Cytoplasmic and nuclear localization sites of phosphatidylinositol 3-kinase in human osteosarcoma sensitive and multidrug-resistant Saos-2 cells

Histochemistry and Cell Biology

Volumn 106, Issue 5, 1996, Pages 457-464

  Zini, Nicoletta ^a   Ognibene, Andrea ^a   Bavelloni, Alberto ^a   Santi, Spartaco ^a   Sabatelli, Patrizia ^a   Baldini, Nicola ^a   Scotlandi, Katia ^a   Serra, Massimo ^a   Maraldi, Nadir Mario ^a  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; PHOSPHATIDYLINOSITOL 3 KINASE;

ARTICLE; CANCER CELL CULTURE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MULTIDRUG RESISTANCE; OSTEOSARCOMA; PRIORITY JOURNAL;

EID: 0029858116     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02473307     Document Type: Article

References (49)

1. Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC (1989) PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 75:167-175
2. Baldini N, Scotlandi K, Serra M, Shikita T, Zini N, Ognibene A, Santi S, Ferracini R, Maraldi NM (1995) Nuclear immunolocalization of P-glycoprotein in multidrug-resistant cell lines showing similar mechanisms of doxorubicin distribution. Eur J Cell Biol 68:226-239
3. Banfic H, Zizak M, Divecha N, Irvine RF (1993) Nuclear diacylglycerol is increased during cell proliferaiton in vivo. Biochem J 290:633-636
4. Berra E, Diaz-Meco MT, Dominguez I, Municio MM, Sanz L, Lozano J, Chapkin RS, Moscat J (1993) Protein kinase C ζ isoform is critical for mitogenic signal transduction. Cell 74:555-563
5. Berridge MJ, Irvine RF (1989) Inositol phosphates and cell signalling. Nature 341:197-204
6. 2+ concentrations in human and rat osteosarcoma cells: actions of bone resorption-stimulating hormones. Endocrinology 118:980-989
7. Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff SP (1991) Oncogenes and signal transduction. Cell 64:281-302
8. Capitani S, Bertagnolo V, Mazzoni M, Santi P, Previati M, Antonucci A, Manzoli FA (1989) Lipid phosphorylation in isolated rat liver nuclei. FEBS Lett 254:194-198
9. Carpenter CL, Duckworth BC, Auger BC, Schaffhausen BS, Cantley LC (1990) Purification and characterization of phosphoinositide 3-kinase from rat liver. J Biol Chem 265:19704-19711
10. Carter AN, Downes CP (1992) Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells. J Biol Chem 267:14563-14567
11. Cocco L, Gilmour RS, Ognibene A, Letcher J, Manzoli FA, Irvine RF (1987) Synthesis of polyphosphoinositides in nuclei of Friend cells. Biochem J 248:765-770
12. Divecha N, Banfic H, Irvine RF (1993) Inositides and the nucleus and inositides in the nucleus. Cell 74:405-407
13. Escobedo JA, Williams LT (1988) A PDGF receptor domain essential for mitogenesis but not for many other responses to PDGF. Nature 335:85-87
14. Fantl WJ, Escobedo JA, Martin GA, Turck CW, Rodario M del, McCormick F, Williams LT (1992) Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell 69:413-423
15. Fojo A, Cornwell M, Cardarelli C, Clark DP, Richer N, Shen DW, Veda K, Willingham M, Gottesman MM, Pastan I (1987) Molecular biology of drug resistance. Breast Cancer Res 9:5-16
16. Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727-736
17. Gottesman MM, Pastan I (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62:385-427
18. Irvine RF, Divecha N (1992) Phospholipids in the nucleus. Metabolism and possible functions. Semin Cell Biol 3:225-235
19. Kapeller R, Cantley LC (1994) Phosphatidylinositol 3-kinase. Bioessays 16:565-576
20. Koch CA, Anderson D, Moran MJ, Ellis C, Pawson T (1991) SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 252:668-674
21. Kucera GL, Rittenhouse SE (1990) Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin. J Biol Chem 265:5345-5348
22. Maraldi NM, Zini N, Squarzoni S, Del Coco R, Sabatelli P, Manzoli FA (1992) Intranuclear localization of phospholipids by ultrastructural cytochemistry. J Histochem Cytochem 40:1383-1392
23. Maraldi NM, Santi S, Zini N, Ognibene A, Rizzoli R, Mazzotti G, Di Primio R, Bareggi R, Bertagnolo V, Pagliarini C, Capitani S (1993a) Decrease in nuclear phospholipids associated with DNA replication. J Cell Sci 104:853-860
