Structural changes induced in p21Ras upon GAP-334 complexation as probed by ESEEM spectroscopy and molecular-dynamics simulation

Structure

Volumn 8, Issue 12, 2000, Pages 1279-1287

  Farrar, C T ^a   Ma, J ^a   Singel, D J ^a   Halkides, C J ^a  

^a UNIVERSITY OF NORTH CAROLINA WILMINGTON   (United States)

Author keywords

ESEEM spectroscopy; GAP; GTP hydrolysis; Molecular dynamics simulation; p21

Indexed keywords

AMIDE; GLYCINE; GUANOSINE TRIPHOSPHATASE; METAL ION; PROTEIN P21;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ELECTRON SPIN RESONANCE; GENE INDUCTION; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIMULATION;

AMINO ACID SUBSTITUTION; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ELECTRON SPIN RESONANCE SPECTROSCOPY; FOURIER ANALYSIS; GLYCINE; HUMANS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; ONCOGENE PROTEIN P21(RAS); P120 GTPASE ACTIVATING PROTEIN; SOLUTIONS; THERMODYNAMICS;

EID: 0034480099     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(00)00532-3     Document Type: Article

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