Human breast adipocytes express interleukin-6 (IL-6) and its receptor system: Increased IL-6 production by β-adrenergic activation and effects of IL-6 on adipocyte function

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 5, 2001, Pages 2281-2288

  Päth, Günter ^a   Bornstein, Stefan R ^b   Gurniak, Matthias ^a   Chrousos, George P ^b   Scherbaum, Werner A ^a   Hauner, Hans ^a  

^a LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; GLUCOCORTICOID; GLYCEROL; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; GLYCOPROTEIN GP 130; HYDROCORTISONE; INSULIN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; ISOPRENALINE;

ADIPOCYTE; ARTICLE; AUTOCRINE EFFECT; BETA ADRENERGIC STIMULATION; BREAST; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIPOLYSIS; PARACRINE SIGNALING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOCYTES; ADULT; ANTIGENS, CD; BREAST; CYTOKINE RECEPTOR GP130; FEMALE; HUMANS; HYDROCORTISONE; INTERLEUKIN-6; LIPOLYSIS; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, INTERLEUKIN-6; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0035016791     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.86.5.2281     Document Type: Article

References (42)

1. Mohamed-Ali V, Pinkney JH, Coppack SW. 1998 Adipose tissue as an endocrine and paracrine organ. Int J Obes Relat Metab Disord. 22:1145-1158.
2. Purohit A, Gilchik MW, Duncan L, et al. 1995 Aromatase activity and interleukin-6 production by normal and malignant breast tissues. J Clin Endocrinol Metab. 80:3052-3058.
3. Mohamed-Ali V, Goodbrick S, Rawesh A, et al. 1997 Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo. J Clin Endocrinol Metab. 82:4196-4200.
4. Fried SK, Bunkin DA, Greenberg AS. 1998 Omental and subcutaneous adipose tissue of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab. 83:847-850.
5. Orban Z, Remaley AT, Sampson M, Trajanoski Z, Chrousos GP. 1999 The differential effect of food intake and beta-adrenergic stimulation on adipose-derived hormones and cytokines in man. J Clin Endocrinol Metab. 84:2126-2133.
6. Hirano T. 1998 Interleukin-6 and its receptor: ten years later. Int Rev Immunol. 16:249-284.
7. Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP. 1998 The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med. 128:127-137.
8. Vgontzas AN, Papanicolaou DA, Bixler EO, Kales A, Tyson K, Chrousos GP. 1997 Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity. J Clin Endocrinol Metab. 82:1313-1316.
9. Coppack SW, Jensen MD, Miles JM. 1994 In vivo regulation of lipolysis in humans. J Lipid Res. 35:177-193.
10. Greenberg AS, Nordan RP, McIntosh J, Calvo JC, Scow RO, Jablons D. 1992 Interleukin-6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3T3-L1 adipocytes: a possible role for interleukin-6 in cancer cachexia. Cancer Res. 52:4113-4116.
11. Fried SK, Russell CD, Grauso NL, Brolin RE. 1993 Lipoprotein lipase regulation by insulin and glucocorticoids in subcutaneous and omental tissues of obese women and men. J Clin Invest. 92:2191-2198.
12. Berg M, Fraker DL, Alexander HR. 1994 Characterization of differentiation of factor/leukaemia inhibitory factor effect on lipoprotein lipase activity and mRNA in 3T3-L1 adipocytes, Cytokine. 6:425-432.
13. Papanicolaou DA, Petrides JS, Tsigos C, et al. 1996 Exercise stimulates interleukin-6 secretion: Inhibition by glucocorticoids and correlations with catecholamines, Am J Physiol. 34:E601-E605.
14. Helfgott DC, May LT, Sthoeger Z, Tamm I, Sehgal PB. 1987 Bacterial lipopolysaccharide (endotoxin) enhances expression and secretion of Interferon by human fibroblasts. J Exp Med. 166:1300-1309.
15. Kohase M, Henriksen-Destefano D, Sehgal PB, Vilcek J. 1987 Dexamethasone inhibits feedback regulation of the mitogenic activity of tumor necrosis factor, interleukin-1, and epidermal growth factor in human fibroblasts. J Cell Physiol. 132:271-278.
16. Rock CS, Coyle SM, Keogh CV, et al. 1992 Influence of hypercortisolemia on the acute-phase protein response to endotoxin in humans. Surgery. 112:467-474.
17. Breuninger LM, Dempsey WL, Uhl J, Murasko DM. 1993 Hydrocortisone regulation of interleukin-6 protein production by a purified population of human peripheral blood monocytes. Clin Immunol Immunopathol. 69:205-214.
18. Zhou D, Kusnecov AW, Shurin MR, DePaoli M, Rabin BS. 1993 Exposure to physical and psychological Stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis. Endocrinology. 133:2523-2530.
