The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation

American Journal of Physiology - Cell Physiology

Volumn 279, Issue 3 48-3, 2000, Pages

  Wang, Suwei ^a,b   Leonard, Stephen S ^a,b   Ye, Jianping ^a   Ding, Min ^a   Shi, Xianglin ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Cr(VI) carcinogenesis; Reactive oxygen species

Indexed keywords

CATALASE; CHROMIUM DERIVATIVE; DEFEROXAMINE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; METAL CHELATE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; PRIORITY JOURNAL; PROTEIN DNA BINDING; REDUCTION; TRANSACTIVATION; TUMOR SUPPRESSOR GENE;

LETHRINIDAE;

EID: 0033829708     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2000.279.3.c868     Document Type: Article

References (49)

1. The p53 network
2. Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells
3. Metabolism of the carcinogenic chromate by cellular constituents
4. Genotoxicity of chromium compounds: A review
5. Mechanisms of chromium metabolism and genotoxicity
6. Exposure to chromium dust from homes in a chromium surveillance project
7. Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents
8. Alterations in NF κ B/Rel family proteins in splenic T-cells from tumor-bearing mice and reversal following therapy
9. p53 In growth control and neoplasia
10. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status
11. Molecular and cellular effects of ultraviolet light-induced genotoxicity
12. Redox modulation of p53 conformation and sequence-specific DNA binding in vitro
13. Review of occupational epidemiology of chromium chemicals and respiratory cancer
14. Bcl-2 functions in an antioxidant pathway to prevent apoptosis
15. Database of p53 gene somatic mutations in human tumors and cell lines
16. Methyl methanesulfonate and hydrogen peroxide differentially regulate p53 accumulation in hepatoblastoma cells
17. Reactive oxygen species are downstream mediators of p53-dependent apoptosis
18. Participation of p53 protein in the cellular response to DNA damage
19. p53: Puzzle and paradigm
20. Generation of PM2 DNA breaks in the course of reduction of chromium(VI) by glutathione
21. One hundred years of chromium and cancer: A review of epidemiological evidence and selected case reports
22. p53, The cellular gatekeeper for growth and division
23. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
24. Low frequency ESR detection of chromium(V) formation by one-electron reduction of chromium(VI) in whole live mice
25. 2 in the presence of chelators in relation to DNA damage and 2'-deoxyguanosine hydroxylation
26. Mitochondrial permeability transition is a central coordinating event of apoptosis
27. Redox state regulates binding of p53 to sequence-specific DNA, but not to nonspecific or mismatched DNA
28. A model for p53-induced apoptosis
29. Role of cysteine residues in regulation of p53 function
30. Reactive oxygen species and silica-induced carcinogenesis
31. Reduction of chromium(VI) and its relationship to carcinogenesis
32. Enhanced generation of hydroxyl radical and sulfur trioxide anion radical from oxidation of sodium sulfite, nickel (II) sulfite, and nickel subsulfide in the presence of nickel (II) complexes
33. Evidence for a Fenton-type mechanism for the generation of hydroxyl radical in the reduction of Cr(VI) in cellular media
34. Hydroxyl radical generation in the NADH/microsomal reduction of vanadate
35. Chromium(V) and hydroxyl radical formation during the glutathione reductase-catalyzed reduction of chromium(VI)
36. On the hydroxyl radical formation in the reaction between hydrogen peroxide and biologically generated chromium(V) species
37. ESR evidence for the hydroxyl radical formation in aqueous suspension of quartz particles and its possible significance to lipid peroxidation in silicosis
38. Cr(IV) causes activation of nuclear transcription factor NF-κB, DNA strand breaks and dG hydroxylation via free radical reactions
39. Reaction of Cr(VI) with ascorbate and hydrogen peroxide generates hydroxyl radicals and causes DNA damage: Role of a Cr(VI)-mediated Fenton-like reaction
40. p53-Mediated protective responses to UV irradiation
41. DNA single-strand breaks and cytotoxicity induced by sodium chromate(VI) in hydrogen peroxide-resistant cell lines
42. Redox regulation of transcriptional activators
43. Chromium(VI)-induced DNA lesions and chromium distribution in rat kidney, liver, and lung
44. Active oxygen species mediate the solar ultraviolet radiation-dependent increase in the tumour suppressor protein p53 in human skin fibroblasts
45. Asbestos catalyzes hydroxyl and superoxide radical generation from hydrogen peroxide
46. DNA damage induced by carcinogenic lead chromate particles in cultured mammalian cells
47. Characterization of a silencer regulatory element in the human interferon-γ promoter
48. Chromium(VI)-induced nuclear factor-κ B activation in intact cells via free radical reactions
49. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo