Molecular recognition at the thrombin active site: Structure-based design and synthesis of potent and selective thrombin inhibitors and the X-ray crystal structures of two thrombin-inhibitor complexes

Chemistry and Biology

Volumn 4, Issue 4, 1997, Pages 287-295

  Obst, Ulrike ^a   Banner, David W ^b   Weber, Lutz ^b   Diederich, François ^a  

^a ETH ZURICH   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

molecular recognition; protein X ray crystallography; structure based inhibitor design; thrombin inhibitors

Indexed keywords

EID: 0031128227     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(97)90072-7     Document Type: Article

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