De novo design, synthesis, and in vitro evaluation of inhibitors for prokaryotic tRNA-guanine transglycosylase: A dramatic sulfur effect on binding affinity

ChemBioChem

Volumn 3, Issue 2-3, 2002, Pages 250-253

  Meyer, Emmanuel A ^a   Brenk, Ruth ^b   Castellano, Ronald K ^a   Furler, Maya ^a   Klebe, Gerhard ^b   Diederich, François ^a  

^a ETH ZURICH   (Switzerland)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Antibiotics; De novo design; Enzyme inhibitors; Structure activity relationships; tRNA

Indexed keywords

GLYCOSYLTRANSFERASE INHIBITOR; SULFUR; TRANSFER RNA;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HYDROGEN BOND; HYDROPHOBICITY; PRIORITY JOURNAL; PROKARYOTE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DYSENTERY, BACILLARY; ENZYME INHIBITORS; MODELS, MOLECULAR; PENTOSYLTRANSFERASES; PROTEIN CONFORMATION; ZYMOMONAS;

PROKARYOTA;

EID: 0036523371     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/1439-7633(20020301)3:2/3<250::AID-CBIC250>3.0.CO;2-J     Document Type: Article

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