-
1
-
-
0030920782
-
G protein mechanisms: Insights from structural analysis
-
Sprang S.R. G protein mechanisms: insights from structural analysis. Annu. Rev. Biochem. 66:1997;639-678.
-
(1997)
Annu. Rev. Biochem.
, vol.66
, pp. 639-678
-
-
Sprang, S.R.1
-
2
-
-
0017566205
-
The regulatory GTPase cycle of turkey erythrocyte adenylate cyclase
-
Cassel D., Levkovitz H., Selinger Z. The regulatory GTPase cycle of turkey erythrocyte adenylate cyclase. J. Cycl. Nucl. Res. 3:1977;393-406.
-
(1977)
J. Cycl. Nucl. Res.
, vol.3
, pp. 393-406
-
-
Cassel, D.1
Levkovitz, H.2
Selinger, Z.3
-
3
-
-
0035282079
-
Substrate assisted catalysis - Application to G proteins
-
Kosloff M., Selinger Z. Substrate assisted catalysis - application to G proteins. Trends Biochem. Sci. 26:2001;161-166.
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 161-166
-
-
Kosloff, M.1
Selinger, Z.2
-
4
-
-
0031283407
-
G-proteins, effectors and GAPs: Structure and mechanism
-
Sprang S.R. G-proteins, effectors and GAPs: structure and mechanism. Curr. Opin. Struct. Biol. 7:1997;849-856.
-
(1997)
Curr. Opin. Struct. Biol.
, vol.7
, pp. 849-856
-
-
Sprang, S.R.1
-
5
-
-
0032127912
-
GTPase-activating proteins: Helping hands to complement an active site
-
Scheffzek K., Ahmadian M.R., Wittinghofer A. GTPase-activating proteins: helping hands to complement an active site. Trends Biochem. Sci. 23:1998;257-262.
-
(1998)
Trends Biochem. Sci.
, vol.23
, pp. 257-262
-
-
Scheffzek, K.1
Ahmadian, M.R.2
Wittinghofer, A.3
-
7
-
-
0024376173
-
Ras oncogenes in human cancer: A review
-
Bos J.L. Ras oncogenes in human cancer: a review. Cancer Res. 49:1989;4682-4689.
-
(1989)
Cancer Res.
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
8
-
-
0035659985
-
The many faces of Ras: Recognition of small GTP-binding proteins
-
Corbett K.D., Alber T. The many faces of Ras: recognition of small GTP-binding proteins. Trends Biochem. Sci. 26:2001;710-716.
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 710-716
-
-
Corbett, K.D.1
Alber, T.2
-
9
-
-
0035834388
-
The guanine nucleotide-binding switch in three dimensions
-
Vetter I.R., Wittinghofer A. The guanine nucleotide-binding switch in three dimensions. Science. 294:2001;1299-1304.
-
(2001)
Science
, vol.294
, pp. 1299-1304
-
-
Vetter, I.R.1
Wittinghofer, A.2
-
10
-
-
0031282504
-
Signaling mechanistics: Aluminum fluoride for molecule of the year
-
Wittinghofer A. Signaling mechanistics: aluminum fluoride for molecule of the year. Curr. Biol. 7:1997;R682-R685.
-
(1997)
Curr. Biol.
, vol.7
-
-
Wittinghofer, A.1
-
11
-
-
0029958571
-
The GTP binding motif: Variations on a theme
-
Kjeldgaard M., Nyborg J., Clark B.F. The GTP binding motif: variations on a theme. FASEB J. 10:1996;1347-1368.
-
(1996)
FASEB J.
, vol.10
, pp. 1347-1368
-
-
Kjeldgaard, M.1
Nyborg, J.2
Clark, B.F.3
-
12
-
-
0027294814
-
A study into the effects of protein binding on nucleotide conformation
-
Moodie S.L., Thornton J.M. A study into the effects of protein binding on nucleotide conformation. Nucl. Acids Res. 21:1993;1369-1380.
-
(1993)
Nucl. Acids Res.
