000) Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial. Ann Intern Med 133:111-122
    • (2000) Ann Intern Med , vol.133 , pp. 111-122
    • Sesmilo, G.1    Biller, B.M.2    Llevadot, J.3
  • 54
    • 0026032419 scopus 로고
    • The metabolic effects of tumor necrosis factor and other cytokines
    • Grunfeld C, Feingold KR (1991) The metabolic effects of tumor necrosis factor and other cytokines. Biotherapy 3:143-158
    • (1991) Biotherapy , vol.3 , pp. 143-158
    • Grunfeld, C.1    Feingold, K.R.2
  • 55
    • 0035905758 scopus 로고    scopus 로고
    • The hormone resistin links obesity to diabetes
    • Steppan CM, Bailey ST, Bhat S et al. (2001) The hormone resistin links obesity to diabetes. Nature 409:307-312
    • (2001) Nature , vol.409 , pp. 307-312
    • Steppan, C.M.1    Bailey, S.T.2    Bhat, S.3
  • 57
    • 0037241112 scopus 로고    scopus 로고
    • Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production
    • Rajala MW, Obici S, Scherer PE, Rossetti L (2003) Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. J Clin Invest 111:225-230
    • (2003) J Clin Invest , vol.111 , pp. 225-230
    • Rajala, M.W.1    Obici, S.2    Scherer, P.E.3    Rossetti, L.4
  • 58
    • 0036365870 scopus 로고    scopus 로고
    • Resistin gene expression in human adipocytes is not related to insulin resistance
    • Janke J, Engeli S, Gorzelniak K, Luft FC, Sharma AM (2002) Resistin gene expression in human adipocytes is not related to insulin resistance. Obes Res 10:1-5
    • (2002) Obes Res , vol.10 , pp. 1-5
    • Janke, J.1    Engeli, S.2    Gorzelniak, K.3    Luft, F.C.4    Sharma, A.M.5
  • 59
    • 0034806403 scopus 로고    scopus 로고
    • Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle
    • Nagaev I, Smith U (2001) Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. Biochem Biophys Res Commun 285:561-564
    • (2001) Biochem Biophys Res Commun , vol.285 , pp. 561-564
    • Nagaev, I.1    Smith, U.2
  • 60
    • 0242641149 scopus 로고    scopus 로고
    • Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists
    • Way JM, Gorgun CZ, Tong Q et al. (2001) Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. J Biol Chem 276:25651-25653
    • (2001) J Biol Chem , vol.276 , pp. 25651-25653
    • Way, J.M.1    Gorgun, C.Z.2    Tong, Q.3
  • 61
    • 0035976808 scopus 로고    scopus 로고
    • Decreased resistin expression in mice with different sensitivities to a high-fat diet
    • Le Lay S, Boucher J, Rey A et al. (2001) Decreased resistin expression in mice with different sensitivities to a high-fat diet. Biochem Biophys Res Commun 289:564-567
    • (2001) Biochem Biophys Res Commun , vol.289 , pp. 564-567
    • Le Lay, S.1    Boucher, J.2    Rey, A.3
  • 62
    • 0035930998 scopus 로고    scopus 로고
    • Suppressed gene expression of adipocyte resistin in an insulin-resistant rat model probably by elevated free fatty acids
    • Juan CC, Au LC, Fang VS et al. (2001) Suppressed gene expression of adipocyte resistin in an insulin-resistant rat model probably by elevated free fatty acids. Biochem Biophys Res Commun 289:1328-1333
    • (2001) Biochem Biophys Res Commun , vol.289 , pp. 1328-1333
    • Juan, C.C.1    Au, L.C.2    Fang, V.S.3
  • 63
    • 0037540732 scopus 로고    scopus 로고
    • Resistin and adiponectin expression in visceral fat of obese rats: Effect of weight loss
    • Milan G, Granzotto M, Scarda A et al. (2002) Resistin and adiponectin expression in visceral fat of obese rats: effect of weight loss. Obes Res 10:1095-1103
    • (2002) Obes Res , vol.10 , pp. 1095-1103
    • Milan, G.1    Granzotto, M.2    Scarda, A.3
  • 64
    • 0036708118 scopus 로고    scopus 로고
    • Expression of resistin in the adipose tissue is modulated by various factors including peroxisome proliferator-activated receptor alpha
    • Fukui Y, Motojima K (2002) Expression of resistin in the adipose tissue is modulated by various factors including peroxisome proliferator-activated receptor alpha. Diabetes Obes Metab 4:342-345
    • (2002) Diabetes Obes Metab , vol.4 , pp. 342-345
    • Fukui, Y.1    Motojima, K.2
  • 65
    • 0036267020 scopus 로고    scopus 로고
    • Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells
    • Shojima N, Sakoda H, Ogihara T et al. (2002) Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells. Diabetes 51:1737-1744
    • (2002) Diabetes , vol.51 , pp. 1737-1744
    • Shojima, N.1    Sakoda, H.2    Ogihara, T.3
  • 66
    • 0035914057 scopus 로고    scopus 로고
    • Inhibition by insulin of resistin gene expression in 3T3-L1 adipocytes
    • Haugen F, Jorgensen A, Drevon CA, Trayhurn P (2001) Inhibition by insulin of resistin gene expression in 3T3-L1 adipocytes. FEBS Lett 507:105-108
    • (2001) FEBS Lett , vol.507 , pp. 105-108
    • Haugen, F.1    Jorgensen, A.2    Drevon, C.A.3    Trayhurn, P.4
  • 67
    • 0034806965 scopus 로고    scopus 로고
    • Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice
    • Moore GB, Chapman H, Holder JC et al. (2001) Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice. Biochem Biophys Res Commun 286:735-741
    • (2001) Biochem Biophys Res Commun , vol.286 , pp. 735-741
    • Moore, G.B.1    Chapman, H.2    Holder, J.C.3
  • 68
    • 0035968099 scopus 로고    scopus 로고
    • Isoproterenol inhibits resistin gene expression through a G(S)-protein-coupled pathway in 3T3-L1 adipocytes
    • Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R (2001) Isoproterenol inhibits resistin gene expression through a G(S)-protein-coupled pathway in 3T3-L1 adipocytes. FEBS Lett 500:60-63
    • (2001) FEBS Lett , vol.500 , pp. 60-63
    • Fasshauer, M.1    Klein, J.2    Neumann, S.3    Eszlinger, M.4    Paschke, R.5
  • 69
    • 0035815608 scopus 로고    scopus 로고
    • A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation
    • Kim KH, Lee K, Moon YS, Sul HS (2001) A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem 276:11252-11256
    • (2001) J Biol Chem , vol.276 , pp. 11252-11256
    • Kim, K.H.1    Lee, K.2    Moon, Y.S.3    Sul, H.S.4
  • 71
    • 0035834574 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes
    • Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R (2001) Tumor necrosis factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes. Biochem Biophys Res Commun 288:1027-1031
    • (2001) Biochem Biophys Res Commun , vol.288 , pp. 1027-1031
    • Fasshauer, M.1    Klein, J.2    Neumann, S.3    Eszlinger, M.4    Paschke, R.5
  • 72
    • 0036092925 scopus 로고    scopus 로고
    • Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats
    • Delhanty PJ, Mesotten D, McDougall F, Baxter RC (2002) Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats. Endocrinology 143:2445-2448
    • (2002) Endocrinology , vol.143 , pp. 2445-2448
    • Delhanty, P.J.1    Mesotten, D.2    McDougall, F.3    Baxter, R.C.4
  • 73
    • 0029980285 scopus 로고    scopus 로고
    • cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1)
    • Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K (1996) cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 221:286-289
    • (1996) Biochem Biophys Res Commun , vol.221 , pp. 286-289
    • Maeda, K.1    Okubo, K.2    Shimomura, I.3    Funahashi, T.4    Matsuzawa, Y.5    Matsubara, K.6
  • 74
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF (1995) A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270:26746-26749
    • (1995) J Biol Chem , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.F.5
  • 75
    • 17544382289 scopus 로고    scopus 로고
    • AdipoQ is a novel adipose-specific gene dysregulated in obesity
    • Hu E, Liang P, Spiegelman BM (1996) AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 271:10697-10703
    • (1996) J Biol Chem , vol.271 , pp. 10697-10703
    • Hu, E.1    Liang, P.2    Spiegelman, B.M.3
  • 76
    • 0029836585 scopus 로고    scopus 로고
