The COP9 signalosome: At the interface between signal transduction and ubiquitin-dependent proteolysis

Journal of Cell Science

Volumn 115, Issue 3, 2002, Pages 467-473

  Bech Otschir, Dawadschargal ^a   Seeger, Michael ^a   Dubiel, Wolfgang ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

26S proteasome; COP9 signalosome; Deneddylation; Kinase activity

Indexed keywords

COP9 SIGNALOSOME; PROTEASOME; PROTEIN KINASE; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; COMPLEX FORMATION; CONTROLLED STUDY; DROSOPHILA; MAMMAL CELL; NONHUMAN; PLANT DEVELOPMENT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SCHIZOSACCHAROMYCES POMBE; SIGNAL TRANSDUCTION;

ANIMALS; CELL CYCLE PROTEINS; HUMANS; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; PEPTIDE HYDROLASES; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN SUBUNITS; PROTEINS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN;

MAMMALIA; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE;

EID: 0036472506     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

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3. The base of the proteasome regulatory particle exhibits chaperone-like activity
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5. A new group of conserved coactivators that increase the specificity of AP-1 transcription factors
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13. Identification of a novel isopeptidase with dual specificity for ubiquitin- and Nedd8-conjugated proteins
14. Function of the ubiquitin-proteasome pathway in auxin response
15. PA28 activator protein forms regulatory caps on proteasome stacked rings
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24. Arabidopsis FUSCA5 encodes a novel phosphoprotein that is a component of the COP9 complex
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26. Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1
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29. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor
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31. A novel protein modification pathway related to the ubiquitin system
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33. HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle
34. The COP9/signalosome complex is conserved in fission yeast and has a role in S phase
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41. Molecular characterization of subunit 6 of the COP9 signalosome and its role in multifaceted developmental processes in Arabidopsis
42. Ubiquitous soluble Mg(2+)-ATPase complex. A structural study
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48. Arabidopsis cop8 and fus4 mutations define the same gene that encodes subunit 4 of the COP9 signalosome
49. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells
50. Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jabl
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52. Proteolysis and the cell cycle: With this RING I do thee destroy
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55. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex
56. Inositol 1, 3, 4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATP-2
57. The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin related Ned8p