Neuronal excitotoxicity: The role of mitochondria

BioFactors

Volumn 8, Issue 3-4, 1998, Pages 287-299

  Nicholls, David G ^a   Budd, Samantha L ^a,b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL DEATH; GLYCOLYSIS; ION TRANSPORT; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NERVE EXCITABILITY; PRIORITY JOURNAL; REVIEW;

EID: 0032421139     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.5520080317     Document Type: Review

References (67)

1. M. Ankarcrona, J.M. Dypbukt, E. Bonfoco, B. Zhivotovsky, S. Orrenius, S.A. Lipton and P. Nicotera, Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function, Neuron 15 (1995), 961-973.
2. M. Ankarcrona, J.M. Dypbukt, S. Orrenius and P. Nicotera, Calcineurin and mitochondrial function in glutamate-induced neuronal cell death, FEBS Lett. 394 (1996), 321-324.
3. R.C. Armstrong, T.J. Aja, K.D. Hoang, S. Gaur, X. Bai, E.S. Alnemri, G. Litwack, D.S. Karanewsky, L.C. Fritz and K.J. Tomaselli, Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis, J. Neurosci. 17 (1997), 553-562.
4. A. Atlante, S. Gagliardi, G.M. Minervini, E. Marra, S. Passarella and P. Calissano, Rapid uncoupling of oxidative phosphorylation accompanies glutamate toxicity in rat cerebellar granule cells, Neuroreport 7 (1996), 2519-2523.
5. K.E.O. Åkerman, Changes in membrane potential during calcium ion influx and efflux across the mitochondrial membrane, Biochim. Biophys. Acta 502 (1978), 359-366.
6. K.E.O. Åkerman and D.G. Nicholls, Intra-synaptosomal compartmentation of Ca during depolarization-induced calcium uptake across the plasma membrane, Biochim. Biophys. Acta 645 (1981), 41-48.
7. K.E.O. Åkerman and D.G. Nicholls, Physiological and bioenergetic aspects of mitochondrial Ca transport, Rev. Physiol. Biochem. Pharmacol. 95 (1983), 149-201.
8. M.F. Beal, E. Brouillet, B. Jenkins, R. Henshaw, B. Rosen and B.T. Hyman, Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate, J. Neurochem. 61 (1993), 1147-1150.
9. M.F. Beal, N. Howell and I. Bodis-Wollner, Mitochondria and Free Radicals in Neurodegenerative Disease, Wiley-Liss, New York, 1997.
10. V.P. Bindokas and R.J. Miller, Excitotoxic degeneration is initiated a non-random sites in cultured rat cerebellar neurons, J. Neurosci. 15 (1995), 6999-7011.
11. V.P. Bindokas, J. Jordan, C.C. Lee and R.J. Miller, Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine, J. Neurosci. (1996).
12. F. Blandini, R.H.P. Porter and J.T. Greenamyre, Glutamate and Parkinson's disease, Mol. Neurobiol. 12 (1996), 73-94.
13. E. Bonfoco, D. Krainc, M. Ankarcrona, P. Nicotera and S.A. Lipton, Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures, Proc. Natl. Acad. Sci. USA 92 (1995), 7162-7166.
14. A. Boveris, N. Oshino and B. Chance, The cellular production of hydrogen peroxide, Biochem. J. 128 (1972), 617-630.
15. S.L. Budd, R.F. Castilho and D.G. Nicholls, Mitochondrial membrane potential and hydroethidine-monitored superoxide generation in cerebellar granule cells, FEBS Lett. 415 (1997), 21-24.
16. S.L. Budd and D.G. Nicholls, A re-evaluation of the role of mitochondria in neuronal calcium homeostasis, J. Neurochem. 66 (1996), 403-411.
17. S.L. Budd and D.G. Nicholls, Mitochondrial calcium regulation and acute glutamate excitotoxicity in cultured cerebellar granule cells, J. Neurochem. 67 (1996), 2282-2291.
18. G.P. Davey and J.B. Clark, Threshold effects and control of oxidative phosphorylation in nonsynaptic rat brain mitochondria, J. Neurochem. 66 (1996), 1617-1624.
19. J.M. Dubinsky, B.S. Kristal and M. Elizondo-Fournier, An obligate role for oxygen in the early stages of glutamate-induced, delayed neuronal death, J. Neurosci. 15 (1995), 7071-7078.
20. J.M. Dubinsky and S.M. Rothman, Intracellular calcium concentration during chemical hypoxia and excitatoxic neuronal injury, J. Neurosci. 11 (1991), 2545-2551.
21. 2+-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons, Biochem. J. 283 (1992), 41-50.
22. M.R. Duchen, M. Valdeolmillos, S.C. O'Neill and D.A. Eisner, Effects of metabolic blockade on the regulation of intracellular calcium in dissociated mouse sensory neurones, J. Physiol. (Lond.) 424 (1990), 411-426.
23. L.L. Dugan, S.L. Sensi, L.M.T. Canzoniero, S.D. Handran, S.M. Rothman, T.S. Lin, M.P. Goldberg and D.W. Choi, Mitochondrial production of reactive oxygen species in cortical neurons following exposure to NMDA, J. Neurosci. 15 (1995), 6377-6388.
24. +: Implications for neurodegeneration, J. Neurochem. 63 (1994), 584-591.
25. S. Eimerl and M. Schramm, The quantity of calcium that appears to induce neuronal death, J. Neurochem. 62 (1994), 1223-1226.
26. M. Erecinska, D. Nelson, J. Deas and I.A. Silver, Limitation of glycolysis by hexokinase in rat brain synaptosomes during intense ion pumping, Brain Res. 726 (1996), 153-159.
27. i, J. Neurosci. 14 (1994), 4007-4024.
28. 2+ accumuation in cortical cell culture correlated with subsequent neuronal degeneration, J. Neurosci. 13 (1993), 1993-2000.
29. G.M. Heaton and D.G. Nicholls, The Ca conductance of the inner membrane of rat liver mitochondria and the determination of the Ca electrochemical gradient, Biochem. J. 156 (1976), 635-646.
30. 2+ loads from rat adrenal chromaffin cells, Neuron 16 (1996), 219-228.
31. J.B. Hoek, D.G. Nicholls and J.R. Williamson, Determination of the mitochondrial protonmotive force in isolated hepatocytes, J. Biol. Chem. 255 (1980), 1458-1464.
32. K. Hyrc, S.D. Handran, S.M. Rothman and M.P. Goldberg, Ionized intracellular calcium concentration predicts excitotoxic neuronal death: Observations with low-affinity fluorescent calcium indicators, J. Neurosci. 17 (1997), 6669-6677.
33. 2+-dependent collapse of mitochondrial membrane potential and ultrastructural alterations of mitochondria, FEES Lett. 392 (1996), 143-147.
34. R.A. Kauppinen and D.G. Nicholls, Failure to maintain glycolysis in anoxic nerve terminals, J. Neurochem. 47 (1986), 1864-1869.
35. J. Keelan, O. Vergun, L. Patterson and M.R. Duchen, Excitotoxicity, cellular Ca signalling and mitochondrial dysfunction in cultured hippocampal cells, Soc. Neurosci. Abstr. (1997), 895.1.
36. 2+ as a tool to study calcium influx pathways, Int. J. Neurosci. 88 (1996), 215-241.
37. B.I. Khodorov, V. Pinelis, O. Vergun, T. Storozhevykh and N. Vinskaya, Mitochondrial deenergization underlies neuronal calcium overload following a prolonged glutamate challenge, FEBS Lett. 397 (1996), 230-234.
38. B.S. Kristal and J.M. Dubinsky, Mitochondrial permeability transition in the central nervous system: induction by calcium-cycling-dependent and -independent pathways, J. Neurochem. 69 (1997), 524-538.
39. 2+ transients evoke concurrent mitochondrial depolarizations, Proc. Natl. Acad. Sci. USA 91 (1994), 12579-12583.
40. D.G. Nicholls, The influence of respiration and ATP hydrolysis on the proton electrochemical potential gradient across the inner membrane of rat liver mitochondria as determined by ion distribution, Eur. J. Biochem. 50 (1974), 305-315.
41. D.G. Nicholls, Calcium transport and proton electrochemical potential in mitochondria from cerebral cortex and rat heart, Biochem. J. 170 (1978), 511-522.
42. D.G. Nicholls and K.E.O. Åkerman, Calcium transport across the plasma membrane and inner mitochondrial membrane in synaptosomes, in: Calcium and Phosphate Transport across Biomembranes, Academic Press, New York, 1981, pp. 83-86.
43. D.G. Nicholls and K.E.O. Åkerman, Mitochondrial calcium transport, Biochim. Biophys. Acta 683 (1982), 57-88.
44. D.G. Nicholls and S.J. Ferguson, Bioenergetics 2, Academic Press, London, 1992.
45. D.G. Nicholls and I.D. Scott, The regulation of brain mitochondrial calcium-ion transport: the role of ATP in the discrimination between kinetic and membrane-potential-dependent Ca efflux mechanisms, Biochem. J. 186 (1980), 833-839.
46. A.L. Nieminen, T.G. Petrie, J.J. Lemasters and W.R. Selman, Cyclosporin a delays mitochondrial depolarization induced by N-methyl-D-aspaparte in cortical neurons: Evidence of the mitochondrial permeability transition, Neurosci. 75 (1996), 993-997.
47. M. Patel, B.J. Day, J.D. Crapo, I. Fridovich and J.O. McNamara, Requirement for superoxide in excitotoxic cell death, Neuron 16 (1996), 345-355.
48. P.X. Petit, S.A. Susin, N. Zamzami, B. Mignotte and G. Kroemer, Mitochondria and programmed cell death: Back to the future, FEBS Lett. 396 (1996), 7-13.
49. J.H. Prehn, V.P. Bindokas, J. Jordan, M.F. Galindo, G.D. Ghadge, R.P. Roos, L.H. Boise, C.B. Thompson, S. Krajewski, J.C. Reed and R.J. Miller, Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons, Mol. Pharmacol. 49 (1996), 319-328.
50. 2+ concentrations associated with glutamate excitotoxicity in cultured rat brain neurons, Neurosci. Lett. 162 (1993), 149-152.
51. R. Sattler, M.P. Charlton, M. Hafner and M. Tymianski, Source-specificity of Ca-neurotoxicity revisited: the route of Ca-loading determines excitotoxic neuronal cell death, Soc. Neurosci. Abstr. (1997), 894.4.
52. A.F. Schinder, E.C. Olson, N.C. Spitzer and M. Montal, Mitochondrial dysfunction is a primary event in glutamate excitotoxicity, J. Neurosci. 16 (1996), 6125-6133.
53. J.M. Scanlon, E. Aizenman and I.J. Reynolds, Effects of pyrroloquinoline quinone on glutamate-induced production of reactive oxygen species in neurones, Eur. J. Pharmacol. 326 (1997), 67-74.
54. I.D. Scott, K.E.O. Åkerman and D.G. Nicholls, Ca transport by intact synaptosomes: intra-synaptosomal compartmentation and the role of the mitochondrial membrane potential, Biochem. J. 192 (1980), 873-880.
55. I.D. Scott and D.G. Nicholls, Energy transduction in intact synaptosomes: influence of plasma-membrane depolarization on the respiration and membrane potential of internal mitochondria determined in situ, Biochem. J. 186 (1980), 21-33.
56. A.K. Stout, H.M. Raphael, J.M. Scanlon and I.J. Reynolds, Glutamate-induced neuronal death is blocked by inhibition of mitochondrial calcium uptake with FCCP, Soc. Neurosci. Abstr. (1997), 650.6
57. T. Tabatabaie, J.D. Potts and R.A. Floyd, Reactive oxygen species-mediated inactivation of pyruvate dehydrogenase, Arch. Biochem. Biophys. 336 (1996), 290-296.
58. S. Tan, Y. Sagara and D. Schubert, Glutamate toxicity: an unusual pathway of cell death, Soc. Neurosci. Abstr. (1997), 542.1
59. S.A. Thayer and R.J. Miller, Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro, J. Physiol. (Lond.) 425 (1990), 85-115.
60. M. Tymianski, M.P. Charlton, P.L. Carlen and C.H. Tator, Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons, J. Neurosci. 13 (1993), 2085-2104.
61. J.J. Vornov, Toxic NMDA-receptor activation occurs during recovery in a tissue culture model of ischemia, J. Neurochem. 65 (1995), 1681-1691.
62. J.L. Werth and S.A. Thayer, Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons, J. Neurosci. 14 (1994), 346-356.
63. 2+ exchange buffer glutamate-induced calcium loads in cultured cortical neurons, J. Neurosci. 15 (1995), 1318-1328.
64. R.J. White and I.J. Reynolds, Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure, J. Neurosci. 16 (1996), 5688-5697.
65. 2+ following intense glutamate stimulation of cultured rat forebrain neurones, J. Physiol. (Lond.) 498 (1997), 31-47.
66. J. Yang, X.S. Liu, K. Bhalla, C.N. Kim, A.M. Ibrado, J.Y. Cai, T.I. Peng, D.P. Jones and X.D. Wang, Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked, Science 275 (1997), 1129-1132.
67. F. Zoccarato and D.G. Nicholls, The role of phosphate in the regulation of the Ca efflux pathway of liver mitochondria, Eur. J. Biochem. 127 (1982), 333-338.