Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum and the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-uridyl) pentaphosphate (UP5A) and Mg2+ at 2.2 Å: Implications for water-mediated specificity

Biochemistry

Volumn 35, Issue 30, 1996, Pages 9716-9727

  Scheffzek, Klaus ^a,b   Kliche, Werner ^a   Wiesmüller, Lisa ^a,c   Reinstein, Jochen ^b  

^a MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^c UNIVERSITY OF HAMBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; CYTIDINE PHOSPHATE KINASE; ENZYME INHIBITOR; P1 (5' ADENOSYL) P5 (5' URIDYL)PENTAPHOSPHATE; UNCLASSIFIED DRUG; URIDINE PHOSPHATE KINASE;

ARTICLE; CRYSTAL STRUCTURE; DICTYOSTELIUM DISCOIDEUM; ENZYME CONFORMATION; ENZYME STRUCTURE; GEOMETRY; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; THREE DIMENSIONAL IMAGING;

AMINO ACID SEQUENCE; ANIMALS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DICTYOSTELIUM; DINUCLEOSIDE PHOSPHATES; ENZYME INHIBITORS; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEOSIDE-PHOSPHATE KINASE; PROTEIN STRUCTURE, SECONDARY; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SWINE; URIDINE MONOPHOSPHATE;

EID: 0029785130     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi960642s     Document Type: Article

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