Arsenic trioxide induces apoptosis in human gastric cancer cells through up-regulation of p53 and activation of caspase-3

International Journal of Cancer

Volumn 91, Issue 2, 2001, Pages 173-179

  Jiang, Xiao Hua ^a   Wong, Benjamin Chun Yu ^a   Yuen, Siu Tsan ^a   Jiang, Shi Hu ^b   Cho, Chi Hin ^a   Lai, Kam Chuen ^a   Lin, Marie C M ^a   Kung, Hsiang Fu ^a   Lam, Shiu Kum ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Arsenic; Caspase; Gastric cancer; P53

Indexed keywords

ACRIDINE ORANGE; ANTISENSE OLIGONUCLEOTIDE; ARSENIC TRIOXIDE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE INHIBITOR; DNA FRAGMENT; MYC PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; PROTEINASE; UNCLASSIFIED DRUG;

ACUTE MYELOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CANCER CELL; CANCER REGRESSION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR UPREGULATION; STOMACH CANCER; WESTERN BLOTTING;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; ARSENICALS; CASPASE 3; CASPASES; CELL CYCLE; CELL DIVISION; DNA DAMAGE; ENZYME ACTIVATION; HUMANS; OLIGONUCLEOTIDES, ANTISENSE; OXIDES; POLY(ADP-RIBOSE) POLYMERASES; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 0035863397     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(200002)9999:9999<::AID-IJC1039>3.0.CO;2-D     Document Type: Article

References (53)

1. Ai-Lin I treated 32 cases of acute promyelocytic leukemia
2. Clinical study on the treatment of APL mainly with composite indigo naturalis tablets
3. 3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients
4. Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide
5. 3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression, proteins
6. Initial clinical study of a novel organic arsenical melarsoprol, in patients with advanced leukemia
7. Arsenic acid as well as retinoic acids have therapeutic potential to adult T ceil leukemia
8. Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RAR alpha independent manner
9. Arsenic induces apoptosis in B-cell leukemic cell line in vitro: Activation of caspases and down-regulation of Bcl-2 protein
10. Arsenic trioxide induces apoptosis of oesophageal carcinoma in vitro
11. Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase-3 in vitro
12. Effect of arsenic trioxide on cell cycle arrest in head and neck cancer cell line PCI-1
13. Arsenic trioxide induces apoptosis of HPV16 DNA-immortalized human cervical epithelial cells and selectively inhibits viral gene expression
14. Induction of apoptosis and inhibition of human gastric cancer MGC-803 cell growth by arsenic trioxide
15. Arsenic trioxide sensitivity is associated with low level of glutathione in cancer cells
16. Apoptosis: Biological and clinical aspects
17. Mechanism and genes of suicide
18. Molecular and cellular mechanisms of T lymphocyte apoptosis
19. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
20. p53 mediates permanent arrest over multiple cell cycles in response to gamma-irradiation
21. Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo
22. L depends on normal p53 function
23. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
24. Induction of apoptosis by wild-type p53 in a human colon tumor derived cell line
25. Arsenic alters cytosine methylation patterns of the tumor suppressor gene p53 promoter in human lung cells: A model for a mechanism of carcinogenesis
26. 2-terminal kinase-dependent p53-independent pathway
27. Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer ceils is blocked by protein kinase C activation through inhibition of c-myc
28. Differential apoptosis by indomethacin in gastric epithelial ceils through the constitutive expression of wild-type p53 and/or up-regulation of c-myc
29. Pharmacological inhibition of protein kinase C activity could induce apoptosis in gastric cancer cells by differential regulation of apoptosis-related genes
30. Caspases: The executioners of apoptosis
31. Mammalian cell death proteases: A family of highly conserved aspartate specific cysteine proteases
32. CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis
33. Activation of the CPP32 protease in apoptosis induced by 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents
34. Decreased apoptosis in the brain the premature lethality in CPP-32-deficient mice
35. Missense mutations and a deletion of the p53 gene in human gastric cancer
36. Chemosensitivity testing of human lung cancer cell lines using the MTT assay
37. Potentiation of the activity of 1-β-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: Association with enhanced fragmentation of mature DNA
38. Measurement of protein using bicinchoninic acid
39. Protein Kinase C-∈ is necessary for erythropoietin's up-regulation of c-myc and for factors-dependent DNA synthesis. Evidence for discrete signals for growth and differentiation
40. Arsenic and cancer
41. Induction of p53 protein expression by sodium arsenite
42. Participation of p53 protein in the cellular response to DNA damage
43. Thymocyte apoptosis induced by p53-dependent and independent pathways
44. p53 in signaling checkpoint arrest or apoptosis
45. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs
46. p53 and c-erbB2 as markers of resistance to adjuvant chemotherapy in breast cancer
47. p53 mediated cell death: Relationship to cell cycle control
48. Differential regulation of p53, c-myc, Bcl-2 and Bax protein expression during apoptosis induced by widely divergent stimuli in human hepatoblastoma cells
49. waf1/cip1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines
50. waf1/cip1 expression by a temperature-sensitive mutant of human p53 does not lead to apoptosis
51. Over-expression of protein kinase C-β1 isoenzyme suppresses indomethacin-induced apoptosis in gastric epithelial cells
52. The role of proteases during apoptosis
53. Arsenic trioxide causes selective necrosis in solid murine tumours by vascular shutdown