Jab1 antagonizes TGF-β signaling by inducing Smad4 degradation

EMBO Reports

Volumn 3, Issue 2, 2002, Pages 171-176

  Wan, Mei ^a   Cao, Xuesong ^a   Wu, Yalei ^a   Bai, Shuting ^b   Wu, Liyu ^c   Shi, Xingming ^d   Wang, Ning ^e   Cao, Xu ^e  

^a DIVISION OF REPRODUCTIVE BIOLOGY   (United States)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c RESEARCH AND DEVELOPMENT   (Australia)

^d College of Chemistry and Molecular Engineering ^*  (China)

^e University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; LACTACYSTIN; PROTEASOME INHIBITOR; PROTEIN C JUN; PROTEIN P27; PROTEIN P53; REGULATOR PROTEIN; SMAD PROTEIN; SMAD4 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR JAB1; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL NUCLEUS; COMPLEX FORMATION; CONTROLLED STUDY; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STEADY STATE; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ANIMALS; COS CELLS; DNA-BINDING PROTEINS; PEPTIDE HYDROLASES; PRECIPITIN TESTS; PROTEIN INTERACTION MAPPING; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA;

EID: 0036198412     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvf024     Document Type: Article

References (31)

1. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system
2. BMP, Wnt and Hedgehog signals: How far can they go?
3. A new group of conserved coactivators that increase the specificity of AP-1 transcription factors
4. Unified nomenclature for the COP9 signalosome and its subunits: An essential regulator of development
5. Regulation of the G1 to S transition by the ubiquitin pathway
6. Smurf1 interacts with transforming growth factor-β type I receptor through Smad7 and induces receptor degradation
7. Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome
8. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF β receptor for degradation
9. The TGF-β superfamily: New members, new receptors, and new genetic tests of function in different organisms
10. Arabidopsis homologs of a c-Jun coactivator are present both in monomeric form and in the COP9 complex, and their abundance is differentially affected by the pleiotropic cop/det/fus mutations
11. Proteasome inhibitors: Valuable new tools for cell biologists
12. Smads bind directly to the Jun family of AP-1 transcription factors
13. Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-β signaling
14. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome
15. TGF-β signal transduction
16. Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis
17. Regulation of differentiation by TGF-β
18. New tumor suppressor found in pancreatic cancer
19. Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response
20. Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling
21. Transcriptional coactivators potentiating AP-1 function in bone
22. Signaling inputs converge on nuclear effectors in TGF-β signaling
23. Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1
24. TGF-β related genes in development
25. Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression
26. Mouse homologue of FAST-1 transduces TGF β superfamily signals and is expressed during early embryogenesis
27. Regulation of Smad activity
28. Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor signaling by targeting Smads to the ubiquitin-proteasome pathway
29. Human Smad3 and Smad4 are sequence-specific transcription activators
30. Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase
31. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation