Cytochrome c is released from mitochondria into the cytosol after cerebral anoxia or ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 19, Issue 1, 1999, Pages 39-43

  Pérez Pinzón, Miguel A ^a   Xu, Guang Ping ^a   Born, James ^a   Lorenzo, José ^a   Busto, Raul ^a   Rosenthal, Myron ^a   Sick, Thomas J ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Anoxia; Apoptosis; Ischemia; Mitochondria; Necrosis; Permeability Transition pore

Indexed keywords

CYTOCHROME C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOXIA; APOPTOSIS; ARTICLE; BRAIN HOMOGENATE; BRAIN HYPOXIA; BRAIN ISCHEMIA; CONTROLLED STUDY; CYTOSOL; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRION; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; REOXYGENATION; REPERFUSION; RESPIRATORY CHAIN; SPECTROPHOTOMETRY;

EID: 17444373424     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199901000-00004     Document Type: Article

References (24)

1. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15:961-973
2. Bogaert YE, Rosenthal RE, Fiskum G (1994) Postischemic inhibition of cerebral cortex pyruvate dehydrogenase. Free Radic Biol Med 16:811-820
3. Charriaut-Marlangue C, Margaill I, Repress A, Popovivi T, Plotkine M, Ben-Ari Y (1996) Apoptosis and necrosis after reversible focal ischemia: an in situ DNA fragmentation analysis. J Cereb Blood Flow Metab 16:186-194
4. +2 and potentiates release of cytochrome c. Soc Neurose Abstr 23:547
5. Flamm ES, Demopoulos HB, Seligman ML, Poser RG, Ransohoff J (1978) Free radicals in cerebral ischemia. Stroke 9:445-447
6. Fridovich I (1979) Hypoxia and oxygen toxicity. Adv Neurol 26:255-259
7. Hall ED, Andrus PK, Althaus JS, VonVoigtlander PF (1993) Hydroxyl radical production and lipid peroxidation parallels selective postischemic vulnerability in gerbil brain. J Neurosci Res 34:107-112
8. Kluck RM, Bossywetzel E, Green DR, Newmeyer DD (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275:1132-1136
9. Kontos HA (1989) Oxygen radicals in CNS damage. Chem Biol Interact 72:229-255
10. LaManna JC, Pikarsky SM, Sick TJ, Rosenthal M (1985) A rapid scanning spectrophotometer designed for biological tissues in vitro or in vivo. Anal Biochem 144:483-493
11. Nitatori T, Sato N, Waguri S, Karasawa Y, Araki H, Shibanai K, Kominami E, Uchiyama Y (1995) Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J Neurosci 15:1001-1011
12. Ouyang YB, Kuroda S, Kristian T, Siesjo BK (1997) Release of mitochondrial aspartate aminotransferase (mAST) following transient focal cerebral ischemia suggests the opening of a mitochondrial permeability transition pore. Neurosci Res Commun 20:167-173
13. Pérez-Pinzón MA, Mumford PL, Rosenthal M, Sick TJ (1997) Antioxidants, mitochondrial hyperoxidation and electrical activity recovery after anoxia in hippocampal slices. Brain Res 754:163-170
14. Pérez-Pinzón MA, Mumford PL, Carranza V, Sick TJ (1998a) Calcium influx from the extracellular space promotes NADH hyperoxidation and electrical dysfunction after anoxia in hippocampal slices. J Cereb Blood Flow Metabol 18:215-221
15. Pérez-Pinzón MA, Mumford PL, Sick TJ (1998b) Prolonged anoxic depolarization exacerbates NADH hyperoxidation and promotes poor electrical recovery after anoxia in hippocampal slices. Brain Res 786:165-170
16. Rosenthal M, Feng ZC, Raffin CN, Harrison M, Sick TJ (1995) Mitochondrial hyperoxidation signals residual intracellular dysfunction after global ischemia in rat neocortex. J Cereb Blood Flow Metab 15:655-665
17. Schinder AF, Olson EC, Spitzer NC, Montal M (1996) Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J Neurosci 16:6125-6133
18. Sciamanna MA, Lee CP (1993) Ischemia/reperfusion-induced injury of forebrain mitochondria and protection by ascorbate. Arch Biochem Biophys 305:215-224
19. Siesjo BK, Bendek G, Koide T, Westerberg E, Wieloch T (1985) Influence of acidosis on lipid peroxidation in brain tissues in vitro. J Cereb Blood Flow Metab 5:253-258
20. Sims NR, Pulsinelli WA (1987) Altered mitochondrial respiration in selectively vulnerable brain subregions following transient forebrain ischemia in the rat. J Neurochem 49:1367-1374
21. Vlessis AA, Widener LL, Bartos D (1990) Effect of peroxide, sodium, and calcium on brain mitochondrial respiration in vitro: potential role in cerebral ischemia and reperfusion. J Neurochem 54:1412-1418
22. Welsh FA, Marcy VR, Sims RE (1991) NADH fluorescence and regional energy metabolites during focal ischemia and reperfusion of rat brain. J Cereb Blood Flow Metab 11:459-465
23. Welsh FA, Vannucci RC, Brierley JB (1982) Columnar alterations of NADH fluorescence during hypoxia ischemia in immature rat brain. J Cereb Blood Flow Metab 2:221-228
24. Yang J, Liu XS, Bhalla K, Kim CN, Ibrado AM, Cai JY, Peng TI, Jones DP, Wang XD (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275:1129-1132