19. Takaki A, Huang QH, Somogyvari-Vigh A, Arimura A. 1994 Immobilization stress may increase plasma interleukin-6 via central and peripheral catecholamines. Neuroimmunomodulation. 1:335-342.
20. DeRijk RH, Boelen A, Tilders FJH, Berkenbosch F. 1994 Induction of plasma interleukin-6 by circulating adrenaline in the rat. Psychoneuroendocrinology. 19:155-163.
21. Burysek L, Houstek J. 1997 β-Adrenergic stimulation of interleukin-1α and interleukin-6 expression in mouse brown adipocytes. FEBS Lett. 411:83-86.
22. Feingold KR, Grunfeld C. 1992 Role of cytokines in inducing hyperlipidaemia. Diabetes. 41(Suppl 2):97-101.
23. Nonogaki K, Fuller GM, Fuentes NL, et al, 1995 Interleukin-6 stimulates hepatic triglyceride secretion in rats. Endocrinology. 136:2143-2149.
24. Strassmann G, Fong M, Kennedy JS, Jacob CO, 1992 Evidence for the involvement of interleukin-6 in experimental cancer cachexia. J Clin Invest. 89:1681-1684.
25. Hauner H, Entenmann G, Wabitsch M, et al. 1989 Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in chemically defined medium. J Clin Invest. 84:1663-1670.
26. Platzer C, Ode-Hakim S, Reinke P, Docke WD, Ewert R, Volk HD. 1994 Quantitative PCR analysis of cytokine transcription patterns in peripheral mononuclear cells after anti-CD3 rejection therapy using two novel multispecific competitor fragments. Transplantation. 58:264-268.
27. Tada M, Diserens AC, Desbaillets I, de Tribolet N. 1994 Analysis of cytokine receptor messenger RNA expression in human glioblastoma cells and normal astrocytes by reverse-transcription polymerase chain reaction. J Neurosurg. 80:1063-73.
28. Shimon I, Yan X, Ray DW, Melmed S. 1997 Cytokine-dependent gp130 receptor subunit regulates human fetal pituitary adrenocorticotropin hormone and growth hormone secretion. J Clin Invest. 15:357-363.
29. Pairault J, Green H. 1979 A study of the adipose conversion of suspended 3T3 cells by using glycerophosphate dehydrogenase as differentiation marker. Proc Natl Acad Sci USA, 76:5138-5142.
30. Hellmer J, Amer P, Lundin A. 1989 Automatic luminometric kinetic assay of glycerol for lipolysis studies. Anal Biochem. 177:132-137.
31. Ailhaud G, Hauner H. 1998 Development of white adipose tissue. In: Bray GA, Bouchard C, James WP, eds. Handbook of obesity. New York: Marcel Dekker; 359-378.
32. Crichton MB, Nichols JE, Zhao Y, Bulun SE, Simpson ER. 1996 Expression of transcripts of interleukin-6 and related cytokines by human breast tumor cells, breast cancer cells, and adipose stromal cells. Mol Cell Endocrinol. 118:215-220.
33. Clarke DK, Mohamed-Ali V. The role of interleukin-6 in energy storage and adipogenesis [Abstract]. Proc of the 82nd Annual Meet of The Endocrine Soc. 2000; 1213.
34. Path G, Bomstein SR, Ehrhart-Bomstein M, Scherbaum WA. 1997 Interleukin-6 and the interleukin-6 receptor in the human adrenal gland: expression and effects on steroidogenesis. J Clin Endocrinol Metab. 82:2343-2349.
35. Stouthard JM, Oude Elferink RP, Sauerwein HP. 1996 Interleukin-6 enhances glucose transport in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 220:241-245.
36. Hauner H, Röhrig K, Spelleken M, Liu LS, Eckel J. 1998 Development of insulin-responsive glucose uptake and GLUT4 expression in differentiating human adipocyte precursor cells, Int J Obes Relat Metab Disord. 22:448-453.
37. Lafontan M, Berlan M, 1993 Fat cell adrenergic receptors and the control of white and brown fat cell function. J Lipid Res. 34:1057-1091.
38. Ray A, Sassone-Corsl P, Sehgal PB. 1989 A multiple cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation. Mol Cell Biol. 9:5537-5547.
39. Raynolds MV, Awald PD, Gordon DF, et al. 1990 Lipoprotein lipase gene expression in rat adipocytes is regulated by isoproterenol and insulin through different mechanisms, Mol Endocrinol. 4:1416-1422.
40. Eckel RH, Jensen DR, Schlaepfer IR, Yost TJ. 1996 Tissue-specific regulation of lipoprotein lipase by isoproterenol in normal-weight humans. Am J Physiol. 271:R1280-R286.
41. Spraul M, Ravussin E, Fontvieille AM, Rising R, Larson DE, Anderson EA. 1993 Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain. J Clin Invest. 92:1730-1735.
42. Reaven GM, Lithell H, Landsberg L. 1996 Hypertension and associated metabolic abnormalities: the role of insulin resistance and the sympathoadrenal system. N Engl J Med. 334:374-381.