Activation of PKC is required for arsenite-induced signal transduction

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 19, Issue 3, 2000, Pages 297-305

  Chen, N Y ^a   Ma, W Y ^a   Huang, C ^a   Ding, M ^a   Dong, Z ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

AP 1; Arsenite; MAP kinase; PKC

Indexed keywords

ARSENIC TRIOXIDE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SAFINGOL; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; CARCINOGEN TESTING; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACETOPHENONES; ANIMALS; ARSENITES; BENZOPYRANS; CARCINOGENS; CELL MEMBRANE; CELLS, CULTURED; CYTOSOL; ENZYME ACTIVATION; ENZYME ACTIVATORS; ENZYME INHIBITORS; ISOENZYMES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN KINASE C-DELTA; PROTEIN KINASE C-EPSILON; SKIN; SPHINGOSINE; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

EID: 0033863570     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Toxic effects of metals
2. Arsenic and cancer
3. The absorption of arsenic and its relation to carcinoma
4. Arsenic can mediate skin neoplasia by chronic stimulation of keratinocyte-derived growth factors
5. Pesticides and cancer
6. Development of hepatic angiosarcoma in man induced by vinyl chloride, thoro-trast, and arsenic. Comparison with cases of unknown etiology
7. Respiratory cancer and occupational exposure to arsenicals
8. Arsenic ingestion and internal cancers: A review
9. Enhancement of UV-mutagenesis by low concentrations of arsenite in E. coli
10. Sodium arsenite potentiates the clastogenicity and mutagenicity of DNA crosslinking agents
11. Genotoxic effects of sodium arsenite on human cells
12. Carcinogenesis of arsenic compounds
13. The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase
14. The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells
15. Stable expression of a c-Jun deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude mice
16. Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells
17. Differential transformation efficiency but not AP-1 induction under anchorage-dependent and -independent conditions
18. Progressive elevation of AP-1 activity during preneoplastic-to-neoplastic progression as modeled in mouse JB6 cell variants
19. Transformation reversion induced in JB6 RT101 cells by AP-1 inhibitors
20. Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid
21. EGF-induced programmed cell death of human mammary carcinoma MDA-MB-468 cells is preceded by activation of AP-1
22. The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway
23. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small teat shock proteins
24. Proteinase inhibitors I and II from potatoes specifically block UV-induced activator protein-1 activation through a pathway that is independent of extracellular signal-regulated kinases, c-Jun N-terminal kinases, and p38 kinase
25. Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins
26. Phosphatidylinositol-3 kinase, Phorbol ester, Protein kinase C: Potentiation of insulin-induced phosphatidylinositol-3 kinase activity by phorbol ester is mediated by protein kinase C-epsilon
27. Bombesin, platelet-derived growth factor, and diacylglycerol induce selective membrane association and down-regulation of protein kinase C isotypes in Swiss 3T3 cells
28. Inhibition of activator protein 1 activity and neoplastic transformation by aspirin
29. Signal transduction through atypical pkcs, but not the egf receptor, is necessary for UVC-induced AP-1 activation in immortal murine cells
30. Protein kinase C. Seeing two domains
31. Rottlerin, a novel protein kinase inhibitor
32. Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C
33. Translocation of protein kinase C epsilon and protein kinase C delta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis
34. Activation of MAP kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
35. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
36. Regulation and function of the JNK subgroup of MAP kinases
37. The extended protein kinase C superfamily
38. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
39. Protein tyrosine phosphatases
40. Protein kinase C as the receptor for the phorbol ester tumor promoters: Sixth Rhoads memorial award lecture
41. The potential of protein kinase C as a target for anticancer treatment