메뉴 건너뛰기




Volumn 3, Issue 10, 2003, Pages 1197-1203

Hepatic insulin gene therapy in insulin-dependent diabetes mellitus

Author keywords

Gene therapy; Insulin; Insulin dependent diabetes mellitus; Liver

Indexed keywords

INSULIN; PREPROINSULIN;

EID: 0141557850     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1600-6143.2003.00221.x     Document Type: Short Survey
Times cited : (19)

References (108)
  • 1
    • 0035928391 scopus 로고    scopus 로고
    • Type 1 diabetes: New perspectives on disease pathogenesis and treatment
    • Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lanet 2001; 358: 221-229.
    • (2001) Lanet , vol.358 , pp. 221-229
    • Atkinson, M.A.1    Eisenbarth, G.S.2
  • 2
    • 0029022917 scopus 로고
    • Genetic analysis of type 1 diabetes using whole genome approaches
    • Todd JA. Genetic analysis of type 1 diabetes using whole genome approaches. Proc Natl Acad Sci U S A 1995; 92: 8560-8565.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 8560-8565
    • Todd, J.A.1
  • 3
    • 0029954214 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus
    • Tisch R, McDevitt H. Insulin-dependent diabetes mellitus. Cell 1996; 85: 291-297.
    • (1996) Cell , vol.85 , pp. 291-297
    • Tisch, R.1    McDevitt, H.2
  • 4
    • 0028779842 scopus 로고
    • The pathogenesis of insulin-dependent diabetes mellitus
    • Atkinson MA, Maclaren NK. The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med 1994; 331: 1428-1436.
    • (1994) N Engl J Med , vol.331 , pp. 1428-1436
    • Atkinson, M.A.1    Maclaren, N.K.2
  • 5
    • 0034635768 scopus 로고    scopus 로고
    • Variation and trends in incidence of childhood diabetes in Europe
    • EURODIAB ACE Study Group. Variation and trends in incidence of childhood diabetes in Europe. Lancet 2000; 355: 873-876.
    • (2000) Lancet , vol.355 , pp. 873-876
  • 6
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977-986.
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 8
    • 0029810878 scopus 로고    scopus 로고
    • Recurrence of autoimmune diabetes mellitus in recipients of cadaveric pancreatic grafts
    • Tyden G, Reinholt FP, Sundkvist G, Bolinder J. Recurrence of autoimmune diabetes mellitus in recipients of cadaveric pancreatic grafts. N Engl J Med 1996; 335: 860-863.
    • (1996) N Engl J Med , vol.335 , pp. 860-863
    • Tyden, G.1    Reinholt, F.P.2    Sundkvist, G.3    Bolinder, J.4
  • 9
    • 0035479846 scopus 로고    scopus 로고
    • Immunotherapy of insulin-dependent diabetes mellitus
    • Bach JF. Immunotherapy of insulin-dependent diabetes mellitus. Curr Opin Immunol 2001; 13: 601-605.
    • (2001) Curr Opin Immunol , vol.13 , pp. 601-605
    • Bach, J.F.1
  • 11
    • 0030998571 scopus 로고    scopus 로고
    • Gene therapy for diabetes mellitus
    • Docherty K. Gene therapy for diabetes mellitus. Clin Sci (Lond) 1997; 92: 321-330.
    • (1997) Clin Sci (Lond) , vol.92 , pp. 321-330
    • Docherty, K.1
  • 12
    • 0035057914 scopus 로고    scopus 로고
    • From stem cells to beta cells: New strategies in cell therapy of diabetes mellitus
    • Soria B, Skoudy A, Martin F. From stem cells to beta cells: new strategies in cell therapy of diabetes mellitus. Diabetologia 2001; 44:407-415.
    • (2001) Diabetologia , vol.44 , pp. 407-415
    • Soria, B.1    Skoudy, A.2    Martin, F.3
  • 13
    • 0023641198 scopus 로고
    • Regulation of insulin-gene expression. Implications for gene therapy
    • Selden RF, Skoskiewicz MJ, Russell PS, Goodman HM. Regulation of insulin-gene expression. Implications for gene therapy. N Engl J Med 1987; 317: 1067-1076.
    • (1987) N Engl J Med , vol.317 , pp. 1067-1076
    • Selden, R.F.1    Skoskiewicz, M.J.2    Russell, P.S.3    Goodman, H.M.4
  • 14
    • 0028008796 scopus 로고
    • Cellular engineering and gene therapy strategies for insulin replacement in diabetes
    • Newgard CB. Cellular engineering and gene therapy strategies for insulin replacement in diabetes. Diabetes 1994; 43: 341-350.
    • (1994) Diabetes , vol.43 , pp. 341-350
    • Newgard, C.B.1
  • 15
    • 0035491791 scopus 로고    scopus 로고
    • Gene and cell-replacement therapy in the treatment of type 1 diabetes: How high must the standards be set?
    • Halban PA, Kahn SE, Lernmark A, Rhodes CJ. Gene and cell-replacement therapy in the treatment of type 1 diabetes: how high must the standards be set? Diabetes 2001; 50: 2181-2191.
    • (2001) Diabetes , vol.50 , pp. 2181-2191
    • Halban, P.A.1    Kahn, S.E.2    Lernmark, A.3    Rhodes, C.J.4
  • 16
    • 0035175577 scopus 로고    scopus 로고
    • A defect in central tolerance in NOD mice
    • Kishimoto H, Sprent J. A defect in central tolerance in NOD mice. Nat Immunol 2001; 2: 1025-1031.
