Role of water in the catalytic cycle of E. coli dihydrofolate reductase

Protein Science

Volumn 11, Issue 6, 2002, Pages 1442-1451

  Shrimpton, Paul ^a   Allemann, Rudolf K ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Active site; Alternative mechanisms; Enzyme catalysis; Molecular dynamics

Indexed keywords

BACTERIAL ENZYME; DIHYDROFOLATE REDUCTASE; DIHYDROFOLIC ACID; HYDROGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TETRAHYDROFOLIC ACID; WATER; ESCHERICHIA COLI PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENERGY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; HYDROGEN BOND; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; SIMULATION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; KINETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

BINDING SITES; CATALYSIS; COMPUTER SIMULATION; ESCHERICHIA COLI PROTEINS; HYDROGEN; KINETICS; MODELS, MOLECULAR; NADP; PROTEIN STRUCTURE, TERTIARY; TETRAHYDROFOLATE DEHYDROGENASE; WATER;

EID: 0036112608     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.5060102     Document Type: Article

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