Dendritic cell heterogeneity in vivo: Two functionally different dendritic cell populations in rat intestinal lymph can be distinguished by CD4 expression

Journal of Immunology

Volumn 161, Issue 3, 1998, Pages 1146-1155

  Liu, LiMing ^a,b   Zhang, ManHua ^a,b   Jenkins, Chris ^a   MacPherson, G Gordon ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD4 ANTIGEN; GLYCOPROTEIN P 15095; INTERCELLULAR ADHESION MOLECULE 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; THY 1 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL HETEROGENEITY; CELL INCLUSION; CELL MIGRATION; CELL POPULATION; CONTROLLED STUDY; CYTOPLASM; DENDRITIC CELL; INTESTINE LYMPH; LYMPH NODE; MIXED LYMPHOCYTE REACTION; NONHUMAN; PRIORITY JOURNAL; PSEUDOPODIUM; RAT;

ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD4; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DENDRITIC CELLS; HEMOCYANIN; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNIZATION; IMMUNOPHENOTYPING; INTERPHASE; INTESTINE, SMALL; KINETICS; LYMPH; LYMPHOCYTE CULTURE TEST, MIXED; MOLLUSCA; RATS; RATS, INBRED STRAINS; T-LYMPHOCYTES;

EID: 0032146227     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271.
2. Liu, L. M., and G. G. MacPherson. 1993. Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo. J. Exp. Med. 177:1299.
3. Schuler, G., and R. M. Steinman. 1985. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J. Exp. Med. 161:526.
4. Austyn, J. M., D. F. Hankins, C. P. Larsen, P. J. Morris, A. S. Rao, and J. A. Roake. 1994. Isolation and characterization of dendritic cells from mouse heart and kidney. J. Immunol. 152:2401.
5. Liu, L.-M., and G. G. MacPherson. 1995. Rat intestinal dendritic cells: immunostimulatory potency and phenotypic characterisation. Immunology 85:88.
6. Reis-e-Sousa, C., P. D. Stahl, and J. M. Austyn. 1993. Phagocytosis of antigens by Langerhans cells in vitro. J. Exp. Med. 178:509.
7. Romani, N., S. Koide, M. Crowley, M. Witmer-Pack, A. M. Livingstone, C. G. Fathman, K. Inaba, and R. M. Steinman. 1989. Presentation of exogenous protein antigens by dendritic cells to T cell clones: intact protein is presented best by immature, epidermal Langerhans cells. J. Exp. Med. 169:1169.
8. Austyn, J. M., and S. Gordon. 1981. F4/80, a mAb directed specifically against the mouse macrophage. Eur. J. Immunol. 11:805.
9. MacPherson, G. G. 1989. Properties of lymph-borne (veiled) dendritic cells in culture. I. Modulation of phenotype, survival and function: partial dependence on GM-CSF. Immunology 68:102.
10. MacPherson, G. G., S. Fossum, and B. Harrison. 1989. Properties of lymph-borne (veiled) dendritic cells in culture. II. Expression of the IL-2 receptor: role of GM-CSF. Immunology 68:108.
11. Finkelman, F. D., A. Lees, R. Birnbaum, W. C. Cause, and S. C. Morris. 1996. Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. J. Immunol. 157:1406.
12. Metlay, J. P., M. D. Witmer-Pack, R. Agger, M. T. Crowley, D. Lawless, and R. M. Steinman. 1990. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J. Exp. Med. 171:1753.
13. Schon-Hegrad, M. A., J. Oliver, P. G. McMenamin, and P. G. Holt. 1991. Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways. J. Exp. Med. 173:1345.
14. Gong, J. L., K. M. McCarthy, J. Telford, T. Tamatani, M. Miyasaka, and E. E. Schneeberger. 1992. Intraepithelial airway dendritic cells: a distinct subset of pulmonary dendritic cells obtained by microdissection. J. Exp. Med. 175:797.
15. -) T cells. Am. J. Pathol. 142:811.
16. Chaux, P., A. Hammann, F. Martin, and M. Martin. 1993. Surface phenotype and functions of tumor-infiltrating dendritic cells: CD8 expression by a cell subpopulation. Eur. J. Immunol. 23:2517.
17. Ardavin, C., L. Wu, I. Ferrera, and K. Shortman. 1993. Mouse thymic dendritic cell subpopulations. Immunol. Lett. 38:19.
18. Winkel, K., F. Sotzik, D. Vremec, P. U. Cameron, and K. Shortman. 1994. CD4 and CD8 expression by human and mouse thymic dendritic cells. Immunol. Lett. 40:93.
19. Peters, J. H., R. Gieseler, B. Thiele, and F. Steinbach. 1996. Dendritic cells: from ontogenetic orphans to myelomonocytic descendants. Immunol. Today 17:273.
20. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by TNF-α. J. Exp. Med. 179:1109.
21. + bone marrow cells by c-kit/ligand, GM-CSF, and TNF-α. Adv. Exp. Med. Biol. 378:17.
22. Inaba, K., R. M. Steinman, M. W. Pack, H. Aya, M. Inaba, T. Sudo, S. Wolpe, and G. Schuler. 1992. Identification of proliferating dendritic cell precursors in mouse blood. J. Exp. Med. 175:1157.
23. Ardavin, C., L. Wu, C. L. Li, and K. Shortman. 1993. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature 362:761.
