Profilin I colocalizes with speckles and Cajal bodies: A possible role in pre-mRNA splicing

Experimental Cell Research

Volumn 286, Issue 1, 2003, Pages 12-21

  Skare, Petra ^a   Kreivi, Jan Peter ^b   Bergström, Åsa ^a,c   Karlsson, Roger ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c Electrum 212   (Sweden)

Author keywords

Nuclear distribution; Pre mRNA splicing; Profilin; Sm proteins

Indexed keywords

DACTINOMYCIN; MESSENGER RNA; PROFILIN; SMALL NUCLEOLAR RIBONUCLEOPROTEIN;

AFFINITY LABELING; ARTICLE; CELL LABELING; CELLULAR DISTRIBUTION; COILED BODY; CONTROLLED STUDY; FIBROBLAST; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RNA SPLICING;

EID: 0242501529     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4827(03)00102-2     Document Type: Article

References (58)

1. Scheer U., Hinssen H., Franke W.W., Jockusch B.M. Microinjection of actin-binding proteins and actin antibodies demonstrates involvement of nuclear actin in transcription of lampbrush chromosomes. Cell. 39:1984;111-122.
2. Rando O.J., Zhao K., Crabtree G.R. Searching for a function for nuclear actin. Trends Cell Biol. 10:2000;92-97.
3. Pestic-Dragovich L., Stojiljkovic L., Philimonenko A.A., Nowale G., Ke Y., Settlage R.E., Shabanowitz J., Hunt D.F., Hozak P., de Lanerolle P. A myosin I isoform in the nucleus. Science. 290:2000;337-341.
4. Andersen J.S., Lyon C.E., Fox A.H., Leung A.K., Lam Y.W., Steen H., Mann M., Lamond A.I. Directed proteomic analysis of the human nucleolus. Curr. Biol. 12:2002;1-11.
5. Zhao K., Wang W., Rando O.J., Xue Y., Swiderek K., Kuo A., Crabtree G.R. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell. 95:1998;625-636.
6. Percipalle P., Zhao J., Pope B., Weeds A., Lindberg U., Daneholt B. Actin bound to the heterogeneous nuclear ribonucleoprotein hrp36 is associated with Balbiani ring mRNA from the gene to polysomes. J. Cell Biol. 153:2001;229-236.
7. Kwiatkowski D.J., Bruns G.A. Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis. J. Biol. Chem. 263:1988;5910-5915.
8. Di Nardo A., Gareus R., Kwiatkowski D., Witke W. Alternative splicing of the mouse profilin II gene generates functionally different profilin isoforms. J. Cell Sci. 113 Pt 21:2000;3795-3803.
9. Lambrechts A., Braun A., Jonckheere V., Aszodi A., Lanier L.M., Robbens J., van Colen I., Vandekerckhove J., Fassler R., Ampe C. Profilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical properties. Mol. Cell. Biol. 20:2000;8209-8219.
10. Hu E., Chen Z., Fredrickson T., Zhu Y. Molecular cloning and characterization of profilin-3 a novel cytoskeleton-associated gene expressed in rat kidney and testes . Exp. Nephrol. 9:2001;265-274.
11. Balasubramanian M.K., Hirani B.R., Burke J.D., Gould K.L. The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis. J. Cell Biol. 125:1994;1289-1301.
12. Verheyen E.M., Cooley L. Profilin mutations disrupt multiple actin-dependent processes during Drosophila development. Development. 120:1994;717-728.
13. Witke W., Sutherland J.D., Sharpe A., Arai M., Kwiatkowski D.J. Profilin I is essential for cell survival and cell division in early mouse development. Proc. Natl. Acad. Sci. USA. 98:2001;3832-3836.
14. Cedergren-Zeppezauer E.S., Goonesekere N.C., Rozycki M.D., Myslik J.C., Dauter Z., Lindberg U., Schutt C.E. Crystallization and structure determination of bovine profilin at 2.0 A resolution. J. Mol. Biol. 240:1994;459-475.
15. Fedorov A.A., Magnus K.A., Graupe M.H., Lattman E.E., Pollard T.D., Almo S.C. X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates. Proc. Natl. Acad. Sci. USA. 91:1994;8636-8640.
16. Thorn K.S., Christensen H.E., Shigeta R., Huddler D., Shalaby L., Lindberg U., Chua N.H., Schutt C.E. The crystal structure of a major allergen from plants. Structure. 5:1997;19-32.
17. Carlsson L., Nyström L.E., Sundkvist I., Markey F., Lindberg U. Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells. J. Mol. Biol. 115:1977;465-483.
18. Schluter K., Jockusch B.M., Rothkegel M. Profilins as regulators of actin dynamics. Biochim. Biophys. Acta. 1359:1997;97-109.
19. Lassing I., Lindberg U. Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin. Nature. 314:1985;472-474.
20. Lu P.J., Shieh W.R., Rhee S.G., Yin H.L., Chen C.S. Lipid products of phosphoinositide 3-kinase bind human profilin with high affinity. Biochemistry. 35:1996;14027-14034.
21. Holt M.R., Koffer A. Cell motility proline-rich proteins promote protrusions . Trends Cell. Biol. 11:2001;38-46.
22. Buss F., Temm-Grove C., Henning S., Jockusch B.M. Distribution of profilin in fibroblasts correlates with the presence of highly dynamic actin filaments. Cell Motil. Cytoskeleton. 22:1992;51-61.
23. Mayboroda O., Schluter K., Jockusch B.M. Differential colocalization of profilin with microfilaments in PtK2 cells. Cell Motil. Cytoskeleton. 37:1997;166-177.
24. Giesemann T., Rathke-Hartlieb S., Rothkegel M., Bartsch J.W., Buchmeier S., Jockusch B.M., Jockusch H. A role for polyproline motifs in the spinal muscular atrophy protein SMN. Profilins bind to and colocalize with smn in nuclear gems. J. Biol. Chem. 274:1999;37908-37914.
25. Liu Q., Dreyfuss G. A novel nuclear structure containing the survival of motor neurons protein. EMBO J. 15:1996;3555-3565.
26. Pellizzoni L., Charroux B., Rappsilber J., Mann M., Dreyfuss G. A functional interaction between the survival motor neuron complex and RNA polymerase II. J. Cell Biol. 152:2001;75-85.
27. Will C.L., Luhrmann R. Spliceosomal UsnRNP biogenesis, structure and function. Curr. Opin. Cell. Biol. 13:2001;290-301.
28. Sleeman J.E., Lamond A.I. Newly assembled snRNPs associate with coiled bodies before speckles, suggesting a nuclear snRNP maturation pathway. Curr. Biol. 9:1999;1065-1074.
29. Zhang G., Taneja K.L., Singer R.H., Green M.R. Localization of pre-mRNA splicing in mammalian nuclei. Nature. 372:1994;809-812.
30. Hirose Y., Manley J.L. RNA polymerase II and the integration of nuclear events. Genes Dev. 14:2000;1415-1429.
31. Misteli T., Caceres J.F., Spector D.L. The dynamics of a pre-mRNA splicing factor in living cells. Nature. 387:1997;523-527.
32. Platani M., Goldberg I., Swedlow J.R., Lamond A.I. In vivo analysis of Cajal body movement, separation, and joining in live human cells. J. Cell Biol. 151:2000;1561-1574.
33. Korenbaum E., Nordberg P., Björkegren-Sjögren C., Schutt C.E., Lindberg U., Karlsson R. The role of profilin in actin polymerization and nucleotide exchange. Biochemistry. 37:1998;9274-9283.
34. Hajkova L., Nyman T., Lindberg U., Karlsson R. Effects of cross-linked profilin:beta/gamma-actin on the dynamics of the microfilament system in cultured cells. Exp. Cell. Res. 256:2000;112-121.
35. Lindberg U., Schutt C.E., Hellsten E., Tjader A.C., Hult T. The use of poly(L-proline)-Sepharose in the isolation of profilin and profilactin complexes. Biochim. Biophys. Acta. 967:1988;391-400.
36. Aspenström P., Karlsson R. Interference with myosin subfragment-1 binding by site-directed mutagenesis of actin. Eur. J. Biochem. 200:1991;35-41.
37. Lamond A.I., Konarska M.M., Sharp P.A. A mutational analysis of spliceosome assembly evidence for splice site collaboration during spliceosome formation . Genes Dev. 1:1987;532-543.
