Gating and flickery block differentially affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 potassium channels

Biophysical Journal

Volumn 78, Issue 1, 2000, Pages 211-226

  Pusch, M ^a   Bertorello, L ^a   Conti, F ^a  

^a CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL; RUBIDIUM;

ARTICLE; CELL ACTIVATION; CELL INTERACTION; CELL MEMBRANE PERMEABILITY; CHANNEL GATING; NONHUMAN; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; STEADY STATE;

TRIXIS;

EID: 0034030261     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(00)76586-6     Document Type: Article

References (26)

1. M.J. Ackerman The long QT syndrome Pediatr. Rev. 19 1998 232 238
2. J. Barhanin F. Lesage E. Guillemare M. Fink M. Lazdunski G. Romey K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current Nature 384 1996 78 80
3. M.D. Cahalan K.G. Chandy T.E. DeCoursey S. Gupta A voltage-gated potassium channel in human T lymphocytes J. Physiol. 358 1985 197 237
4. F. Gambale M. Bregante F. Stragapede A.M. Cantù Ionic channels of the sugar beet tonoplast are regulated by a multi-ion single-file permeation mechanism J. Membr. Biol. 154 1996 69 79
5. + channel alter ion selectivity and open-channel block Neuron 7 1991 403 408
6. + channel Biophys. J. 65 1993 2089 2096
7. L.K. Kaczmarek E.M. Blumenthal Properties and regulation of the minK potassium channel protein Physiol. Rev. 77 1997 627 641
8. D.R. Matteson R.P. Swenson Jr. External monovalent cations that impede the closing of K channels J. Gen. Physiol. 87 1986 795 816
9. M. Pusch Increase of the single-channel conductance of KvLQT1 potassium channels induced by the association with minK Pflügers Archiv. 437 1998 172 174
10. M. Pusch R. Magrassi B. Wollnik F. Conti Activation and inactivation of homomeric KvLQT1 potassium channels Biophys. J. 75 1998 785 792
11. + J. Gen. Physiol. 98 1991 535 554
12. M.C. Sanguinetti M.E. Curran A. Zou J. Shen P.S. Spector D.L. Atkinson M.T. Keating Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel Nature 384 1996 80 83
13. E. Schulze-Bahr Q. Wang H. Wedekind W. Haverkamp Q. Chen Y. Sun C. Rubie M. Hördt J.A. Towbin M. Borggrefe G. Assmann X. Qu J.C. Somberg G. Breithardt C. Oberti H. Funke KCNE1 mutations cause Jervell and Lange-Nielsen syndrome Nat. Genet. 17 1997 267 268
14. M.S. Shapiro T.E. DeCoursey Selectivity and gating of the type L potassium channel in mouse lymphocytes J. Gen. Physiol. 97 1991 1227 1250
15. M.S. Shapiro T.E. DeCoursey Permeant ion effects on the gating kinetics of the type L potassium channel in mouse lymphocytes J. Gen. Physiol. 97 1991 1251 1278
16. F. Sesti S.A.N. Goldstein Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome J. Gen. Physiol. 112 1998 651 663
17. I. Splawski M. Tristani-Firouzi M.H. Lehmann M.C. Sanguinetti M.T. Keating Mutations in the hminK gene cause long QT syndrome and suppress IKs function Nat. Genet. 17 1997 338 340[[page end]]
18. + Nature 291 1981 427 429
19. K.-K. Tai S.A.N. Goldstein The conduction pore of a cardiac potassium channel Nature 391 1998 605 608
20. T. Takumi H. Ohkubo S. Nakanishi Cloning of a membrane protein that induces a slow voltage-gated potassium current Science 242 1988 1042 1045
21. + channel (minK) subunits J Physiol. 510 1998 37 45
22. K.P. Wagoner G.S. Oxford Cation permeation through the voltage-dependent potassium channel in the squid axon. Characteristics and Mechanisms J. Gen. Physiol. 90 1987 261 290
23. Q. Wang M.E. Curran I. Splawski T.C. Burn J.M. Millholland T.J. VanRaay J. Shen K.W. Timothy G.M. Vincent T. de Jager P.J. Schwartz J.A. Toubin A.J. Moss D.L. Atkinson G.M. Landes T.D. Connors M.T. Keating Positional cloning of a novel potassium channel gene: KvLQT1 mutations cause cardiac arrhythmias Nat. Genet. 12 1996 17 23
24. K.-W. Wang K.-K. Tai S.A.N. Goldstein MinK residues line a potassium channel pore Neuron 16 1996 571 577
25. W.P. Yang P.C. Levesque W.A. Little M.L. Conder F.Y. Shalaby M.A. Blanar KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias Proc. R. Soc. London Ser. A. Natl. Acad. Sci. USA 94 1997 4017 4021
26. Y. Yang F.J. Sigworth Single-channel properties of IKs potassium channels J. Gen. Physiol. 112 1998 665 678