Phosphorylation of nuclear phospholipase C β1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor I

Molecular and Cellular Biology

Volumn 21, Issue 9, 2001, Pages 2981-2990

  Xu, A ^a   Suh, P G ^a   Marmy Conus, N ^a   Pearson, R B ^a   Oh Yong Seok, ^a   Cocco, L ^a   Gilmour, R S ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; GLYCINE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C; PHOSPHOLIPASE C BETA1; SERINE; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN TARGETING; RAT;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL NUCLEUS; ENZYME ACTIVATION; INSULIN-LIKE GROWTH FACTOR I; ISOENZYMES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MITOGENS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHOLIPASE C; PHOSPHORYLATION; SERINE; SPODOPTERA;

ANIMALIA;

EID: 0035052817     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.9.2981-2990.2001     Document Type: Article

References (58)

1. Two coexisting mechanisms for nuclear import of MAP kinase: Passive diffusion of a monomer and active transport of a dimer
2. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
3. Two forms of phospholipase C-β1 generated by alternative splicing
4. Heterotrimeric and small molecular mass GTP-binding proteins of rat brain neuronal and glial nuclei
5. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry
6. Interferon beta mediated intracellular signalling traffic in human lymphocytes
7. Nuclear localization and regulation of erk- and rsk-encoded protein kinases
8. MAP kinase pathways
9. Inositides in the nucleus: Further developments on phospholipase C beta 1 signalling during erythroid differentiation and IGF-I induced mitogenesis
10. Changes in nuclear inositol phospholipids induced in intact cells by insulin-like growth factor I
11. Rapid changes in phospholipid metabolism in the nuclei of Swiss 3T3 cells induced by treatment of the cells with insulin-like growth factor I
12. Growth factor-induced cell division is paralleled by translocation of Gi alpha to the nucleus
13. The GTP-binding protein Giα translocates to kinetochores and regulates the M-G(1) cell cycle transition of Swiss 3T3 cells
14. The G-protein G(i) regulates mitosis but not DNA synthesis in growth factor-activated fibroblasts: A role for the nuclear translocation of G(i)
15. The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase C to the nucleus
16. Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state
17. Een DAG uit het leven van de inositide signalering in de nucleus
18. A role for nuclear PLCβ1 in cell cycle control
19. Role of nuclear protein kinase C in the mitogenic response to platelet-derived growth factor
20. Protein kinase C isozyme-mediated cell cycle arrest involves induction of p21(waf1/cip1) and p27(kip1) and hypophosphorylation of the retinoblastoma protein in intestinal epithelial cells
21. Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus
22. Identification of nuclear beta II protein kinase C as a mitotic lamin kinase
23. Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits
24. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ
25. The role of carboxyl-terminal basic amino acids in Gqα-dependent activation, particulate association, and nuclear localization of phospholipase C-β1
26. Activation of phospholipase C-β2 mutants by G protein alpha q and beta gamma subunits
27. Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins
28. Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts
29. Signal transduction through MAP kinase cascades
30. Essential role for nuclear phospholipase C β1 in insulin-like growth factor I-induced mitogenesis
31. Nuclear inositol lipid cycle: A new central intermediary in signal transduction
32. Lipid-dependent nuclear signalling: Morphological and functional features
33. Stimulation of nuclear polyphosphoinositide synthesis by GTP-gamma-S: A potential regulatory role for nuclear GTP-binding proteins
34. Phosphoinositide signaling in nuclei of Friend cells: Phospholipase C β down-regulation is related to cell differentiation
35. Insulin-like growth factor-I-dependent stimulation of nuclear phospholipase C-β1 activity in Swiss 3T3 cells requires an intact cytoskeleton and is paralleled by increased phosphorylation of the phospholipase
36. Nuclear localization and signalling activity of phosphoinositidase C β1 in Swiss 3T3 cells
37. Nuclear but not cytoplasmic phospholipase C β1 inhibits differentiation of erythroleukemia cells
38. Discrete subcellular localization of phosphoinositidase C beta, gamma and delta in PC12 rat pheochromocytoma cells
39. Nuclear diacylglycerol produced by phosphoinositide-specific phospholipase C is responsible for nuclear translocation of protein kinase C-alpha
40. Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation
41. Activation of phospholipase C isozymes by G protein beta gamma subunits
42. Identification of the regulatory phosphorylation sites in pp42/mitogen- activated protein kinase (MAP kinase)
43. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
44. Monoclonal antibodies to three phospholipase C isozymes from bovine brain
45. Inositol phospholipid-specific phospholipase (C) complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products
46. A role for nuclear phosphatidylinositol-specific phospholipase C in the G2/M phase transition
47. A GTP-binding protein in rat liver nuclei serving as the specific substrate of pertussis toxin-catalyzed ADP-ribosylation
48. βII protein kinase C is required for the G2/M phase transition of cell cycle
49. Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta
50. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor
51. Insulin and insulin antagonists evoke phosphorylation of P20 at serine 157 and serine 16 respectively in rat skeletal muscle
52. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
53. Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells
54. Expression of translationally controlled tumour protein is regulated by calcium at both the transcriptional and post-transcriptional level
55. A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export
56. Molecular mechanism of the inhibition of phospholipase C beta3 by protein kinase C
57. Phosphoinositidase C isoforms are specifically localized in the nuclear matrix and cytoskeleton of Swiss 3T3 cells
58. Increase of nuclear phosphatidylinositol 4,5-bisphosphate and phospholipase C beta 1 is not associated to variations of protein kinase C in multidrug-resistant Saos-2 cells