Glucose sensing by the hepatoportal sensor is GLUT2-dependent: In vivo analysis in GLUT2-null mice

Diabetes

Volumn 49, Issue 10, 2000, Pages 1643-1648

  Burcelin, Rémy ^a   Dolci, Wanda ^a   Thorens, Bernard ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER; INSULIN; SOMATOSTATIN; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMORAL VEIN; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; GLUCOSE UTILIZATION; GLYCOGEN SYNTHESIS; GLYCOLYSIS; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; LIVER CELL; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PORTAL VEIN; PRIORITY JOURNAL; SENSOR; SIGNAL TRANSDUCTION; TRANSGENE; TURNOVER TIME;

EID: 0033810262     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.10.1643     Document Type: Article

References (22)

1. Participation of hepatic glucoreceptors in the control of intake of food
2. Demonstration of the influence of an hepatic glucosensitive mechanism on food-intake
3. Influence of hepatic portal receptors on hypothalamic feeding and satiety centers
4. The nerves, the liver, and the route of feeding: An integrated response to nutrient delivery
5. A portal-arterial glucose concentration gradient as a signal for an insulin-dependent net glucose uptake in perfused rat liver
6. Regulation of liver metabolism by the hepatic nerves
7. Sensing by intrahepatic muscarinic nerves of a portal-arterial glucose concentration gradient as a signal for insulin-dependent glucose uptake in the perfused rat liver
8. Role of the liver as a glucose sensor in the integrated response to hypoglycemia
9. The role of liver glucosensors in the integrated sympathetic response induced by deep hypoglycemia in dogs
10. Primacy of liver glucosensors in the sympathetic response to progressive hypoglycemia
11. Portal glucose infusion in the mouse induces hypoglycemia: Evidence that the hepatoportal glucose sensor stimulates glucose utilization
12. A lesson in metabolic regulation inspired by the glucokinase paradigm
13. Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut2
14. Transgenic reexpression of GLUT1 or GLUT2 in pancreatic β-cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion
15. Normal hepatic glucose production in the absence of GLUT2 reveals an alternative pathway for glucose release from hepatocytes
16. Liver hyperplasia and paradoxical regulation of glycogen metabolism and glucose-sensitive gene expression in GLUT2-null hepatocytes: Further evidence for the existence of a membrane-based glucose release pathway
17. Metabolic coupling between glia and neurons
18. The hepatic vagal nerve is receptive to incretin hormone glucagon-like peptide-1, but not to glucose-dependent insulinotropic polypeptide, in the portal vein
19. Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut
20. Specific inhibition of GLUT2 in arcuate nucleus by antisense oligonucleotides suppresses nervous control of insulin secretion
21. Glucose transporter 2(GLUT2): Expression in specific brain nuclei
22. Insulinotropin: Glucagon-like peptide I(7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas