Cadmium induces c-myc, p53, and c-jun expression in normal human prostate epithelial cells as a prelude to apoptosis

Toxicology and Applied Pharmacology

Volumn 164, Issue 3, 2000, Pages 291-300

  Achanzar, William E ^a   Achanzar, Karen B ^b   Lewis, James G ^b   Webber, Mukta M ^c   Waalkes, Michael P ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Cadmium; Cytotoxicity; Human; Prostate

Indexed keywords

CADMIUM; MYC PROTEIN; PROTEIN C JUN; PROTEIN P53;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; GENE EXPRESSION; GROWTH REGULATION; HUMAN; HUMAN CELL; MODEL; ONCOGENE; PROSTATE CANCER; PROSTATE EPITHELIUM; TUMOR SUPPRESSOR GENE;

EID: 0034193451     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1999.8907     Document Type: Article

References (50)

1. Abshire M. K., Buzard G. S., Shiraishi N., Waalkes M. P. Induction of c-myc and c-jun proto-oncogene expression in rat L6 myoblasts by cadmium is inhibited by zinc preinduction of the metallothionein gene. J. Toxicol. Environ. Health. 48:1996a;359-377.
2. Abshire M. K., Devor D. E., Diwan B. A., Shaughnessy J. D., Waalkes M. P. In vitro exposure to cadmium in rat L6 myoblasts can result in both enhancement and suppression of malignant progression in vivo. Carcinogenesis. 17:1996b;1349-1356.
3. Angel P., Karin M. The role of Jun, Fos, and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta. 1072:1991;129-157.
4. Askew D., Ashmun R., Simmons B., Cleveland J. Constitutive c-myc expression in IL-3-dependent myeloid cell line suppresses cycle arrest and accelerates apoptotsis. Oncogene. 6:1991;1915-1922.
5. Bello D., Webber M. M., Kleinman H. K., Wartinger D. D., Rhim J. S. Androgen responsive adult human prostatic epithelial cell lines immortalized by human papillomavirus 18. Carcinogenesis. 18:1997;1215-1223.
6. Beyersmann D., Hechtenberg S. Cadmium, gene regulation, and cellular signalling in mammalian cells. Toxicol. Appl. Pharmacol. 144:1997;247-261.
7. Buttyan R., Shabsigh A., Perlman H., Colombel M. Regulation of apoptosis in the prostate gland by androgenic steroids. Trends Endocrinol. Metab. 10:1999;47-54.
8. Cai D., Webber M. M., De Luca L. M. Retinoids enhance lectin binding to gp130, a glycoprotein of NIH-3T3 cells: Correlation with cell growth and adhesion. Exp. Cell Res. 192:1991;366-372.
9. Cohen S. M. Cell proliferation and carcinogenesis. Drug Metab. Rev. 30:1998;339-357.
10. Dinjens W. N., van der Weiden M. M., Schroeder F. H., Bosman F. T., Trapman J. Frequency and characterization of p53 mutations in primary and metastatic human prostate cancer. Int. J. Cancer. 56:1994.
11. Eaton D. L., Toal B. F. Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol. Appl. Pharmacol. 66:1982;134-142.
12. Effert P. J., McCoy R. H., Walther P. J., Liu E. T. p53 gene alterations in human prostate carcinoma. J. Urol. 150:1993;257-261.
13. Facchini L. M., Penn L. Z. The molecular role of Myc in growth and transformation: Recent discoveries lead to new insights. FASEB J. 12:1998;633-651.
14. Goering P. L., Waalkes M. P., Klaassen C. D. Toxicology of cadmium. Goyer R. A., Cherian M. G. Toxicology of Metals: Biochemical Aspects. 1995;189-214 Springer-Verlag, Berlin.
15. Goldsworthy T. L., Butterworth B. E., Maronpot R .R. Concepts, labeling procedures, and design of cell proliferation studies relating to carcinogenesis. Environ. Health Perspect. 101:1993;59-65.
