Control of growth by the somatropic axis: Growth hormone and the insulin-like growth factors have related and independent roles

Annual Review of Physiology

Volumn 63, Issue , 2001, Pages 141-164

  Butler, A A ^a   Le Roith, D ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Cell proliferation; Conditional knockouts; Somatomedin hypothesis

Indexed keywords

FATTY ACID; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; GROWTH HORMONE RELEASING FACTOR; INSULIN; LEPTIN; NEUROPEPTIDE Y; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C; SOMATOMEDIN RECEPTOR; SOMATOSTATIN;

ARTICLE; AUTOCRINE EFFECT; BONE GROWTH; CARCINOGENESIS; CELL CYCLE; CELL PROLIFERATION; CLINICAL TRIAL; GLUCOSE TRANSPORT; GROWTH; GROWTH HORMONE RELEASE; HUMAN; HYPOPHYSIS; KNOCKOUT GENE; LIPOLYSIS; LIVER; NITROGEN BALANCE; NONHUMAN; OVARY FOLLICLE DEVELOPMENT; PARACRINE SIGNALING; POSTNATAL GROWTH; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SKELETAL MUSCLE; STEROIDOGENESIS;

ANIMALS; CELL DIVISION; GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, KNOCKOUT;

EID: 0035043918     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.63.1.141     Document Type: Article

References (137)

1. A novel family of growth factor receptors: A common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor beta-chain
2. Haemopoietic receptors and helical cytokines
3. A new cytokine receptor superfamily
4. Structure and evolution of the growth hormone gene family
5. Sequences of pituitary and placental lactogenic and growth hormones: Evolution from a primordial peptide by gene reduplication
6. Growth hormone secretory profiles in conscious female rats
7. Age- and sex-related differences in episodic growth hormone secretion in the rat
8. Dynamic studies of growth hormone and prolactin secretion in the female rat
9. Females secrete growth hormone with more process irregularity than males in both humans and rats
10. Different effects of intermittent and continuous growth hormone (GH) administration on serum somatomedin-C/insulin-like growth factor I and liver GH receptors in hypophysectomized rats
11. Regulation of insulin-like growth factor messenger ribonucleic acid in rat growth plate by growth hormone
12. STAT5b-deficient mice are growth hormone pulse-resistant. Role of STAT5b in sex-specific liver p450 expression
13. Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption
14. Growth hormone as a cytokine
15. Characterization of rat hypothalamic growth hormone-releasing factor
16. Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: Growth hormone-releasing factor
17. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone
18. A receptor in pituitary and hypothalamus that functions in growth hormone release
19. Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland
20. The influence of plasma triglycerides on human growth hormone response to arginine and insulin: A study in hyperlipemics and normal subjects
21. The effect of free fatty acids on growth hormone (GH)-releasing hormone-mediated GH secretion in man
22. Regulation of in vivo growth hormone secretion by leptin
23. Leptin is a potent stimulator of spontaneous pulsatile growth hormone (GH) secretion and the GH response to GH-releasing hormone
24. Evidence for a leptin-neuropeptide Y axis for the regulation of growth hormone secretion in the rat
25. Regulation of hypothalamic neuropeptide-Y neurons by growth hormone in the rat
26. Growth hormone receptor gene is expressed in neuropeptide Y neurons in hypothalamic arcuate nucleus of rats
27. Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects
28. GH-releasing activity of Hexarelin, a new growth hormone releasing peptide, in infant and adult rats
29. Ghrelin is a growth-hormone-releasing acylated peptide from stomach
30. A comparison of lanreotide and octreotide LAR for treatment of acromegaly
31. Octreotide inhibits insulin-like growth factor-I hepatic gene expression in the hypophysectomized rat: Evidence for a direct and indirect mechanism of action
32. The effects of octreotide on GH receptor and IGF-I expression in the GH-deficient rat
33. Mechanisms of antineoplastic action of somatostatin analogs
34. Somatostatin analogues inhibit growth of pancreatic cancer by stimulating tyrosine phosphatase
35. Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells
36. Divergent responses of serum insulin-like growth factor-I and liver growth hormone (GH) receptors to exogenous GH in proteinrestricted rats
37. Dexamethasone inhibits growth hormone induction of insulin-like growth factor-I (IGF-I) messenger ribonucleic acid (mRNA) in hypophysectomized rats and reduces IGF-I mRNA abundance in the intact rat
38. Dexamethasone inhibits both growth hormone (GH)-induction of insulin-like growth factor-I (IGF-I) mRNA and GH receptor (GHR) mRNA levels in rat primary cultured hepatocytes
39. Dexamethasone impairs growth hormone (GH)-stimulated growth by suppression of local insulin-like growth factor (IGF)-I production and expression of GH- and IGF-I-receptor in cultured rat chondrocytes
40. The fetal adrenal and the maturation of the growth hormone and prolactin axes
41. A specific growth hormone-binding protein in human plasma: Initial characterization
42. Alternatively spliced forms in the cytoplasmic domain of the human growth hormone (GH) receptor regulate its ability to generate a soluble GH-binding protein
43. Monkey growth hormone (GH) receptor gene expression. Evidence for two mechanisms for the generation of the GH binding protein
44. The effect of circulating growth hormone-binding protein on metabolic clearance, distribution, and degradation of human growth hormone
45. Rapid effects of growth hormone on amino acid transport and protein synthesis
46. Growth hormone and insulin combine to improve whole-body and skeletal muscle protein kinetics
47. Human growth hormone prevents the protein catabolic side effects of prednisone in humans
48. Insulin-like growth factor I exerts growth hormone- and insulin-like actions on human muscle protein metabolism
49. The effects of growth hormone on protein metabolism in adult growth hormone deficient patients
50. Growth hormone treatment of obese women for 5 weeks: Effect on body composition and adipose tissue LPL activity
51. Growth hormone inhibits lipoprotein lipase activity in human adipose tissue
52. Growth hormone alters lipolysis and hormone-sensitive lipase activity in 3T3-F442 A adipocytes
53. Growth-hormone-induced changes in postheparin plasma lipoprotein lipase and hepatic triglyceride lipase activities
54. Both human pituitary growth hormone and recombinant DNA-derived human growth hormone cause insulin resistance at a postreceptor site
55. Biological activity of bacterial derived human growth hormone in adipose tissue of hypophysectomized rats
56. Signalling pathway of GH
57. The glucose-fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
58. Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats
59. Additive effects on body growth of insulin-like growth factor-I and growth hormone in hypophysectomized rats
60. Insulin-like growth factor-I and growth hormone (GH) have distinct and overlapping effects in GH-deficient rats
61. Differential long-term effects of insulin-like growth factor-I (IGF-I) growth hormone (GH), and IGF-I plus GH on body growth and IGF binding proteins in hypophysectomized rats
62. The effects of growth hormone and insulin-like growth factor I on the immune system of aged female monkeys
63. Recombinant human insulin-like growth factor binding protein-3 (rhIGFBP-3): Effects on the glycemic and growth promoting activities of rhIGF-1 in the rat
64. Organization and chromosomal localization of the gene encoding the mouse acid labile subunit of the insulin-like growth factor binding complex
65. Cellular localization and regulation of gene expression for components of the insulin-like growth factor ternary binding protein complex
