Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML

Nucleic Acids Research

Volumn 31, Issue 18, 2003, Pages 5356-5367

  Kim, Eun Joo ^a,b,d   Park, Jong Sup ^b,c   Um, Soo Jong ^a  

^a Sejong University   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c The Catholic University of Korea College of Medicine   (South Korea)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOPLASM PROTEIN; DAXX PROTEIN; FAS ANTIGEN; GLUTATHIONE TRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; NUCLEAR PROTEIN; PROTEIN P21; PROTEIN P53; PROTEIN P73; TRICHOSTATIN A; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME INHIBITION; GENE ACTIVITY; GENE EXPRESSION; GENE INTERACTION; GENE LOCATION; GENE OVEREXPRESSION; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC REGULATION; GENETIC SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; LEUKEMOGENESIS; OLIGOMERIZATION; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TWO HYBRID SYSTEM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BINDING SITES; BINDING, COMPETITIVE; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE, TUMOR; CELL NUCLEUS; CHLORAMPHENICOL O-ACETYLTRANSFERASE; DNA-BINDING PROTEINS; ENZYME INHIBITORS; GENES, TUMOR SUPPRESSOR; GLUTATHIONE TRANSFERASE; GREEN FLUORESCENT PROTEINS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUMINESCENT PROTEINS; MICROSCOPY, CONFOCAL; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0345570517     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg741     Document Type: Article

References (49)

