CREB-binding protein (CBP)/p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus

Journal of Cell Biology

Volumn 150, Issue 1, 2000, Pages 265-273

  Von Mikecz, Anna ^a,d   Zhang, Suisheng ^b   Montminy, Marc ^c   Tan, Eng M ^d   Hemmerich, Peter ^b,d  

^a Heinrich Heine Universat Dusseldorf   (Germany)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Coactivators; Nuclear body; Promyelocytic leukemia; RNA polymerase II; Transcription

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; PROTEIN P300; RNA POLYMERASE II;

ARTICLE; CELL NUCLEUS; CELL STRAIN MCF 7; ENZYME ACTIVATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HELA CELL; HEP 2 CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TRANSCRIPTION INITIATION;

ACETYLTRANSFERASES; CELL CYCLE PROTEINS; CELL LINE; CELL NUCLEUS; CREB-BINDING PROTEIN; HISTONE ACETYLTRANSFERASES; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, FLUORESCENCE; NUCLEAR PROTEINS; PRECIPITIN TESTS; RNA POLYMERASE II; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0034631852     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.150.1.265     Document Type: Article

References (65)

1. Antoniou, M., M. Carmo-Fonseca, J. Ferreira, and A.I. Lamond. 1993. Nuclear organization of splicing snRNPs during differentiation of murine erythroleukemia cells in vitro. J. Cell Biol. 123:1055-1068.
2. Arany, Z., W.R. Sellers, D.M. Livingston, and R. Eckner. 1994. E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell. 77:799-800.
3. Arias, J., A.S. Alberts, P. Brindle, F.X. Claret, T. Smeal, M. Karin, J. Feramisco, and M. Montminy. 1994. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature. 370:226-229.
4. Bannister, A.J., and T. Kouzarides. 1996. The CBP coactivator is a histone acetyltransferase. Nature. 384:641-643.
5. Bex, F., M.J. Yin, A. Burny, and R.B. Gaynor. 1998. Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300. Mol. Cell. Biol. 18:2392-2405.
6. Bloch, D.B., J.D. Chiehe, D. Orth, S.M. de la Monte, A. Rosenzweig, and K.D. Bloch. 1999, Structural and functional heterogeneity of nuclear bodies. Mol. Cell. Biol. 19:4423-4430.
7. Boisvert, F.-M., M.J. Hendzel, and D.P. Bazett-Jones. 2000. Promyelocytic leukemia (PML) nuclear bodies are protein structures that do not accumulate RNA. J. Cell Biol. 148:283-292.
8. Brasch, K., and R.L. Ochs. 1992. Nuclear bodies (NBs): a newly "rediscovered" organelle. Exp. Cell Res. 202:211-223.
9. Bregman, D.B., L. Du, S. van der Zee, and S.L. Warren. 1995. Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains. J. Cell Biol. 129:287-298.
10. Cho, H., G. Orphanides, X. Sun, V. Ogryzko, E. Lees, Y. Nakatani, and D. Reinberg. 1998. A human RNA polymerase II complex containing factors that modify chromatin structure. Mol. Cell. Biol. 18:5355-5362.
11. Chrivia, J.C., R.P. Kwok, N. Lamb, M. Hagiwara, M.R. Montminy, and R.H. Goodman. 1993. Phosphorylated CREB hinds specifically to the nuclear protein CBP. Nature. 365:855-859.
12. Cleveland, D.W. 1995. NuMa: a protein involved in nuclear structure, spindle assembly, and nuclear reformation. Trends Cell Biol. 5:60-64.
13. Dahmus, M.E. 1995, Phosphorylation of the C-terminal domain of RNA polymerase II. Biochim. Biophys. Acta. 1261:171-182.
14. Doucas, V., and R.M. Evans. 1996. The PML nuclear compartment and cancer. Biochim. Biophys. Acta. 1288:25-29.
15. Doucas, V., A.M. Ishov, A. Romo, H. Juguilon, M.D. Weitzmann, R.M. Evans, and G.G. Maul. 1996. Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure. Genes Dev. 10:196-207.
16. Doucas, V., Tini, M., D.A. Egan, and R.M. Evans. 1999. Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. Proc. Natl. Acad. Sci. USA. 96: 2627-2632.
17. Eckner, R., M.E. Ewen, D. Newsome, M. Gerdes, J.A. DeCaprio, J.B. Lawrence, and D.M. Livingston. 1994. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-KD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 8:869-884.
