Nuclear inositides: Facts and perspectives

Pharmacology and Therapeutics

Volumn 101, Issue 1, 2004, Pages 47-64

  Martelli, Alberto M ^a,b   Manzoli, Lucia ^a   Cocco, Lucio ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b CNR   (Italy)

Author keywords

Diacylglycerol; Inositol phosphates; Nuclear Ca 2+; Phosphoinositide 3 kinase; Phospholipase C

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 3 [2 [4 (4,4' DIFLUOROBENZHYDRYLIDENE)PIPERIDINO]ETHYL] 2,3 DIHYDRO 2 THIOXO 4(1H) QUINAZOLINONE; 6 [2 [4 [(4 FLUOROPHENYL)PHENYLMETHYLENE] 1 PIPERIDYL]ETHYL] 7 METHYL 5H THIAZOLO[3,2 A]PYRIMIDIN 5 ONE; ALLOGRAFT INFLAMMATORY FACTOR 4; CALCIUM ION; CYCLIN D1; CYCLIN D3; CYCLIN E; DIACYLGLYCEROL; DIMETHYL SULFOXIDE; GAMMA INTERFERON; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; INOSITOL 1,4,5 TRISPHOSPHATE; INTERLEUKIN 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; PROTEIN; PROTEIN KINASE C ALPHA; RECOMBINANT PROTEIN; RETINOIC ACID; SOMATOMEDIN C; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL GROWTH; CELL NUCLEUS; CELL STRAIN; CELL STRAIN 3T3; CHROMATIN STRUCTURE; ENZYME ACTIVITY; FIBROBLAST; HEPATOMA CELL; HUMAN; IMMUNOELECTRON MICROSCOPY; LIPID METABOLISM; LUNG FIBROBLAST; MEIOSIS; MUTAGENESIS; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PHEOCHROMOCYTOMA CELL; PHOSPHOINOSITIDE METABOLISM; PHOSPHORYLATION; PRIORITY JOURNAL; REVIEW; RNA SPLICING;

EID: 0346056793     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2003.10.003     Document Type: Review

References (181)

1. Adebanjo O.A., Biswas G., Moonga B.S., Anandatheerthavarada H.K., Sun L., Bevis P.J., Sodam B.R., Lai F.A., Avadhani N.G., Zaidi M. Novel biochemical and functional insights into nuclear Ca(2+) transport through IP(3)Rs and RyRs in osteoblasts. Novel biochemical and functional insights into nuclear Ca(2+) transport through IP(3)Rs and RyRs in osteoblasts. Am J Physiol Renal Physiol. 278:2000;F784-F791.
2. Allbritton N.L., Oancea E., Kuhn M.A., Meyer T. Source of nuclear calcium signals. Proc Natl Acad Sci USA. 91:1994;12458-12462.
3. Avazeri N., Courtot A.M., Pesty A., Duquenne C., Lefevre B. Cytoplasmic and nuclear phospholipase C-β1 relocation: role in resumption of meiosis in the mouse oocyte. Mol Biol Cell. 11:2000;4369-4380.
4. Bacqueville D., Deleris P., Mendre C., Pieraggi M.T., Chap H., Guillon G., Perret B., Breton-Douillon M. Characterization of a G protein-activated phosphoinositide 3-kinase in vascular smooth muscle cell nuclei. J Biol Chem. 276:2001;22170-22176.
5. Bae S.S., Lee Y.H., Chang J.S., Galadari S.H., Kim Y.S., Ryu S.H., Suh P.G. Src homology domains of phospholipase Cγ1 inhibit nerve growth factor-induced differentiation of PC12 cells. J Neurochem. 71:1998;1781-1785.
6. Banno Y., Nakashima T., Kumada T., Ebisawa K., Nonomura Y., Nozawa Y. Effects of gelsolin on human platelet cytosolic phosphoinositide-phospholipase C isozymes. J Biol Chem. 267:1992;6488-6494.
7. Bavelloni A., Santi S., Sirri A., Riccio M., Faenza I., Zini N., Cecchi S., Ferri A., Auron P., Maraldi N.M., Marmiroli S. Phosphatidylinositol 3-kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells. J Cell Sci. 112:1999;631-640.
8. Berezney R. Regulating the mammalian genome: the role of nuclear architecture. Adv Enzyme Regul. 42:2002;39-52.
9. Bertagnolo V., Mazzoni M., Ricci D., Carini C., Neri L.M., Previati M., Capitani S. Identification of PI-PLC β1, γ1, and δ1 in rat liver: subcellular distribution and relationship to inositol lipid nuclear signalling. Cell Signal. 7:1995;669-678.
10. Bertagnolo V., Marchisio M., Capitani S., Neri L.M. Intranuclear translocation of phospholipase C β2 during HL-60 myeloid differentiation. Biochem Biophys Res Commun. 235:1997;831-837.
11. Bertagnolo V., Marchisio M., Volinia S., Caramelli E., Capitani S. Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-γ1 and phosphoinositide 3-kinase during granulocytic differentiation of HL-60 cells. FEBS Lett. 441:1998;480-484.
12. Bertagnolo V., Neri L.M., Marchisio M., Mischiati C., Capitani S. Phosphoinositide 3-kinase activity is essential for ATRA-induced granulocytic differentiation of HL-60 cells. Cancer Res. 59:1999;542-546.
