Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components

Genes Chromosomes and Cancer

Volumn 34, Issue 4, 2002, Pages 416-427

  Actor, Bertrand ^a   Ludwig Cobbers, J M J ^b   Büschges, Rainer ^b   Wolter, Marietta ^b   Knobbe, Christiane B ^a,b   Reifenberger, Guido ^b   Weber, Ruthild G ^a,c,d  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 4; EPIDERMAL GROWTH FACTOR RECEPTOR; GENE PRODUCT; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN KINASE B; PROTEIN MDM2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHROMOSOME 10; CHROMOSOME 13Q; CHROMOSOME 7; CHROMOSOME 9P; CHROMOSOME ABERRATION; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; FEMALE; GENE AMPLIFICATION; GENE MAPPING; GENETIC STABILITY; GLIOSARCOMA; HUMAN; MALE; MOLECULAR CLONING; PHENOTYPE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADULT; AGED; BRAIN NEOPLASMS; CHROMOSOME DELETION; CYTOGENETIC ANALYSIS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; GENE AMPLIFICATION; GLIOBLASTOMA; GLIOSARCOMA; HUMANS; IMMUNOHISTOCHEMISTRY; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; NUCLEIC ACID HYBRIDIZATION; SARCOMA;

EID: 0036077133     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.10087     Document Type: Article

References (49)

1. Minimal size of deletions detected by comparative genomic hybridization
2. Identical mutations of the p53 tumor-suppressor gene in the gliomatous and the sarcomatous components of gliosarcomas suggest a common origin from glial cells
3. The glial and mesenchymal elements of gliosarcomas share similar genetic alterations
4. Amplification and expression of cyclin D genes (CCND1, CCND2 and CCND3) in human malignant gliomas
5. Frequent inactivation of CDKN2A and rare mutation of TP53 in PCNSL
6. Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA
7. Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization
8. Quantitative analysis of comparative genomic hybridization
9. Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors
10. Clinical outcome of gliosarcoma compared with glioblastoma multiforme: North Central Cancer Treatment Group results
11. Gliosarcoma: An immunohistochemical study
12. Smooth muscle can comprise the sarcomatous component of gliosarcomas
13. Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas
14. Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene
15. Genetic reflection of glioblastoma biopsy material in xenografts: Characterization of 11 glioblastoma xenograft lines by comparative genomic hybridization
16. Spindle-cell glioblastoma or gliosarcoma
17. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors
18. Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors
19. Chromosomal abnormalities in glioblastoma multiforme tumors and glioma cell lines detected by comparative genomic hybridization
20. Glioblastoma
21. Molecular genetic analysis of human glioblastomas for aberrations of genes encoding members of the Pten/PI3K/Akt signal transduction pathway
22. Contribution of histiocytic cells to sarcomatous development of the gliosarcoma: An immunohistochemical study
23. Tumours of the nervous system
24. Detection of chromosomal aberrations by means of molecular cytogenetics: Painting of chromosomes and chromosomal subregions and comparative genomic hybridization
25. Gliosarcoma: A histologic and immunohistochemical reaffirmation
26. Mixed glioblastoma multiforme and sarcoma: A clinicopathologic study of 26 radiation therapy oncology group cases
27. Detection of multiple gains and losses of genetic material in ten glioma cell lines by comparative genomic hybridization
28. Genetic analysis of glioblastoma multiforme provides evidence for subgroups within the grade
29. Gliosarcoma
30. Interphase cytogenetics of glioblastoma and gliosarcoma
31. Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2
32. Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets
33. Chordoid glioma of the third ventricle: Immunohistochemical and molecular genetic characterization of a novel tumor entity
34. Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression
35. Genetic profile of gliosarcomas
36. GFAP, F VIII/RAg, laminin, and fibronectin in gliosarcomas: An immunohistochemical study
37. Detection of complex genetic alterations in human glioblastoma multiforme using comparative genomic hybridization
38. Comparative genomic hybridization of human malignant gliomas reveals multiple amplification sites and non-random chromosomal gains and losses
39. Gliosarcomas: Histological, immunohistochemical, ultrastructural, and tissue culture studies
40. Amplification of the platelet-derived growth factor receptor-A (PDGFRA) gene occurs in oligodendrogliomas with grade IV anaplastic features
41. Degenerate oligonucleotide-primed PCR: General amplification of target DNA by a single degenerate primer
42. Genomic changes in glioblastoma cell lines detected by comparative genomic hybridization
43. Characterization of genomic alterations associated with glioma progression by comparative genomic hybridization
44. Clinically distinct subgroups of glioblastoma multiforme studied by comparative genomic hybridization
45. Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: Toward a genetic model of meningioma progression
46. Chromosomal imbalances associated with response to chemotherapy and cytotoxic cytokines in human malignant glioma cell lines
47. Two independent amplification events on chromosome 7 in glioma: Amplification of the epidermal growth factor receptor gene and amplification of the oncogene MET
48. Comparative genomic hybridisation for the analysis of chromosomal imbalances in solid tumours and haematological malignancies