18. Fu, X.D., and T. Maniatis. 1990. Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature. 343:437-441.
19. Grande, M.A., I. van der Kraan, B. van Steensel, W. Schul, H. de The. H.T. van der Voort, L. de Jong, and R. van Driel. 1996. PML-containing nuclear bodies: their spatial distribution in relation to other nuclear components. J. Cell. Biochem. 63:280-291.
20. Grande, M.A., I. van der Kraan, J. de Jong, and R. van Driel. 1997. Nuclear distribution of transcription factors in relation to sites of transcription and RNA polymerase II. J. Cell Sci. 110:1781-1791.
21. Gui, J.F., W.S. Lane, and X.D. Fu. 1994. A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature. 369:678-682.
22. Iborra, F.J., A. Pombo, D.A. Jackson, and P.R. Cook. 1996. Active RNA polymerases are localized within discrete transcription "factories" in human nuclei. J. Cell Sci. 109:1427-1436.
23. JacKson, D.A., A.B. Hassan, R.J. Errington, and P.R. Cook. 1993. Visualization of focal sites of transcription within human nuclei. EMBO (Eur. Mol. Biol. Organ.) J. 12:1059-1065.
24. Janknecht, R., and T. Hunter. 1996. Transcription. A growing coactivator network. Nature. 383:22-23.
25. Kee, B.L., J. Arias, and M.R. Montminy. 1996. Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator. J. Biol. Chem. 271: 2373-2375.
26. Kornberg, R.D. 1999. Eukaryotic transcriptional control. Trends Cell Biol. 9:M46-M49.
27. Kwok, R.P., J.R. Lundblad, J.C. Chrivia, J.P. Richards, H.P. Bachinger, R.G. Brennan, S.G. Roberts, M.R. Green, and R.H. Goodman. 1994. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature. 370: 223-226.
28. Lamond, A.I., and W.C. Earnshaw. 1998. Structure and function in the nucleus. Science. 280:547-553.
29. LaMorte, V.J., J.A. Dyck, R.L. Ochs, and R.M. Evans. 1998. Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body. Proc. Natl. Acad. Sci. USA. 95:4991-4996.
30. Lindell, T.J., F. Weinberg, P.W. Morris, R.G. Roeder, and W.J. Rutter. 1970. Specific inhibition of nuclear RNA polymerase II by alpha-amanitin. Science. 170:447-449.
31. Lundblad, J.R., R.P. Kwok, M.E. Laurance, M.L. Harter, and R.H. Goodman. 1995. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional coactivator CBP. Nature. 374:85-88.
32. Matera, A.G. 1999. Nuclear bodies: multifaceled subdomains of the interchromatin space. Trends Cell Biol. 9:302-3119.
33. Maul, G.G. 1998. Nuclear domain 10, the site of DNA virus transcription and replication. Bioessays. 20:660-667.
34. Newton, A.L., B.K. Sharpe, A. Kwan, J.P. Mackay, and M. Crossley. 2000. The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules. J. Biol. Chem. 275:15128-15134.
35. Misteli, T., and D.L. Spector. 1998. The cellular organization of gene expression. Curr. Opin. Cell Biol. 10:323-331.
36. Misteli, T., J.F. Caceres, and D.L. Spector. 1997. The dynamics of a pre-mRNA splicing factor in living cells. Nature. 387:523-527.
37. Montminy, M.R. 1997. Something new to hang your HAT on. Nature. 387: 654-655.
38. Nakajima, T., C. Uchida, S.F. Anderson, C.G. Lee, J. Hurwitz, J.D. Parvin, and M.R. Montminy. 1997a. RNA helicase A mediates association of CBP with RNA polymerase II. Cell. 90:1107-1112.
39. Nakajima, T., C. Uchida, S.F. Anderson, J.D. Parvin, and M.R. Montminy. 1997b. Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors. Genes Dev. 11:738-747.
40. Neish, A.S., S.F. Anderson, B.P. Schlegel, W. Wei, and J.D. Parvin. 1998. Factors associated with the mammalian RNA polymerase II holoenzyme. Nacleic Acids Res. 26:847-853
41. Neugebauer, K.M., and M.B. Roth. 1997. Transcription units as RNA processing units. Genes Dev. 11:3279-3285.
42. Ogryzko, V.V., R.L. Schiltz, V. Russanova, B.H. Howard, and Y. Nakatani. 1996. The transcriptional coactivalors p300 and CBP are historic acetyltransferases. Cell. 87:953-959.
43. Pao, G.M., R. Janknecht, H. Ruffner, T. Hunter, and I.M. Verma. 2000. CBP/ p300 interact with and function as transcriptional coactivators of BRCAI. Proc. Natl. Acad. Sci. USA. 97:1020-1025.
44. Parvin, J.D., and R.A. Young. 1998. Regulatory targets in the RNA polymerase II holoenzyme. Curr. Opin. Genet. Dev. 8:565-570.
45. Patturajan, M., R.J. Schulte, B.M. Sefton, R. Berezney, M. Vincent, O. Bensaude, S.I., Warren, and J.L. Corden. 1998. Growth-related changes in phosphorylation of yeast RNA polymerase II. J. Biol. Chem. 273:4689-4694.
46. Payne, J., P. Laybourne, and M. Dahmus. 1989. The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carhoxyl-terminal domain of suhunil IIa. J. Biol. Chem. 264:19621-19629.
47. Reyes, J.C., C. Muchardt, and M. Yaniv. 1997. Components of the human SWI/ SNF complex are enriched in active chromatin and are associated with the nuclear matrix. J. Cell Biol. 137:263-274.
48. Schul, W., L. de Jong, and R. van Driel. 1998a. Nuclear neighbours: the spatial and functional organization of genes and nuclear domains. J. Cell. Biochem. 70:159-171.
49. Schul, W., R. van Driel, and L. de Jong. 1998b. Coiled bodies and U2 snRNA genes adjacent to coiled bodies are enriched in factors required for snRNA transcription. Mol. Biol. Cell. 5:1025-11136.
50. Scully, R., S.F. Anderson, D.M. Chao, W. Wei, L. Ye, R.A. Young, D.M. Livingston, and J.D. Parvin. 1997. BRCA1 is a component of the RNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. USA. 94:5605-5610.
51. Shikama, N., J. Lyon, and N. La Thangue. 1997. The p300/CBP family: integrating signals with transcription factors and chromatin. Trends Cell. Biol. 7:230-236.
52. Singer, R.H., and M.R. Green. 1997. Compartmentalization of eukaryotic gene expression: causes and effects. Cell. 91:291-294.
53. Spector, D.I., 1993. Macromolecular domains within the cell nucleus. Annu. Rev. Cell Biol. 9:265-315.
54. Stenoien, D., Z.D. Sharp, C.L. Smith, and M.A. Mancini. 1998. Functional subnuclear partitioning of transcription factors. J. Cell. Biochem. 70:213-221.
55. Sternsdorf, T., T. Grotzinger, K. Jensen, and H. Will. 1997. Nuclear dots: actors on many stages. Immunobiology. 198:307-331.
56. Thompson, N.K., T.H. Steinberg, D.B. Aranson, and R.B. Burgess. 1989. Inhibition of in vivo and in vitro transcription by monoclonal antibodies prepared against wheat germ RNA polymerase II that react with the heptapeptide repeat of eukaryotic RNA polymerase II. J. Biol. Chem. 264:4350-4354.
57. Torchia, J., C. Glass, and M.G. Rosenfeld. 1998. Co-activators and co-repressors in the integration of transcriptional responses. Curr. Opin. Cell Biol. 10: 373-383.
58. van Steensel, B., M. Brink, K. van der Meulen, E.P. van Binnendijk, D.G. Wansink, L. de Jong, E.R. de Kloet, and R. van Driel. 1995. Localization of the glucocorticoid receptor in discrete clusters in the cell nucleus. J. Cell Sci. 108: 3003-3011.
59. von Mikecz, A., K. Konstantinov, D. Buchwald, L. Gerace, and E.M. Tan, 1997. High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome. Arthritis Rheum. 40:295-305.
60. Wansink, D.G., W. Schul, I. van der Kraan, B. van Steensel, R. van Driel, and L. de Jong. 1993. Fluorescent labeling of nascent RNA reveals transcription by RNA polvmerase II in domains scattered throughout the nucleus. J. Cell Biol. 122:283-293.
61. Xing, Y., C.V. Johnson, P.R. Dobner, and J.B. Lawrence. 1993. Higher level organization of individual gene transcription and RNA splicing. Science. 259: 1326-1330.
62. Yang, X.J., V.V. Ogryzko, J. Nishikawa, B.H. Howard, and Y. Nakatani. 1996. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature. 382:319-324.
63. Zeng, C., E. Kim, S.L. Warren, and S.M. Berget. 1997. Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity. EMBO (Eur. Mol. Biol. Organ.) J. 16:1401-1412.
64. Zhang, G., K.L. Taneja, R.H. Singer, and M.R. Green. 1994. Localization of pre-mRNA splicing in mammalian nuclei. Nature. 372:809-812.
65. Zhang, S., C. Herrman, and F. Grosse. 1999. Nucleolar localization of murine nuclear DNA helicase II (RNA helicase II). J. Cell. 112: 2693-2703.