38. Song C.S., Yu J.H., Bai D.H., Hester P.Y., Kim K.H. Antibodies to the alpha-subunit of insulin receptor from eggs of immunized hens. J. Immunol. 135:1985;3354-3359.
39. Karlsson, R., Cell Motility. Doctorial thesis, Department of Cell Biology, WGI, Stockholm University, Stockholm, 1984. ISBN 91-7146-285-6.
40. Babich M., Foti L.R., Sykaluk L.L., Clark C.R. Profilin forms tetramers that bind to G-actin. Biochem. Biophys. Res. Commun. 218:1996;125-131.
41. Marchalonis J.J., Adelman M.K., Robey I.F., Schluter S.F., Edmundson A.B. Exquisite specificity and peptide epitope recognition promiscuity, properties shared by antibodies from sharks to humans. J. Mol. Recognit. 14:2001;110-121.
42. Carvalho T., Almeida F., Calapez A., Lafarga M., Berciano M.T., Carmo-Fonseca M. The spinal muscular atrophy disease gene product, SMN a link between snRNP biogenesis and the Cajal (coiled) body . J. Cell Biol. 147:1999;715-728.
43. Brahms H., Raymackers J., Union A., de Keyser F., Meheus L., Lührmann R. The C-terminalRG dipeptide repeats of the spiceosomal Sm proteins D1 and D3 contain symmetrical demethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies. J. Biol. Chem. 275:2000;17122-17129.
44. Wittenmayer N., Rothkegel M., Jockusch B.M., Schlüter K. Functional characterization of green fluorescent protein-profilin fusion proteins. Eur. J. Biochem. 267:2000;5247-5256.
45. Carlander D., Stalberg J., Larsson A. Chicken antibodies a clinical chemistry perspective . Ups. J. Med. Sci. 104:1999;179-189.
46. Carmo-Fonseca M., Pepperkok R., Carvalho M.T., Lamond A.I. Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies. J. Cell. Biol. 117:1992;1-14.
47. Dundr M., Misteli T. Functional architecture in the cell nucleus. Biochem. J. 356:2001;297-310.
48. Kang F., Purich D.L., Southwick F.S. Profilin promotes barbed-end actin filament assembly without lowering the critical concentration. J. Biol. Chem. 274:1999;36963-36972.
49. Hartwig J.H., Bokoch G.M., Carpenter C.L., Janmey P.A., Taylor L.A., Toker A., Stossel T.P. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell. 82:1995;643-653.
50. Suetsugu S., Miki H., Takenawa T. The essential role of profilin in the assembly of actin for microspike formation. EMBO J. 17:1998;6516-6526.
51. Dickinson R.B., Purich D.L. Clamped-filament elongation model for actin-based motors. Biophys. J. 82:2002;605-617.
52. Matera A.G., Frey M.R. Coiled bodies and gems janus or gemini? Am. J. Hum. Genet. 63:1998;317-321.
53. Patton J.G., Porro E.B., Galceran J., Tempst P., Nadal-Ginard B. Cloning and characterization of PSF, a novel pre-mRNA splicing factor. Genes Dev. 7:1993;393-406.
54. Charroux B., Pellizzoni L., Perkinson R.A., Yong J., Shevchenko A., Mann M., Dreyfuss G. Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. J. Cell Biol. 148:2000;1177-1186.
55. Boronenkov I.V., Loijens J.C., Umeda M., Anderson R.A. Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. Mol. Biol. Cell. 9:1998;3547-3560.
56. Osborne S.L., Thomas C.L., Gschmeissner S., Schiavo G. Nuclear PtdIns(4,5)P2 assembles in a mitotically regulated particle involved in pre-mRNA splicing. J. Cell. Sci. 114:2001;2501-2511.
57. Sotiropoulos A., Gineitis D., Copeland J., Treisman R. Signal-regulated activation of serum response factor is mediated by changes in actin dynamics. Cell. 98:1999;159-169.
58. Aplin A.E., Juliano R.L. Regulation of nucleocytoplasmic trafficking by cell adhesion receptors and the cytoskeleton. J. Cell Biol. 155:2001;187-191.