Structure-based design, synthesis, and in vitro evaluation of bisubstrate inhibitors for catechol O-methyltransferase (COMT)

Chemistry - A European Journal

Volumn 6, Issue 6, 2000, Pages 971-982

  Masjost, Birgit ^a   Ballmer, Patrick ^a   Borroni, Edilio ^b   Zürcher, Gerhard ^b   Winkler, Fritz K ^b   Jakob Roetne, Roland ^b   Diederich, François ^a  

^a ETH ZURICH   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Catechol O methyltransferase; Chemical biology; Drug research; Enzyme inhibitors; Structure based design

Indexed keywords

ANTIPARKINSON AGENT; CATECHOL DERIVATIVE; CATECHOL METHYLTRANSFERASE; CATECHOL METHYLTRANSFERASE INHIBITOR; DRUG DERIVATIVE; ENZYME INHIBITOR; N [2 [[5 (4 AMINO 2 OXO 1,2 DIHYDROPYRIMIDIN 1 YL) 3,4 DIHYDROXYTETRAHYDROFURAN 2 YL]METHOXY]ETHYL] 2,3 DIHYDROXY 5 NITROBENZAMIDE; N [2 [[5 (4 AMINO 6 OXO 1,6 DIHYDROPYRIMIDIN 1 YL) 3,4 DIHYDROXYTETRAHYDROFURAN 2 YL]METHOXY]ETHYL] 2,3 DIHYDROXY 5 NITROBENZAMIDE; N [2 [[5 (6 AMINOPURIN 9 YL) 3,4 DIHYDROXYTETRAHYDROFURAN 2 YL]METHOXY]ETHYL] 2,3 DIHYDROXY 5 NITROBENZAMIDE; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; DRUG DESIGN; DRUG RESEARCH; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; ENZYMOLOGY; KINETICS; LIVER; METABOLISM; NEUROLOGIC DISEASE; NONHUMAN; PARKINSON DISEASE; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BINDING SITES; CATECHOL O-METHYLTRANSFERASE; CATECHOLS; DRUG DESIGN; ENZYME INHIBITORS; KINETICS; LIVER; MODELS, MOLECULAR; PARKINSON DISEASE; RATS; S-ADENOSYLMETHIONINE;

EID: 0034677685     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3765(20000317)6:6<971::AID-CHEM971>3.0.CO;2-0     Document Type: Article

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