    • (2001) Nat Immunol , vol.2 , pp. 1025-1031
    • Kishimoto, H.1    Sprent, J.2
  • 17
    • 0031025574 scopus 로고    scopus 로고
    • Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice
    • French MB, Allison J, Cram DS et al. Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice. Diabetes 1997; 46: 34-39.
    • (1997) Diabetes , vol.46 , pp. 34-39
    • French, M.B.1    Allison, J.2    Cram, D.S.3
  • 18
    • 0026695423 scopus 로고
    • Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birth
    • Posselt AM, Barker CF, Friedman AL, Naji A. Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birth. Science 1992; 256: 1321-1324.
    • (1992) Science , vol.256 , pp. 1321-1324
    • Posselt, A.M.1    Barker, C.F.2    Friedman, A.L.3    Naji, A.4
  • 19
    • 0028151263 scopus 로고
    • Prevention of diabetes and insulitis by neonatal intrathymic islet administration in NOD mice
    • Charlton B, Taylor-Edwards C, Tisch R, Fathman CG. Prevention of diabetes and insulitis by neonatal intrathymic islet administration in NOD mice. J Autoimmun 1994; 7: 549-560.
    • (1994) J Autoimmun , vol.7 , pp. 549-560
    • Charlton, B.1    Taylor-Edwards, C.2    Tisch, R.3    Fathman, C.G.4
  • 20
    • 0035253510 scopus 로고    scopus 로고
    • Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination
    • Tisch R, Wang B, Weaver DJ et al. Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination. J Immunol 2001; 166: 2122-2132.
    • (2001) J Immunol , vol.166 , pp. 2122-2132
    • Tisch, R.1    Wang, B.2    Weaver, D.J.3
  • 22
    • 0032531423 scopus 로고    scopus 로고
    • Prud'homme GJTGF-beta1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice
    • Piccirillo CA, Chang Y. Prud'homme GJTGF-beta1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice. J Immunol 1998; 161: 3950-3956.
    • (1998) J Immunol , vol.161 , pp. 3950-3956
    • Piccirillo, C.A.1    Chang, Y.2
  • 23
    • 0031065148 scopus 로고    scopus 로고
    • Targeted expression of the neuropeptide calcitonin gene-related peptide to beta cells prevents diabetes in NOD mice
    • Khachatryan A, Guerder S, Palluault F et al. Targeted expression of the neuropeptide calcitonin gene-related peptide to beta cells prevents diabetes in NOD mice. J Immunol 1997; 158: 1409-1416.
    • (1997) J Immunol , vol.158 , pp. 1409-1416
    • Khachatryan, A.1    Guerder, S.2    Palluault, F.3
  • 24
  • 25
    • 0031812835 scopus 로고    scopus 로고
    • Transduction of non-dividing adult human pancreatic beta cells by an integrating lentiviral vector
    • Ju Q, Edelstein D, Brendel MD et al. Transduction of non-dividing adult human pancreatic beta cells by an integrating lentiviral vector. Diabetologia 1998; 41: 736-739.
    • (1998) Diabetologia , vol.41 , pp. 736-739
    • Ju, Q.1    Edelstein, D.2    Brendel, M.D.3
  • 26
    • 7844230594 scopus 로고    scopus 로고
    • Local expression of immunoregulatory IL-12p4O gene prolonged syngeneic islet graft survival in diabetic NOD mice
    • Yasuda H, Nagata M, Arisawa K et al. Local expression of immunoregulatory IL-12p4O gene prolonged syngeneic islet graft survival in diabetic NOD mice. J Clin Invest 1998; 102: 1807-1814.
    • (1998) J Clin Invest , vol.102 , pp. 1807-1814
    • Yasuda, H.1    Nagata, M.2    Arisawa, K.3
  • 27
    • 0033721160 scopus 로고    scopus 로고
    • Immunotherapy of spontaneous type 1 diabetes in nonobese diabetic mice by systemic interleukin-4 treatment employing adenovirus vector-mediated gene transfer
    • Cameron MJ, Arreaza GA, Waldhauser L, Gauldie J, Delovitch TL. Immunotherapy of spontaneous type 1 diabetes in nonobese diabetic mice by systemic interleukin-4 treatment employing adenovirus vector-mediated gene transfer. Gene Ther 2000; 7: 1840-1846.
    • (2000) Gene Ther , vol.7 , pp. 1840-1846
    • Cameron, M.J.1    Arreaza, G.A.2    Waldhauser, L.3    Gauldie, J.4    Delovitch, T.L.5
  • 30
    • 0029801229 scopus 로고    scopus 로고
    • Expression of the bcl-2 gene from a defective HSV-1 amplicon vector protects pancreatic beta-cells from apoptosis
    • Liu Y, Rabinovitch A, Suarez-Pinzon W et al. Expression of the bcl-2 gene from a defective HSV-1 amplicon vector protects pancreatic beta-cells from apoptosis. Hum Gene Ther 1996; 7: 1719-1726.
    • (1996) Hum Gene Ther , vol.7 , pp. 1719-1726
    • Liu, Y.1    Rabinovitch, A.2    Suarez-Pinzon, W.3
  • 31
    • 0029328373 scopus 로고
    • Analysis of families at risk for insulin-dependent diabetes mellitus reveals that HLA antigens influence progression to clinical disease
    • Honeyman MC, Harrison LC, Drummond B, Colman PG, Tait BD. Analysis of families at risk for insulin-dependent diabetes mellitus reveals that HLA antigens influence progression to clinical disease. Mol Med 1995; 1: 576-582.
