Down-regulation of insulin-like growth factor-I receptor and insulin receptor substrate-1 expression in advanced human breast cancer

International Journal of Cancer

Volumn 89, Issue 6, 2000, Pages 506-513

  Schnarr, Bernd ^a   Strunz, Kathrin ^a   Ohsam, Jürgen ^a   Benner, Axel ^a   Wacker, Jürgen ^b   Mayer, Doris ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR; KI 67 ANTIGEN; RECEPTOR SUBTYPE; SOMATOMEDIN C RECEPTOR; TUMOR MARKER;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BREAST CANCER; BREAST CARCINOMA; CANCER GRADING; CANCER GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA FLANKING REGION; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, LOBULAR; CELL DIVISION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MIDDLE AGED; PHOSPHOPROTEINS; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; RECEPTORS, ESTROGEN; TUMOR MARKERS, BIOLOGICAL;

EID: 0034693680     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20001120)89:6<506::AID-IJC7>3.0.CO;2-F     Document Type: Article

References (49)

1. Role of IRS-1 signaling in insulin-induced modulation of estrogen receptors in breast cancer cells
2. Insulin-like growth factors control the regulation of oestrogen and progesterone receptor expression by oestrogens
3. Relationship between estrogen levels, use of hormone replacement therapy, and breast cancer
4. Insulin and related factors in premenopansal breast cancer risk
5. Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach
6. Obese mice have higher insulin receptor levels in the hepatocyte nucleus following insulin stimulation in vivo with an oral glucose meal
7. Tamoxifen interferes with the insulin-like growth factor I receptor (IGF-IR) signaling pathway in breast cancer cells
8. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer
9. The localization of the insulin-like growth factor receptor 1 (IGFR-1) in benign and malignant breast tissue
10. Regulation of insulin-like growth factor I receptor expression by the pure antiestrogen ICI 182780
11. Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin and interleukin-4 in estrogen receptor-positive human breast cancer cells
12. Nuclear localization of insulin-like growth factor binding protein-3 in a lung cancer cell line
13. Structure of insulin receptor substrate 1 and role in insulin signaling as a docking protein for SH2 domain-containing proteins
14. Insulin rapidly induces translocation of PI3-kinase in HepG2 cells
15. Genetic engineering in mice: Impact on insulin signalling and action
16. Classification and regression trees (CART) for the exploration of prognostic factors measured on different scales
17. IGF system components as prognostic markers in breast cancer
18. Enhancement of insulin-like growth factor signaling in human breast cancer: Estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo
19. Molecular and cellular aspects of the insulin-like growth factor I receptor
20. Insulin receptor expression and clinical outcome in node-negative breast cancer
21. Practical breast carcinoma cell kinetics: Review and update
22. Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells
23. Insulin receptor substrate-1 expression is regulated by estrogen in the MCF-7 human breast cancer cell line
24. Overexpression of insulin receptor substrate-1 emerges early in hepatocarcinogenesis and elicits preneoplastic hepatic glycogenosis
25. Insulin receptor substrate-1 is overexpressed in glycogenotic but not in amphophilic preneoplastic hepatic foci induced in rats by N-nitrosomorpholine and dehydroepiandrosterone
26. Effect of oestradiol and insulin on the proliferative pattern and on oestrogen and progesterone receptor contents in MCF-7 cells
27. Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer
28. Sporadic amplification of the insulin receptor gene in human breast cancer
29. Type I IGF receptor in human breast diseases
30. Insulin-like growth factor 1 receptors in human breast cancer and their relation to estradiol and progesterone receptors
31. IGF-I physiology and breast cancer
32. Nuclear localization signal in insulin-like growth factor-binding protein type 3
33. Insulin receptor alpha-subunit: A putative gene regulatory molecule
34. Breast cancer and the role of cytokines in regulating estrogen synthesis: An emerging hypothesis
35. Insulin-like growth factor binding protein-3 and insulin receptor substrate-1 in breast cancer: Correlation with clinical parameters and disease-free survival
36. IL-4 receptor complexes containing or lacking the gamma C chain are inhibited by an overlapping set of antagonistic IL-4 mutant proteins
37. Family histories of diabetes mellitus and breast cancer and incidence of postmenopausal breast cancer
38. Type I insulin-like growth factor receptor function in breast cancer
39. Insulin-like growth factor-I overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation
40. The IRS-signaling system: A network of docking proteins that mediate insulin and cytokine action
41. Intranuclear localization of insulin-like growth factor binding protein-3 (IGFBP-3) during cell division in human keratinocytes
42. The insulin-like growth factor system as a target in breast cancer
43. The assessment of cellular proliferation by immunohistochemistry: A review of currently available methods and their applications