13. Bertagnolo V., Marchisio M., Brugnoli F., Bavelloni A., Boccafogli L., Colamussi M.L., Capitani S. Requirement of tyrosine-phosphorylated Vav for morphological differentiation of all-trans-retinoic acid-treated HL-60 cells. Cell Growth Differ. 12:2001;193-200.
14. Bootman M.D., Thomas D., Tovey S.C., Berridge M.J., Lipp P. Nuclear calcium signalling. Cell Mol Life Sci. 57:2000;371-378.
15. Boronenkov I.V., Loijens J.C., Umeda M., Anderson R.A. Phosphoinositide pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. Mol Biol Cell. 9:1998;3547-3560.
16. Bunney T.D., Watkins P.A., Beven A.F., Shaw P.J., Hernandez L.E., Lomonossoff G.P., Shanks M., Peart J., Drobak B.K. Association of phosphatidylinositol 3-kinase with nuclear transcription sites in higher plants. Plant Cell. 12:2000;1679-1688.
17. Calcerrada M.C., Miguel B.G., Martin L., Catalan R.E., Martinez A.M. Involvement of phosphatidylinositol 3-kinase in nuclear translocation of protein kinase C ζ induced by C2-ceramide in rat hepatocytes. FEBS Lett. 514:2002;361-365.
18. Capitani S., Caramelli E., Felaco M., Miscia S., Manzoli F.A. Effect of phospholipid vesicles on endogenous RNA polymerase activity of isolated rat liver nuclei. Physiol Chem Phys. 13:1981;153-158.
19. Cenciarelli C., De Santa F., Puri P.L., Mattei E., Ricci L., Bucci F., Felsani A., Caruso M. Critical role played by cyclin D3 in the MyoD-mediated arrest of cell cycle during myoblast differentiation. Mol Cell Biol. 19:1999;5203-5217.
20. Chawla S., Hardingham G.E., Quinn D.R., Bading H. CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV. Science. 281:1998;1505-1509.
21. Chen R., Kang V.H., Chen J., Shope J.C., Torabinejad J., DeWald D.B., Prestwich G.D. A monoclonal antibody to visualize PtdIns(3,4,5)P(3) in cells. J Histochem Cytochem. 50:2002;697-708.
22. Ciruela A., Hinchliffe K.A., Divecha N., Irvine R.F. Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7. Biochem J. 346:2000;587-591.
23. Civitelli R., Kim Y.S., Gunsten S.L., Fujimori A., Huskey M., Avioli L.V., Hruska K.A. Nongenomic activation of the calcium message system by vitamin D metabolites in osteoblast-like cells. Endocrinology. 127:1990;2253-2262.
24. Clarke J.H., Letcher A.J., D'Santos C.S., Halstead J.R., Irvine R.F., Divecha N. Inositol lipids are regulated during cell cycle progression in the nuclei of murine erythroleukaemia cells. Biochem J. 357:2001;905-910.
25. Cocco L., Maraldi N.M., Manzoli F.A., Gilmour R.S., Lang A. Biochem Biophys Res Commun. 96:1980;890-898.
26. Cocco L., Gilmour R.S., Maraldi N.M., Martelli A.M., Papa S., Manzoli F.A. Increase of globin RNA synthesis induced by phosphatidylserine liposomes in isolated erythroleukemic cell nuclei. Morphological and functional features. Biol Cell. 54:1985;49-56.
27. Cocco L., Gilmour R.S., Ognibene A., Manzoli F.A., Irvine R.F. Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for phosphoinositide metabolism inside the nucleus which changes with cell differentiation. Biochem J. 248:1987;765-770.
28. Cocco L., Martelli A.M., Gilmour R.S. Inositol lipid cycle in the nucleus. Cell Signal. 6:1994;481-485.
29. Cocco L., Manzoli L., Billi A.M., Faenza I., Peruzzi D., Matteucci A., Gilmour R.S., Rhee S.G. Inositides in the nucleus: presence and characterisation of the isozymes of PLCβ family in NIH 3T3 cells. Biochim Biophys Acta. 1438:1999;295-299.
30. Cocco L., Martelli A.M., Gilmour R.S., Rhee S.G., Manzoli F.A. Nuclear phospholipase C and signaling. Biochim Biophys Acta. 1530:2001;1-14.
31. Cocco L., Martelli A.M., Barnabei O., Manzoli F.A. Nuclear inositol lipid signaling. Adv Enzyme Regul. 41:2001;361-384.
32. Cocco L., Martelli A.M., Vitale M., Falconi M., Barnabei O., Gilmour R.S., Manzoli F.A. Inositides in the nucleus: regulation of nuclear PI-PLCβ1. Adv Enzyme Regul. 42:2002;181-193.
33. Collins S. The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. Blood. 70:1987;1233-1244.
34. i. FASEB J. 11:1997;189-198.
35. Dangi S., Cha H., Shapiro P. Requirement for phosphatidylinositol-3 kinase activity during progression through S-phase and entry into mitosis. Cell Signal. 15:2003;667-675.
36. De Carcer G., Lallena M.J., Correas I. Protein 4.1 is a component of the nuclear matrix of mammalian cells. Biochem J. 312:1995;871-877.
37. Déléris P., Bacqueville D., Gayral S., Carrez L., Salles J.P., Perret P., Breton-Douillon M. SHIP-2 and PTEN are expressed and active in vascular smooth muscle cell nuclei, but only SHIP-2 is associated with nuclear speckles. J Biol Chem. 278:2003;38884-38891.
38. Dempsey E.C., Newton A.C., Mochly-Rosen D., Fields A.P., Reyland M.E., Insel P.A., Messing R.O. Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol. 279:2000;L429-L438.
39. Diakanova M., Chilov D., Arnaoutov A., Alexeyev V., Nikolsky N., Medvedeva N. Intracellular distribution of phospholipase C γ1 in cell lines with different levels of transformation. Eur J Cell Biol. 73:1997;360-367.
40. Didichenko S.A., Thelen M. Phosphatidylinositol 3-kinase C2α contains a nuclear localization sequenze and associates with nuclear speckles. J Biol Chem. 276:2001;48135-48142.
41. Divecha N., Irvine R.F. Phospholipid signalling. Cell. 80:1995;269-278.
42. Divecha N., Banfic H., Irvine R.F. The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase C to the nucleus. EMBO J. 10:1991;3207-3214.
43. Divecha N., Rhee S.G., Letcher A.J., Irvine R.F. Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform β1 is specifically, but not predominantly, located in the nucleus. Biochem J. 289:1993;617-620.
44. Divecha N., Letcher A.J., Banfic H.H., Rhee S.G., Irvine R.F. Changes in the components of a nuclear inositide cycle during differentiation in murine erythroleukaemia cells. Biochem J. 312:1995;63-67.
45. Divecha N., Clarke J.H., Roefs M., Halstead J.R., D'Santos C. Nuclear inositides: inconsistent consistencies. Cell Mol Life Sci. 57:2000;379-393.
46. Divecha N., Roefs M., Los A., Halstead J., Bannister A., D'Santos C. Type I PIPkinases interact with and are regulated by the retinoblastoma susceptibility gene product-pRB. Curr Biol. 12:2002;582-587.
47. Dowler S., Currie R.A., Campbell D.G., Deak M., Kular G., Downes C.P., Alessi D.R. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J. 351:2000;19-31.
48. Drøbak B.K., Heras B. Nuclear phosphoinositides could bring FYVE alive. Trends Plant Sci. 7:2002;132-138.
49. D'Santos C.S., Clarke J.H., Divecha N. Phospholipid signalling in the nucleus Een DAG uit het leven van de inositide signalering in de nucleus. Biochim Biophys Acta. 1436:1998;201-232.
50. Dundr M., Misteli T. Functional architecture in the cell nucleus. Biochem J. 356:2001;297-310.
51. Echevarria W., Leite M.F., Guerra M.T., Zipfel W.R., Nathanson M.H. Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nat Cell Biol. 5:2003;440-446.
52. Faenza I., Matteucci A., Manzoli L., Billi A.M., Aluigi M., Peruzzi D., Vitale M., Castorina S., Suh P.G., Cocco L. A role for nuclear phospholipase Cβ 1 in cell cycle control. J Biol Chem. 275:2000;30520-30524.
53. Faenza I., Matteucci A., Bavelloni A., Marmiroli S., Martelli A.M., Gilmour R.S., Suh P.G., Manzoli L., Cocco L. Nuclear PLCβ(1) acts as a negative regulator of p45/NF-E2 expression levels in Friend erythroleukemia cells. Biochim Biophys Acta. 1589:2002;305-310.
54. Faenza I., Bavelloni A., Fiume R., Lattanzi G., Maraldi N.M., Gilmour R.S., Martelli A.M., Suh P.G., Billi A.M., Cocco L. Up-regulation of nuclear PLCbeta1 in myogenic differentiation. J Cell Physiol. 195:2003;446-452.
55. Foster D.A., Xu L. Phospholipase D in cell proliferation and cancer. Mol Cancer Res. 1:2003;789-800.
56. Freyberg Z., Sweeney D., Siddhanta A., Bourgoin S., Frohman M., Shields D. Intracellular localization of phospholipase D1 in mammalian cells. Mol Biol Cell. 12:2001;943-955.
57. Fricker M., Hollinshead M., White N., Vaux D. Interphase nuclei of many mammalian cell types contain deep, dynamic, tubular membrane-bound invaginations of the nuclear envelope. J Cell Biol. 136:1997;531-544.
58. 2+ from the nuclear envelope. Cell. 80:1995;439-444.
59. Gillooly D.J., Morrow I.C., Lindsay M., Gould R., Bryant N.J., Gaullier J.M., Parton R.G., Stenmark H. Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO J. 19:2000;4577-4588.
60. Ginisty H., Sicard H., Roger B., Bouvet P. Structure and functions of nucleolin. J Cell Sci. 112:1999;761-772.
61. Gozani O., Karuman P., Jones D.R., Ivanov D., Cha J., Lugovskoy A.A., Baird C.L., Zhu H., Field S.J., Lessnick S.L., Villasenor J., Mehrotra B., Chen J., Rao V.R., Brugge J.S., Ferguson C.G., Payrastre B., Myszka D.G., Cantley L.C., Wagner G., Divecha N., Prestwich G.D., Yuan J. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 114:2003;99-111.
62. Gruber J.R., Desai S., Blusztajn J.K., Niles R.M. Retinoic acid specifically increases nuclear PKC α and stimulates AP-1 transcriptional activity in B16 mouse melanoma cells. Exp Cell Res. 221:1995;377-384.
63. Hardingham G.E., Chawla S., Johnson C.M., Bading H. Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression. Nature. 385:1997;260-265.
64. Hardingham G.E., Cruzalegui F.H., Chawla S., Bading H. Mechanisms controlling gene expression by nuclear calcium signals. Cell Calcium. 23:1998;131-134.
65. 2+ concentration. J Biol Chem. 270:1995;4959-4962.
66. Hinchliffe K.A., Ciruela A., Irvine R.F. PIPkins, their substrates and their products: new functions for old enzymes. Biochim Biophys Acta. 1436:1998;87-104.
67. 32P into the phospholipids of pancreas slices. J Biol Chem. 203:1953;967-977.
68. Hokin L.E., Hokin M.R. Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices. Biochim Biophys Acta. 18:1955;102-110.
69. Humbert J.P., Matter N., Artault J.C., Koppler P., Malviya A.N. Inositol 1,4,5-trisphosphate receptor is located to the inner nuclear membrane vindicating regulation of nuclear calcium signaling by inositol 1,4,5-trisphosphate. Discrete distribution of inositol phosphate receptors to inner and outer nuclear membranes. J Biol Chem. 271:1996;478-485.
70. Hutchison C.J. Lamins: building blocks or regulators of gene expression? Nat Rev Mol Cell Biol. 3:2002;848-858.
71. Kim S.J. Insulin rapidly induces nuclear translocation of PI3-kinase in HepG2 cells. Biochem Mol Biol Int. 46:1998;187-196.
72. Kim C.G., Park D., Rhee S.G. The role of carboxyl-terminal basic amino acids in the Gqα-dependent activation, particulate association, and nuclear localization of phospholipase C-β1. J Biol Chem. 271:1996;21187-21192.
73. Krugmann S., Anderson K.E., Ridley S.H., Risso N., McGregor A., Coadwell J., Davidson K., Eguinoa A., Ellson C.D., Lipp P., Manifava M., Ktistakis N., Painter G., Thuring J.W., Cooper M.A., Lim Z.Y., Holmes A.B., Dove S.K., Michell R.H., Grewal A., Nazarian A., Erdjument-Bromage H., Tempst P., Stephens L.R., Hawkins P.T. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Mol Cell. 9:2002;95-108.
74. Irvine R.F. Nuclear lipid signaling. Nat Rev Mol Cell Biol. 4:2003;1-12.
75. Itoh T., Takenawa T. Phosphoinositide-binding domains. Functional units for temporal and spatial regulation of intracellular signaling. Cell Signal. 14:2002;733-743.
76. Jamney P.A. Phosphoinositides and calcium as regulators of cellular actin assembly and disassembly. Annu Rev Physiol. 56:1994;169-191.
77. 1. Curr Biol. 9:1999;512-521.
78. Lee S.B., Rhee S.G. Molecular cloning, splice variants, expression, and purification of phospholipase C-δ 4. J Biol Chem. 271:1996;25-31.
79. Leite M.F., Thrower E.C., Echevarria W., Koulen P., Hirata K., Bennett A.M., Ehrlich B.E., Nathanson M.H. Nuclear and cytosolic calcium are regulated independently. Proc Natl Acad Sci USA. 100:2003;2975-2980.
80. Lemmon M.A., Ferguson K.M. Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem J. 350:2000;1-18.
81. Lieberherr M. Effects of vitamin D3 metabolites on cytosolic free calcium in confluent mouse osteoblasts. J Biol Chem. 262:1987;13168-13173.
82. Lipp P., Thomas D., Berridge M.J., Bootman M.D. Nuclear calcium signalling by individual cytoplasmic calcium puffs. EMBO J. 16:1997;7166-7173.
83. Litosch I. G-protein γ subunits antagonize protein kinase C-dependent phosphorylation and inhibition of phospholipase C-β1. Biochem J. 326:1997;701-707.
84. Liu N., Fukami K., Yu H., Takenawa T. A new phospholipase C δ4 is induced at S-phase of the cell cycle and appears in the nucleus. J Biol Chem. 271:1996;355-360.
85. Lu P.J., Hsu A.L., Wang D.S., Yan H.Y., Yin H.L., Chen C.S. Phosphoinositide 3-kinase in rat liver nuclei. Biochemistry. 37:1998;5738-5745.
86. Malviya A.N., Rogue P.J. "Tell me where is calcium bred": clarifying the roles of nuclear calcium. Cell. 92:1998;17-23.
87. Manzoli F.A., Muchmore J.H., Bonora B., Sabbioni A., Stefoni S. Interaction between sphingomyelin and DNA. Biochim Biophys Acta. 277:1972;251-255.
88. Manzoli F.A., Muchmore J.H., Bonora B., Capitani S., Bartoli S. Lipid-DNA interactions II. Phospholipids, glycerophospholipids, sphingosine and fatty acids. Biochim Biophys Acta. 340:1974;1-15.
89. Manzoli F.A., Maraldi N.M., Cocco L., Capitani S., Facchini A. Chromatin phospholipids in normal and chronic lymphocytic leukemia lymphocytes. Cancer Res. 37:1977;843-849.
90. Manzoli F.A., Capitani S., Maraldi N.M., Cocco L., Bernabei O. Chromatin lipids and their possible role in gene expression. A study in normal and neoplastic cells. Adv Enzyme Regul. 17:1978;175-194.
91. Manzoli L., Billi A.M., Rubbini S., Bavelloni A., Faenza I., Gilmour R.S., Rhee S.-G., Cocco L. Essential role for nuclear phospholipase C β1 in insulin-like growth factor 1-induced mitogenesis. Cancer Res. 57:1997;2137-2139.
92. Maraldi N.M., Capitani S., Caramelli E., Cocco L., Barnabei O., Manzoli F.A. Conformational changes of nuclear chromatin related to phospholipid induced modifications of the template availability. Adv Enzyme Regul. 22:1984;447-464.
93. Maraldi N.M., Zini N., Santi S., Manzoli F.A. Topology of inositol lipid signal transduction in the nucleus. J Cell Physiol. 181:1999;203-217.
94. Marchisio M., Bertagnolo V., Colamussi M.L., Capitani S., Neri L.M. Phosphatidylinositol 3-kinase in HL-60 nuclei is bound to the nuclear matrix and increases during granulocytic differentiation. Biochem Biophys Res Commun. 253:1998;346-351.
95. Martelli A.M., Gilmour R.S., Bertagnolo V., Neri L.M., Manzoli L., Cocco L. Nuclear localisation and signalling activity of phosphoinositidase C β1 in Swiss 3T3 cells. Nature. 358:1992;242-245.
96. Martelli A.M., Billi A.M., Gilmour R.S., Neri L.M., Manzoli L., Ognibene A., Cocco L. Phosphoinositide signaling in nuclei of Friend cells: phospholipase C β down-regulation is related to cell differentiation. Cancer Res. 54:1994;2536-2540.
97. Martelli A.M., Castaldi A., Manzoli L., Billi A.M., Rubbini S., Gilmour R.S., Cocco L. Inositides in nuclei of Friend cells: changes of polyphosphoinositide and diacylglycerol levels accompany cell differentiation. Cell Signal. 7:1995;53-56.
98. Martelli A.M., Bareggi R., Cocco L., Manzoli F.A. Stimulation of nuclear polyphosphoinositide synthesis by GTP-γ-S. A potential regulatory role for nuclear GTP-binding proteins. Biochem Biophys Res Commun. 218:1996;182-186.
99. Martelli A.M., Capitani S., Neri L.M. The generation of lipid signaling molecules in the nucleus. Prog Lipid Res. 38:1999;273-308.
100. Martelli A.M., Cocco L., Bareggi R., Tabelloni G., Rizzoli R., Ghibellini M.D., Narducci P. Insulin-like growth factor-I-dependent stimulation of nuclear phospholipase C-β1 activity in Swiss 3T3 cells requires an intact cytoskeleton and is paralleled by increased phosphorylation of the phospholipase. J Cell Biochem. 72:1999;339-348.
101. Martelli A.M., Tabellini G., Bortul R., Manzoli L., Bareggi R., Baldini G., Grill V., Zweyer M., Narducci P., Cocco L. Enhanced nuclear diacylglycerol kinase activity in response to a mitogenic stimulation of quiescent Swiss 3T3 cells with insulin-like growth factor-I. Cancer Res. 60:2000;815-821.
102. Martelli A.M., Billi A.M., Manzoli L., Faenza I., Aluigi M., Falconi M., De Pol A., Gilmour R.S., Cocco L. Insulin selectively stimulates nuclear phosphoinositide-specific phospholipase C (PI-PLC) β1 activity through a mitogen-activated protein (MAP) kinase-dependent serine phosphorylation. FEBS Lett. 486:2000;230-236.
103. Martelli A.M., Borgatti P., Bortul R., Manfredini M., Massari L., Capitani S., Neri L.M. Phosphatidylinositol 3-kinase translocates to the nucleus of osteoblast-like MC3T3-E1 cells in response to insulin-like growth factor I and platelet-derived growth factor but not to the proapoptotic cytokine tumor necrosis factor α J Bone Miner Res. 15:2000;1716-1730.
104. Martelli A.M., Bortul R., Tabellini G., Aluigi M., Peruzzi D., Bareggi R., Narducci P., Cocco L. Re-examination of the mechanisms regulating nuclear inositol lipid metabolism. FEBS Lett. 505:2001;1-6.
105. Martelli A.M., Bortul R., Tabellini G., Bareggi R., Manzoli L., Narducci P., Cocco L. Diacylglycerol kinases in nuclear-lipid-dependent signal transduction pathways. Cell Mol Life Sci. 59:2002;1129-1137.
106. Martelli A.M., Manzoli L., Faenza I., Bortul R., Billi A.M., Cocco L. Nuclear inositol lipid signaling and its potential involvement in neoplastic transformation. Biochim Biophys Acta. 1603:2002;11-17.
107. Martelli A.M., Falcieri E., Zweyer M., Bortul R., Tabellini G., Cappellini A., Cocco L., Manzoli L. The controversial nuclear matrix: a balanced point of view. Histol Histopathol. 17:2002;1193-1205.