    • (1995) Mol Med , vol.1 , pp. 576-582
    • Honeyman, M.C.1    Harrison, L.C.2    Drummond, B.3    Colman, P.G.4    Tait, B.D.5
  • 32
    • 0025141413 scopus 로고
    • Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes
    • Bonifacio E, Bingley PJ, Shattock M et al. Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet 1990; 335: 147-149.
    • (1990) Lancet , vol.335 , pp. 147-149
    • Bonifacio, E.1    Bingley, P.J.2    Shattock, M.3
  • 34
    • 0030432477 scopus 로고    scopus 로고
    • Pancreatic development and maturation of the islet B cell. Studies of pluripotent islet cultures
    • Madsen OD, Jensen J, Blume N et al. Pancreatic development and maturation of the islet B cell. Studies of pluripotent islet cultures. Eur J Biochem 1996; 242: 435-445.
    • (1996) Eur J Biochem , vol.242 , pp. 435-445
    • Madsen, O.D.1    Jensen, J.2    Blume, N.3
  • 35
    • 0027449197 scopus 로고
    • A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development
    • Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 1993; 42: 1715-1720.
    • (1993) Diabetes , vol.42 , pp. 1715-1720
    • Bonner-Weir, S.1    Baxter, L.A.2    Schuppin, G.T.3    Smith, F.E.4
  • 36
    • 0028793314 scopus 로고
    • Duct-to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats
    • Wang RN, Kloppel G, Bouwens L. Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats. Diabetologia 1995; 38: 1405-1411.
    • (1995) Diabetologia , vol.38 , pp. 1405-1411
    • Wang, R.N.1    Kloppel, G.2    Bouwens, L.3
  • 37
    • 0027276885 scopus 로고
    • Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice
    • Gu D, Sarvetnick N. Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice. Development 1993; 118: 33-46.
    • (1993) Development , vol.118 , pp. 33-46
    • Gu, D.1    Sarvetnick, N.2
  • 38
    • 0031048470 scopus 로고    scopus 로고
    • Effect of vascular endothelial growth factor on growth and differentiation of pancreatic ductal epithelium
    • Rooman I, Schuit F, Bouwens L. Effect of vascular endothelial growth factor on growth and differentiation of pancreatic ductal epithelium. Lab Invest 1997; 76: 225-232.
    • (1997) Lab Invest , vol.76 , pp. 225-232
    • Rooman, I.1    Schuit, F.2    Bouwens, L.3
  • 39
    • 0030912531 scopus 로고    scopus 로고
    • Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters
    • Rafaeloff R, Pittenger GL, Barlow SW et al. Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J Clin Invest 1997; 99: 2100-2109.
    • (1997) J Clin Invest , vol.99 , pp. 2100-2109
    • Rafaeloff, R.1    Pittenger, G.L.2    Barlow, S.W.3
  • 40
    • 0031985552 scopus 로고    scopus 로고
    • Culture of adult human islet preparations with hepatocyte growth factor and 804G matrix is mitogenic for duct cells but not for beta-cells
    • Lefebvre VH, Otonkoski T, Ustinov J, Huotari MA, Pipeleers DG, Bouwens L. Culture of adult human islet preparations with hepatocyte growth factor and 804G matrix is mitogenic for duct cells but not for beta-cells. Diabetes 1998; 47: 134-137.
    • (1998) Diabetes , vol.47 , pp. 134-137
    • Lefebvre, V.H.1    Otonkoski, T.2    Ustinov, J.3    Huotari, M.A.4    Pipeleers, D.G.5    Bouwens, L.6
  • 41
    • 0028331909 scopus 로고
    • Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein
    • Watanabe T, Yonemura Y, Yonekura H et al. Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein. Proc Natl Acad Sci U S A 1994; 91: 3589-3592.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 3589-3592
    • Watanabe, T.1    Yonemura, Y.2    Yonekura, H.3
  • 42
    • 0031454362 scopus 로고    scopus 로고
    • The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract
    • Goldfine ID, German MS, Tseng HC et al. The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract. Nat Biotechnol 1997; 15: 1378-1382.
    • (1997) Nat Biotechnol , vol.15 , pp. 1378-1382
    • Goldfine, I.D.1    German, M.S.2    Tseng, H.C.3
  • 43
    • 0032850751 scopus 로고    scopus 로고
    • Gene therapy in diabetes mellitus: Promises and pitfalls
    • Welsh N. Gene therapy in diabetes mellitus: promises and pitfalls. Curr Opin Mol Ther 1999; 1: 464-470.
    • (1999) Curr Opin Mol Ther , vol.1 , pp. 464-470
    • Welsh, N.1
  • 44
    • 0037058934 scopus 로고    scopus 로고
    • Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells
    • Hori Y, Rulifson IC, Tsai BC, Heit JJ, Cahoy JD, Kim SK. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci U S A 2002; 99: 16105-16110.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 16105-16110
    • Hori, Y.1    Rulifson, I.C.2    Tsai, B.C.3    Heit, J.J.4    Cahoy, J.D.5    Kim, S.K.6
  • 45
    • 0036297914 scopus 로고    scopus 로고
    • Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter
    • Lechner A, Leech CA, Abraham EJ, Nolan AL, Habener JF. Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter. Biochem Biophys Res Commun 2002; 293: 670-674.