, vol.21
, pp. 1369-1380
-
-
Moodie, S.L.1
Thornton, J.M.2
-
13
-
-
0030297640
-
Protein recognition of adenylate: An example of a fuzzy recognition template
-
Moodie S.L., Mitchell J.B., Thornton J.M. Protein recognition of adenylate: an example of a fuzzy recognition template. J. Mol. Biol. 263:1996;486-500.
-
(1996)
J. Mol. Biol.
, vol.263
, pp. 486-500
-
-
Moodie, S.L.1
Mitchell, J.B.2
Thornton, J.M.3
-
14
-
-
0030826293
-
A method to search for similar protein local structures at ligand binding sites and its application to adenine recognition
-
Kobayashi N., Go N. A method to search for similar protein local structures at ligand binding sites and its application to adenine recognition. Eur. Biophys. J. 26:1997;135-144.
-
(1997)
Eur. Biophys. J.
, vol.26
, pp. 135-144
-
-
Kobayashi, N.1
Go, N.2
-
15
-
-
0032972775
-
Structural motif of phosphate-binding site common to various protein superfamilies: All-against-all structural comparison of protein-mononucleotide complexes
-
Kinoshita K., Sadanami K., Kidera A., Go N. Structural motif of phosphate-binding site common to various protein superfamilies: all-against-all structural comparison of protein-mononucleotide complexes. Protein Eng. 12:1999;11-14.
-
(1999)
Protein Eng.
, vol.12
, pp. 11-14
-
-
Kinoshita, K.1
Sadanami, K.2
Kidera, A.3
Go, N.4
-
16
-
-
0034651543
-
When fold is not important: A common structural framework for adenine and AMP binding in 12 unrelated protein families
-
Denessiouk K.A., Johnson M.S. When fold is not important: a common structural framework for adenine and AMP binding in 12 unrelated protein families. Proteins: Struct. Funct. Genet. 38:2000;310-326.
-
(2000)
Proteins: Struct. Funct. Genet.
, vol.38
, pp. 310-326
-
-
Denessiouk, K.A.1
Johnson, M.S.2
-
17
-
-
0036408749
-
Conserved positions for ribose recognition: Importance of water bridging interactions among ATP, ADP and FAD-protein complexes
-
Babor M., Sobolev V., Edelman M. Conserved positions for ribose recognition: importance of water bridging interactions among ATP, ADP and FAD-protein complexes. J. Mol. Biol. 323:2002;523-532.
-
(2002)
J. Mol. Biol.
, vol.323
, pp. 523-532
-
-
Babor, M.1
Sobolev, V.2
Edelman, M.3
-
18
-
-
0030666313
-
Lectin-carbohydrate interactions: Different folds, common recognition principles
-
Elgavish S., Shaanan B. Lectin-carbohydrate interactions: different folds, common recognition principles. Trends Biochem. Sci. 22:1997;462-467.
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 462-467
-
-
Elgavish, S.1
Shaanan, B.2
-
19
-
-
0034242324
-
Modeling of substrate-binding region of the active site of monoamine oxidase A
-
Veselovsky A.V., Medvedev A.E., Tikhonova O.V., Skvortsov V.S., Ivanov A.S. Modeling of substrate-binding region of the active site of monoamine oxidase A. Biochemistry (Mosc). 65:2000;910-916.
-
(2000)
Biochemistry (Mosc)
, vol.65
, pp. 910-916
-
-
Veselovsky, A.V.1
Medvedev, A.E.2
Tikhonova, O.V.3
Skvortsov, V.S.4
Ivanov, A.S.5
-
20
-
-
0035238608
-
An approach for visualization of the active site of enzymes with unknown three-dimensional structures
-
Veselovsky A.V., Tikhonova O.V., Skvortsov V.S., Medvedev A.E., Ivanov A.S. An approach for visualization of the active site of enzymes with unknown three-dimensional structures. SAR QSAR Environ. Res. 12:2001;345-358.
-
(2001)
SAR QSAR Environ. Res.
, vol.12
, pp. 345-358
-
-
Veselovsky, A.V.1
Tikhonova, O.V.2
Skvortsov, V.S.3
Medvedev, A.E.4
Ivanov, A.S.5
-
22
-
-
0034502457
-
Modulation of host signaling by a bacterial mimic: Structure of the Salmonella effector SptP bound to Rac1
-
Stebbins C.E., Galan J.E. Modulation of host signaling by a bacterial mimic: structure of the Salmonella effector SptP bound to Rac1. Mol. Cell. 6:2000;1449-1460.
-
(2000)
Mol. Cell
, vol.6
, pp. 1449-1460
-
-
Stebbins, C.E.1
Galan, J.E.2
-
23
-
-
0035171524
-
How the Pseudomonas aeruginosa ExoS toxin downregulates Rac
-
Wurtele M., Wolf E., Pederson K.J., Buchwald G., Ahmadian M.R., Barbieri J.T., Wittinghofer A. How the Pseudomonas aeruginosa ExoS toxin downregulates Rac. Nature Struct. Biol. 8:2001;23-26.
-
(2001)
Nature Struct. Biol.
, vol.8
, pp. 23-26
-
-
Wurtele, M.1
Wolf, E.2
Pederson, K.J.3
Buchwald, G.4
Ahmadian, M.R.5
Barbieri, J.T.6
Wittinghofer, A.7
-
24
-
-
0030724727
-
Mechanisms of signaling and related enzymes
-
Mildvan A.S. Mechanisms of signaling and related enzymes. Proteins: Struct. Funct. Genet. 29:1997;401-416.
-
(1997)
Proteins: Struct. Funct. Genet.
, vol.29
, pp. 401-416
-
-
Mildvan, A.S.1
-
25
-
-
0030759770
-
Crystal structure of a small G protein in complex with the GTPase activating protein rhoGAP
-
Rittinger K., Walker P.A., Eccleston J.F., Nurmahomed K., Owen D., Laue E., et al. Crystal structure of a small G protein in complex with the GTPase activating protein rhoGAP. Nature. 388:1997;693-697.
-
(1997)
Nature
, vol.388
, pp. 693-697
-
-
Rittinger, K.1
Walker, P.A.2
Eccleston, J.F.3
Nurmahomed, K.4
Owen, D.5
Laue, E.6
-
27
-
-
0025310575
-
Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 Å resolution: Implications for the mechanism of GTP hydrolysis
-
Pai E.F., Krengel U., Petsko G.A., Goody R.S., Kabsch W., Wittinghofer A. Refined crystal structure of the triphosphate conformation of H-ras p21 at 1. 35 Å resolution: implications for the mechanism of GTP hydrolysis. EMBO. 9:1990;2351-2359.
-
(1990)
EMBO
, vol.9
, pp. 2351-2359
-
-
Pai, E.F.1
Krengel, U.2
Petsko, G.A.3
Goody, R.S.4
Kabsch, W.5
Wittinghofer, A.6
-
28
-
-
0033571343
-
The pre-hydrolysis state of p21(ras) in complex with GTP: New insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins
-
Scheidig A.J., Burmester C., Goody R.S. The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins. Struct. Fold. Des. 7:1999;1311-1324.
-
(1999)
Struct. Fold. Des.
, vol.7
, pp. 1311-1324
-
-
Scheidig, A.J.1
Burmester, C.2
Goody, R.S.3
-
29
-
-
0030818825
-
Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein
-
Ito Y., Yamasaki K., Iwahara J., Terada T., Kamiya A., Shirouzu M., et al. Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein. Biochemistry. 36:1997;9109-9119.
-
(1997)
Biochemistry
, vol.36
, pp. 9109-9119
-
-
Ito, Y.1
Yamasaki, K.2
Iwahara, J.3
Terada, T.4
Kamiya, A.5
Shirouzu, M.6
-
30
-
-
0025275582
-
Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis
-
Schlichting I., Almo S.C., Rapp G., Wilson K., Petratos K., Lentfer A., et al. Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis. Nature. 345:1990;309-315.
-
(1990)
Nature
, vol.345
, pp. 309-315
-
-
Schlichting, I.1
Almo, S.C.2
Rapp, G.3
Wilson, K.4
Petratos, K.5
Lentfer, A.6
-
31
-
-
0029156702
-
Molecular dynamics simulation of the solution structures of Ha-ras-p21 GDP and GTP complexes: Flexibility, possible hinges, and levers of the conformational transition
-
Diaz J.F., Wroblowski B., Engelborghs Y. Molecular dynamics simulation of the solution structures of Ha-ras-p21 GDP and GTP complexes: flexibility, possible hinges, and levers of the conformational transition. Biochemistry. 34:1995;12038-12047.
-
(1995)
Biochemistry
, vol.34
, pp. 12038-12047
-
-
Diaz, J.F.1
Wroblowski, B.2
Engelborghs, Y.3
-
32
-
-
0030700726
-
Ligand-induced conformational changes in ras p21: A normal mode and energy minimization analysis
-
Ma J., Karplus M. Ligand-induced conformational changes in ras p21: a normal mode and energy minimization analysis. J. Mol. Biol. 274:1997;114-131.
-
(1997)
J. Mol. Biol.
, vol.274
, pp. 114-131
-
-
Ma, J.1
Karplus, M.2
-
33
-
-
0034480099
-
Structural changes induced in p21Ras upon GAP-334 complexation as probed by ESEEM spectroscopy and molecular-dynamics simulation
-
Farrar C.T., Ma J., Singel D.J., Halkides C.J. Structural changes induced in p21Ras upon GAP-334 complexation as probed by ESEEM spectroscopy and molecular-dynamics simulation. Struct. Fold. Des. 8:2000;1279-1287.
-
(2000)
Struct. Fold. Des.
, vol.8
, pp. 1279-1287
-
-
Farrar, C.T.1
Ma, J.2
Singel, D.J.3
Halkides, C.J.4
-
35
-
-
0027297116
-
Mechanism of GTP hydrolysis by p21N-ras catalyzed by GAP: Studies with a fluorescent GTP analogue
-
Moore K.J., Webb M.R., Eccleston J.F. Mechanism of GTP hydrolysis by p21N-ras catalyzed by GAP: studies with a fluorescent GTP analogue. Biochemistry. 32:1993;7451-7459.
-
(1993)
Biochemistry
, vol.32
, pp. 7451-7459
-
-
Moore, K.J.1
Webb, M.R.2
Eccleston, J.F.3
-
36
-
-
0028789134
-
Kinetics of inorganic phosphate release during the interaction of p21ras with the GTPase-activating proteins, p120-GAP and Neurofibromin
-
Nixon A.E., Brune M., Lowe P.N., Webb M.R. Kinetics of inorganic phosphate release during the interaction of p21ras with the GTPase-activating proteins, p120-GAP and Neurofibromin. Biochemistry. 34:1995;15592-15598.
-
(1995)
Biochemistry
, vol.34
, pp. 15592-15598
-
-
Nixon, A.E.1
Brune, M.2
Lowe, P.N.3
Webb, M.R.4
-
37
-
-
0030772378
-
The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants
-
Scheffzek K., Ahmadian M.R., Kabsch W., Weismuller L., Lautwein A., Schmitz F., Wittinghofer A. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science. 277:1997;333-338.
-
(1997)
Science
, vol.277
, pp. 333-338
-
-
Scheffzek, K.1
Ahmadian, M.R.2
Kabsch, W.3
Weismuller, L.4
Lautwein, A.5
Schmitz, F.6
Wittinghofer, A.7
-
38
-
-
0022471217
-
Biological and biochemical properties of human rasH genes mutated at codon 61
-
Der C.J., Finkel T., Cooper G.M. Biological and biochemical properties of human rasH genes mutated at codon 61. Cell. 44:1986;167-176.
-
(1986)
Cell
, vol.44
, pp. 167-176
-
-
Der, C.J.1
Finkel, T.2
Cooper, G.M.3
-
39
-
-
0025193871
-
Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules
-
Krengel U., Schlichting I., Scherer A., Schumann R., Frech M., John J., et al. Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell. 62:1990;539-548.
