Crystal structure at 2.4 Å resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: Evidence of a substrate-induced hinged-lid motion by loop 6

Biochemistry

Volumn 39, Issue 15, 2000, Pages 4533-4542

  McMillan, Fiona M ^a   Cahoon, Marguerite ^a   White, André ^a   Hedstrom, Lizbeth ^a   Petsko, Gregory A ^a   Ringe, Dagmar ^a  

^a BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE; INOSINATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; XANTHOSINE;

ARTICLE; BORRELIA BURGDORFERI; CATALYSIS; CHEMOTHERAPY; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE; NONHUMAN; NUCLEOTIDE METABOLISM; OXIDATION; PRIORITY JOURNAL; PURINE SYNTHESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BORRELIA BURGDORFERI GROUP; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DRUG DESIGN; ELECTROSTATICS; HUMANS; IMP DEHYDROGENASE; INOSINE MONOPHOSPHATE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOTION; NAD; PLIABILITY; PROTEIN CONFORMATION; RIBONUCLEOTIDES; SEQUENCE ALIGNMENT; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFATES;

BACTERIA (MICROORGANISMS); BORRELIA; BORRELIA BURGDORFERI; CRICETINAE; CRICETULUS GRISEUS; SPIROCHAETALES;

EID: 0034681940     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992645l     Document Type: Article

References (52)