66. Insulin-like growth factors and their binding proteins: Biological actions
67. Insulin-like growth factors and cancer
68. Insulin-like growth factor receptors
69. Insulin-like growth factor: A model for tertiary structure accounting for immunoreactivity and receptor binding
70. Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors
71. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin
72. Role of insulin-like growth factors in embryonic and postnatal growth
73. Insulin-like growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity
74. Expression and characterization of a functional human insulin-like growth factor I receptor
75. High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum
76. Insulin-like growth factor binding protein-1 induces insulin release in the rat
77. Human insulin-like growth factor (IGF) binding protein-1 inhibits IGF-I-stimulated body growth but stimulates growth of the kidney in snell dwarf mice
78. A central domain binding site in insulin-like growth factor binding protein-5 for the acid-labile subunit
79. Insulin-like growth factor binding proteins
80. IGF binding proteins as modulators of IGF action
81. Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: Manipulation using the Cre/loxP system in transgenic mice
82. IGF-I is required for normal embryonic growth in mice
83. Serum levels of insulin-like growth factor (IGF) and IGF binding protein in constitutionally tall children and adolescents
84. Genetic selection for insulin-like growth factor-1 in growing mice is associated with altered growth
85. Insulin-like growth factor I regulates gonadotropin responsiveness in the murine ovary
86. Natural history of the classical form of primary growth hormone (GH) resistance (Laron syndrome)
87. Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms
88. Acute effects of insulin-like growth factor I on glucose and amino acid metabolism in the awake fasted rat. Comparison with insulin
89. Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: Quantification of individual receptor species by selective immunoprecipitation and immunoblotting
90. The effects of repeated daily recombinant human insulin-like growth factor I administration in adolescents with type 1 diabetes
91. Insulin-like growth factor I (rhIGF-I) as a therapeutic agent for hyperinsulinemic insulin-resistant diabetes mellitus
92. Recombinant human insulin-like growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes
93. Short-term effects of recombinant human insulin-like growth factor I on metabolic control of patients with type II diabetes mellitus
94. Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus
95. Insulin-like growth factor I receptor betasubunit heterogeneity. Evidence for hybrid tetramers composed of insulin-like growth factor I and insulin receptor heterodimers
96. In vivo metabolic effects of insulin-like growth factor-I not mediated through the insulin receptor
97. Is there a local IGF-system in human adrenocortical cells?
98. The p53/IGF-1 receptor axis in the regulation of programmed cell death
99. G1 events and regulation of cell proliferation
100. Dual control of cell growth by somatomedins and platelet-derived growth factor
101. Insulin-like growth factor-I receptor. Its role in cell proliferation, apoptosis, and tumorigenicity
102. Insulin-like growth factor 1 is required for G2 progression in the estradiol-induced mitotic cycle
103. Diminished G1 checkpoint after gamma-irradiation and altered cell cycle regulation by insulin-like growth factor II overexpression
104. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro
105. The effect of hypophysectomy and growth hormone on cartilage sulfate metabolism
106. Synchronous activation of DNA synthesis in hypophysectomized rat cartilage by growth hormone
107. Somatomedin: Proposed designation for sulphation factor
108. Sequence analysis of somatomedin-C: Confirmation of identity with insulin-like growth factor I
109. Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary
110. Evidence that somatomedin is synthesized by multiple tissues in the fetus
111. Structure and expression of a chicken insulin-like growth factor I precursor
112. Molecular cloning of rat insulin-like growth factor I complementary deoxyribonucleic acids: Differential messenger ribonucleic acid processing and regulation by growth hormone in extrahepatic tissues
113. Expression of somatomedin/insulin-like growth factor messenger ribonucleic acids in the human fetus: Identification, characterization, and tissue distribution
114. A dual effector theory of growth-hormone action
115. Growth hormone and the adipose conversion of 3T3 cells
116. Properties of growth hormone receptors in relation to the adipose conversion of 3T3 cells
117. Activity of human growth hormone and related polypeptides on the adipose conversion of 3T3 cells
118. Local injections of human or rat growth hormone or of purified human somatomedin-C stimulate unilateral tibial epiphyseal growth in hypophysectomized rats
119. Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin
120. Growth hormone and bone
121. Mechanism of the stimulatory effect of growth hormone on longitudinal bone growth
122. Targeted in-activation of the insulin receptor gene in mouse 3T3-L1 fibroblasts via homologous recombination
123. A clonal analysis of the differentiation of 3T3-L1 preadipose cells: Role of insulin
124. Growth hormone induces multiplication of the slowly cycling germinal cells of the rat tibial growth plate
125. Differential effects of insulin-like growth factor I and growth hormone on developmental stages of rat growth plate chondrocytes in vivo
126. Igf1 promotes longitudinal bone growth by insulin-like actions augmenting chondrocyte hypertrophy
127. Differential expression of insulin-like growth factor-I (IGF-I) and IGF-II messenger ribonucleic acid in growing rat bone
128. Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis
129. Commitment, fusion, and biochemical differentiation of a myogenic cell line in the absence of DNA synthesis
130. Growth hormone and the insulin-like growth factor system in myogenesis
131. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting
132. Manipulation of transgenes by site-specific recombination: Use of Cre recombinase
133. Normal growth and development in the absence of hepatic insulin-like growth factor I
134. Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice
135. Differential association of insulin-like growth factor I mRNA variants with polysomes in vivo
136. Differential regulation of insulin-like growth factor-I (IGF-I) receptor gene expression by IGF-I and basic fibroblastic growth factor
137. Up-regulation of insulin-like growth factor-I (IGF-I) receptor gene expression in patients with reduced serum IGF-I levels