-
(1990)
Cell
, vol.62
, pp. 539-548
-
-
Krengel, U.1
Schlichting, I.2
Scherer, A.3
Schumann, R.4
Frech, M.5
John, J.6
-
40
-
-
0031471341
-
Structural and biochemical characterization of the GTPγS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42→Val mutant of Giα1
-
Raw A.S., Coleman D.E., Gilman A.G., Sprang S.R. Structural and biochemical characterization of the GTPγS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42→Val mutant of Giα1. Biochemistry. 36:1997;15660-15669.
-
(1997)
Biochemistry
, vol.36
, pp. 15660-15669
-
-
Raw, A.S.1
Coleman, D.E.2
Gilman, A.G.3
Sprang, S.R.4
-
41
-
-
0025346513
-
Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product
-
Frech M., John J., Pizon V., Chardin P., Tavitian A., Clark R., et al. Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product. Science. 249:1990;169-171.
-
(1990)
Science
, vol.249
, pp. 169-171
-
-
Frech, M.1
John, J.2
Pizon, V.3
Chardin, P.4
Tavitian, A.5
Clark, R.6
-
42
-
-
0027171116
-
Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras
-
Franken S.M., Scheidig A.J., Krengel U., Rensland H., Lautwein A., Geyer M., et al. Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras. Biochemistry. 32:1993;8411-8420.
-
(1993)
Biochemistry
, vol.32
, pp. 8411-8420
-
-
Franken, S.M.1
Scheidig, A.J.2
Krengel, U.3
Rensland, H.4
Lautwein, A.5
Geyer, M.6
-
43
-
-
0026596419
-
X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis
-
Prive G.G., Milburn M.V., Tong L., de Vos A.M., Yamaizumi Z., Nishimura S., Kim S.H. X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis. Proc. Natl Acad. Sci. USA. 89:1992;3649-3653.
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 3649-3653
-
-
Prive, G.G.1
Milburn, M.V.2
Tong, L.3
De Vos, A.M.4
Yamaizumi, Z.5
Nishimura, S.6
Kim, S.H.7
-
44
-
-
0035201079
-
Molecular dynamics simulations of Gly-12→Val mutant of p21(ras): Dynamic inhibition mechanism
-
Futatsugi N., Tsuda M. Molecular dynamics simulations of Gly-12→Val mutant of p21(ras): dynamic inhibition mechanism. Biophys. J. 81:2001;3483-3488.
-
(2001)
Biophys. J.
, vol.81
, pp. 3483-3488
-
-
Futatsugi, N.1
Tsuda, M.2
-
45
-
-
0033535950
-
Guanosine triphosphatase stimulation of oncogenic Ras mutants
-
Ahmadian M.R., Zor T., Vogt D., Kabsch W., Selinger Z., Wittinghofer A., Scheffzek K. Guanosine triphosphatase stimulation of oncogenic Ras mutants. Proc. Natl Acad. Sci. USA. 96:1999;7065-7070.
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 7065-7070
-
-
Ahmadian, M.R.1
Zor, T.2
Vogt, D.3
Kabsch, W.4
Selinger, Z.5
Wittinghofer, A.6
Scheffzek, K.7
-
46
-
-
0032483117
-
Raman difference studies of GDP and GTP binding to c-Harvey ras
-
Wang J.H., Xiao D.G., Deng H., Webb M.R., Callender R. Raman difference studies of GDP and GTP binding to c-Harvey ras. Biochemistry. 37:1998;11106-11116.
-
(1998)
Biochemistry
, vol.37
, pp. 11106-11116
-
-
Wang, J.H.1
Xiao, D.G.2
Deng, H.3
Webb, M.R.4
Callender, R.5
-
47
-
-
0032516479
-
Time-resolved FTIR studies of the GTPase reaction of H-ras p21 reveal a key role for the beta-phosphate
-
Cepus V., Scheidig A.J., Goody R.S., Gerwert K. Time-resolved FTIR studies of the GTPase reaction of H-ras p21 reveal a key role for the beta-phosphate. Biochemistry. 37:1998;10263-10271.
-
(1998)
Biochemistry
, vol.37
, pp. 10263-10271
-
-
Cepus, V.1
Scheidig, A.J.2
Goody, R.S.3
Gerwert, K.4
-
48
-
-
0034708735
-
The mechanism of GTP hydrolysis by Ras probed by Fourier transform infrared spectroscopy
-
Du X., Frei H., Kim S.H. The mechanism of GTP hydrolysis by Ras probed by Fourier transform infrared spectroscopy. J. Biol. Chem. 275:2000;8492-8500.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8492-8500
-
-
Du, X.1
Frei, H.2
Kim, S.H.3
-
49
-
-
0034945818
-
Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time
-
Allin C., Ahmadian M.R., Wittinghofer A., Gerwert K. Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time. Proc. Natl Acad. Sci. USA. 98:2001;7754-7759.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 7754-7759
-
-
Allin, C.1
Ahmadian, M.R.2
Wittinghofer, A.3
Gerwert, K.4
-
50
-
-
0035852966
-
Ras catalyzes GTP hydrolysis by shifting negative charges from gamma- to beta-phosphate as revealed by time-resolved FTIR difference spectroscopy
-
Allin C., Gerwert K. Ras catalyzes GTP hydrolysis by shifting negative charges from gamma- to beta-phosphate as revealed by time-resolved FTIR difference spectroscopy. Biochemistry. 40:2001;3037-3046.
-
(2001)
Biochemistry
, vol.40
, pp. 3037-3046
-
-
Allin, C.1
Gerwert, K.2
-
51
-
-
0032796313
-
Ab initio study of the role of lysine 16 for the molecular switching mechanism of Ras protein p21
-
Futatsugi N., Hata M., Hoshino T., Tsuda M. Ab initio study of the role of lysine 16 for the molecular switching mechanism of Ras protein p21. Biophys. J. 77:1999;3287-3292.
-
(1999)
Biophys. J.
, vol.77
, pp. 3287-3292
-
-
Futatsugi, N.1
Hata, M.2
Hoshino, T.3
Tsuda, M.4
-
52
-
-
0030739172
-
Structures of active conformations of UMP kinase from Dictyostelium discoideum suggest phosphoryl transfer is associative
-
Schlichting I., Reinstein J. Structures of active conformations of UMP kinase from Dictyostelium discoideum suggest phosphoryl transfer is associative. Biochemistry. 36:1997;9290-9296.
-
(1997)
Biochemistry
, vol.36
, pp. 9290-9296
-
-
Schlichting, I.1
Reinstein, J.2
-
55
-
-
0034487212
-
Phosphoryl transfer by a concerted reaction mechanism in UMP/CMP-kinase
-
Hutter M.C., Helms V. Phosphoryl transfer by a concerted reaction mechanism in UMP/CMP-kinase. Protein Sci. 9:2000;2225-2231.
-
(2000)
Protein Sci.
, vol.9
, pp. 2225-2231
-
-
Hutter, M.C.1
Helms, V.2
-
56
-
-
0029644728
-
Movie of the structural changes during a catalytic cycle of nucleoside monophosphate kinases
-
Vonrhein C., Schlauderer G.J., Schulz G.E. Movie of the structural changes during a catalytic cycle of nucleoside monophosphate kinases. Structure. 3:1995;483-490.
-
(1995)
Structure
, vol.3
, pp. 483-490
-
-
Vonrhein, C.1
Schlauderer, G.J.2
Schulz, G.E.3
-
57
-
-
0031762533
-
Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP
-
Nassar N., Hoffman G.R., Manor D., Clardy J.C., Cerione R.A. Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP. Nature Struct. Biol. 5:1998;1047-1052.
-
(1998)
Nature Struct. Biol.
, vol.5
, pp. 1047-1052
-
-
Nassar, N.1
Hoffman, G.R.2
Manor, D.3
Clardy, J.C.4
Cerione, R.A.5
-
58
-
-
0034663856
-
How does GAP catalyze the GTPase reaction of Ras? A computer simulation study
-
Glennon T.M., Villa J., Warshel A. How does GAP catalyze the GTPase reaction of Ras? A computer simulation study. Biochemistry. 39:2000;9641-9651.
-
(2000)
Biochemistry
, vol.39
, pp. 9641-9651
-
-
Glennon, T.M.1
Villa, J.2
Warshel, A.3
-
60
-
-
0037069410
-
Impact of enzyme motion on activity
-
Hammes-Schiffer S. Impact of enzyme motion on activity. Biochemistry. 41:2002;13335-13343.
-
(2002)
Biochemistry
, vol.41
, pp. 13335-13343
-
-
Hammes-Schiffer, S.1
-
61
-
-
0031231083
-
Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras
-
Ahmadian M.R., Stege P., Scheffzek K., Wittinghofer A. Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras. Nature Struct. Biol. 4:1997;686-689.
-
(1997)
Nature Struct. Biol.
, vol.4
, pp. 686-689
-
-
Ahmadian, M.R.1
Stege, P.2
Scheffzek, K.3
Wittinghofer, A.4
-
62
-
-
0033579936
-
The conserved arginine in rho-GTPase-activating protein is essential for efficient catalysis but not for complex formation with Rho.GDP and aluminum fluoride
-
Graham D.L., Eccleston J.F., Lowe P.N. The conserved arginine in rho-GTPase-activating protein is essential for efficient catalysis but not for complex formation with Rho.GDP and aluminum fluoride. Biochemistry. 38:1999;985-991.
-
(1999)
Biochemistry
, vol.38
, pp. 985-991
-
-
Graham, D.L.1
Eccleston, J.F.2
Lowe, P.N.3
-
64
-
-
0037075886
-
GTPase activating proteins: Critical regulators of intracellular signaling
-
Donovan S., Shannon K.M., Bollag G. GTPase activating proteins: critical regulators of intracellular signaling. Biochim. Biophys. Acta. 1602:2002;23-45.
-
(2002)
Biochim. Biophys. Acta
, vol.1602
, pp. 23-45
-
-
Donovan, S.1
Shannon, K.M.2
Bollag, G.3
-
65
-
-
0028464366
-
Why have mutagenesis studies not located the general base in ras p21
-
Schweins T., Langen R., Warshel A. Why have mutagenesis studies not located the general base in ras p21. Nature Struct. Biol. 1:1994;476-484.
-
(1994)
Nature Struct. Biol.
, vol.1
, pp. 476-484
-
-
Schweins, T.1
Langen, R.2
Warshel, A.3
-
67
-
-
0029843561
-
Mechanistic analysis of the observed linear free energy relationships in p21ras and related systems
-
Schweins T., Warshel A. Mechanistic analysis of the observed linear free energy relationships in p21ras and related systems. Biochemistry. 35:1996;14232-14243.
-
(1996)
Biochemistry
, vol.35
, pp. 14232-14243
-
-
Schweins, T.1
Warshel, A.2
-
68
-
-
0029825324
-
Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5′-triphosphate hydrolysis of p21ras
-
Schweins T., Geyer M., Kalbitzer H.R., Wittinghofer A., Warshel A. Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5′-triphosphate hydrolysis of p21ras. Biochemistry. 35:1996;14225-14231.
-
(1996)
Biochemistry
, vol.35
, pp. 14225-14231
-
-
Schweins, T.1
Geyer, M.2
Kalbitzer, H.R.3
Wittinghofer, A.4
Warshel, A.5
-
69
-
-
0035799325
-
Vibrational structure of GDP and GTP bound to RAS: An isotope-edited FTIR study
-
Cheng H., Sukal S., Deng H., Leyh T.S., Callender R. Vibrational structure of GDP and GTP bound to RAS: an isotope-edited FTIR study. Biochemistry. 40:2001;4035-4043.