    • (2002) Biochem Biophys Res Commun , vol.293 , pp. 670-674
    • Lechner, A.1    Leech, C.A.2    Abraham, E.J.3    Nolan, A.L.4    Habener, J.F.5
  • 46
    • 0033979603 scopus 로고    scopus 로고
    • Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice
    • Soria B, Roche E, Berna G, Leon-Quinto T, Reig JA, Martin F. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 2000; 49: 157-162.
    • (2000) Diabetes , vol.49 , pp. 157-162
    • Soria, B.1    Roche, E.2    Berna, G.3    Leon-Quinto, T.4    Reig, J.A.5    Martin, F.6
  • 47
    • 0033856775 scopus 로고    scopus 로고
    • Viral vectors for gene transfer: A review of their use in the treatment of human diseases
    • Walther W, Stein U. Viral vectors for gene transfer: a review of their use in the treatment of human diseases. Drugs 2000; 60: 249-271.
    • (2000) Drugs , vol.60 , pp. 249-271
    • Walther, W.1    Stein, U.2
  • 48
    • 0034623757 scopus 로고    scopus 로고
    • Glucose-dependent insulin release from genetically engineered K cells
    • Cheung AT, Dayanandan B, Lewis JT et al. Glucose-dependent insulin release from genetically engineered K cells. Science 2000; 290: 1959-1962.
    • (2000) Science , vol.290 , pp. 1959-1962
    • Cheung, A.T.1    Dayanandan, B.2    Lewis, J.T.3
  • 49
    • 0022345249 scopus 로고
    • Secretory protein targeting in a pituitary cell line: Differential transport of foreign secretory proteins to distinct secretory pathways
    • Moore HP, Kelly RB. Secretory protein targeting in a pituitary cell line: differential transport of foreign secretory proteins to distinct secretory pathways. J Cell Biol 1985; 101 (5 Part 1): 1773-1781.
    • (1985) J Cell Biol , vol.101 , Issue.5 PART 1 , pp. 1773-1781
    • Moore, H.P.1    Kelly, R.B.2
  • 50
    • 0026569634 scopus 로고
    • Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells
    • Hughes SD, Johnson JH, Quaade C, Newgard CB. Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells. Proc Natl Acad Sci U S A 1992; 89: 688-692.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 688-692
    • Hughes, S.D.1    Johnson, J.H.2    Quaade, C.3    Newgard, C.B.4
  • 51
    • 0029738626 scopus 로고    scopus 로고
    • Insulin-secreting non-islet cells are resistant to autoimmune destruction
    • Lipes MA, Cooper EM, Skelly R et al. Insulin-secreting non-islet cells are resistant to autoimmune destruction. Proc Natl Acad Sci U S A 1996; 93: 8595-8600.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 8595-8600
    • Lipes, M.A.1    Cooper, E.M.2    Skelly, R.3
  • 52
    • 0034778099 scopus 로고    scopus 로고
    • Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia
    • Shifrin AL, Auricchio A, Yu QC, Wilson J, Raper SE. Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia. Gene Ther 2001; 8: 1480-1489.
    • (2001) Gene Ther , vol.8 , pp. 1480-1489
    • Shifrin, A.L.1    Auricchio, A.2    Yu, Q.C.3    Wilson, J.4    Raper, S.E.5
  • 53
    • 0034761343 scopus 로고    scopus 로고
    • Prevention of diabetes in the NOD mouse by intra-muscular injection of recombinant adenoassociated virus containing the preproinsulin II gene
    • Jindal RM, Karanam M, Shah R. Prevention of diabetes in the NOD mouse by intra-muscular injection of recombinant adenoassociated virus containing the preproinsulin II gene. Int J Exp Diabetes Res 2001; 2: 129-138.
    • (2001) Int J Exp Diabetes Res , vol.2 , pp. 129-138
    • Jindal, R.M.1    Karanam, M.2    Shah, R.3
  • 54
    • 0036314659 scopus 로고    scopus 로고
    • Counteraction of type 1 diabetic alterations by engineering skeletal muscle to produce insulin: Insights from transgenic mice
    • Riu E, Mas A, Ferre T et al. Counteraction of type 1 diabetic alterations by engineering skeletal muscle to produce insulin: insights from transgenic mice. Diabetes 2002; 51: 704-711.
    • (2002) Diabetes , vol.51 , pp. 704-711
    • Riu, E.1    Mas, A.2    Ferre, T.3
  • 55
    • 0036124978 scopus 로고    scopus 로고
    • Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo
    • Shaw JA, Delday MI, Hart AW, Docherty HM, Maltin CA, Docherty K. Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo. J Endocrinol 2002; 172: 653-672.
    • (2002) J Endocrinol , vol.172 , pp. 653-672
    • Shaw, J.A.1    Delday, M.I.2    Hart, A.W.3    Docherty, H.M.4    Maltin, C.A.5    Docherty, K.6
  • 56
    • 0028064783 scopus 로고
    • Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin
    • Groskreutz DJ, Sliwkowski MX, Gorman CM. Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin. J Biol Chem 1994; 269: 6241-6245.
    • (1994) J Biol Chem , vol.269 , pp. 6241-6245
    • Groskreutz, D.J.1    Sliwkowski, M.X.2    Gorman, C.M.3
  • 57
    • 0026726773 scopus 로고
    • Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3
    • Smeekens SP, Montag AG, Thomas G et al. Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3. Proc Natl Acad Sci U S A 1992; 89: 8822-8826.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 8822-8826
    • Smeekens, S.P.1    Montag, A.G.2    Thomas, G.3
  • 58
    • 84995842413 scopus 로고
    • Processing of mutated proinsulin with tetrabasic cleavage sites to mature insulin reflects the expression of furin in nonendocrine cell lines
    • Yanagita M, Hoshino H, Nakayama K, Takeuchi T. Processing of mutated proinsulin with tetrabasic cleavage sites to mature insulin reflects the expression of furin in nonendocrine cell lines. Endocrinology 1993; 133: 639-644.
    • (1993) Endocrinology , vol.133 , pp. 639-644
    • Yanagita, M.1    Hoshino, H.2    Nakayama, K.3    Takeuchi, T.4
  • 59
    • 0028173313 scopus 로고
    • The pancreatic beta-cell glucose sensor
    • Efrat S, Tal M, Lodish HF. The pancreatic beta-cell glucose sensor. Trends Biochem Sci 1994; 19: 535-538.
    • (1994) Trends Biochem Sci , vol.19 , pp. 535-538
    • Efrat, S.1    Tal, M.2    Lodish, H.F.3
  • 60
    • 0037184731 scopus 로고    scopus 로고
    • Glucose-regulated insulin production in hepatocytes
    • Alam T, Sollinger HW. Glucose-regulated insulin production in hepatocytes. Transplantation 2002; 74: 1781-1787.
    • (2002) Transplantation , vol.74 , pp. 1781-1787
    • Alam, T.1    Sollinger, H.W.2
  • 61
    • 0036328505 scopus 로고    scopus 로고
    • Constitutive and regulated expression of processed insulin following in vivo hepatic gene transfer
    • Auricchio A, Gao GP, Yu QC et al. Constitutive and regulated expression of processed insulin following in vivo hepatic gene transfer. Gene Ther 2002; 9: 963-971.
    • (2002) Gene Ther , vol.9 , pp. 963-971
    • Auricchio, A.1    Gao, G.P.2    Yu, Q.C.3
  • 62
    • 0033693585 scopus 로고    scopus 로고
    • Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells
    • Chen R, Meseck M, McEvoy RC, Woo SL. Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells. Gene Ther 2000; 7: 1802-1809.
    • (2000) Gene Ther , vol.7 , pp. 1802-1809
    • Chen, R.1    Meseck, M.2    McEvoy, R.C.3    Woo, S.L.4
  • 63
    • 0029058252 scopus 로고
    • Glucose responsiveness of a reporter gene transduced into hepatocytic cells using a retroviral vector
    • Chen R, Doiron B, Kahn A. Glucose responsiveness of a reporter gene transduced into hepatocytic cells using a retroviral vector. FEBS Lett 1995; 365: 223-226.
    • (1995) FEBS Lett , vol.365 , pp. 223-226
    • Chen, R.1    Doiron, B.2    Kahn, A.3
  • 64
    • 0034984540 scopus 로고    scopus 로고
    • Auto-regulated hepatic insulin gene expression in type 1 diabetic rats
    • Chen R, Meseck ML, Woo SL. Auto-regulated hepatic insulin gene expression in type 1 diabetic rats. Mol Ther 2001; 3: 584-590.
    • (2001) Mol Ther , vol.3 , pp. 584-590
    • Chen, R.1    Meseck, M.L.2    Woo, S.L.3
  • 66
    • 0036091935 scopus 로고    scopus 로고
    • Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats
    • Dong H, Altomonte J, Morral N, Meseck M, Thung SN, Woo SL. Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats. Diabetes 2002; 51: 130-138.
    • (2002) Diabetes , vol.51 , pp. 130-138
    • Dong, H.1    Altomonte, J.2    Morral, N.3    Meseck, M.4    Thung, S.N.5    Woo, S.L.6
  • 67
    • 0033007447 scopus 로고    scopus 로고
    • Human proinsulin production in primary rat hepatocytes after retroviral vector gene transfer
    • Falqui L, Martinenghi S, Berra C et al. Human proinsulin production in primary rat hepatocytes after retroviral vector gene transfer. J Mol Med 1999; 77: 250-253.
    • (1999) J Mol Med , vol.77 , pp. 250-253
    • Falqui, L.1    Martinenghi, S.2    Berra, C.3
  • 69
    • 0028963345 scopus 로고
    • Gene therapy for diabetes mellitus in rats by hepatic expression of insulin
    • Kolodka TM, Finegold M, Moss L, Woo SL. Gene therapy for diabetes mellitus in rats by hepatic expression of insulin. Proc Natl Acad Sci U S A 1995; 92: 3293-3297.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 3293-3297
    • Kolodka, T.M.1    Finegold, M.2    Moss, L.3    Woo, S.L.4
  • 70
    • 0034707028 scopus 로고    scopus 로고
    • Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue
    • Lee HC, Kim SJ, Kim KS, Shin HC, Yoon JW. Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. Nature 2000; 408: 483-488.
    • (2000) Nature , vol.408 , pp. 483-488
    • Lee, H.C.1    Kim, S.J.2    Kim, K.S.3    Shin, H.C.4    Yoon, J.W.5
  • 71
    • 0033665027 scopus 로고    scopus 로고
    • Insulin gene transfer improves posthepatectomized status of diabetic rats
    • Matsumoto T, Yamaguchi M, Kuzume M et al. Insulin gene transfer improves posthepatectomized status of diabetic rats. Transplant Proc 2000; 32: 2378-2379.
    • (2000) Transplant Proc , vol.32 , pp. 2378-2379
    • Matsumoto, T.1    Yamaguchi, M.2    Kuzume, M.3
  • 72
    • 0032536095 scopus 로고    scopus 로고
    • Regulated expression of mature human insulin in the liver of transgenic mice
    • Mitanchez D, Chen R, Massias JF et al. Regulated expression of mature human insulin in the liver of transgenic mice. FEBS Lett 1998; 421: 285-289.
    • (1998) FEBS Lett , vol.421 , pp. 285-289
    • Mitanchez, D.1    Chen, R.2    Massias, J.F.3
  • 73
    • 0030946203 scopus 로고    scopus 로고
    • Hepatic insulin gene expression as treatment for type 1 diabetes mellitus in rats
    • Muzzin P, Eisensmith RC, Copeland KC, Woo SL. Hepatic insulin gene expression as treatment for type 1 diabetes mellitus in rats. Mol Endocrinol 1997; 11: 833-837.
    • (1997) Mol Endocrinol , vol.11 , pp. 833-837
    • Muzzin, P.1    Eisensmith, R.C.2    Copeland, K.C.3    Woo, S.L.4
  • 74
    • 0031730473 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of a modified human proinsulin gene reverses hyperglycemia in diabetic mice
    • Short DK, Okada S, Yamauchi K, Pessin JE. Adenovirus-mediated transfer of a modified human proinsulin gene reverses hyperglycemia in diabetic mice. Am J Physiol 1998; 275 (5 Part 1): E748-E756.
    • (1998) Am J Physiol , vol.275 , Issue.5 PART 1
    • Short, D.K.1    Okada, S.2    Yamauchi, K.3    Pessin, J.E.4
  • 75
    • 0029067889 scopus 로고
    • Functional expression of the human insulin gene in a human hepatoma cell line (HEP G2)
    • Simpson AM, Tuch BE, Swan MA, Tu J, Marshall GM. Functional expression of the human insulin gene in a human hepatoma cell line (HEP G2). Gene Ther 1995; 2: 223-231.
    • (1995) Gene Ther , vol.2 , pp. 223-231
    • Simpson, A.M.1    Tuch, B.E.2    Swan, M.A.3    Tu, J.4    Marshall, G.M.5
  • 76
    • 0031450881 scopus 로고    scopus 로고
    • Defective adenoassociated viral-mediated transfection of insulin gene by direct injection into liver parenchyma decreases blood glucose of diabetic mice
    • Sugiyama A, Hattori S, Tanaka S et al. Defective adenoassociated viral-mediated transfection of insulin gene by direct injection into liver parenchyma decreases blood glucose of diabetic mice. Horm Metab Res 1997; 29: 599-603.
    • (1997) Horm Metab Res , vol.29 , pp. 599-603
    • Sugiyama, A.1    Hattori, S.2    Tanaka, S.3
  • 77
    • 0033765795 scopus 로고    scopus 로고
    • Regulated hepatic insulin gene therapy of STZ-diabetic rats
    • Thule PM, Liu JM. Regulated hepatic insulin gene therapy of STZ-diabetic rats. Gene Ther 2000; 7: 1744-1752.
    • (2000) Gene Ther , vol.7 , pp. 1744-1752
    • Thule, P.M.1    Liu, J.M.2
  • 78
    • 0034004456 scopus 로고    scopus 로고
    • Glucose regulated production of human insulin in rat hepatocytes
    • Thule PM, Liu J, Phillips LS. Glucose regulated production of human insulin in rat hepatocytes. Gene Ther 2000; 7: 205-214.
    • (2000) Gene Ther , vol.7 , pp. 205-214
    • Thule, P.M.1    Liu, J.2    Phillips, L.S.3
  • 79
    • 0344642953 scopus 로고    scopus 로고
    • Function of a genetically modified human liver cell line that stores, processes and secretes insulin
    • Tuch BE, Szymanska B, Yao M et al. Function of a genetically modified human liver cell line that stores, processes and secretes insulin. Gene Ther 2003; 10: 490-503.
    • (2003) Gene Ther , vol.10 , pp. 490-503
    • Tuch, B.E.1    Szymanska, B.2    Yao, M.3
  • 80
    • 0030695820 scopus 로고    scopus 로고
    • Specific problems facing gene therapy for insulin-dependent diabetes mellitus: Glucose-regulated insulin secretion from hepatocytes
    • Wanke IE, Wong NC. Specific problems facing gene therapy for insulin-dependent diabetes mellitus: glucose-regulated insulin secretion from hepatocytes. Proc West Pharmacol Soc 1997; 40: 131-133.
    • (1997) Proc West Pharmacol Soc , vol.40 , pp. 131-133
    • Wanke, I.E.1    Wong, N.C.2
  • 81
    • 0031828799 scopus 로고    scopus 로고
    • Regulatable production of insulin from primary-cultured hepatocytesinsulin production is up-regulated by glucagon and cAMP and down-regulated by insulin
    • Lu D, Tamemoto H, Shibata H, Saito I, Takeuchi T. Regulatable production of insulin from primary-cultured hepatocytesinsulin production is up-regulated by glucagon and cAMP and down-regulated by insulin. Gene Ther 1998; 5: 888-895.
    • (1998) Gene Ther , vol.5 , pp. 888-895
    • Lu, D.1    Tamemoto, H.2    Shibata, H.3    Saito, I.4    Takeuchi, T.5
  • 82
    • 0028228376 scopus 로고
    • Regulated expression of human insulin in the liver of transgenic mice corrects diabetic alterations
    • Valera A, Fillat C, Costa C et al. Regulated expression of human insulin in the liver of transgenic mice corrects diabetic alterations. FASEB J 1994; 8: 440-447.
    • (1994) FASEB J , vol.8 , pp. 440-447
    • Valera, A.1    Fillat, C.2    Costa, C.3
  • 83
    • 0032797852 scopus 로고    scopus 로고
    • Regulation of glucose production by the liver
    • Nordlie RC, Foster JD, Lange AJ. Regulation of glucose production by the liver. Annu Rev Nutr 1999; 19: 379-406.
    • (1999) Annu Rev Nutr , vol.19 , pp. 379-406
    • Nordlie, R.C.1    Foster, J.D.2    Lange, A.J.3
  • 84
    • 0033810262 scopus 로고    scopus 로고
    • Glucose sensing by the hepatoportal sensor is GLUT2-dependent: In vivo analysis in GLUT2-null mice
    • Burcelin R, Dolci W, Thorens B. Glucose sensing by the hepatoportal sensor is GLUT2-dependent: in vivo analysis in GLUT2-null mice. Diabetes 2000; 49: 1643-1648.
    • (2000) Diabetes , vol.49 , pp. 1643-1648
    • Burcelin, R.1    Dolci, W.2    Thorens, B.3
  • 85
    • 0035507872 scopus 로고    scopus 로고
    • Susceptibility of insulin-secreting hepatocytes to the toxicity of proinflammatory cytokines
    • Tabiin MT, Tuch BE, Bai L, Han XG, Simpson AM. Susceptibility of insulin-secreting hepatocytes to the toxicity of proinflammatory cytokines. J Autoimmun 2001; 17: 229-242.
    • (2001) J Autoimmun , vol.17 , pp. 229-242
    • Tabiin, M.T.1    Tuch, B.E.2    Bai, L.3    Han, X.G.4    Simpson, A.M.5
  • 86
    • 0028055281 scopus 로고
    • Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus
    • Lewis PF, Emerman M. Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus. J Virol 1994; 68: 510-516.
    • (1994) J Virol , vol.68 , pp. 510-516
    • Lewis, P.F.1    Emerman, M.2
  • 87
    • 0035663103 scopus 로고    scopus 로고
    • A highly efficient and consistent method for harvesting large Volumes of high-titre lentiviral vectors
    • Zhang B, Xia HQ, Cleghorn G, Gobe G, West M, Wei MQ. A highly efficient and consistent method for harvesting large Volumes of high-titre lentiviral vectors. Gene Ther 2001; 8: 1745-1751.
    • (2001) Gene Ther , vol.8 , pp. 1745-1751
    • Zhang, B.1    Xia, H.Q.2    Cleghorn, G.3    Gobe, G.4    West, M.5    Wei, M.Q.6
  • 88
    • 0026131053 scopus 로고
    • Persistent gene expression after retroviral gene transfer into liver cells in vivo
    • Kaleko M, Garcia JV, Miller AD. Persistent gene expression after retroviral gene transfer into liver cells in vivo. Hum Gene Ther 1991; 2: 27-32.
    • (1991) Hum Gene Ther , vol.2 , pp. 27-32
    • Kaleko, M.1    Garcia, J.V.2    Miller, A.D.3
  • 89
    • 0028158811 scopus 로고
    • Liver-directed gene therapy: Quantitative evaluation of promoter elements by using in vivo retroviral transduction
    • Rettinger SD, Kennedy SC, Wu X et al. Liver-directed gene therapy: quantitative evaluation of promoter elements by using in vivo retroviral transduction. Proc Natl Acad Sci U S A 1994; 91: 1460-1464.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 1460-1464
    • Rettinger, S.D.1    Kennedy, S.C.2    Wu, X.3
  • 90
    • 0037441587 scopus 로고    scopus 로고
    • Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: Risk of insertional mutagenesis
    • Woods NB, Muessig A, Schmidt M et al. Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis. Blood 2003; 101: 1284-1289.
    • (2003) Blood , vol.101 , pp. 1284-1289
    • Woods, N.B.1    Muessig, A.2    Schmidt, M.3
  • 92
    • 0034913116 scopus 로고    scopus 로고
    • Nonviral vectors in the new millennium: Delivery barriers in gene transfer
    • Nishikawa M, Huang L. Nonviral vectors in the new millennium: delivery barriers in gene transfer. Hum Gene Ther 2001; 12: 861-870.
    • (2001) Hum Gene Ther , vol.12 , pp. 861-870
    • Nishikawa, M.1    Huang, L.2
  • 93
    • 0035401236 scopus 로고    scopus 로고
    • Nonviral gene therapy
    • Li S, Ma Z. Nonviral gene therapyCurr Gene Ther 2001; 1: 201-226.
    • (2001) Curr Gene Ther , vol.1 , pp. 201-226
    • Li, S.1    Ma, Z.2
  • 94
    • 0033166561 scopus 로고    scopus 로고
    • High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA
    • Zhang G, Budker V, Wolff JA. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 1999; 10: 1735-1737.
    • (1999) Hum Gene Ther , vol.10 , pp. 1735-1737
    • Zhang, G.1    Budker, V.2    Wolff, J.A.3
  • 96
    • 0037348748 scopus 로고    scopus 로고
    • Progress and prospects naked DNA gene transfer and therapy
    • Herweijer H, Wolff JA. Progress and prospects naked DNA gene transfer and therapy. Gene Ther 2003; 10: 453-458.
    • (2003) Gene Ther , vol.10 , pp. 453-458
    • Herweijer, H.1    Wolff, J.A.2
  • 97
    • 0030751585 scopus 로고    scopus 로고
    • Glucose-stimulated genes and prospects of gene therapy for type I diabetes
    • Mitanchez D, Doiron B, Chen R, Kahn A. Glucose-stimulated genes and prospects of gene therapy for type I diabetes. Endocr Rev 1997; 18: 520-540.
    • (1997) Endocr Rev , vol.18 , pp. 520-540
    • Mitanchez, D.1    Doiron, B.2    Chen, R.3    Kahn, A.4
  • 98
    • 0028158283 scopus 로고
    • Transcriptional control of metabolic regulation genes by carbohydrates
    • Vaulont S, Kahn A. Transcriptional control of metabolic regulation genes by carbohydrates. FASEB J 1994; 8: 28-35.
    • (1994) FASEB J , vol.8 , pp. 28-35
    • Vaulont, S.1    Kahn, A.2
  • 99
    • 0024450962 scopus 로고
    • Sequences within the 5′-flanking region of the S14 gene confer responsiveness to glucose in primary hepatocytes
    • Jacoby DB, Zilz ND, Towle HC. Sequences within the 5′-flanking region of the S14 gene confer responsiveness to glucose in primary hepatocytes. J Biol Chem 1989; 264: 17623-17626.
    • (1989) J Biol Chem , vol.264 , pp. 17623-17626
    • Jacoby, D.B.1    Zilz, N.D.2    Towle, H.C.3
  • 100
    • 0026691776 scopus 로고
    • Definition of the carbohydrate response element of the rat S14 gene. Evidence for a common factor required for carbohydrate regulation of hepatic genes
    • Shih HM, Towle HC. Definition of the carbohydrate response element of the rat S14 gene. Evidence for a common factor required for carbohydrate regulation of hepatic genes. J Biol Chem 1992; 267: 13222-13228.
    • (1992) J Biol Chem , vol.267 , pp. 13222-13228
    • Shih, H.M.1    Towle, H.C.2
  • 101
    • 0026316816 scopus 로고
    • Transcriptional and posttranscriptional effects of glucose on liver phosphoenolpyruvate-carboxykinase gene expression
    • Meyer S, Hoppner W, Seitz HJ. Transcriptional and posttranscriptional effects of glucose on liver phosphoenolpyruvate-carboxykinase gene expression. Eur J Biochem 1991; 202: 985-991.
    • (1991) Eur J Biochem , vol.202 , pp. 985-991
    • Meyer, S.1    Hoppner, W.2    Seitz, H.J.3
  • 102
    • 0028206043 scopus 로고
    • Respective roles of glucose, fructose, and insulin in the regulation of the liver-specific pyruvate kinase gene promoter
    • Doiron B, Cuif MH, Kahn A, Diaz-Guerra MJ. Respective roles of glucose, fructose, and insulin in the regulation of the liver-specific pyruvate kinase gene promoter. J Biol Chem 1994; 269: 10213-10216.
    • (1994) J Biol Chem , vol.269 , pp. 10213-10216
    • Doiron, B.1    Cuif, M.H.2    Kahn, A.3    Diaz-Guerra, M.J.4
  • 103
    • 0030991979 scopus 로고    scopus 로고
    • A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin
    • Streeper RS, Svitek CA, Chapman S, Greenbaum LE, Taub R, O'Brien RM. A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin. J Biol Chem 1997; 272: 11698-11701.
    • (1997) J Biol Chem , vol.272 , pp. 11698-11701
    • Streeper, R.S.1    Svitek, C.A.2    Chapman, S.3    Greenbaum, L.E.4    Taub, R.5    O'Brien, R.M.6
  • 105
    • 0034603114 scopus 로고    scopus 로고
    • Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum
    • Rivera VM, Wang X, Wardwell S et al. Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science 2000; 287: 826-830.
    • (2000) Science , vol.287 , pp. 826-830
    • Rivera, V.M.1    Wang, X.2    Wardwell, S.3
  • 106
    • 0034068602 scopus 로고    scopus 로고
    • Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
    • Ferber S, Halkin A, Cohen H et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 2000; 6: 568-572.
    • (2000) Nat Med , vol.6 , pp. 568-572
    • Ferber, S.1    Halkin, A.2    Cohen, H.3
  • 107
    • 0038413922 scopus 로고    scopus 로고
    • NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
    • Kojima H, Fujimiya M, Matsumura K et al. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 2003; 9: 596-603.
    • (2003) Nat Med , vol.9 , pp. 596-603
    • Kojima, H.1    Fujimiya, M.2    Matsumura, K.3
  • 108
    • 0030927342 scopus 로고    scopus 로고
    • The beta cell transcription factors and development of the pancreas
    • Sander M, German MS. The beta cell transcription factors and development of the pancreas. J Mol Med 1997; 75: 327-340.
    • (1997) J Mol Med , vol.75 , pp. 327-340
    • Sander, M.1    German, M.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.