1. Weber, G. (1983) Cancer Res. 43, 3466-3492.
2. Natsumeda, Y., Ohno, S., Kawasaki, H., Konno, Y., Weber, G., and Suzuki, K. (1990) J. Biol. Chem. 265, 5292-5295.
3. Nagai, M., Natsumeda, Y., and Weber, G. (1992) Cancer Res. 52, 258-261.
4. Konno, Y., Natsumeda, Y., Nagai, M., Yamaji, Y., Ohno, S., Suzuki, K., and Weber, G. (1991) J. Biol. Chem. 266, 506-509.
5. Nagai, M., Natsumeda, Y., Konno, Y., Hoffman, R., Irino, S., and Weber, G. (1991) Cancer Res. 51, 3886-3890.
6. Cooney, D., Jayaram, H., Gebeyehu, G., Betts, C., Kelley, J., Marquez, V., and Johns, D. (1982) Biochem. Pharmacol. 31, 2133-2136.
7. Smith, C., Fontenelle, L., Muzik, H., Paterson, A., Unger, H., Brox, L., and Henderson, J. (1974) Biochem. Pharmacol. 23, 2727-2735.
8. Franklin, T., and Cook, J. (1969) Biochem. J. 113, 515-524.
9. Streeter, D. G., Witkowski, J. T., Khare, G. P., Sidwell, R. W., Bauer, R. J., Robins, R. K., and Simon, L. N. (1973) Proc. Natl. Acad. Sci. U.S.A. 70, 1184-1188.
10. Franklin, T., and Morris, W. P. (1994) Adv. Enzyme Regul. 34, 107-118.
11. Koyama, H., and Tsuji, M. (1983) Biochem. Pharmacol. 32, 3547-3553.
12. Allison, A. C. (1993) Immunol. Rev. 136, 5-28.
13. Zhou, X., Cahoon, M., Rosa, P., and Hedstrom, L. (1997) J. Biol. Chem. 272, 21977-21981.
14. Hupe, D. J., Azzolina, B. A., and Behrens, N. D. (1986) J. Biol. Chem. 261, 8363-8369.
15. Wang, W., Papov, V. V., Minakawa, N., Matsuda, A., Biemann, K., and Hedstrom, L. (1996) Biochemistry 35, 95-101.
16. Verham, R., Meek, T. D., Hedstrom, L., and Wang, C. C. (1987) Mol. Biochem. Parasitol. 24, 1-12.
17. Huete-Perez, J. A., Wu, J. C., Whitby, F. G., and Wang, C. C. (1995) Biochemistry 34, 13889-13894.
18. Wang, W., and Hedstrom, L. (1997) Biochemistry 36, 8479-8483.
19. Xiang, B., and Markham, G. D. (1997) Arch. Biochem. Biophys. 348, 378-382.
20. Digits, J. A., and Hedstrom, L. (1999) Biochemistry 38, 2695-2306.
21. Link, J. O., and Straub, K. (1996) J. Am. Chem. Soc. 118, 2091-2092.
22. Cooney, D., Hamel, E., Cohen, M., Kang, G. J., Dalal, M., and Marquez, V. (1987) Biochim. Biophys. Acta 916, 89-93.
23. Harris, J. I., and Waters, M. (1976) Enzymes (3rd Ed.) 13, 1-49.
24. Whitby, F. G., Luecke, H., Kuhn, P., Somoza, J. R., Huete-Perez, J. A., Phillips, J. D., Hill, C. P., Fletterick, R. J., and Wang, C. C. (1997) Biochemistry 36, 10666-10674.
25. Zhang, R., Evans, G., Rotella, F. J., Westbrook, E. M., Beno, D., Huberman, E., Joachimiak, A., and Collart, F. R. (1999) Biochemistry 38, 4691-4700.
26. Sintchak, M. D., Fleming, M. A., Futer, O., Raybuck, S. A., Chambers, S. P., Caron, P. R., Murcko, M., and Wilson, K. P. (1996) Cell 85, 921-930.
27. Colby, T. D., Vanderveen, K., Strickler, M. D., Markham, G. D., and Goldstein, B. M. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 3531-3536.
28. Kerr, K. M. (1997) Doctoral Thesis, Department of Biochemistry, Brandeis University, Waltham, MA.
29. Farber, G. K., and Petsko, G. A. (1990) Trends Biochem. Sci. 15, 268-234.
30. Brzovic, P. S., Hyde, C. C., Miles, E. W., and Dunn, M. F. (1993) Biochemistry 32, 10404-10413.
31. Joseph, D., Petsko, G. A., and Karplus, M. (1990) Science 249, 1425-1428.
32. Lundqvist, T., and Schneider, G. (1991) J. Biol. Chem. 266, 12604-12611.
33. Burgdorfer, W., Barbour, A. G., Hayes, S. F., Benach, J. L., Grunwaldt, E., and Davis, J. P. (1982) Science 216, 1318-1319.
34. Otwinowski, Z., (1993) Oscillation Data Reduction Program, in Data Reduction and Processing, Proceedings of the CCP4 Study Weekend, 29-30 January, 1993, (Sawyer, L., Issacs, N., and Bailey, S., Eds.) pp 56-62, SERC Daresbury Laboratory, Warrington, England.
35. Navaza, J. (1994) Acta Crystallogr. A50, 157-163.
36. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. A47, 110-119.
37. Brunger, A. T. (1992) X-PLOR: A System for X-ray Crystallography and NMR, The Howard Hughes Medical Institute and the Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT.
38. Brunger, A. T., Adams, P. D., Clore, G. M., Delano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J.-S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D54, 905-921.
39. Hodel, A., Kim, S. H., and Brunger, A. T. (1992) Acta Crystallogr. A48, 851-858.
40. Kleygwegt, G. J., and Jones, T. A. (1997) Methods Enzymol. 277, 525-545.
41. Engh, R. A., and Huber, R. (1991) Acta Crystallogr. A47, 392-399.
42. Bork, P., Gellerich, J., Groth, H., Hooft, R., and Martin, F. (1995) Protein Sci. 4, 268-274.
43. Bellamacina, C. R. (1996) FASEB J. 10, 1257-1269.
44. Pompliano, D. L., Peyman, A., and Knowles, J. R. (1990) Biochemistry 29, 3186-3194.
45. Rhee, S., Parris, K. D., Hyde, C. C., Ahmed, S. A., Miles, E. W., and Davies, D. R. (1997) Biochemistry 36, 7664-7680.
46. Brzovic, P. S., Sawa, Y., Hyde, C. C., Miles, E. W., and Dunn, M. F. (1992) J. Biol. Chem. 267, 13028-13088.
47. Priestle, J. P.; Grutter, M. G., White, J. L., Vincent, M. G., Kania, M., Wilson, E., Jardetzky, T. S., Kirschner, K., and Jansonius, J. N. (1987) Proc. Natl. Acad. Sci. U.S.A. 87, 5690-5694.
48. Noble, M. E., Zeelen, J. P., and Wierenga, R. K. (1993) Proteins: Struct., Funct., Genet. 16, 311-326.
49. Gruessner, R. W., Sutherland, D. E., Drangstveit, M. B., Wrenshall, L., Humar, A., and Gruessner, A. C. (1998) Transplantation 66, 318-323.
50. Pirsch, J. D., and Sollinger, H. W. (1996) Ther. Drug Monit. 18, 357-361.
51. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
52. Barton, G. J. (1993) Protein Eng. 6, 37-40.