108. Martelli A.M., Tabellini G., Borgatti R., Bortul R., Capitani S., Neri L.M. Nuclear lipids: new functions for old molecules? J Cell Biochem. 88:2003;455-461.
109. Matteucci A., Faenza I., Gilmour R.S., Manzoli L., Billi A.M., Peruzzi D., Bavelloni A., Rhee S.-G., Cocco L. Nuclear but not cytoplasmic phospholipase C β1 inhibits differentiation of erythroleukemia cells. Cancer Res. 58:1998;5057-5060.
110. Mazzotti G., Zini N., Rizzi E., Rizzoli R., Galanti A., Ognibene A., Santi S., Matteucci A., Martelli A.M., Maraldi N.M. Immunocytochemical detection of phosphatidylinositol 4.5-bisphosphate localization sites within the nucleus. J Histochem Cytochem. 43:1995;181-191.
111. Metjian A., Roll R.L., Ma A.D., Abrams C.S. Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gβγ- dependent pathway that requires the p110γ amino terminus. J Biol Chem. 274:1999;27943-27947.
112. 1 phase. Biochem Biophys Res Commun. 222:1996;95-100.
113. Nalaskowski M.M., Deschermeier C., Fanick W., Mayr G.W. The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. Biochem J. 366:2002;549-556.
114. Neri L.M., Ricci D., Carini C., Marchisio M., Capitani S., Bertagnolo V. Changes of nuclear PI-PLC γ1 during rat liver regeneration. Cell Signal. 9:1997;353-362.
115. Neri L.M., Borgatti P., Capitani S., Martelli A.M. Nuclear diacylglycerol produced by phosphoinositide-specific phospholipase C is responsible for nuclear translocation of protein kinase C-α J Biol Chem. 273:1998;29738-29741.
116. Neri L.M., Martelli A.M., Colamussi M.L., Borgatti P., Marchisio M., Capitani S. Increase in nuclear phosphatidylinositol 3-kinase activity and phosphatidylinositol (3,4,5) trisphosphate synthesis precede PKC-δ translocation to the nucleus of NGF-treated PC12 cells. FASEB J. 13:1999;2299-2310.
117. Neri L.M., Marchisio M., Colamussi M.L., Bertagnolo V. Monocytic differentiation of HL-60 cells is characterized by the nuclear translocation of phosphatidylinositol 3-kinase and of definite phosphatidylinositol-specific phospholipase C isoforms. Biochem Biophys Res Commun. 259:1999;314-320.
118. Neri L.M., Borgatti P., Capitani S., Martelli A.M. The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system. Biochim Biophys Acta. 1584:2002;73-80.
119. Neri L.M., Bortul R., Borgatti P., Tabellini G., Baldini G., Capitani S., Martelli A.M. Proliferating or differentiating stimuli act on different lipid-dependent signaling pathways in nuclei of human leukemia cells. Mol Biol Cell. 13:2002;947-964.
120. Neri L.M., Bortul R., Tabellini G., Borgatti P., Baldini G., Celeghini C., Capitani S., Martelli A.M. Erythropoietin-induced erythroid differentiation of K562 cells is accompanied by the nuclear translocation of phosphatidylinositol 3-kinase and intranuclear generation of phosphatidylinositol (3,4,5) trisphosphate. Cell Signal. 14:2002;21-29.
121. Nickerson J. Experimental observations of a nuclear matrix. J Cell Sci. 114:2001;463-474.
122. Odom A.R., Stahlberg A., Wente S.R., York J.D. A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. Science. 287:2000;2026-2029.
123. Onoda K., Yin H.L. gCap39 is phosphorylated. Stimulation by okadaic acid and preferential association with nuclei. J Biol Chem. 268:1993;4106-4112.
124. Osborne S.L., Thomas C.L., Gschmeissner S., Schiavo G. Nuclear PtdIns(4,5)P2 assembles in a mitotically regulated particle involved in pre-mRNA splicing. J Cell Sci. 114:2001;2501-2511.
125. Payrastre B., Missy K., Giuriato S., Bodin S., Plantavid M., Gratacap M. Phosphoinositides: key players in cell signalling, in time and space. Cell Signal. 13:2001;377-387.
126. Pederson T. Half a century of "the nuclear matrix" Mol Biol Cell. 11:2000;799-805.
127. Pendaries C., Tronchère H., Plantavid M., Payrastre B. Phosphoinositide signaling disorders in human diseases. FEBS Lett. 2003;. (in press).
128. 2+ stores. Science. 273:1996;1875-1877.
129. Prestwich G.D., Chen R., Feng L., Ozaki S., Ferguson C.G., Drees B.E., Neklason D.A., Mostert C.G., Porter-Gill P.A., Kang V.H., Shope J.C., Neilsen P.O., Dewald D.B. In situ detection of phospholipid and phosphoinositide metabolism. Adv Enzyme Regul. 42:2002;19-38.
130. Pusl T., Wu J.J., Zimmerman T.L., Zhang L., Ehrlich B.E., Berchtold M.W., Hoek J.B., Karpen S.J., Nathanson M.H., Bennett A.M. Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium. J Biol Chem. 277:2002;27517-27527.
131. Rando O.J., Zhao K., Janmey P., Crabtree G.R. Phosphatidylinositol- dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex. Proc Natl Acad Sci USA. 99:2002;2824-2829.