-
(2001)
Biochemistry
, vol.40
, pp. 4035-4043
-
-
Cheng, H.1
Sukal, S.2
Deng, H.3
Leyh, T.S.4
Callender, R.5
-
70
-
-
0032538627
-
Electrostatic origin of the catalytic power of enzymes and the role of preorganized active sites
-
Warshel A. Electrostatic origin of the catalytic power of enzymes and the role of preorganized active sites. J. Biol. Chem. 273:1998;27035-27038.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 27035-27038
-
-
Warshel, A.1
-
71
-
-
0023687515
-
Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction
-
John J., Frech M., Wittinghofer A. Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction. J. Biol. Chem. 263:1988;11792-11799.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 11792-11799
-
-
John, J.1
Frech, M.2
Wittinghofer, A.3
-
72
-
-
0030716497
-
Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue
-
Rittinger K., Walker P.A., Eccleston J.F., Smerdon S.J., Gamblin S.J. Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue. Nature. 389:1997;758-762.
-
(1997)
Nature
, vol.389
, pp. 758-762
-
-
Rittinger, K.1
Walker, P.A.2
Eccleston, J.F.3
Smerdon, S.J.4
Gamblin, S.J.5
-
74
-
-
0035931919
-
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 Å
-
Slep K.C., Kercher M.A., He W., Cowan C.W., Wensel T.G., Sigler P.B. Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 Å Nature. 409:2001;1071-1077.
-
(2001)
Nature
, vol.409
, pp. 1071-1077
-
-
Slep, K.C.1
Kercher, M.A.2
He, W.3
Cowan, C.W.4
Wensel, T.G.5
Sigler, P.B.6
-
75
-
-
0025941877
-
Three-dimensional structure of p21 in the active conformation and analysis of an oncogenic mutant
-
Wittinghofer F., Krengel U., John J., Kabsch W., Pai E.F. Three-dimensional structure of p21 in the active conformation and analysis of an oncogenic mutant. Environ. Health Perspect. 93:1991;11-15.
-
(1991)
Environ. Health Perspect.
, vol.93
, pp. 11-15
-
-
Wittinghofer, F.1
Krengel, U.2
John, J.3
Kabsch, W.4
Pai, E.F.5
-
76
-
-
0033231561
-
The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1
-
Maesaki R., Ihara K., Shimizu T., Kuroda S., Kaibuchi K., Hakoshima T. The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1. Mol. Cell. 4:1999;793-803.
-
(1999)
Mol. Cell
, vol.4
, pp. 793-803
-
-
Maesaki, R.1
Ihara, K.2
Shimizu, T.3
Kuroda, S.4
Kaibuchi, K.5
Hakoshima, T.6
-
77
-
-
0031034136
-
The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue
-
Hirshberg M., Stockley R.W., Dodson G., Webb M.R. The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue. Nature Struct. Biol. 4:1997;147-152.
-
(1997)
Nature Struct. Biol.
, vol.4
, pp. 147-152
-
-
Hirshberg, M.1
Stockley, R.W.2
Dodson, G.3
Webb, M.R.4
-
78
-
-
0027132717
-
The 2.2 Å crystal structure of transducin-α complexed with GTPγS
-
Noel J.P., Hamm H.E., Sigler P.B. The 2.2 Å crystal structure of transducin-α complexed with GTPγS. Nature. 366:1993;654-663.
-
(1993)
Nature
, vol.366
, pp. 654-663
-
-
Noel, J.P.1
Hamm, H.E.2
Sigler, P.B.3
-
79
-
-
0033546001
-
Structure of Giα1.GppNHp, autoinhibition in a Gγ protein-substrate complex
-
Coleman D.E., Sprang S.R. Structure of Giα1.GppNHp, autoinhibition in a Gγ protein-substrate complex. J. Biol. Chem. 274:1999;16669-16672.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 16669-16672
-
-
Coleman, D.E.1
Sprang, S.R.2
-
80
-
-
0032769396
-
PH influences fluoride coordination number of the AlFx phosphoryl transfer transition state analog
-
Schlichting I., Reinstein J. pH influences fluoride coordination number of the AlFx phosphoryl transfer transition state analog. Nature Struct. Biol. 6:1999;721-723.
-
(1999)
Nature Struct. Biol.
, vol.6
, pp. 721-723
-
-
Schlichting, I.1
Reinstein, J.2
|