Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells

Journal of Biological Chemistry

Volumn 278, Issue 11, 2003, Pages 8935-8941

  Rothem, Lilah ^a   Aronheim, Ami ^a   Assaraf, Yehuda G ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG THERAPY; GENES; RNA; TUMORS;

MUTATIONS;

BIOCHEMISTRY;

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FOLIC ACID; FOLIC ACID ANTAGONIST; MESSENGER RNA; METHOTREXATE; N [[5 [2 (2 AMINO 4,6,7,8 TETRAHYDRO 4 OXO 1H PYRIMIDO[5,4 B][1,4]THIAZIN 6 YL)ETHYL] 2 THIENYL]CARBONYL]GLUTAMIC ACID; NALPHA (4 AMINO 4 DEOXYPTEROYL) NDELTA HEMIPHTHALOYLORNITHINE; PLEVITREXED; RALTITREXED; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1; CARRIER PROTEIN; CREB1 PROTEIN, HUMAN; DNA BINDING PROTEIN; ISOPROTEIN; LUCIFERASE; OLIGONUCLEOTIDE; REDUCED FOLATE CARRIER; SP3 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SP3;

ALLELE; ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; DRUG TRANSPORT; GEL MOBILITY SHIFT ASSAY; GENE ACTIVITY; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; GENETIC TRANSFECTION; HRFC GENE; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPORTER GENE; WESTERN BLOTTING; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; CELL NUCLEUS; CHEMISTRY; GENE VECTOR; GENETIC TRANSCRIPTION; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T CELL LEUKEMIA; TRANSPORT AT THE CELLULAR LEVEL;

ALLELES; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CARRIER PROTEINS; CELL DIVISION; CELL NUCLEUS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA-BINDING PROTEINS; FOLIC ACID; FOLIC ACID ANTAGONISTS; GENE SILENCING; GENES, REPORTER; GENETIC VECTORS; HUMANS; LEUKEMIA; LEUKEMIA, T-CELL; LUCIFERASES; MEMBRANE TRANSPORT PROTEINS; OLIGONUCLEOTIDES; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0038322025     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209578200     Document Type: Article

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