16. Greenblatt M. S., Bennett W. P., Hollstein M., Harris C. C. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54:1994;4855-4878.
17. Gumerlock P. H., Chi S. G., Shi X. B., Voeller H. J., Jacobson J. W., Gelmann E. P., de Vere White R. W. p53 abnormalities in primary prostate cancer: Single-strand conformation polymorphism analysis of complementary DNA in comparison with genomic DNA. The Cooperative Prostate Network. J. Natl. Cancer Inst. 89:1997;66-71.
18. Hermeking H., Eick D. Mediation of c-myc-induced apoptosis by p53. Science. 265:1994;2091-2093.
19. International Agency for Research on Cancer (IARC), 1993, Beryllium, cadmium, mercury, and exposure in the glass manufacturing industry, International Agency for Research on Cancer Monographs on the Evaluation of the Carcinogenic Risks to Humans, 58, IARC Scientific Publications, Lyon.
20. Jin P., Ringertz N. R. Cadmium induces transcription of proto-oncogenes c-jun and c-myc in rat L6 myoblasts. J. Biol. Chem. 265:1990;14061-14064.
21. Key T. J. Hormones and cancer in humans. Mutat Res. 333:1995;59-67.
22. Liebermann D. A., Gregory B., Hoffman B. AP-1 (Fos/Jun) transcription factors in hemapoietic differentiation and apoptosis. Int. J. Oncol. 12:1998;685-700.
23. Lowe S. W. The role of p53 in apoptosis. Sluyser M. Apoptosis in Normal Development and Cancer. 1996;97-126 Taylor and Francis, Bristol.
24. Manning F. C. R., Patierno S. R. Apoptosis: Inhibitor or instigator of carcinogenesis? Cancer Invest. 14:1996;455-465.
25. Matsuoka M., Call K. M. Cadmium-induced expression of immediate early genes in LLC-PK1 cells. Kidney Int. 48:1995;383-389.
26. McKenna S. L., McGowan A. J., Cotter T. H. Molecular mechanisms of programmed cell death. Scheper T., Al-Rubeai M. Advances in Biochemical Engineering Biotechnology. 1998;1-31 Springer-Verlag, Berlin.
27. Meyers F. J., Gumerlock P. H., Chi S. G., Borchers H., Deitch A. D., deVere White R. W. Very frequent p53 mutations in metastatic prostate carcinoma and in matched primary tumors. Cancer. 83:1998;2534-2539.
28. Misra R. R., Page J. E., Smith G. T., Waalkes M. P., Dipple A. Effect of cadmium exposure on background and anti-5-methylchrysene-1,2-dihydrodiol 3,4-epoxide-induced mutagenesis in the supF gene of pS189 in human Ad293 cells. Chem. Res. Toxicol. 11:1998;211-216.
29. Mottaz A. E., Markwalder R., Fey M. F., Klima I., Merz V. W., Thalmann G. N., Ball R. K., Studer U. E. Abnormal p53 expression is rare in clinically localized human prostate cancer: Comparison between immunohistochemical and molecular detection of p53 mutations. Prostate. 31:1997;209-215.
30. Moussa M., Kloth D., Peers G., Cherian M. G., Frei J. V., Chin J. L. Metallothionein expression in prostatic carcinoma: Correlation with Gleason grade, pathologic stage, DNA content and serum level of prostate-specific antigen. Clin. Invest. Med. 20:1997;371-380.
31. Patel H. H. H., Hewer A., Phillips D. H., Hayes J. D., Wolf C. R., Campbell F. C. Metabolic competence and susceptibility of intestinal epithelium to genotoxic injury during regeneration. Carcinogenesis. 18:1997;2171-2177.
32. Prasad V. S., LaFond R. E., Zhou M., Jacobsen K. A., Osmond D. G., Sidman C. L. Upregulation of endogenous p53 and induction of in vivo apoptosis in B-lineage lymphomas of Eμ-myc transgenic mice by deregulated c-myc transgene. Mol. Carcinog. 18:1997;66-77.
33. Preston-Martin S., Pike M. C., Ross R. K., Henderson B. E. Epidemiologic evidence for the increased cell proliferation model of carcinogenesis. Environ. Health Perspect. 101:1993;137-138.
34. Reed J. C. Bcl-2 and the regulation of programmed cell death. Sluyser M. Apoptosis in Normal Development and Cancer. 1996;127-170 Taylor and Francis, Bristol.
35. Thompson E. B. The many roles of c-Myc in apoptosis. Annu. Rev. Physiol. 60:1998;575-600.
36. Vermes I., Haanen C., Steffens-Nakken H., Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods. 184:1995;39-51.
37. Waalkes M. P., Rehm S., Riggs C. W., Bare R. M., Devor D. E., Poirer L. A., Wenk M. L., Henneman J. R., Balaschak M. S. Cadmium carcinogenesis in male Wistar [Crl:(WI)BR] rats: Dose-response analysis of tumor induction in the prostate and testes and at the injection site. Cancer Res. 48:1988;4656-4663.
38. Waalkes M. P., Rehm S., Riggs C. W., Bare R. M., Devor D. E., Poirer L. A., Wenk M. L., Henneman J. R. Cadmium carcinogenesis in male Wistar [Crl:(WI)BR] rats: Dose-response analysis of effects of zinc on tumor induction in the prostate, in the testes, and at the injection site. Cancer Res. 49:1989;4282-4288.
39. Waalkes M. P., Coogan T. P., Barter R. A. Toxicological principles of metal carcinogenesis with special emphasis on cadmium. Crit. Rev. Toxicol. 22:1992;175-201.
40. Waalkes M. P., Rehm S. Carcinogenicity of oral cadmium in the male Wistar (WF/NCr) rat: Effect of chronic dietary zinc deficiency. Fundam. Appl. Toxicol. 19:1992;512-520.
41. Waalkes M. P., Rehm S. Cadmium and prostate cancer. J. Toxicol. Environ. Health. 43:1994;251-269.
42. Waalkes M. P., Rehm S., Devor D. E. The effects of continuous testosterone exposure on spontaneous and cadmium-induced tumors in the male Fisher (F34/NCr) rat: Loss of testicular response. Toxicol. Appl. Pharmacol. 142:1997;50-57.
43. Waalkes M. P., Anver M., Diwan B. Carcinogenic effects of cadmium in the Noble (NBL/Cr) rat: Induction of pituitary, testicular, and injection site tumors and intraepithelial proliferative lesions in the dorsolateral prostate. Toxicol. Sci. 52:1999a;154-161.
44. Waalkes M. P., Anver M., Diwan B. Chronic toxic and carcinogenic effects of oral cadmium in the Noble (NBL/Cr) rat: Induction of neoplastic and proliferative lesions of the adrenal, kidney, prostate and testes. J. Toxicol. Environ. Health. 58:1999b;199-214.
45. Waalkes M. P., Rehm S., Cherian M. G. Repeated cadmium exposures enhance the malignant progression of ensuing tumors in rats. Toxicol. Sci. 54:2000.
46. Wagner A. J., Kokontis J. M., Hay N. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21 waf1/cip1. Genes Dev. 8:1994;2817-2830.
47. Webber M. M., Bello D., Kleinman H. K., Hoffman M. P. Acinar differentiation by non-malignant immortalized human prostatic epithelial cells and its loss by malignant cells. Carcinogenesis. 18:1997;1225-1231.
48. Wilding G. Endocrine control of prostate cancer. Cancer Surv. 23:1995;43-62.
49. Yan H., Carter C. E., Xu C., Singh P. K., Jones M. M., Johnson J. E., Dietrich M. S. Cadmium-induced apoptosis in the urogenetial organs of the male rat and its suppression by chelation. J. Toxicol. Environ. Health. 52:1997;149-168.
50. Zheng H., Liu J., Choo A., Michalska A. E., Klaassen C. D. Metallothionein-I and -II knock-out mice are sensitive to cadmium-induced liver mRNA expression of c-jun and p53. Toxicol. Appl. Pharmacol. 136:1996;229-235.