The dendritic cell: Its role in intestinal inflammation and relationship with gut bacteria

Gut

Volumn 52, Issue 10, 2003, Pages 1522-1529

  Stagg, A J ^a   Hart, A L ^a   Knight, S C ^a   Kamm, M A ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ST MARK S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; BACTERIUM LIPOPOLYSACCHARIDE; CHOLERA TOXIN; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 23; INTERLEUKIN 4; PERTUSSIS TOXIN; UNCLASSIFIED DRUG;

ACTIVE IMMUNIZATION; ANTIGEN PRESENTING CELL; BORDETELLA PERTUSSIS; CANDIDA ALBICANS; CELL FUNCTION; CELLULAR IMMUNITY; CORRELATION ANALYSIS; CROHN DISEASE; CYTOLOGY; CYTOPATHOLOGY; DENDRITIC CELL; ENTERITIS; ESCHERICHIA COLI; HOMEOSTASIS; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; INFLUENZA VIRUS; INTESTINE FLORA; NONHUMAN; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; REVIEW; SCHISTOSOMA MANSONI; ULCERATIVE COLITIS; VIBRIO CHOLERAE;

BACTERIAL INFECTIONS; CYTOKINES; DENDRITIC CELLS; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINES; LYMPHOCYTE ACTIVATION; LYMPHOID TISSUE; MICROSCOPY, ELECTRON, SCANNING; T-LYMPHOCYTES;

EID: 0141534407     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.52.10.1522     Document Type: Review

References (102)

1. Banchereau J, Briere F, Caux C, et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000;18:767-811.
2. Heath WR, Carbone FR. Cross-presentation, dendritic cells, tolerance and immunity. Annu Rev Immunol 2001;19:47-64.
3. Liu YJ. Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell 2001;106:259-62.
4. Moser M, Murphy KM. Dendritic cell regulation of TH1-TH2 development. Nat Immunol 2000;1:199-205.
5. Shortman K, Liu YJ. Mouse and human dendritic cell subtypes. Nature Rev Immunol 2002;2:151-61.
6. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245-52.
7. Grewal IS, Flavell RA. CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 2000;16:111-35.
8. Theill LE, Boyle WJ, Penninger JM. RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol 2002;20:795-823.
9. Scheinecker C, McHugh R, Shevach EM, et al. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J Exp Med 2002;196:1079-90.
10. Lutz M, Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol 2002;23:445.
11. Steinman RM, Nussenzweig MC. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A 2002;99:351-8.
12. Hawiger D, Inaba K, Dorsett Y, et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 2001;194:769-79.
13. + cells. J Immunol 1995;154:5071-9.
14. Kelleher P, Maroof A, Knight SC. Retrovirally induced switch from production of IL-12 to IL-4 in dendritic cells. Eur J Immunol 1999;29:2309-18.
15. Iwasaki A, Kelsall BL. Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J Exp Med 1999;190:229-39.
16. Gilliet M, Liu YJ. Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J Exp Med 2002;195:695-704.
17. Albert ML, Jegathesan M, Darnell RB. Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells. Nat Immunol 2001;2:1010-17.
18. Reid SD, Penna G, Adorini L. The control of T cell responses by dendritic cell subsets. Curr Opin Immunol 2000;12:114-21.
19. Ardavin C, Martinez DH, Martin P, et al. Origin and differentiation of dendritic cells. Trends Immunol 2001;22:691-700.
20. Merad M, Fong L, Bogenberger J, et al. Differentiation of myeloid dendritic cells into CD8alpha-positive dendritic cells in vivo. Blood 2000;96:1865-72.
21. Traver D, Akashi K, Manz M, et al. Development of CD8alpha-positive dendritic cells from a common myeloid progenitor. Science 2000;290:2152-4.
22. Manz MG, Traver D, Miyamoto T, et al. Dendritic cell potentials of early lymphoid and myeloid progenitors. Blood 2001;97:3333-41.
23. del Hoyo GM, Martin P, Vargas HH, et al. Characterization of a common precursor population for dendritic cells. Nature 2002;415:1043-7.
24. Siegal FP, Kadowaki N, Shodell M, et al. The nature of the principal type 1 interferon-producing cells in human blood. Science 1999;284:1835-7.
25. Nakano H, Yanagita M, Gunn MD. CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J Exp Med 2001;194:1171-8.
26. Asselin-Paturel C, Boonstra A, Dalod M, et al. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat Immunol 2001;2:1144-50.
27. Rissoan M-C, Soumelis V, Kadowaki N, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999;283:1183-6.
28. Pulendran B, Smith JL, Caspary G, et al. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc Natl Acad Sci U S A 1999;96:1036-41.
29. Maldonado L, De Smedt T, Michel P, et al. CD8alpha+ and CD8alpha-subclasses of dendritic cells direct the development of distinct T helper cells in vivo. J Exp Med 1999;189:587-92.
30. Iwasaki A, Kelsall BL. Unique functions of cd11b(+), cd8alpha(+), and double-negative Peyer's patch dendritic cells. J Immunol 2001;166:4884-90.
31. Vieira PL, de Jong EC, Wierenga EA, et al. Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. J Immunol 2000;164:4507-12.
32. Whelan M, Harnett MM, Houston KM, et al. A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells. J Immunol 2000;164:6453-60.
33. de Jong EC, Vieira PL, Kalinski P, et al. Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals. J Immunol 2002;168:1704-9.
34. Pulendran B, Kumar P, Cutler CW, et al. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J Immunol 2001;167:5067-76.
35. d'Ostiani CF, Del Sero G, Bacci A, et al. Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J Exp Med 2000;191:1661-74.
36. Palma JP, Yauch RL, Kang HK, et al. Preferential induction of IL-10 in APC correlates with a switch from Th1 to Th2 response following infection with a low pathogenic variant of Theiler's virus. J Immunol 2002;168:4221-30.
37. Huang Q, Liu d, Majewski P, et al. The plasticity of dendritic cell responses to pathogens and their components. Science 2001;294:870-5.
38. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001;2:675-80.
39. Takeuchi O, Hoshino K, Kawai T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999;11:443-51.
40. Kaisho T, Takeuchi O, Kawai T, et al. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol 2001;166:5688-94.
41. Kadowaki N, Ho S, Antonenko S, et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 2001;194:863-9.
42. Jarrossay D, Napolitani G, Colonna M, et al. Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol 2001;31:3388-93.
43. Krug A, Towarowski A, Britsch S, et al. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur J Immunol 2001;31:3026-37.
44. Bauer M, Redecke V, Ellwart JW, et al. Bacterial CpG-DNA triggers activation and maturation of human CD11c-, CD123+ dendritic cells. J Immunol 2001;166:5000-7.
45. Figdor CG, van Kooyk Y, Adema GJ. C-type lectin receptors on dendritic cells and Langerhans cells. Nature Rev Immunol 2002;2:77-84.
46. Geijtenbeek TB, Krooshoop DJ, Bleijs DA, et al. DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking. Nat Immunol 2000;1:353-7.
47. Geijtenbeek TB, Torensma R, van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000;100:575-85.
48. Geijtenbeek TB, Kwon DS, Torensma R, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000;100:587-97.
49. Jameson B, Baribaud F, Pohlmann S, et al. Expression of DC-SIGN by dendritic cells of intestinal and genital mucosae in humans and rhesus macaques. J Virol 2002;76:1866-75.
50. Geijtenbeek TB, van Viler SJ, Koppel EA, et al. Mycobacteria Target DC-SIGN to suppress dendritic cell function. J Exp Med 2003;197:7-17.
51. Tailleux L, Schwartz O, Herrmann JL, et al. DC-SIGN is the major mycobacterium tuberculosis receptor on human dendritic cells. J Exp Med 2003;197:121-7.
52. Kanamori Y, Ishimaru K, Nanno M, et al. Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thyl+ lympho-hemopoietic progenitors develop. J Exp Med 1996;184:1449-59.
53. Hamada H, Hiroi T, Nishiyama Y, et al. Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J Immunol 2002;168:57-64.
54. Moghaddami M, Cummins A, Mayrhofer G. Lymphocyte-filled villi: comparison with other lymphoid aggregations in the mucosa of the human small intestine. Gastroenterology 1998;115:1414-25.
55. Maric I, Holt PG, Perdue MH, et al. Class II MHC antiden (la)-bearing dendritic cells in the epithelium of the rat intestine. J Immunol 1996;156:1408-14.
56. Liu L, Zhang M, Jenkins C, et al. Dendritic cell heterogeneity in vivo: two functionally different dendritic cell populations in rat intestinal lymph can be distinguished by CD4 expression. J Immunol 1998;161:1146-55.
57. Huang FP, Platt N, Wykes M, et al. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to t cell areas of mesenteric lymph nodes. J Exp Med 2000;191:435-44.
58. Stagg AJ, Kamm MA, Knight SC. Intestinal dendritic cells increase T cell expression of alpha4beta7 integrin. Eur J Immunol 2002;32:1445-54.
59. Pugh CW, Macpherson GG, Steer HW. Characterization of nonlymphoid cells derived from rat peripheral lymph. J Exp Med 1983;157:1758-79.
60. Holt PG, Haining S, Nelson DJ, et al. Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways. J Immunol 1994;153:256-61.
61. Ruedl C, Koebel P, Bachmann M, et al. Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes. J Immunol 2000;165:4910-16.
62. Macpherson GG, Jenkins CD, Stein MJ, et al. Endotoxin-mediated dendritic cell release from the intestine. Charaterization of released dendritic cells and TNFα dependence. J Immunol 1995;154:1317-22.
63. Bell SJ, Rigby R, English N, et al. Migration and maturation of human colonic dendritic cells. J Immunol 2001;166:4958-67.
64. Liu LM, Macpherson GG. Lymph-borne (veiled) dendritic cells can acquire and present intestinally administered antigens. Immunology 1991;73:281-6.
65. Kelsall BL, Strober W. Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's Patch. J Exp Med 1996;183:237-47.
66. Rescigno M, Urbano M, Valzasina B, et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2001;2:361-7.
67. van Niel G, Raposo G, Candalh C, et al. Intestinal epithelial cells secrete exosome-like vesicles. Gastroenterology 2000;121:337-49.
68. Karlsson M, Lundin S, Dahlgren U, et al. "Tolerosomes" are produced by intestinal epithelial cells. Eur J Immunol 2001;31:2892-900.
69. Williamson E, Bilsborough JM, Viney JL. Regulation of mucosal dendritic cell function by receptor activator of NF-kappa B (RANK)/RANK ligand interactions: impact on tolerance induction. J Immunol 2002;169:3606-12.
70. Akbari O, DeKruyff RH, Umetsu DT. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2001;2:725-31.
71. Nagata S, McKenzie C Pender SL, et al. Human Peyer's patch T cells are sensitized to dietary antigen and display a Th cel type 1 cytokine profile. J Immunol 2000;165:5315-21.
72. MacDonald TT, Monteleone G. IL-12 and Th1 immune responses in human Peyer's patches. Trends Immunol 2001;22:244-7.
73. Viney JL, Mowat AM, O'Malley JM, et al. Expanding dendritic cells in vivo enhances the induction of oral tolerance. J Immunol 1998;160:5815-25.
74. Williamson E, Westrich GM, Viney JL. Modulating dendritic cells to optimize mucosal immunization protocols. J Immunol 1999;163:3668-75.
75. Butcher EC, Williams M, Youngman K, et al. Lymphocyte trafficking and regional immunity. Adv Immunol 1999;72:209-53.
76. Campbell JJ, Hedrick J, Zlotnik A, et al. Chemokines and the arrest of lymphocytes rolling under flow conditions. Science 1998;279;381-4.
77. Butcher EC, Picker U. Lymphocyte homing and homeostasis. Science 1996;272:60-6.
78. Strunk D, Egger C, Leitner G, et al. A skin homing molecule defines the langerhans cell progenitor in human peripheral blood. J Exp Med 1997;185:1131-6.
79. Ito T, Inaba M, Inaba K, et al. A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells. J Immunol 1999;163:1409-19.
80. Rigby RJ, Jones AM, Hart AL, et al. Identification of possible gut homing dendritic cells in perioheral blood by expression of β7 integrin. Gastroenterology 2002;122:A153.
81. Stagg AJ, Bell SJ, Rigby RJ, et al. Treatment with anti-TNFα antibody reduces expression of CD40 on lamina propria dendritic cells. Gastroenterology 2000;118:A353.
82. Vuckovic S, Florin TH, Khalil D, et al. CD40 and CD86 upregulation with divergent CMRF44 expression on blood dendritic cells in inflammatory bowel diseases. Am J Gastroenterol 2001;96:2946-56.
83. Ikeda Y, Akbar F, Matsui H, et al. Characterization of antigen-presenting dendritic cells in the peripheral blood and colonic mucosa of patients with ulcerative colitis. Eur J Gastroenterol Hepatol 2001;13:841-50.
84. - dendritic cell populations in the colonic mucosa of patients with Crohn's disease. Eur J Immunol 2003;33:143-151.
85. Liu Z, Colpaert S, D'Haens GR, et al. Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production. J Immunol 1999;163:4049-57.
86. Waraich T, Sarsfield P, Wright DH. The accessory cell populations in ulcerative colitis: a comparison between the colon and appendix in colitis and acute appendicitis. Hum Pathol 1997;28:297-303.
87. Sarsfield P, Jones DB, Wright DH. Accesory cells in Crohn's disease of the terminal ileum. Histopathology 1996;28:213-19.
88. Pavli P, Maxwell L, van de Pol E, et al. Distribution of human colonic dendritic cells and macrophages. Clin Exp Immunol 1996;104:124-32.
89. Oshitani N, Sawa Y, Hara J, et al. Functional and phenotypical activation of leucocytes in inflamed human colonic mucosa. J Gastroenterol Hepatol 1997;12:809-14.
90. Oshitani N, Kitano A, Kakazu T, et al. Functional diversity of infiltrating macrophages in inflamed human colonic mucosa ulcerative colitis. Clin Exp Pharmacol Physiol 1998;25:50-3.
91. Krajina T, Leithauser F, Moller P, et al. Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis. Eur J Immunol 2003;33:1073-83.
92. Leithauser F, Trobonjaca Z, Moller P, et al. Clustering of colonic lamina propria CD4(+) T cells to subepithelial dendritic cell aggregates precedes the development of colitis in a murine adoptive transfer model. Lab Invest 2001;81:1339-49.
93. Malmstrom V, Shipton D, Singh B, et al. CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice. J Immunol 2001;166:6972-81.
94. Julia V, McSorley SS, Malherbe L, et al. Priming by microbial antigens from the intestinal flora determines the ability of CD4+ T cells to rapidly secrete IL-4 in BALB/c mice infected with Leishmania major. J Immunol 2000;165:5637-45.
95. Macpherson AJ, Gatto D, Sainsbury E, et al. A primitive T cetl-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 2000;288:2222-6.
96. Khoo UY, Proctor IE, Macpherson AJ. CD4+ T cell down-regulation in human intestinal mucosa: evidence For intestinal tolerance to luminal bacterial antigens. J Immunol 1997;158:3626-34.
97. O'Boyle CJ, MacFie J, Mitchell CJ, et al. Microbiology of bacterial translocation in humans. Gut 1998;42:29-35.
98. Shiloh MU, MacMicking JD, Nicholson S, et al. Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity 1999;10:29-38.
99. Rigby RJ, Hart AL, Kamm MA, et al. Differential production of IL-12 and IL-10 by colonic dendritic cells (DC) in response to bacterial stimuli. Gastroenterology 2002;122:A75.
100. Hart AL, Stagg AJ, Frame M et al. The role of the gut flora in health and disease, and its modification as therapy. Aliment Pharmacol Ther 2002;16:1383-93.
101. Mimura T, Rizzello F, Schreiber S, et al. Once daily high dose probiotic therapy maintains remission and improves quality of life in patients with recurrent or refractory pouchitis: a randomised placebo-controlled, double blind trial. Gastroenterology 2002;122:A81.
102. Campbell DJ, Butcher EC. Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues. J Exp Med 2002;195:135-41.