    • Isolation and characterization of GBP28, a novel gelatin-binding protein
    • Tokyo
    • Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M (1996) Isolation and characterization of GBP28, a novel gelatin-binding protein. J Biochem (Tokyo) 120:803-812
    • (1996) J Biochem , vol.120 , pp. 803-812
    • Nakano, Y.1    Tobe, T.2    Choi-Miura, N.H.3    Mazda, T.4    Tomita, M.5
  • 77
    • 0035852760 scopus 로고    scopus 로고
    • Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    • Fruebis J, Tsao TS, Javorschi S et al. (2001) Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 98:2005-2010
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 2005-2010
    • Fruebis, J.1    Tsao, T.S.2    Javorschi, S.3
  • 78
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T, Kamon J, Waki H et al. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941-946
    • (2001) Nat Med , vol.7 , pp. 941-946
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3
  • 79
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • Yamauchi T, Kamon J, Minokoshi Y et al. (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8:1288-1295
    • (2002) Nat Med , vol.8 , pp. 1288-1295
    • Yamauchi, T.1    Kamon, J.2    Minokoshi, Y.3
  • 80
    • 0037059013 scopus 로고    scopus 로고
    • Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation
    • Tomas E, Tsao TS, Saha AK et al. (2002) Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci USA 99:16309-16313
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 16309-16313
    • Tomas, E.1    Tsao, T.S.2    Saha, A.K.3
  • 81
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • Berg AH, Combs TP, Du X, Brownlee M, Scherer PE (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7:947-953
    • (2001) Nat Med , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 82
    • 0036063777 scopus 로고    scopus 로고
    • Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
    • Maeda N, Shimomura I, Kishida K et al. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8:731-737
    • (2002) Nat Med , vol.8 , pp. 731-737
    • Maeda, N.1    Shimomura, I.2    Kishida, K.3
  • 83
    • 0037135523 scopus 로고    scopus 로고
    • Disruption of adiponectin causes insulin resistance and neointimal formation
    • Kubota N, Terauchi Y, Yamauchi T et al. (2002) Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 277:25863-25866
    • (2002) J Biol Chem , vol.277 , pp. 25863-25866
    • Kubota, N.1    Terauchi, Y.2    Yamauchi, T.3
  • 84
    • 0037144394 scopus 로고    scopus 로고
    • Increased beta-oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin
    • Ma K, Cabrero A, Saha PK et al. (2002) Increased beta-oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem 277:34658-34661
    • (2002) J Biol Chem , vol.277 , pp. 34658-34661
    • Ma, K.1    Cabrero, A.2    Saha, P.K.3
  • 85
    • 0037462684 scopus 로고    scopus 로고
    • Globular adiponectin protected ob/ob mice from diabetes and apoE deficient mice from atherosclerosis
    • Yamauchi T, Kamon J, Waki H et al. (2003) Globular adiponectin protected ob/ob mice from diabetes and apoE deficient mice from atherosclerosis. J Biol Chem 278:2461-2468
    • (2003) J Biol Chem , vol.278 , pp. 2461-2468
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3
  • 86
    • 0037452139 scopus 로고    scopus 로고
    • Adiponectin and protection against type 2 diabetes mellitus
    • Spranger J, Kroke A, Mohlig M et al. (2003) Adiponectin and protection against type 2 diabetes mellitus. Lancet 361:226-228
    • (2003) Lancet , vol.361 , pp. 226-228
    • Spranger, J.1    Kroke, A.2    Mohlig, M.3
  • 87
    • 0037494960 scopus 로고    scopus 로고
    • Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
    • Yamauchi T, Kamon J, Ito Y et al. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423:762-769
    • (2003) Nature , vol.423 , pp. 762-769
    • Yamauchi, T.1    Kamon, J.2    Ito, Y.3
  • 88
    • 0034999667 scopus 로고    scopus 로고
    • Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia
    • Weyer C, Funahashi T, Tanaka S et al. (2001) Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86:1930-1935
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1930-1935
    • Weyer, C.1    Funahashi, T.2    Tanaka, S.3
  • 89
    • 0034096988 scopus 로고    scopus 로고
    • Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    • Hotta K, Funahashi T, Arita Y et al. (2000) Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20:1595-1599
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 1595-1599
    • Hotta, K.1    Funahashi, T.2    Arita, Y.3
  • 90
    • 0034891684 scopus 로고    scopus 로고
    • Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin
    • Yang WS, Lee WJ, Funahashi T et al. (2001) Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab 86:3815-3819
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3815-3819
    • Yang, W.S.1    Lee, W.J.2    Funahashi, T.3
  • 91
    • 0036785619 scopus 로고    scopus 로고
    • Adiponectin is not altered with exercise training despite enhanced insulin action
    • Hulver MW, Zheng D, Tanner CJ et al. (2002) Adiponectin is not altered with exercise training despite enhanced insulin action. Am J Physiol Endocrinol Metab 283:E861-E865
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Hulver, M.W.1    Zheng, D.2    Tanner, C.J.3
  • 92
    • 0035462629 scopus 로고    scopus 로고
    • PPAR-gamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
    • Maeda N, Takahashi M, Funahashi T et al. (2001) PPAR-gamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 50:2094-2099
    • (2001) Diabetes , vol.50 , pp. 2094-2099
    • Maeda, N.1    Takahashi, M.2    Funahashi, T.3
  • 93
    • 0036789137 scopus 로고    scopus 로고
    • The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects
    • Yu JG, Javorschi S, Hevener AL et al. (2002) The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes 51:2968-2974
    • (2002) Diabetes , vol.51 , pp. 2968-2974
    • Yu, J.G.1    Javorschi, S.2    Hevener, A.L.3
  • 94
    • 0036930844 scopus 로고    scopus 로고
    • Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: Effects of insulin and rosiglitazone
    • Motoshima H, Wu X, Sinha MK et al. (2002) Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone. J Clin Endocrinol Metab 87:5662-5667
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 5662-5667
    • Motoshima, H.1    Wu, X.2    Sinha, M.K.3
  • 95
    • 0036481709 scopus 로고    scopus 로고
    • Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients
    • Yang WS, Jeng CY, Wu TJ et al. (2002) Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients. Diabetes Care 25:376-380
    • (2002) Diabetes Care , vol.25 , pp. 376-380
    • Yang, W.S.1    Jeng, C.Y.2    Wu, T.J.3
  • 96
    • 4243645912 scopus 로고    scopus 로고
    • Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: A potential mechanism of insulin sensitization
    • Combs TP, Wagner JA, Berger J et al. (2002) Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology 143:998-1007
    • (2002) Endocrinology , vol.143 , pp. 998-1007
    • Combs, T.P.1    Wagner, J.A.2    Berger, J.3
  • 97
    • 0035955453 scopus 로고    scopus 로고
    • Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes
    • Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R (2001) Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes. FEBS Lett 507:142-146
    • (2001) FEBS Lett , vol.507 , pp. 142-146
    • Fasshauer, M.1    Klein, J.2    Neumann, S.3    Eszlinger, M.4    Paschke, R.5
  • 98
    • 0036845876 scopus 로고    scopus 로고
    • Pre- and post-translational negative effect of beta-adrenoceptor agonists on adiponectin secretion: In vitro and in vivo studies
    • Delporte ML, Funahashi T, Takahashi M, Matsuzawa Y, Brichard SM (2002) Pre-and post-translational negative effect of beta-adrenoceptor agonists on adiponectin secretion: in vitro and in vivo studies. Biochem J 367:677-685
    • (2002) Biochem J , vol.367 , pp. 677-685
    • Delporte, M.L.1    Funahashi, T.2    Takahashi, M.3    Matsuzawa, Y.4    Brichard, S.M.5
  • 99
    • 0037459090 scopus 로고    scopus 로고
    • Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes
    • Fasshauer M, Kralisch S, Klier M et al. (2003) Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun 301:1045-1050
    • (2003) Biochem Biophys Res Commun , vol.301 , pp. 1045-1050
    • Fasshauer, M.1    Kralisch, S.2    Klier, M.3
  • 100
    • 0034471789 scopus 로고    scopus 로고
    • Influences of ionomycin, dibutyryl-cycloAMP and tumour necrosis factor-alpha on intracellular amount and secretion of apM1 in differentiating primary human preadipocytes
    • Kappes A, Loffler G (2000) Influences of ionomycin, dibutyryl-cycloAMP and tumour necrosis factor-alpha on intracellular amount and secretion of apM1 in differentiating primary human preadipocytes. Horm Metab Res 32:548-554
    • (2000) Horm Metab Res , vol.32 , pp. 548-554
    • Kappes, A.1    Loffler, G.2
  • 101
    • 0036812398 scopus 로고    scopus 로고
    • Human serum adiponectin levels are not under short-term negative control by free fatty acids in vivo
    • Staiger H, Tschritter O, Kausch C, Lammers R, Stumvoll M, Haring HU (2002) Human serum adiponectin levels are not under short-term negative control by free fatty acids in vivo. Horm Metab Res 34:601-603
    • (2002) Horm Metab Res , vol.34 , pp. 601-603
    • Staiger, H.1    Tschritter, O.2    Kausch, C.3    Lammers, R.4    Stumvoll, M.5    Haring, H.U.6
  • 103
    • 0036068133 scopus 로고    scopus 로고
    • Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance
    • Bluher M, Michael MD, Peroni OD et al. (2002) Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell 3:25-38
    • (2002) Dev Cell , vol.3 , pp. 25-38
    • Bluher, M.1    Michael, M.D.2    Peroni, O.D.3
  • 104
    • 0142033704 scopus 로고    scopus 로고
    • Brown adipocytes are novel sites of expression and regulation of adiponectin and resistin
    • Viengchareun S, Zennaro MC, Pascual-Le TL, Lombes M (2002) Brown adipocytes are novel sites of expression and regulation of adiponectin and resistin. FEBS Lett 532:345-350
    • (2002) FEBS Lett , vol.532 , pp. 345-350
    • Viengchareun, S.1    Zennaro, M.C.2    Pascual-Le, T.L.3    Lombes, M.4
  • 105
    • 0035900614 scopus 로고    scopus 로고
    • Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue
    • Halleux CM, Takahashi M, Delporte ML et al. (2001) Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue. Biochem Biophys Res Commun 288:1102-1107
    • (2001) Biochem Biophys Res Commun , vol.288 , pp. 1102-1107
    • Halleux, C.M.1    Takahashi, M.2    Delporte, M.L.3
  • 106
    • 0036889009 scopus 로고    scopus 로고
    • Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA
    • Makimura H, Mizuno TM, Bergen H, Mobbs CV (2002) Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA. Am J Physiol Endocrinol Metab 283:E1266-E1271
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Makimura, H.1    Mizuno, T.M.2    Bergen, H.3    Mobbs, C.V.4
  • 107
    • 0035824440 scopus 로고    scopus 로고
    • A transgenic model of visceral obesity and the metabolic syndrome
    • Masuzaki H, Paterson J, Shinyama H et al. (2001) A transgenic model of visceral obesity and the metabolic syndrome. Science 294:2166-2170
    • (2001) Science , vol.294 , pp. 2166-2170
    • Masuzaki, H.1    Paterson, J.2    Shinyama, H.3
  • 108
    • 0036724336 scopus 로고    scopus 로고
    • Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein
    • Nishizawa H, Shimomura I, Kishida K et al. (2002) Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes 51:2734-2741
    • (2002) Diabetes , vol.51 , pp. 2734-2741
    • Nishizawa, H.1    Shimomura, I.2    Kishida, K.3