132. Rebecchi M.J., Pentyala S.N. Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol Rev. 80:2000;1291-1335.
133. Rhee S.G. Regulation of phosphoinositide-specific phospholipase C. Annu Rev Biochem. 70:2001;281-312.
134. Rose H.G., Frenster J.H. Composition and metabolism of lipids within repressed and active chromatin of interphase lymphocytes. Biochim Biophys Acta. 106:1965;577-591.
135. Ryu S.H., Kim U.H., Wahl M.I., Brown A.B., Carpenter G., Huang K.P., Rhee S.G. Feedback regulation of phospholipase C-β by protein kinase C. J Biol Chem. 265:1990;17941-17945.
136. Schmalz D., Kalkbrenner F., Hucho F., Buchner K. Transport of protein kinase C α into the nucleus requires intact cytoskeleton while the transport of a protein containing a canonical nuclear localization signal does not. J Cell Sci. 109:1996;2401-2406.
137. Schmalz D., Hucho F., Buchner K. Nuclear import of protein kinase C occurs by a mechanism distinct from the mechanism used by proteins with a classical nuclear localization signal. J Cell Sci. 111:1998;1823-1830.
138. Shen X., Xiao H., Ranallo R., Wu W.-H., Wu C. Modulation of ATP-dependent chromatin-remodeling complexes by inositol phosphates. Science. 299:2003;112-114.
139. Shumaker D.K., Kuczmarski E.R., Goldman R.D. The nucleoskeleton: lamins and actin are major players in essential nuclear functions. Curr Opin Cell Biol. 15:2003;358-366.
140. Sindic A., Aleksandrova A., Fields A.P., Volinia S., Banfic H. Presence and activation of nuclear phosphoinositide 3-kinase C2β during compensatory liver growth. J Biol Chem. 276:2001;17754-17761.
141. Skare P., Karlsson R. Evidence for two interaction regions for phosphatidylinositol(4,5)-bisphosphate on mammalian profilin I. FEBS Lett. 522:2002;119-124.
142. Skare P., Kreivi J.P., Bergstrom A., Karlsson R. Profilin I colocalizes with speckles and Cajal bodies: a possible role in pre-mRNA splicing. Exp Cell Res. 286:2003;12-21.
143. Smith C.D., Wells W.W. Phosphorylation of rat liver nuclear envelopes: II. Characterization of in vitro lipid phosphorylation. J Biol Chem. 258:1983;9368-9373.
144. Soh J.W., Weinstein I.B. Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes. J Biol Chem. 278:2003;. (in press).
145. Sorensen A.M., Baran D.T. 1α,25-Dihydroxyvitamin D3 rapidly alters phospholipids metabolism in the nuclear envelope of osteoblasts. J Cell Biochem. 58:1995;15-21.
146. Steger D.J., Haswell E.S., Milelr A.L., Wente S.R., O'Shea E.K. Regulation of chromatin remodelling by inositol polyphosphates. Science. 299:2003;114-116.
147. 2+ store. Science. 270:1995;1835-1838.
148. 2/M phase transition. J Biol Chem. 272:1997;26313-26317.
149. Tabellini G., Bortul R., Santi S., Riccio M., Baldini G., Cappellini A., Billi A.M., Berezney R., Ruggeri A., Cocco L., Martelli A.M. Diacylglycerol kinase-θ is localized in the speckle domains of the nucleus. Exp Cell Res. 287:2003;143-154.
150. Tamiya-Koizumi K. Nuclear lipid metabolism and signaling. J Biochem. 132:2002;13-22.
151. Tanaka K., Horiguchi K., Yoshida T., Takeda M., Fujisawa H., Takeuchi K., Umeda M., Kato S., Ihara S., Nagata S., Fukui Y. Evidence that a phosphatidylinositol 3,4,5-trisphosphate-binding protein can function in nucleus. J Biol Chem. 274:1999;3919-3922.
152. Toker A. Phosphoinositides and signal transduction. Cell Mol Life Sci. 59:2002;761-779.
153. Topham M.K., Prescott S.M. Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions. J Biol Chem. 274:1999;11447-11450.
154. Topham M.K., Bunting M., Zimmerman G.A., McIntyre T.M., Blackshear P.J., Prescott S.M. Protein kinase C regulates the nuclear localization of diacylglycerol kinase-ζ Nature. 394:1998;697-700.
155. Turpin P., Hay R.T., Dargemont C. Characterization of IkappaBα nuclear import pathway. J Biol Chem. 274:1999;6804-6812.
156. Vanhaesebroeck B., Waterfield M.D. Signaling by distinct classes of phosphoinositide 3 kinases. Exp Cell Res. 253:1999;239-254.
157. Vanhaesebroeck B., Leevers S.J., Ahmadi K., Timms J., Katso R., Driscoll P.C., Woscholski R., Parker P.J., Waterfield M.D. Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem. 70:2001;535-602.
158. Vann L.R., Wooding F.B.P., Irvine R.F., Divecha N. Metabolism and possible compartmentalization of inositols lipids in isolated rat liver nuclei. Biochem J. 327:1997;569-576.
159. Ventura C., Zinellu E., Maninchedda E., Maioli M. Dynorphin B is an agonist of nuclear opioid receptors coupling nuclear protein kinase C activation to the transcription of cardiogenic genes in GTR1 embryonic stem cells. Circ Res. 92:2003;623-629.