1. Somasundaram, K. and El-Deiry, W.S. (2000) Tumor suppressor p53: regulation and function. Front. Biosci., 5, 424-437.
2. Zhao, R., Gish, K., Murphy, M., Yin, Y., Notterman, D., Hoffman, W.H., Tom, E., Mack, D.H. and Levine, A.J. (2000) Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev., 44, 981-993.
3. Sang, B.C., Chen, J.Y., Minna, J. and Barbosa, M.S. (1994) Distinct regions of p53 have a differential role in transcriptional activation and repression functions. Oncogene, 9, 853-859.
4. Shaulian, E., Haviv, I., Shaul, Y. and Oren, M. (1995) Transcriptional repression by the C-terminal domain of p53. Oncogene, 10, 671-680.
5. Hong, T.M., Chen, J.J., Peck, K., Yang, P.C. and Wu, C.W. (2001) p53 amino acids 339-346 represent the minimal p53 repression domain. J. Biol. Chem., 276, 1510-1515.
6. Murphy, M., Ahn, J., Walker, K.K., Hoffman, W.H., Evans, R.M., Levine, A.J. and George, D.L. (1999) Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev., 13, 2490-2501.
7. Juan, L.J., Shia, W.J., Chen, M.H., Yang, W.M., Seto, E., Lin, Y.S. and Wu, C.W. (2000) Histone deacetylases specifically down-regulate p53-dependent gene activation. J. Biol. Chem., 275, 20436-20443.
8. Kim, E.J., Park, J.S. and Um S.J. (2002) Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo. J. Biol. Chem., 277, 32020-32028.
9. Kaelin, W.G., Jr (1999) The p53 gene family. Oncogene, 18, 7701-7705.
10. Lohrum, M.A. and Vousden, K.H. (2000) Regulation and activation of the p53-related proteins: same family, different rules. Trends Cell Biol., 10, 197-202.
11. Irwin, M.S. and Kaelin, W.G. (2001) p53 family update: p73 and p63 develop their own identities. Cell Death Differ., 12, 337-349.
12. Yang, A., Kaghad, M., Caput, D. and McKeon, F. (2002) On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet., 18, 90-95.
13. Thanos, C.D. and Bowie, J.U. (1999) p53 family members p63 and p73 are SAM domain-containing proteins. Protein Sci., 8, 1708-1710.
14. Yang, X., Khosravi-Far, R., Chang, H.Y. and Baltimore, D. (1997) Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell, 89, 1067-1076.
15. Chang, H.Y., Nishitoh, H., Yang, X., Ichijo, H. and Baltimore, D. (1998) Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science, 281, 1860-1863.
16. Charette, S.J., Lavoie, J.N., Lambert, H. and Landry, J. (2000) Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol. Cell. Biol., 20, 7602-7612.
17. Charette, S.J., Lambert, H. and Landry, J. (2001) A kinase-independent function of Ask1 in caspase-independent cell death. J. Biol. Chem., 276, 36071-36074.
18. Ko, Y.G., Kang, Y.S., Park, H., Seol, W., Kim, J., Kim, T., Park, H.S., Choi, E.J. and Kim, S. (2001) Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm. J. Biol. Chem., 276, 39103-39106.
19. Hollenbach, A.D., Sublett, J.E., McPherson, C.J. and Grosveld, G. (1999) The Pax3-FKER oncoprotein is unresponsive to the Pax3-associated repressor hDaxx. EMBO J, 18, 3702-3711.
20. Li, H., Leo, C., Zhu, J., Wu, X., O'Neil, J., Park, E.J. and Chen, J.D. (2000) Sequestration and inhibition of Daxx-mediated transcriptional repression by PML. Mol. Cell. Biol., 20, 1784-1796.
21. Li, R., Pei, H., Watson, D.K. and Papas, T.S. (2000) EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes. Oncogene, 19, 745-753.
22. Emelyanov, A.V., Kovac, C.R., Sepulveda, M.A. and Birshteins B.K. (2002) The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells. J. Biol. Chem., 277, 11156-11164.
23. Michaelson, J.S., Bader, D., Kuo, F., Kozak, C. and Leder, P. (1999) Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development. Genes Dev., 13, 1918-1923.
24. Michaelson, J.S. and Leder, P. (2003) RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX J. Cell Sci., 116, 345-352.
25. Ishov, A.M., Sotnikov, A.G., Negorev, D., Vladimirova, O.V., Neff, N., Kamitani, T., Yeh, E.T., Strauss, J.F., III and Maul, G.G. (1999) PML is critical for ND10 formation and recruits the PML-interacting protein Daxx to this nuclear structure when modified by SUMO-1. J. Cell Biol., 147, 221-234.
26. Zhong, S., Salomoni, P., Ronchetti, S., Guo, A., Ruggero, D. and Pandolfi, P.P. (2000) Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J. Exp. Med., 191, 631-640.
27. Hollenbach, A.D., McPherson, C.J., Mientjes, E.J., Iyengar, R. and Grosveld, G. (2002) Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. J. Cell Sci., 115, 3319-3330.
28. Lehembre, F., Muller, S., Pandolfi, P.P. and Dejean, A. (2001) Regulation of Pax3 transcriptional activity by SUMO-1-modified PML. Oncogene, 20, 1-9.
29. Lin, D.Y. and Shih, H.M. (2002) Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration. J. Biol. Chem., 277, 25446-25456.
30. Guo, A., Salomoni, P., Luo, J., Shih, A., Zhong, S., Gu, W. and Pandolfi, P.P. (2000) The function of PML in p53-dependent apoptosis. Nature Cell Biol., 2, 730-736.
31. Fogal, V., Gostissa, M., Sandy, P., Zacchi, P., Sternsdorf, T., Jensen, K., Pandolfi, P.P., Will, H., Schneider, C. and Del Sal G. (2000) Regulation of p53 activity in nuclear bodies by a specific PML isoform. EMBO J., 19, 6185-6195.
32. Salomoni, P. and Pandolfi, P.P. (2002) The role of PML in tumor suppression. Cell, 108, 165-170.
33. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
34. Pluta, A.F., Earnshaw, W.C. and Goldberg, I.G. (1998) Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death. J. Cell Sci., 111, 2029-2041.
35. Pearson, M. and Pelicci, P.G. (2001) PML interaction with p53 and its role in apoptosis and replicative senescence. Oncogene, 20, 7250-7256.
36. Everett, R.D. (2001) DNA viruses and viral proteins that interact with PML nuclear bodies. Oncogene, 20, 7266-7273.
37. Borden, K.L. (2002) Pondering the promyelocytic leukemia protein (PML) puzzle: possible functions for PML nuclear bodies. Mol. Cell. Biol., 22, 5259-5269.
38. LaMorte, V.J., Dyck, J.A., Ochs, R.L. and Evans, R.M. (1998) Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body. Proc. Natl Acad. Sci. USA, 95, 4991-4996.
39. vonMikecz, A., Zhang, S., Montminy, M., Tan, E.M. and Hemmerich, P. (2000) CREB-binding protein (CBP)/p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus. J. Cell Biol., 150, 265-273.
40. Wu, W.S., Vallian, S., Seto, E., Yang, W.M., Edmondson, D., Roth, S. and Chang, K.S. (2001) The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. Mol. Cell. Biol., 21, 2259-2268.
41. Hofmann, T.G., Moller, A., Sinna, H., Zentgraf, H., Taya, Y., Droge, W., Will, H. and Schmitz, M.L. (2002) Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nature Cell Biol., 4, 1-10.
42. D'Orazi, G., Cecchinelli, B., Bruno, T., Manni, J., Higashimoto, Y., Saito, S., Gostissa, M., Coen, S., Marchetti, A., Del Sal, G., Piaggio, G., Fanciulli, M., Appella, E. and Soddu, S. (2002) Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser46 and mediates apoptosis. Nature Cell Biol., 4, 11-19.
43. Ecsedy, J.A., Michaelson, J.S. and Leder, P. (2003) Homeodomain-interacting protein kinase 1 modulates daxx localization, phosphorylation and transcriptional activity. Mol. Cell. Biol., 23, 950-960.
44. Krause, K., Wasner, M., Reinhard, W., Haugwitz, U., Dohna, C.L., Mossner, J. and Engeland, K. (2000) The tumour suppressor protein p53 can repress transcription of cyclin B. Nucleic Acids Res., 28, 4410-4418.
45. Miyashita, T., Harigai, M., Hanada, M. and Reed, J.C. (1994) Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res., 54, 3131-3135.
46. Murphy, M., Himnan, A. and Levine, A.J. (1996) Wild-type p53 negatively regulates the expression of a microtubule-associated protein. Genes Dev., 10, 2971-2980.
47. Hoffman, W.H., Biade, S., Zilfou, J.T., Chen, J. and Murphy, M. (2002) Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J. Biol. Chem., 277, 3247-3257.
48. Roperch, J.P., Alvaro, V., Prieur, S., Tuynder, M., Nemani, M., Lethrosne, F., Piouffre, L., Gendron, M.C., Israeli, D., Dausset, J., Oren, M., Amson, R. and Telerman, A. (1998) Inhibition of presenilin 1 expression is promoted by p53 and p21WAF1 and results in apoptosis and tumor suppression. Nature Med., 4, 835-838.
49. Ohiro, Y., Usheva, A., Kobayashi, S., Duffy, S.L., Nantz, R., Gius, D. and Horikoshi, N. (2003) Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53. Mol. Cell. Biol., 23, 322-334.