Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: Therapeutic implications

Cancer Research

Volumn 62, Issue 21, 2002, Pages 6035-6038

  Chang, Qing ^a   Li, Yu ^a   White, Morris F ^a   Fletcher, Jonathan A ^a   Xiao, Sheng ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PHENYLALANINE; SOMATOMEDIN;

ADRENAL CORTEX CARCINOMA; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CELL CULTURE; CELL DIFFERENTIATION; CELL TRANSFORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEIOMYOSARCOMA; LIPOSARCOMA; MALIGNANT TRANSFORMATION; NEPHROBLASTOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION; SOLID TUMOR;

BREAST NEOPLASMS; CELL DIVISION; HUMANS; NEOPLASMS; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0036828097     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Myers, M. G., Jr., Sun, X. J., Cheatham, B., Jachna, B. R., Glasheen, E. M., Backer, J. M., and White, M. F. IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3′-kinase. Endocrinology, 132: 1421-1430, 1993.
2. Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., and White, M. F. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature (Lond.), 352: 73-77, 1991.
3. Melillo, R. M., Carlomagno, F., De Vita, G., Formisano, P., Vecchio, G., Fusco, A., Billaud, M., and Santoro, M. The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: Evidence for a competition between Shc and IRS-1 for the binding to Ret. Oncogene, 20: 209-218, 2001.
4. Burfoot, M. S., Rogers, N. C., Watling, D., Smith, J. M., Pons, S., Paonessaw, G., Pellegrini, S., White, M. F., and Kerr, I. M. Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons. J. Biol. Chem., 272: 24183-24190, 1997.
5. Eck, M. J., Dhe-Paganon, S., Trub, T., Nolte, R. T., and Shoelson, S. E. Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor. Cell, 85: 695-705, 1996.
6. White, M. F. The insulin signalling system and the IRS proteins. Diabetologia, 40 (Suppl, 2): S2-S17, 1997.
7. Wang, L. M., Myers, M. G., Jr., Sun, X. J., Aaronson, S. A., White, M., and Pierce, J. H. IRS-1: Essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells. Science (Wash. DC), 261: 1591-1594, 1993.
8. Taouis, M., Dupont, J., Gillet, A., Derouet, M., and Simon, J. Insulin receptor substrate 1 antisense expression in an hepatoma cell line reduces cell proliferation and induces overexpression of the Src homology 2 domain and collagen protein (SHC). Mol. Cell. Endocrinol., 137: 177-186, 1998.
9. Waters, S. B., Yamauchi, K., and Pessin, J. E. Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling. J. Biol. Chem., 268: 22231-22234, 1993.
10. Rose, D. W., Saltiel, A. R., Majumdar, M., Decker, S. J., and Olefsky, J. M. Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction. Proc, Natl. Acad. Sci, USA, 91: 797-801, 1994.
11. Ito, T., Sasaki, Y., and Wands, J. R. Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases. Mol. Cell. Biol., 16: 943-951, 1996.
12. Tanaka, S., Ito, T., and Wands, J. R. Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signaling molecules. J. Biol. Chem., 271: 14610-14616, 1996.
13. D'Ambrosio, C., Keller, S. R., Morrione, A., Lienhard, G. E., Baserga, R., and Surmacz, E. Transforming potential of the insulin receptor substrate 1. Cell Growth Differ., 6: 557-562, 1995.
14. Fei, Z. L., D'Ambrosio, C., Li, S., Surmacz, E., and Baserga, R. Association of insulin receptor substrate 1 with simian virus 40 large T antigen. Mol. Cell. Biol., 15: 4232-4239, 1995.
15. Valentinis, B., Romano, G., Peruzzi, F., Morrione, A., Prisco, M., Soddu, S., Cristofanelli, B., Saechi, A., and Baserga, R. Growth and differentiation signals by the insulin-like growth factor 1 receptor in hemopoietic cells are mediated through different pathways, J. Biol. Chem., 274: 12423-12430, 1999.
16. Reiss, K., Wang, J. Y., Romano, G., Furnari, F. B., Cavenee, W. K., Morrione, A., Tu, X., and Baserga, R. IGF-1 receptor signaling in a prostatic cancer cell line with a PTEN mutation. Oncogene, 19: 2687-2694, 2000.
17. Myers, M. G., Jr., Zhang, Y., Aldaz, G. A., Grammer, T., Glasheen, E. M., Yenush, L. Wang, L. M., Sun, X. J., Blenis, J., Pierce, J. H., and White, M. F. YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites. Mol. Cell. Biol., 16: 4147-4155, 1996.
18. Dupont, J., and LeRoith, D. Insulin and insulin-like growth factor 1 receptors: similarities and differences in signal transduction. Horm. Res., 55 (Suppl. 2): 22-26, 2001.
19. Jiang, Y., Rom, W. N., Yie, T. A., Chi, C. X., and Tchou-Wong. K, M. Induction of tumor suppression and glandular differentiation of A549 lung carcinoma cells by dominant-negative IGF-I receptor. Oncogene, 18: 6071-6077, 1999.
20. O'Dell, S. D., and Day, I. N. Insulin-like growth factor II (IGF-II). Int. J. Biochem. Cell Biol. 30: 767-771, 1998.
21. Morrione, A., Valentinis, B., Xu, S. Q., Yumet, G., Louvi, A., Efstratiadis, A., and Baserga, R. Insulin-like growth factor 11 stimulates cell proliferation through the insulin receptor. Proc. Natl. Acad. Sci. USA, 94: 3777-3782, 1997.
22. Tavare, J. M., O'Brien, R. M., Siddle, K., and Denton, R. M. Analysis of insulin-receptor phosphorylation sites in intact cells by two-dimensional phosphopeptide mapping. Biochem, J. 253: 783-788, 1988.
23. Egawa, K., Macgawa, H., Shimizu, S., Morino, K., Nishio, Y., Bryer-Ash, M., Cheung, A. T., Kolls, J. K., Kikkawa, R., and Kashiwagi, A. Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in 16 myocytes and Fao hepatoma cells. J. Biol. Chem., 276, 10207-10211, 2001.
24. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C. Ittinann, M., Tycko, B., Hibshoosh, H., Wigler, M. H., and Parsons, R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (Wash. DC), 275: 1943-1947, 1997.
25. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D. H., and Tavtigian, S. V. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet., 15: 356-362, 1997.