SCOPUS 정보 검색 플랫폼

Helvetica Chimica Acta

Volumn 85, Issue 5, 2002, Pages 1210-1245

Structure-based design of nonpeptidic thrombin inhibitors: Exploring the D-pocket and the oxyanion hole

(5) Betschmann, Patrick a Sahli, Stefan a Diederich, François a,b Obst, Ulrike b Gramlich, Volker a

a ETH ZURICH (Switzerland)

b F HOFFMANN LA ROCHE LTD (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITION REACTIONS; BLOOD; COAGULATION; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL); X RAY ANALYSIS;

LIPOPHILIC RESIDUES;

ENZYME INHIBITION;

ANILIDE; BENZHYDRYL DERIVATIVE; SERINE PROTEINASE; THROMBIN; THROMBIN INHIBITOR;

ARTICLE; BINDING SITE; BLOOD CLOTTING; CYCLOADDITION; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; ENANTIOMER; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 0036272239 PISSN: 0018019X EISSN: None Source Type: Journal
DOI: 10.1002/1522-2675(200205)85:5<1210::AID-HLCA1210>3.0.CO;2-T Document Type: Article

Times cited : (26)

References (58)

1
- 0004081262
- VCH, Weinheim
- (1992) Biochemie
- Voet, D.¹ Voet, J.G.²

2
- 0002423427
- Ed. K, F. Tipton, Portland Press, London
- (1996) Essays in Biochemistry , pp. 17-36
- Scully, M.F.¹

3
- 0024431034
- (1989) EMBO J. , vol.8 , pp. 3467
- Bode, W.¹ Mayr, I.² Baumann, U.³ Huber, R.⁴ Stone, S.R.⁵ Hofsteenge, J.⁶

4
- 0025837452
- (1991) J. Biol. Chem. , vol.266 , pp. 20085
- Banner, D.W.¹ Hadváry, P.²

5
- 0031928676
- (1998) Pharm. Unserer Zeit , vol.27 , pp. 158
- Kubinyi, H.¹

6
- 0031694158
- (1998) Curr. Med. Chem. , vol.5 , pp. 289
- Naylor-Olson, A.M.¹ Sanderson, P.E.J.²

7
- 0031664267
- (1998) Biol. Chem. , vol.379 , pp. 987
- Pavone, V.¹ De Simone, G.² Nastri, F.³ Galdiero, S.⁴ Staiono, N.⁵ Lombardi, A.⁶ Pedone, C.⁷

8
- 0031771350
- (1998) Curr. Med. Chem. , vol.5 , pp. 457
- Menear, K.¹

9
- 0031128227
- (1997) Chem. Biol. , vol.4 , pp. 287
- Obst, U.¹ Banner, D.W.² Weber, L.³ Diederich, F.⁴

10
- 0034084514
- (2000) Helv. Chim. Acta , vol.83 , pp. 855
- Obst, U.¹ Betschmann, P.² Lerner, C.³ Seiler, P.⁴ Diederich, F.⁵ Gramlich, V.⁶ Weber, L.⁷ Banner, D.W.⁸ Schönholzer, P.⁹

11
- 0000437776
- (1995) Angew. Chem. , vol.107 , pp. 1874
- Obst, U.¹ Gramlich, V.² Diederich, F.³ Weber, L.⁴ Banner, D.W.⁵

12
- 0028873745
- (1995) Angew. Chem., Int. Ed. , vol.34 , pp. 1739

13
- 0034354473
- (2000) Chimia , vol.54 , pp. 633
- Betschmann, P.¹ Lerner, C.² Sahli, S.³ Obst, U.⁴ Diederich, F.⁵

14
- 0035904869
- (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 3161
- Lévesque, S.¹ St-Denis, Y.² Bachand, B.³ Préville, P.⁴ Leblond, L.⁵ Winocour, P.D.⁶ Edmunds, J.J.⁷ Rubin, J.R.⁸ Siddiqui, M.A.⁹

15
- 0035814038
- (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 2851
- Chackalamannil, S.¹ Doller, D.² Eagen, K.³ Czarniecki, M.⁴ Ahn, H.-S.⁵ Foster, C.J.⁶ Boykow, G.⁷

16
- 0030895222
- (1997) J. Med. Chem. , vol.40 , pp. 830
- Tucker, T.J.¹ Lumma, W.C.² Mulichak, A.M.³ Chen, Z.⁴ Naylor-Olsen, A.M.⁵ Lewis, S.D.⁶ Lucas, R.⁷ Freidinger, R.M.⁸ Kuo, L.C.⁹

17
- 0343443219
- (1997) J. Med. Chem. , vol.40 , pp. 1565
- Tucker, T.J.¹ Lumma, W.C.² Lewis, S.D.³ Gardell, S.J.⁴ Lucas, B.J.⁵ Baskin, E.P.⁶ Woltmann, R.⁷ Lynch, J.J.⁸ Lyle, E.A.⁹ Appleby, S.D.¹⁰ Chen, I.-W.¹¹ Dancheck, K.B.¹² Vacca, J.P.¹³

18
- 9844258333
- (1997) J. Med. Chem. , vol.40 , pp. 3687
- Tucker, T.J.¹ Lumma, W.C.² Lewis, S.D.³ Gardell, S.J.⁴ Lucas, B.J.⁵ Sisko, J.T.⁶ Lynch, J.J.⁷ Lyle, E.A.⁸ Baskin, E.P.⁹ Woltmann, R.F.¹⁰ Appleby, S.D.¹¹ Chen, I.-W.¹² Dancheck, K.B.¹³ Naylor-Olsen, A.M.¹⁴ Krueger, J.A.¹⁵ Cooper, C.M.¹⁶ Vacca, J.P.¹⁷

19
- 0029315603
- (1995) J. Comput.-Aided Mol. Design , vol.9 , pp. 251
- Gerber, P.R.¹ Müller, K.²

20
- 0000333165
- (1992) Synlett. , pp. 979
- Braish, T.F.¹ Fox, D.E.²

21
- 37049108419
- (1984) J. Chem. Soc., Chem. Commun. , pp. 180
- Grigg, R.¹ Thianpatanagul, S.²

22
- 8744290197
- (1989) Adv. Heterocycl. Chem. , vol.45 , pp. 231
- Tsuge, O.¹ Kasemasa, S.²

23
- 0026089664
- (1991) Tetrahedron , vol.47 , pp. 1311
- Brown, D.S.¹ Charreau, P.² Hansson, T.³ Ley, S.V.⁴

24
- 0017579672
- (1977) Pharmazie , vol.32 , pp. 76
- Wagner, G.¹ Wunderlich, I.²

25
- 84972883243
- (1877) Ber. Dtsch. Chem. Ges. , vol.10 , pp. 1889
- Pinner, A.¹ Klein, F.²

26
- 37049076697
- (1988) J. Chem. Soc., Perkin Trans. 1 , pp. 2703
- Grigg, R.¹ Idle, J.² McMeekin, P.³ Surendrakumar, S.⁴ Vipond, D.⁵

27
- 84980121331
- (1905) Ber. Dtsch. Chem. Ges. , vol.38 , pp. 880
- Eschweiler, W.¹

28
- 33947339438
- (1933) J. Am. Chem. Soc. , vol.55 , pp. 4571
- Clarke, H.T.¹ Gillespie, H.B.² Weisshaus, S.Z.³

29
- 0003505803
- John Wiley & Sons, New York
- (1998) The Ch/π Interaction: Evidence, Nature, Consequences
- Nishio, M.¹ Hirota, M.² Umezawa, Y.³

30
- 0003653494
- Oxford University Press, Oxford
- (1999) The Weak Hydrogen Bond in Structural Chemistry
- Desiraju, G.R.¹ Steiner, T.²

31
- 0003463148
- Wiley, New York
- (1999) Protective Groups in Organic Synthesis
- Greene, T.W.¹ Wuts, P.G.M.²

32
- 0003405157
- Thieme, Stuttgart
- (1994) Protecting Groups
- Kocienski, P.J.¹

33
- 0030590420
- (1996) Tetrahedron , vol.52 , pp. 12521
- McAlonan, H.¹ Murphy, J.P.² Stevenson, P.J.³ Treacy, A.B.⁴

34
- 0001341624
- (1982) J. Org. Chem. , vol.47 , pp. 4577
- Marcuzzi, F.¹ Modena, G.²

35
- 37049089349
- (1990) J. Chem. Soc., Chem. Commun. , pp. 1270
- Toda, F.¹ Takumi, H.² Akehi, M.³

36
- 0000084732
- (1978) J. Am. Chem. Soc. , vol.100 , pp. 6182
- Swenton, J.S.¹ Jackson, D.K.² Raynolds, M.J.M.P.W.³

37
- 0028879303
- (1995) Bioorg. Med. Chem. Lett. , vol.5 , pp. 2835
- Wiley, M.R.¹ Chirgadze, N.Y.² Clawson, D.K.³ Craft, T.J.⁴ Gifford-Moore, D.S.⁵ Jones, N.D.⁶ Olkowski, J.L.⁷ Schacht, A.L.⁸ Weir, L.C.⁹ Smith, G.F.¹⁰

38
- 0033378391
- (1999) Curr. Pharm. Design , vol.5 , pp. 1043
- Rewinkel, J.B.M.¹ Adang, A.E.P.²

39
- 0025094310
- (1990) J. Biol. Chem. , vol.265 , pp. 18289
- Kettner, C.¹ Mersinger, L.² Knabb, R.³

40
- 0029147936
- (1995) Blood Coag. Fibrinol. , vol.6 , pp. 511
- Kimball, S.D.¹

41
- 0029742578
- (1996) J. Med. Chem. , vol.39 , pp. 3039
- Costanzo, M.J.¹ Maryanoff, B.E.² Hecker, L.R.³ Schott, M.R.⁴ Yabut, S.C.⁵ Zhang, H.-C.⁶ Andrade-Gordon, P.⁷ Kauffman, J.A.⁸ Lewis, J.M.⁹ Krishnan, R.¹⁰ Tulinsky, A.¹¹

42
- 0028938348
- (1995) J. Enzyme Inhib. , vol.9 , pp. 43
- Jones, D.M.¹ Atrash, B.² Ryder, H.³ Teger-Nilsson, A.-C.⁴ Gyzander, E.⁵ Szelke, M.⁶

43
- 0029093733
- (1995) Bioorg. Med. Chem. , vol.3 , pp. 1063
- Brady, S.F.¹ Sisko, J.T.² Stauffer, K.J.³ Colton, C.D.⁴ Qiu, H.⁵ Lewis, S.D.⁶ Ng, A.S.⁷ Shafer, J.A.⁸ Bogusky, M.J.⁹ Veber, D.F.¹⁰ Nutt, R.F.¹¹

44
- 0031050773
- (1997) Biochemistry , vol.36 , pp. 1034
- Malikayil, J.A.¹ Burkhart, J.P.² Schreuder, H.A.³ Broersma, R.J.⁴ Tardif, C.⁵ Kutcher, L.W.⁶ Mehdi, S.⁷ Schatzmann, G.L.⁸ Neises, B.⁹ Peet, N.P.¹⁰

45
- 0026088196
- (1991) Tetrahedron Lett. , vol.32 , pp. 7333
- Cheng, L.¹ Goodwin, C.A.² Scully, M.F.³ Kakkar, V.V.⁴ Claeson, G.⁵

46
- 0026677017
- (1992) Tetrahedron Lett. , vol.33 , pp. 7667
- Wang, C.-L.J.¹ Taylor, T.L.² Mical, A.J.³ Spitz, S.⁴ Reilly, T.M.⁵

47
- 2142666194
- Doctoral Dissertation ETH-Zürich No. 1 2037
- (1997)
- Obst, U.¹

48
- 0028846738
- (1995) J. Org. Chem. , vol.60 , pp. 8084
- Pirrung, M.C.¹ Chau, J.H.-L.²

49
- 84977344554
- (1964) Liebigs Ann. Chem. , vol.673 , pp. 196
- Schröder, E.¹ Klieger, E.²

50
- 0028132716
- (1994) J. Org. Chem. , vol.59 , pp. 4862
- Guzzo, P.R.¹ Miller, M.J.²

51
- 0003671857
- (1982) Synth. Commun. , pp. 989
- Levin, J.I.¹ Turos, E.² Weinreb, S.M.³

52
- 0025673823
- (1990) J. Org. Chem. , vol.55 , pp. 6121
- Dijkstra, G.D.H.¹ Kellogg, R.M.² Wynberg, H.³

53
- 0002032141
- (1998) Am. Lab. , vol.30 , Issue.8 , pp. 71
- Lämmerhofer, M.¹ Maier, N.M.² Lindner, W.³

54
- 0033407597
- (1999) Tetrahedron: Asymmetry , vol.10 , pp. 3537
- Chelucci, G.¹ Culeddu, N.² Saba, A.³ Valenti, R.⁴

55
- 0003550131
- Thieme, Stuttgart
- (1991) Reaktionen und Synthesen im organisch-chemischen Praktikum , pp. 73-74
- Tietze, L.F.¹ Eicher, T.²

56
- 0028143534
- (1994) J. Med. Chem. , vol.37 , pp. 3889
- Hilpert, K.¹ Ackermann, J.² Banner, D.W.³ Gast, A.⁴ Gubcrnator, K.⁵ Hadvary, P.⁶ Labler, L.⁷ Müller, K.⁸ Schmid, G.⁹ Tschopp, T.B.¹⁰ Van de Waterbeemd, H.¹¹

57
- 0020655601
- (1983) Biochim. Biophys. Acta , vol.742 , pp. 539
- Lottenberg, R.¹ Hall, J.A.² Blinder, M.³ Binder, E.P.⁴ Jackson, C.M.⁵

58
- 2142721440
- (1974) J. Org. Chem. , vol.30 , pp. 21
- Schwarz, A.L.¹ Lerner, L.M.²

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.