  • 110
    • 0034840521 scopus 로고    scopus 로고
    • Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: A potential mechanism for hyperinsulinaemia-associated leptin resistance
    • Kellerer M, Lammers R, Fritsche A et al. (2001) Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: a potential mechanism for hyperinsulinaemia-associated leptin resistance. Diabetologia 44:1125-1132
    • (2001) Diabetologia , vol.44 , pp. 1125-1132
    • Kellerer, M.1    Lammers, R.2    Fritsche, A.3
  • 111
    • 0036020281 scopus 로고    scopus 로고
    • Long-term food restriction prevents ageing-associated central leptin resistance in wistar rats
    • Fernandez-Galaz C, Fernandez-Agullo T, Perez C et al. (2002) Long-term food restriction prevents ageing-associated central leptin resistance in wistar rats. Diabetologia 45:997-1003
    • (2002) Diabetologia , vol.45 , pp. 997-1003
    • Fernandez-Galaz, C.1    Fernandez-Agullo, T.2    Perez, C.3
  • 113
    • 15444347751 scopus 로고    scopus 로고
    • Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat
    • Hallakou S, Doare L, Foufelle F et al. (1997) Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat. Diabetes 46:1393-1399
    • (1997) Diabetes , vol.46 , pp. 1393-1399
    • Hallakou, S.1    Doare, L.2    Foufelle, F.3
  • 114
    • 15844415080 scopus 로고    scopus 로고
    • Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice
    • Zhang B, Graziano MP, Doebber TW et al. (1996) Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice. J Biol Chem 271:9455-9459
    • (1996) J Biol Chem , vol.271 , pp. 9455-9459
    • Zhang, B.1    Graziano, M.P.2    Doebber, T.W.3
  • 115
    • 0029894050 scopus 로고    scopus 로고
    • Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes
    • Kallen CB, Lazar MA (1996) Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes. Proc Natl Acad Sci USA 93:5793-5796
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5793-5796
    • Kallen, C.B.1    Lazar, M.A.2
  • 116
    • 0000113890 scopus 로고    scopus 로고
    • Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma
    • De Vos P, Lefebvre AM, Miller SG et al. (1996) Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma. J Clin Invest 98:1004-1009
    • (1996) J Clin Invest , vol.98 , pp. 1004-1009
    • De Vos, P.1    Lefebvre, A.M.2    Miller, S.G.3
  • 117
    • 0030015246 scopus 로고    scopus 로고
    • Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice
    • Mantzoros CS, Qu D, Frederich RC, Susulic VS et al. (1996) Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes 45:909-914
    • (1996) Diabetes , vol.45 , pp. 909-914
    • Mantzoros, C.S.1    Qu, D.2    Frederich, R.C.3    Susulic, V.S.4
  • 118
    • 0029976448 scopus 로고    scopus 로고
    • Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP
    • Slieker LJ, Sloop KW, Surface PL et al. (1996) Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J Biol Chem 271:5301-5304
    • (1996) J Biol Chem , vol.271 , pp. 5301-5304
    • Slieker, L.J.1    Sloop, K.W.2    Surface, P.L.3
  • 119
    • 0030040740 scopus 로고    scopus 로고
    • Regulation of ob gene mRNA levels in cultured adipocytes
    • Rentsch J, Chiesi M (1996) Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Lett 379:55-59
    • (1996) FEBS Lett , vol.379 , pp. 55-59
    • Rentsch, J.1    Chiesi, M.2
  • 120
    • 0030601101 scopus 로고    scopus 로고
    • Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA
    • Hardie LJ, Rayner DV, Holmes S, Trayhurn P (1996) Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochem Biophys Res Commun 223:660-665
    • (1996) Biochem Biophys Res Commun , vol.223 , pp. 660-665
    • Hardie, L.J.1    Rayner, D.V.2    Holmes, S.3    Trayhurn, P.4
  • 121
    • 0029157428 scopus 로고
    • Transient increase in obese gene expression after food intake or insulin administration
