Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: A potential mechanism for hyperinsulinaemia-associated leptin resistance

Diabetologia

Volumn 44, Issue 9, 2001, Pages 1125-1132

  Kellerer, M ^a   Lammers, R ^a   Fritsche, A ^a   Strack, V ^a   Machicao, F ^a   Borboni, P ^c   Ullrich, A ^b   Haring H U ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Insulin; Insulin receptor; Insulin secretion; Janus kinase; Leptin; Leptin receptor

Indexed keywords

INSULIN; JANUS KINASE; LEPTIN RECEPTOR;

ARTICLE; CELL CULTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYPERINSULINEMIA; INSULIN RELEASE; INSULIN RESISTANCE; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CARRIER PROTEINS; CELL LINE; DRUG RESISTANCE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EMBRYO; GENE EXPRESSION; HUMANS; HYPERINSULINISM; INSULIN; INSULINOMA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JANUS KINASE 2; KIDNEY; LEPTIN; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; RATS; RECEPTOR, INSULIN; RECEPTORS, CELL SURFACE; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034840521     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250100614     Document Type: Article

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