Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development

Genes and Development

Volumn 13, Issue 15, 1999, Pages 1918-1923

  Michaelson, Jennifer S ^a   Bader, Debra ^a   Frank, Kuo ^a   Kozak, Christine ^b   Leder, Philip ^c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NONE

Author keywords

Apoptosis; Daxx; Fas; Yeast two hybrid

Indexed keywords

DAXX PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN 3T3; EMBRYO; EMBRYO DEVELOPMENT; GENE MUTATION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ANIMALIA; MAMMALIA; RODENTIA; VERTEBRATA;

EID: 0033179775     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.15.1918     Document Type: Article

References (27)

1. Adachi, M., S. Suematsu, T. Kondo, J. Ogasawara, T. Tanaka, N. Yoshida, and S. Nagata. 1995. Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nat. Genet. 11: 294-300.
2. Adachi, M., S. Suematsu, T. Suda, D. Watanabe, H. Fukuyama, J. Ogasawara, T. Tanaka, N. Yoshida, and S. Nagata. 1996. Enhanced and accelerated lymphoproliferation in Fas-null mice. Proc. Natl. Acad. Sci. 93: 2131-2136.
3. Adamson, M.C., J. Silver, and C.A. Kozak. 1991. The mouse homolog of the Gibbon ape leukemia virus receptor: Genetic mapping and a possible receptor function in rodents. Virology 183: 778-781.
4. Ausubel, F.M., R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl. 1990. Current protocols in molecular biology. Green Publishing Associates/Wiley Interscience, New York, NY.
5. Boldin, M.P., E.E. Varfolomeev, Z. Pancer, I.L. Mett, J.H. Camonis, and D. Wallach. 1995. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J. Biol. Chem. 270: 7795-7798.
6. Boldin, M.P., T.M. Goncharov, Y.V. Goltsev, and D. Wallach. 1996. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85: 803-805.
7. Chan, D.C. and P. Leder. 1996. Genetic evidence that formins function within the nucleus. J. Biol. Chem. 271: 23472-23477.
8. Chang, H.Y., H. Nishitoh, X. Yang, H. Ichijo, and D. Baltimore. 1998. Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science 281: 1860-1863.
9. Chang, H.Y., X. Yang, and D. Baltimore. 1999. Dissecting Fas signaling with an altered-specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation. Proc. Natl. Acad. Sci. 96: 1252-1256.
10. Chester, N., F. Kuo, C. Kozak, C.D. O'Hara, and P. Leder. 1998. Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene. Genes & Dev. 12: 3382-3393.
11. Chinnaiyan, A.M., K. O'Rourke, M. Tewari, and V.M. Dixit. 1995. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: 505-512.
12. Deng, C., A. Wynshaw-Boris, M.M. Shen, C. Daugherty, D. Ornitz, and P. Leder. 1994. Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes & Dev. 8: 3045-3057.
13. Deng, C., A. Wynshaw-Boris, A. Kuo, F. Zhou, and P. Leder. 1996. Fibroblast growth receptor 3 is a negative regulator of bone growth. Cell 84: 911-921.
14. Grimm, S. and P. Leder. 1997. An apoptosis-inducing isoform of neu differentiation factor (NDF) identified using a novel screen for dominant, apoptosis-inducing genes. J. Exp. Med. 185: 1137-1142.
15. Juo, P., C.J. Kuo, J. Yuan, and J. Blenis. 1998. Essential requirement for caspase-8/FLlCE in the initiation of the Fas-induced apoptotic cascade. Curr. Biol. 8: 1001-1008.
16. Kiriakidou, M., D.A. Driscoll, J.M. Lopez-Guisa, and J.F. Strauss III. 1997. Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region. DNA Cell Biol. 16: 1289-1298.
17. Lei, H., S.P. Oh, M. Okano, R. Juttermann, K.A. Goss, R. Jaenisch, and E. Li. 1996. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development 122: 3195-3205.
18. Li, E., T.H. Bestor, and R. Jaenisch. 1992. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69: 915-926.
19. Lim, D.S. and P. Hasty. 1996. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol. Cell Biol. 16: 7133-7143.
20. Muzio, M., A.M. Chinnaiyan, F.C. Kischkel, K. O'Rourke, A. Shevchenko, J. Ni, C. Scaffidi, J.D. Bretz, M. Zhang, R. Gentz, M. Mann, P.H. Krammer, M.E. Peter, and V.M. Dixit. 1996. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85: 817-827.
21. Pluta, A.F., W.C. Eamshaw, and I.G. Goldberg. 1998. Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death. J. Cell Sci. 111: 2029-2041.
22. Tybulewicz, V.L., C.E. Crawford, P.K. Jackson, R.T. Bronson, and R.C. Mulligan. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65: 1153-1163.
23. Varfolomeev, E.E., M. Schuchmann, V. Luria, N. Chiannilkulchai, J.S. Beckmann, I.L. Mett, D. Rebrikov, V.M. Brodianski, O.C. Kemper, O. Kollet, T. Lapidot, D. Soffer, T. Sobe, K.B. Avraham, T. Goncharov, H. Holtmann, P. Lonai, and D. Wallach. 1998. Targeted disruption of the mouse caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 9: 267-276.
24. Yang, X., R. Khosravi-Far, H.Y. Chang, and D. Baltimore. 1997. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89: 1067-1076.
25. Yeh, W.C., J.L. Pompa, M.E. McCurrach, H.B. Shu, A.J. Elia, A. Shahinian, M. Ng, A. Wakeham, W. Khoo, K. Mitchell, W.S. El-Deiry, S.W. Lowe, D.V. Goeddel, and T.W. Mak. 1998. FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 279: 1954-1958.
26. Zeitlin, S., J.-P. Liu, D.L. Chapman, V.E. Papaioannou, and A. Efstratiadis. 1995. Increased apoptosis and early embryoic lethality in mice nullizygous for the Huntington's disease gene homologue. Nat. Genet. 11: 155-163.
27. Zhang, J., D. Cado, A. Chen, N.H. Kabra, and A. Winoto. 1998. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mortl. Nature 392: 296-300.