Signaling mechanistics: Aluminum fluoride for molecule of the year

Current Biology

Volumn 7, Issue 11, 1997, Pages

  Wittinghofer, Alfred ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0031282504     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0960-9822(06)00355-1     Document Type: Article

References (20)

1. Rall TW, Sutherland EW: Formation of a cyclic adenine ribonucleotide by tissue particles. J Biol Chem 1958, 232:1065-1067.
2. Steinweis PC, Gilman AG: Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride. Proc Natl Acad Sci USA 1982, 79:4888-4891.
3. Chabre M: Aluminofluoride and beryllofluoride complexes: new phosphate analogs in enzymology. Trends Biochem Sci 1990, 15:6-10.
4. -. Nature 1994, 372:276-279.
5. iα1 and the mechanism of GTP hydrolysis. Science 1994, 265:1405-1412.
6. 4-stabilized nitrogenase complex and its implications for signal transduction. Nature 1997, 387:370-376.
7. Scheffzek K, Ahmadian MR, Kabsch W, Wiesmüller L, Lautwein A, Schmitz F, Wittinghofer A: Ras-RasGAP communication: Structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 1997, 277:333-338.
8. Howard JB, Rees DC: Nitrogenase: nucleotide-dependent molecular switch. Annu Rev Biochem 1994, 634:235-264.
9. Saraste M, Sibbald PR, Wittinghofer A: The P-loop - a common motif in ATP- and GTP-binding proteins. Trends Biochem Sci 1990, 15:430-434.
10. Duyvis MG, Wassink H, Haaker H: Formation and characterization of a transition state complex of Azotobacter vinelandii nitrogenase. FEBS Lett 1996, 380:233-236.
11. Renner KA, Howard JB: Aluminum fluoride inhibition of nitrogenase: stabilization of a nucleotide·Fe-protein(Table Presented)MoFe-protein complex. Biochemistry 1996, 35:5353-5358.
12. Wittinghofer A, Pai E: The structure of ras protein: a model for a universal molecular switch. Trends Biochem Sci 1991, 16:383-387.
13. Ahmadian MR, Stege P, Scheffzek K, Wittinghofer A: Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras. Nat Struct Biol, 4:686-689.
14. Rittinger K, Walker PA, Eccleston JF, Nurmahomed K, Owen D, Laue E, Gamblin SJ, Smerdon SJ: Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Nature 1997, 388:693-697.
15. H-ras complexed with the effector protein Raf-RBD and the GTPase activating protein GAP. Biochemistry 1996, 35:10308-10320.
16. iα1: stabilization of the transition state for GTP hydrolysis. Cell 1997, 89:251-261.
17. -. Biochemistry 1995, 34:8960-8972.
18. 3 mimics the transition state of protein phosphorylation in the crystal structure of nucleoside diphosphate kinase and MgADP. Proc Natl Acad Sci USA 1997, 94:3579-3583.
19. Schlichting I, Reinstein J: Structures of active conformations of UMP kinase from Dictyostelium discoideum suggest phosphoryl transfer is associative. Biochemistry 1997, 36:9290-9296.
20. Maegley KA, Admiraal SJ, Herschlag D: Ras-catalyzed hydrolysis of GTP: a new perspective from model studies. Proc Natl Acad Sci USA 1996, 93:8160-8166.