Retrovirally induced switch from production of IL-12 to IL-4 in dendritic cells

European Journal of Immunology

Volumn 29, Issue 7, 1999, Pages 2309-2318

  Kelleher, Peter ^a   Maroof, Asher ^a   Knight, Stella C ^a  

^a NORTHWICK PARK INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

HIV type 1; Immunosuppression; Rauscher leukemia virus

Indexed keywords

CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 4;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HELPER CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAUSCHER LEUKEMIA VIRUS; RETROVIRUS; T LYMPHOCYTE;

ANIMALS; BASE SEQUENCE; DENDRITIC CELLS; DNA PRIMERS; DNA, VIRAL; HIV INFECTIONS; HIV-1; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-12; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED CBA; RAUSCHER VIRUS; TH1 CELLS; TH2 CELLS;

EID: 0033041868     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199907)29:07<2309::AID-IMMU2309>3.0.CO;2-5     Document Type: Article

References (33)

1. Banchereau, J. and Steinman, R. M., Dendritic cells and the control of immunity. Nature 1998. 392: 245-252.
2. De Saint-Vis, B., Fugier-Vivier, I., Massacrier, C., Gaillard, C., Vanbervliet, B., Ait-Yahia, S., Banchereau, J., Liu, Y. J., Lebecque, S. and Caux, C., The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation. J. Immunol. 1998. 160: 1666-1676.
3. Cumberbatch, M., Dearman, R. J. and Kimber, I., Interleukin-1β and the stimulation of Langerhans cell migration, comparisons with tumour necrosis factor-α. Arch. Dermatol. Res. 1997. 289: 277-284.
4. Kelleher, P. and Knight, S. C., Interleukin-12 increases CD80 expression and the stimulatory capacity of bone marrow derived dendritic cells. Int. Immunol. 1998. 10: 749-755.
5. Buelens, C., Verhasselt, V., De-Groote, D., Thielemans, K., Goldman, M. and Willems, F., Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin-10. Eur. J. Immunol. 1997. 27: 1848-1852.
6. Sallusto, F. and Lanzavecchia, A., Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 1995. 182: 389-400.
7. Winzler, C., Rovere, P., Rescigno, M., Granucci, F., Penna, G., Adorini, L., Zimmermann, V. S., Davoust, J. and Ricciardi-Catagnoli, P., Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J. Exp. Med. 1997. 185: 317-328.
8. Sallusto, F. and Lanzavecchia, A., Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 1994. 179: 1109-1118.
9. Fugier-Vivier, I., Servet-Delprat, C., Rivailler, P., Rissoan, M. C., Liu, Y. J. and Rabourdin-Combe, C., Measles virus suppresses cell-mediated immunity by interfering with the survival and functions of dendritic and T cells. J. Exp. Med. 1997. 186: 813-823.
10. Fisher, G., M., Iqball, S. and Knight, S. C., Gene expression during differentiation of human dendritic cells from cord blood CD34 stem cells. Cytokine 1999. 11: 111-117.
11. Knight, S. C. and Patterson, S., Bone marrow-derived dendritic cells, infection with human immunodeficiency virus and immunopathology. Annu. Rev. Immunol. 1994. 15: 593-615.
12. Fan, Z., Huang, X. L., Zheng, L., Wilson, C., Borowski, L., Liebmann, J., Gupta, P., Margolick, J. and Rinaldo, C., Cultured blood dendritic cells retain HIV-1 antigen-presenting capacity for memory CTL during progressive HIV-1 infection. J. Immunol. 1997. 159: 4973-4982.
13. Clerici, M., Fusi, M. L., Ruzzante, S., Piconi, S., Biaisin, M., Arienti, D., Trabattoni, D. and Villa, M. L., Type 1 and type 2 cytokines in HIV infection - a possible role in apoptosis and disease progression. Ann. Med. 1997. 29: 185-188.
14. Gazzinelli, R. T., Giese, N. A. and Merze, H. C., In vivo treatment with interleukin 12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS). J. Exp. Med. 1994. 180: 2199-2208.
15. Williams, N. J., Harvey, J. J., Duncan, I., Booth, R. and Knight, S. C., IL-12 restores dendritic cell function and cell mediated immunity in retrovirus infected mice. Cell. Immunol. 1998. 183: 121-130.
16. Gabrilovich, D. I., Woods, G. M., Patterson, S., Harvey, J. J. and Knight, S. C., Retrovirus-induced immunosuppression via blocking of dendritic cell migration and down-regulation of adhesion molecules. Immunology 1994. 82: 82-87.
17. Grohmann, U., Belladonna, M. L., Bianchi, R., Orabona, C., Ayroidi, E., Fioretti, M. C. and Puccetti, P., IL-12 acts directly on DC to promote nuclear localization of NF-(greek small letter script kappa) B and primes DC for IL-12 production. Immunity 1998. 9: 315-323.
18. Gabrilovich, D. I., Patterson, S., Timofeev, A. V., Harvey, J. J. and Knight, S. C., Mechanism of dendritic cell dysfunction in retroviral infection of mice. Clin. Immunol. Immunopathol. 1996. 80: 139-146.
19. Gabrilovich, D. I., Patterson, S., Harvey, J. J., Woods, G. M., Elsley, W. and Knight, S. C., Murine retrovirus induces defects in function of dendritic cells at early stages of infection. Cell. Immunol. 1994. 158: 167-181.
20. Trinchieri, G., Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen specific immunity. Annu. Rev. Immunol. 1995. 13: 251-276.
21. Carter, L. and Swain, S., Single cell analysis of cytokine production. Curr. Opin. Immunol. 1997. 9: 177-182.
22. + T cells. J. Immunol. 1995. 154: 5071-5079.
23. Ridge, J. P., Fuchs, E. J. and Matzinger, P., Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science 1996. 271: 1723-1726.
24. Forsthuber, T., Yip, H. C. and Lehmann, P. V., Induction of Th1 and Th2 immunity in neonatal mice. Science 1996. 271: 1728-1730.
25. Orange, J. S., Wolf, S. F. and Biron, C. A., Effects of IL-12 on the response and susceptibility to experimental viral infections. J. Immunol. 1994. 152: 253-1264.
26. Orange, J. S., Wang, B., Terhorst, C. and Biron, C. A., Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin-12 administration. J. Exp. Med. 1995. 182: 1045-1056.
27. + individuals: relationship with in vitro Th1/Th2-type responses. Clin. Exp. Immunol. 1998. 114: 61-65.
28. Taoufik, Y., Lantz, O., Wallon, C., Dussaix, E. and Delfraissy, J. F., Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect. Blood 1997. 89: 2842-2848.
29. Landay, A. L., Clerici, M., Hashemi, F., Kessler, H., Berzofsky, J. H. and Shearer, G. M., In vitro restoration of T cell immune function in human immunodeficiency virus-positive persons: effects of interleukin (IL)-12 and anti-IL-10. J. Infect. Diss. 1996. 173: 1085-1091.
30. Knight, S. C., Bone-marrow-derived dendritic cells and the pathogenesis of AIDS. AIDS 1996. 10: 807-817.
31. Bassin, R. H., Tuttle, N. and Fischinger, P. J., Rapid cell culture assay technique for murine leukaemia viruses. Nature 1971. 229: 564-566.
32. Knight, S. C., Lymphocyte proliferation assays. In G. G. B. Klaus (Ed.) Lymphocytes - A practical approach, IRL Press 1988, pp 189-207.
33. Donaldson, Y. K., Bell, J. E., Holmes, E. C., Hughes, E. S., Brown, H. K. and Simmonds, P., In vivo distribution and cytopathology of variants of human immunodeficiency virus type 1 showing restricted sequence variability in the V3 loop. J. Virol. 1994. 68: 5991-6005.