24. Maraldi NM, Zini N, Santi S, Bavelloni A, Valmori A, Marmiroli S, Ognibene A (1993b) Phosphoinositidase C isozymes in Saos-2 cells: immunocytochemical detection in nuclear and cytoplasmic compartments. Biol Cell 79:243-250
25. 1 in cells exposed to mitogenic or differentiating agonists. Biol Cell 83:201-210
26. 580 multidrug resistant human osteosarcoma cells. J Submicrosc Cytol Pathol 28:93-100
27. Marmiroli S, Ognibene A, Bavelloni A, Cinti C, Cocco L, Maraldi NM (1994) Interleukin-1α stimulated nuclear phosphoinositidase C in human osteosarcoma Saos-2 cells. J Biol Chem 268:13-16
28. Martelli AM, Gilmour RS, Bertagnolo V, Neri LM, Manzoli L, Cocco L (1992) Nuclear localization and signalling activity of phosphoinositidase C β in Swiss 3T3 cells. Nature 358:242-244
29. Morrow CS, Cowan KH (1993) Drug-resistance and cancer. Adv Exp Med Biol 33:287-305
30. Nakanishi H, Brewer KA, Exton JH (1993) Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 268:13-16
31. Neri LM, Milani D, Bertolaso L, Stroscio M, Bertagnolo V, Capitani S (1994) Nuclear translocation of phosphatidylinositol 3-kinase in rat pheochromocytoma PC12 cells after treatment with nerve growth factor. Cell Mol Biol 40:619-626
32. Panayotou G, Waterfield MD (1992) Phosphatidylinositol 3-kinase: a key enzyme in diverse signalling processes. Trends Cell Biol 2:358-362
33. Payrastre B, Nievers M, Boonstra J, Breton M, Verkeleij AJ, Bergen en Henegouwen PMP van (1992) A differential localization of phosphoinositide kinases, diacylglycerol kinase. and phospholipase C in the nuclear matrix. J Biol Chem 267: 5078-5084
34. Raffioni S, Bradshaw RA (1992) Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor and nerve growth factor in PC12 pheochromocytoma cells. Proc Natl Acad Sci USA 89:9121-9125
35. Reedijk M, Liu XQ, Pawson T (1990) Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor. Mol Cell Biol 10:5601-5608
36. 2 stimulation of cAMP production. J Immunol 145:1231-1237
37. Sebti SM, Jani JP, Mistry JS, Gorelik E, Lazo JS (1991) Metabolic inactivation, a mechanism of human tumour resistance to bleomycin. Cancer Res 51:227-232
38. Serra M, Scotlandi K, Manara MC, Maurici D, Lollini PL, De Giovanni C, Toffoli G, Baldini N (1993) Establishment and characterization of multidrug-resistant human osteosarcoma cell lines. Anticancer Res 13:323-330
39. Serunian LA, Haber MT, Fukui T, Kim JW, Rhee SG, Lowenstein JM, Cantley LC (1989) Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipase C from rat liver and bovine brain. J Biol Chem 264:17809-17815
40. Soltoff SP, Rabin SL, Cantley LC, Kapalan DR (1992) Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase. J Biol Chem 267:17472-17477
41. Stephens LR, Huges KT, Irvine RF (1991) Pathway of phosphatidylinositol (3,4,5)-triphosphate synthesis in activated neutrophils. Nature 351:33-39
42. Tatakis DN, Dolce C, Dziak R (1989) Thrombin's effects on osteoblastic cells. I. Cytosolic calcium and phosphoinositides. Biochem Biophys Res Commun 164:119-127
43. 2 receptors. Bone Mineral 18:1-14
44. Whitman M, Kaplan D, Roberts T, Cantley C (1987) Evidence for two distinct phosphatidylinositol kinases in fibroblasts: implications for cellular regulation. Biochem J 247:165-174
45. Yamaguchi DT, Hahn TJ, Beeker TG, Kleeman CR, Muallem S (1988) Relationship of cAMP and calcium messenger systems in prostaglandin-stimulated UMR-106 cells. J Biol Chem 263:10745-10753
46. Yu JC, Heiduran MA, Pierce JH, Gutkind JS, Lombardi D, Ruggiero M, Aaronson SA (1991) Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol 3-kinase activity without affecting mitogenic or chemotactic signal transduction. Mol Cell Biol 11:3780-3785
47. Zini N, Martelli AM, Cocco L, Manzoli FA, Maraldi NM (1993) Phosphoinositidase C isoforms are specifically localized in the nuclear matrix and cytoskeleton of Swiss 3T3 cells. Exp Cell Res 208:257-269
48. Zini N, Scotlandi K, Baldini N, Nini G, Sabatelli P, Maraldi NM (1995) Multidrug resistance (MDR) phenotype of human osteosarcoma cells evaluated by quantitative morphological and electron microscopy analyses. Biol Cell 84:195-204
49. 1 is not associated to variations of protein kinase C in multidrug-resistant Saos-2 cells. Microsc Res Tech (in press)