    • Saladin R, De Vos P, Guerre-Millo M et al. (1995) Transient increase in obese gene expression after food intake or insulin administration. Nature 377:527-529
    • (1995) Nature , vol.377 , pp. 527-529
    • Saladin, R.1    De Vos, P.2    Guerre-Millo, M.3
  • 122
    • 0029021599 scopus 로고
    • Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake
    • De Vos P, Saladin R, Auwerx J, Staels B (1995) Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem 270:15958-15961
    • (1995) J Biol Chem , vol.270 , pp. 15958-15961
    • De Vos, P.1    Saladin, R.2    Auwerx, J.3    Staels, B.4
  • 123
    • 0036789252 scopus 로고    scopus 로고
    • Troglitazone antagonizes metabolic effects of glucocorticoids in humans: Effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin
    • Willi SM, Kennedy A, Wallace P, Ganaway E, Rogers NL, Garvey WT (2002) Troglitazone antagonizes metabolic effects of glucocorticoids in humans: effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin. Diabetes 51:2895-2902
    • (2002) Diabetes , vol.51 , pp. 2895-2902
    • Willi, S.M.1    Kennedy, A.2    Wallace, P.3    Ganaway, E.4    Rogers, N.L.5    Garvey, W.T.6
  • 124
    • 0034573603 scopus 로고    scopus 로고
    • Effects of 22K or 20K human growth hormone on lipolysis, leptin production in adipocytes in the presence and absence of human growth hormone binding protein
    • Asada N, Takahashi Y, Honjo M (2000) Effects of 22K or 20K human growth hormone on lipolysis, leptin production in adipocytes in the presence and absence of human growth hormone binding protein. Horm Res 54:203-207
    • (2000) Horm Res , vol.54 , pp. 203-207
    • Asada, N.1    Takahashi, Y.2    Honjo, M.3
  • 125
    • 0031865371 scopus 로고    scopus 로고
    • Increased levels but preserved diurnal variation of serum leptin in GH-deficient patients: Lack of impact of different modes of GH administration
    • Norrelund H, Gravholt CH, Englaro P et al. (1998) Increased levels but preserved diurnal variation of serum leptin in GH-deficient patients: lack of impact of different modes of GH administration. Eur J Endocrinol 138:644-652
    • (1998) Eur J Endocrinol , vol.138 , pp. 644-652
    • Norrelund, H.1    Gravholt, C.H.2    Englaro, P.3
  • 126
    • 0033048889 scopus 로고    scopus 로고
    • Hyperleptinaemia in young adults following cranial irradiation in childhood: Growth hormone deficiency or leptin insensitivity?
    • Oxf
    • Brennan BM, Rahim A, Blum WF, Adams JA, Eden OB, Shalet SM (1999) Hyperleptinaemia in young adults following cranial irradiation in childhood: growth hormone deficiency or leptin insensitivity? Clin Endocrinol (Oxf) 50:163-169
    • (1999) Clin Endocrinol , vol.50 , pp. 163-169
    • Brennan, B.M.1    Rahim, A.2    Blum, W.F.3    Adams, J.A.4    Eden, O.B.5    Shalet, S.M.6
  • 127
    • 0031796402 scopus 로고    scopus 로고
    • Effect of growth hormone (GH) on serum concentrations of leptin: Study in patients with acromegaly and GH deficiency
    • Miyakawa M, Tsushima T, Murakami H, Isozaki O, Demura H, Tanaka T (1998) Effect of growth hormone (GH) on serum concentrations of leptin: study in patients with acromegaly and GH deficiency. J Clin Endocrinol Metab 83:3476-3479
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3476-3479
    • Miyakawa, M.1    Tsushima, T.2    Murakami, H.3    Isozaki, O.4    Demura, H.5    Tanaka, T.6
  • 128
    • 0034457292 scopus 로고    scopus 로고
    • Serum leptin levels in patients with acromegaly before and after correction of hypersomatotropism by transsphenoidal surgery
    • Damjanovic SS, Petakov MS, Raicevic S et al. (2000) Serum leptin levels in patients with acromegaly before and after correction of hypersomatotropism by transsphenoidal surgery. J Clin Endocrinol Metab 85:147-154
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 147-154
    • Damjanovic, S.S.1    Petakov, M.S.2    Raicevic, S.3


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