Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): Influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity

Organic and Biomolecular Chemistry

Volumn 1, Issue 1, 2003, Pages 42-49

  Lerner, Christian ^a   Masjost, Birgit ^a   Ruf, Armin ^b   Gramlich, Volker ^a   Jakob Roetne, Roland ^b   Zürcher, Gerhard ^b   Borroni, Edilio ^b   Diederich, François ^a  

^a ETH ZURICH   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; CONFORMATIONS; CRYSTAL STRUCTURE; DISEASES; MAGNESIUM PRINTING PLATES; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POSITIVE IONS; SYNTHESIS (CHEMICAL); X RAY CRYSTALLOGRAPHY;

ADENOSINE; BISUBSTRATE INHIBITOR; CATHECOL-O-METHYLTRANSFERASE; PARKINSON DISEASE; X RAY STRUCTURE ANALYSIS;

ENZYME INHIBITION;

EID: 0038287023     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b208690p     Document Type: Article

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