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Volumn 11, Issue 6, 2002, Pages 1442-1451
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Role of water in the catalytic cycle of E. coli dihydrofolate reductase
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Author keywords
Active site; Alternative mechanisms; Enzyme catalysis; Molecular dynamics
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Indexed keywords
BACTERIAL ENZYME;
DIHYDROFOLATE REDUCTASE;
DIHYDROFOLIC ACID;
HYDROGEN;
REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;
TETRAHYDROFOLIC ACID;
WATER;
ESCHERICHIA COLI PROTEIN;
NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;
ARTICLE;
CATALYSIS;
CHEMICAL REACTION;
CONFORMATIONAL TRANSITION;
CRYSTAL STRUCTURE;
ENERGY;
ENZYME ACTIVE SITE;
ENZYME CONFORMATION;
ENZYME STRUCTURE;
ENZYME SUBSTRATE;
ESCHERICHIA COLI;
HYDROGEN BOND;
MOLECULAR DYNAMICS;
NONHUMAN;
PRIORITY JOURNAL;
PROTON TRANSPORT;
SIMULATION;
BINDING SITE;
CHEMICAL STRUCTURE;
CHEMISTRY;
COMPUTER SIMULATION;
KINETICS;
METABOLISM;
PROTEIN TERTIARY STRUCTURE;
BACTERIA (MICROORGANISMS);
ESCHERICHIA COLI;
NEGIBACTERIA;
BINDING SITES;
CATALYSIS;
COMPUTER SIMULATION;
ESCHERICHIA COLI PROTEINS;
HYDROGEN;
KINETICS;
MODELS, MOLECULAR;
NADP;
PROTEIN STRUCTURE, TERTIARY;
TETRAHYDROFOLATE DEHYDROGENASE;
WATER;
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EID: 0036112608
PISSN: 09618368
EISSN: None
Source Type: Journal
DOI: 10.1110/ps.5060102 Document Type: Article |
Times cited : (44)
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References (41)
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