24. Patterson, S., and S. C. Knight. 1987. Susceptibility of human peripheral blood dendritic cells to infection by human immunodeficiency virus. J. Gen. Virol. 68:1177.
25. O'Doherty, U., R. M. Steinman, M. Peng, P. U. Cameron, S. Gezelter, I. Kopeloff, W. J. Swiggard, M. Pope, and N. Bhardwaj. 1993. Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium. J. Exp. Med. 178:1067.
26. Nestle, F. O., X. G. Zheng, C. B. Thompson, L. A. Turka, and B. J. Nickoloff. 1993. Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. J. Immunol. 151:6535.
27. Suss, G., and K. Shortman. 1996. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J. Exp. Med. 183:1789.
28. Pugh, C. W., G. G. MacPherson, and H. W. Steer. 1983. Characterization of nonlymphoid cells derived from rat peripheral lymph. J. Exp. Med. 157:1758.
29. Robinson, A. P., T. M. White, and D. W. Mason. 1986. Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42 the latter recognizing complement receptor type 3. Immunology 57:239.
30. Brenan, M., and M. Puklavec. 1992. The MRC OX-62 antigen: a useful marker in the purification of rat veiled cells with the biochemical properties of an integrin. J. Exp. Med. 175:1457.
31. Fisch, A., and K. Reske. 1992. Cell surface display of rat invariant γ-chain: detection by monoclonal antibodies directed against a C-terminal γ-chain segment. Eur. J. Immunol. 22:1413.
32. Liu, L. M., and G. G. MacPherson. 1995. Antigen processing: cultured lymphborne dendritic cells can process and present native protein antigens. Immunology 84:241.
33. Woo, J., L. Lu, A. S. Rao, Y. Li, V. Subbotin, T. E. Starzl, and A. W. Thomson. 1994. Isolation, phenotype, and allostimulatory activity of mouse liver dendritic cells. Transplantation 58:484.
34. + bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and TNF-α. J. Exp. Med. 182:1111.
35. + hematopoietic progenitor cells. Blood 87:2376.
36. Kelsall, B. L., and W. Strober. 1996. Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch. J. Exp. Med. 183:237.
37. Witmer Pack, M. D., J. Valinsky, W. Olivier, and R. M. Steinman. 1988. Quantitation of surface antigens on cultured murine epidermal Langerhans cells: rapid and selective increase in the level of surface MHC products. J. Invest. Dermatol. 90:387.
38. Bell, E. B., and J. Botham. 1982. Antigen transport. I. Demonstration and characterization of cells laden with antigen in thoracic duct lymph and blood. Immunology 47:477.
39. Xu, H., M. Kramer, H. P. Spengler, and J. H. Peters. 1995. Dendritic cells differentiated from human monocytes through a combination of IL-4, GM-CSF and IFN-γ exhibit phenotype and function of blood dendritic cells. Adv. Exp. Med. Biol. 378:75.
40. Reizis, B., C. Schramm, I. R. Cohen, and F. Mor. 1994. Expression of major histocompatibility complex class II molecules in rat T cells. Eur. J. Immunol. 24:2796.
41. Koch, F., C. Heufler, E. Kampgen, D. Schneeweiss, G. Bock, and G. Schuler. 1990. Tumor necrosis factor-α maintains the viability of murine epidermal Langerhans cells in culture, but in contrast to granulocyte/macrophage colony-stimulating factor, without inducing their functional maturation. J. Exp. Med. 171:159.
42. Romani, N., A. Lenz, H. Glassel, H. Stossel, U. Stanzl, O. Majdic, P. Fritsch, and G. Schuler. 1989. Cultured human Langerhans cells resemble lymphoid dendritic cells in phenotype and function. J. Invest. Dermatol. 93:600.
43. Stossel, H., F. Koch, E. Kampgen, P. Stoger, A. Lenz, C. Heufler, N. Romani, and G. Schuler. 1990. Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells. J. Exp. Med. 172:1471.
44. Schuler, G., and R. M. Steinman. 1985. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J. Exp. Med. 161:526.
45. Kampgen, E., N. Koch, F. Koch, P. Stoger, C. Heufler, G. Schuler, and N. Romani. 1991. Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture. Proc. Natl. Acad. Sci. USA 88:3014.
46. Koch, F., B. Trockenbacher, E. Kampgen, O. Grauer, H. Stossel, A. M. Livingstone, G. Schuler, and N. Romani. 1995. Antigen processing in populations of mature murine dendritic cells is caused by subsets of incompletely matured cells. J. Immunol. 155:93.
47. Moll, H., H. Fuchs, C. Blank, and M. Rollinghoff. 1993. Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells. Eur. J. Immunol. 23:1595.
48. Howard, C. J., P. Sopp, J. Brownlie, L. S. Kwong, K. R. Parsons, and G. Taylor. 1997. Identification of two distinct populations of dendritic cells in afferent lymph that vary in their ability to stimulate T cells. J. Immunol. 159:5372.