Two open states and rate-limiting gating steps revealed by intracellular Na+ block of human KCNQ1 and KCNQ1/KCNE1 K+ channels

Journal of Physiology

Volumn 533, Issue 1, 2001, Pages 135-144

  Pusch, Michael ^a   Ferrera, Loretta ^a   Friedrich, Thomas ^b  

^a CNR   (Italy)

^b MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MEGLUMINE; POTASSIUM; POTASSIUM CHANNEL; SODIUM; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CHANNEL GATING; CHO CELL; CONTROLLED STUDY; NONHUMAN; PATCH CLAMP; POTASSIUM CELL LEVEL; POTASSIUM CURRENT; PRIORITY JOURNAL; SODIUM CELL LEVEL; CHO CELL LINE; EXTRACELLULAR POTASSIUM; EXTRACELLULAR SPACE; WHOLE CELL PATCH CLAMP;

ANIMALS; CHO CELLS; CRICETINAE; GLUTAMATES; HUMANS; ION CHANNEL GATING; KCNQ POTASSIUM CHANNELS; KCNQ1 POTASSIUM CHANNEL; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; SODIUM;

EID: 0035866994     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2001.0135b.x     Document Type: Article

References (35)

1. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
2. K(V)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current
3. Negative conductance caused by entry of sodium and cesium ions into the potassium channels of squid axons
4. Fitting curves to data. The simplex algorithm is the answer
5. + conduction and selectivity
6. Sodium ions as blocking agents and charge carriers in the potassium channel of the squid giant axon
7. Improved patch clamp techniques for high-resolution current recording from cells and cell-free membrane patches
8. + channels: Functional asymmetries and sidedness of proton activation
9. Neuronal KCNQ potassium channels: Physiology and role in disease
10. Visual identification of individual transfected cells for electrophysiology using antibody-coated beads
11. + in voltage-gated potassium channels: Evidence for cation binding sites with different affinity
12. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness
13. Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity
14. Increase of the single-channel conductance of KvLQT1 potassium channels induced by the association with minK
15. Gating and flickery block differentially affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 potassium channels
16. Activation and inactivation of homomeric KvLQT1 potassium channels
17. Evidence for multiple open and inactivated states of the hKv1.5 delayed rectifier
18. Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel
19. + channels causes epilepsy
20. A constitutively open potassium channel formed by KCNQ1 and KCNE3
21. The LQT syndromes - Current status of molecular mechanisms
22. Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome
23. KS potassium channel pore with sensitivity to internal tetraethylammonium
24. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns
25. The conduction pore of a cardiac potassium channel
26. Cloning of a membrane protein that induces a slow voltage-gated potassium current
27. Interaction between quaternary ammonium ions in the pore of potassium channels: Evidence against an electrostatic repulsion mechanism
28. + channel (minK) subunits
29. Positional cloning of a novel potassium channel gene: KvLQT1 mutations cause cardiac arrhythmias
30. + channel mutations found in inherited cardiac arrhythmias
31. KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias
32. Single-channel properties of IKs potassium channels
33. + channels of bovine chromaffin cells
34. + channels by external cations
35. Selectivity changes during activation of mutant Shaker potassium channels