Reduced Folate Carrier Gene Silencing in Multiple Antifolate-resistant Tumor Cell Lines Is Due to a Simultaneous Loss of Function of Multiple Transcription Factors but Not Promoter Methylation

Journal of Biological Chemistry

Volumn 279, Issue 1, 2004, Pages 374-384

  Rothem, Lilah ^a   Stark, Michal ^a   Kaufman, Yotam ^a   Mayo, Lior ^a   Assaraf, Yehuda G ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMOTHERAPY; ONCOLOGY; TUMORS;

TRANSCRIPTION FACTORS;

HUMAN ENGINEERING;

2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; CIS ACTING ELEMENT; EDATREXATE; FOLIC ACID ANTAGONIST; N [[5 [2 (2 AMINO 4,6,7,8 TETRAHYDRO 4 OXO 1H PYRIMIDO[5,4 B][1,4]THIAZIN 6 YL)ETHYL] 2 THIENYL]CARBONYL]GLUTAMIC ACID; NALPHA (4 AMINO 4 DEOXYPTEROYL) NDELTA HEMIPHTHALOYLORNITHINE; OLIGONUCLEOTIDE; PLEVITREXED; PROTEIN C FOS; REDUCED FOLATE CARRIER; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3;

ARTICLE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; DNA SEQUENCE; E BOX ELEMENT; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; REPRESSOR GENE; TANDEM REPEAT; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

AMINO ACID SUBSTITUTION; BASE SEQUENCE; CARRIER PROTEINS; CELL LINE; CODON, TERMINATOR; DINUCLEOSIDE PHOSPHATES; DNA METHYLATION; GENE SILENCING; HUMANS; LEUKEMIA, T-CELL; MEMBRANE TRANSPORT PROTEINS; MUTATION; MUTATION, MISSENSE; OLIGODEOXYRIBONUCLEOTIDES; PROMOTER REGIONS (GENETICS); RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0347683427     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309092200     Document Type: Article

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