160. Visnjic D., Crljen V., Curic J., Batinic D., Volinia S., Banfic H. The activation of nuclear phosphoinositide 3-kinase C2β in all-trans-retinoic acid-differentiated HL-60 cells. FEBS Lett. 529:2002;268-274.
161. 2/M phase of the cell cycle in HL-60 cells. Biochim Biophys Acta. 1631:2003;61-71.
162. Vitale M., Matteucci A., Manzoli L., Rodella L., Mariani A.R., Zauli G., Falconi M., Billi A.M., Martelli A.M., Gilmour R.S., Cocco L. Interleukin 2 activates nuclear phospholipase Cbeta by mitogen-activated protein
163. Vlcek S., Dechat T., Foisner R. Nuclear envelope and nuclear matrix: interactions and dynamics. Cell Mol Life Sci. 58:2001;1758-1765.
164. Watt S.A., Kular G., Fleming I.N., Downes P., Lucocq J.M. Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domains of phospholipase C δ1. Biochem J. 363:2002;657-666.
165. Xia X., Cheng A., Akinmade D., Hamburger A.W. The N-terminal 24 amino acids of the p55 gamma regulatory subunit of phosphoinositide 3-kinase binds Rb and induces cell cycle arrest. Mol Cell Biol. 23:2003;1717-1725.
166. Xu A., Suh P.G., Marmy-Conus N., Pearson R.B., Seok O.Y., Cocco L., Gilmour R.S. Phosphorylation of nuclear phospholipase C β1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor I. Mol Cell Biol. 21:2001;2981-2990.
167. Xu A., Wang Y., Xu L.Y., Gilmour R.S. Protein kinase C α-mediated negative feedback regulation is responsible for the termination of insulin-like growth factor I-induced activation of nuclear phospholipase C β1 in Swiss 3T3 cells. J Biol Chem. 276:2001;14980-14986.
168. Yamaga M., Fujii M., Kamata H., Hirata H., Yagisawa H. Phospholipase C-δ1 contains a functional nuclear export signal sequence. J Biol Chem. 274:1999;28537-28541.
169. Ye K., Hurt K.J., Wu F.Y., Fang M., Luo H.R., Hong J.J., Blackshaw S., Ferris C.D., Snyder S.H. Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. Cell. 103:2000;919-930.
170. Ye K., Aghdasi B., Luo H.R., Moriarty J.L., Wu F.Y., Hong J.L., Hurt J., Bae S.S., Suh P.-G., Snyder S.H. Phospholipase Cγ1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature. 415:2002;541-544.
171. Yin H.L., Janmey P.A. Phosphoinositide regulation of the actin cytoskeleton. Annu Rev Physiol. 65:2003;761-789.
172. Yokogawa T., Nagata S., Nishio Y., Tsutsumi T., Ihara S., Shirai R., Morita K., Umeda M., Shirai Y., Saitoh N., Fukui Y. Evidence that 3′-phosphorylated polyphosphoinositides are generated at the nuclear surface: use of immunostaining technique with monoclonal antibodies specific for PI 3,4-P(2). FEBS Lett. 473:2000;222-226.
173. York J.D., Odom A.R., Murphy R., Ives E.B., Wente S.R. A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. Science. 285:1999;96-100.
174. York J.D., Guo S., Odom A.R., Spiegelberg B.D., Stolz L.E. An expanded view of inositol signaling. Adv Enzyme Regul. 41:2001;57-71.
175. Zhang J., Banfic H., Straforini F., Tosi L., Volinia S., Rittenhouse S.E. J Biol Chem. 273:1998;14081-14084.
176. Zhao L., Brinton R.D. Vasopressin-induced cytoplasmic and nuclear calcium signaling in embryonic cortical astrocytes: dynamics of calcium and calcium-dependent kinase translocation. J Neurosci. 23:2003;4228-4239.
177. Zhao K., Wang W., Rando O.J., Xue Y., Swiderek K., Kuo A., Crabtree G.R. Rapid and phosphatidylinositol-dependent binding of the SWI-SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell. 95:1998;625-636.
178. Zhou W., Takuwa N., Kumada M., Takuwa Y. Protein kinase C-mediated bidirectional regulation of DNA synthesis, RB protein phosphorylation, and cyclin-dependent kinases in human vascular endothelial cells. J Biol Chem. 268:1993;23041-23048.
179. Zhou W., Takuwa N., Kumada M., Takuwa Y. E2F1, B-myb and selective members of cyclin/cdk subunits are targets for protein kinase C-mediated bimodal growth regulation in vascular endothelial cells. Biochem Biophys Res Commun. 199:1994;191-198.
180. Zhou G., Seibenhener M.L., Wooten M.W. Nucleolin is a protein kinase C-ζ substrate. J Biol Chem. 272:1997;31130-31137.
181. Zini N., Ognibene A., Bavelloni A., Santi S., Sabatelli P., Baldini N., Scotlandi K., Serra M., Maraldi N.M. Cytoplasmic and nuclear localization sites of phosphatidylinositol 3-kinase in human osteosarcoma sensitive and multidrug-resistant Saos-2 cells. Histochem Cell Biol. 106:1996;457-464.