X-ray crystal structure of a bisubstrate inhibitor bound to the enzyme catechol-O-methyltransferase: A dramatic effect of inhibitor preorganization on binding affinity

Angewandte Chemie - International Edition

Volumn 40, Issue 21, 2001, Pages 4040-4042

  Lerner, Christian ^a   Ruf, Armin ^a   Gramlich, Volker ^b   Masjost, Birgit ^a   Zrcher, Gerhard ^b   Jakob Roetne, Roland ^b   Borroni, Edilio ^a   Diederich, Franois ^a,b  

^a ETH ZURICH   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Drug research; Enzyme inhibitors; Medicinal chemistry; Structure activity relationships; Transferases

Indexed keywords

BRAIN; DISEASES; ENZYME INHIBITION; X RAY CRYSTALLOGRAPHY;

INHIBITOR PREORGANIZATION;

ENZYMES;

CATECHOL METHYLTRANSFERASE INHIBITOR;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME INHIBITOR INTERACTION; ENZYME SUBSTRATE COMPLEX; IC 50; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; X RAY ANALYSIS;

EID: 0035813866     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3773(20011105)40:21<4040::AID-ANIE4040>3.0.CO;2-C     Document Type: Article

References (20)