Immunosuppressant rapamycin inhibits protein kinase C α and p38 mitogen-activated protein kinase leading to the inhibition of chondrogenesis

European Journal of Pharmacology

Volumn 427, Issue 3, 2001, Pages 175-185

  Oh, Chun Do ^a   Kim, Song Ja ^a   Ju, Jung Won ^a   Song, Woo Keun ^a   Kim, Jae Hong ^a   Yoo, Yung Joon ^a   Chun, Jang Soo ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

Chondrogenesis; Mesenchymal cells; Micromass culture; p38 MAP (mitogen activated protein) kinase; Protein kinase C ; Rapamycin

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; COLLAGEN TYPE 2; GLYCOSAMINOGLYCAN POLYSULFATE; IMMUNOSUPPRESSIVE AGENT; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE CALPHA; RAPAMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE METABOLISM; CELL DIFFERENTIATION; CHONDROGENESIS; CONTROLLED STUDY; DRUG EFFECT; ENCHONDRAL OSSIFICATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; MESENCHYME CELL; NONHUMAN; OSSIFICATION; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0035929234     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01241-9     Document Type: Article

References (41)

1. Stage-related capacity for limb chondrogenesis in cell culture
2. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
3. The detection of a precartilage, blastema-specific marker
4. Rapamycin inhibits human adipocyte differentiation in primary culture
5. A signaling pathway to translational control
6. A mammalian protein targeted by G1-arresting rapamycin-receptor complex
7. Control of p70 S6 kinase by kinase activity of FRAP in vivo
8. Protein kinase C regulates chondrogenesis of mesenchymes via mitogen-activated protein kinase signaling
9. Expression of protein kinase C isozymes that are required for chondrogenesis of chick limb bud mesenchymal cells
10. The 70 kDa S6 kinase: Regulation of a kinase with multiple roles in mitogenic signalling
11. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
12. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
13. The deleterious effects of long-term cyclosporine A, cyclosporine G, and FK506 on bone mineral metabolism in vivo
14. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)
15. Effects of cyclosporin A on experimental new bone formation in rats
16. PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints
17. Activation of protein kinase A is a pivotal step involved in both BMP-2- and cyclic AMP-induced chondrogenesis
18. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
19. Hyaluronan-mediated aggregation of limb bud mesenchyme and mesenchymal condensation during chondrogenesis
20. The extended protein kinase C superfamily
21. Expression and functional involvement of N-cadherin in embryonic limb chondrogenesis
22. Opposing role of mitogen-activated protein kinase subtypes, Erk-1/2 and p38, in the regulation of chondrogenesis of mesenchymes
23. Mammalian TOR controls one of two kinase pathways acting upon nPKC delta and nPKC epsilon
24. Multiple pathways control protein kinase C phosphorylation
25. Tenascin is associated with articular cartilage development
26. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
27. Transforming growth factor-beta and bone morphogenetic protein-2 act by distinct mechanisms to promote chick limb cartilage differentiation in vitro
28. Developmental patterns of cartilage
29. Inhibition of chondrogenesis by integrin antibody in vitro
30. Differentiation of cartilage and bone
31. A tissue culture analysis of the steps in limb chondrogenesis
32. Activity of protein kinase C during the differentiation of chick limb bud mesenchymal cells
33. Successive formative stages of precartilaginous mesenchymal condensations in vitro: Modulation of cell adhesion by Wnt-7A and BMP-2
34. N-CAM and N-cadherin expression during in vitro chondrogenesis
35. Regulated expression of fibronectin, laminin and related integrin receptors during the early chondrocyte differentiation
36. TOR signalling and control of cell growth
37. Activation of MAP kinases, pp90rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or Fc epsilon RI: Rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells
38. Immunosuppression with FK506 increases bone induction in demineralized isogeneic and xenogeneic bone matrix in the rat
39. Protein kinase A regulates chondrogenesis of mesenchymal cells at the post-precartilage condensation stage via protein kinase C α signaling
40. Epidermal growth factor negatively regulates chondrogenesis of mesenchymal cells by modulating the protein kinase C α, Erk-1, and p38 MAP kinase signaling pathways
41. Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex