Decreased secretion of Th2 cytokines precedes up-regulated and delayed secretion of Th1 cytokines in activated peripheral blood mononuclear cells from patients with insulin-dependent diabetes mellitus

Journal of Autoimmunity

Volumn 11, Issue 6, 1998, Pages 635-642

  Rapoport, M J ^b   Mor, A ^b   Vardi, P ^a   Ramot, Y ^b   Winker, R ^b   Hindi, A ^b   Bistritzer, T ^b  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b NONE

Author keywords

Cytokines; IDDM; Th1; Th2

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; HELPER CELL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL;

EID: 0032413626     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1998.0240     Document Type: Article

References (27)

1. Mosmann T.R., Cherwinski H., Bond M.W., Giedlin M.A., Coffman R.L. Two types of murine T helper/T cell clone I: Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:1986;2348-2357.
2. Castano L., Eisenbarth G.S. Type-I diabetes: a chronic autoimmune disease of human, mouse and rat. Ann. Rev. Immunol. 8:1990;647-679.
3. Rabinovitch A. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation? Diabetes. 43:1994;613-621.
4. Kaye W.A., Adri M.N., Soldner J.S., Rabinowe S.L., Kaldany A., Kahn C.R., Bistrian B., Strikanta S., Ganda O.P., Eisenbarth G.S. Acquired defect in Interleukin-2 production in patients with Type I diabetes mellitus. N. Engl. J. Med. 315:1986;920-924.
5. Giordano C., De Maria R., Todaro M., Stassi G., Mattina A., Richiusa P., Galluzzo G., Panto F., Galluzzo A. Study of T cell activation in Type I diabetic patients and pre-Type I diabetic subjects by cytomeric analysis: antigen expression defectin vitro. J. Clin. Immunol. 13:1993;68-78.
6. Zier K.S., Leo M.M., Spielman R.S., Baker L. Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus. Diabetes. 33:1984;552-555.
7. Tomoda T., Kurashige T., Taniguchi T. Imbalance of the Interleukin-2 system in children with IDDM. Diabetologia. 37:1994;476-482.
8. Cavallo M.G., Pozzili P., Bird C., Wadhwa M., Meager A., Visalli N., Gearing A.J., Andreani D., Thorpe R. Cytokines in sera from insulin-dependent diabetic patients at diagnosis. Clin. Exp. Immunol. 86:1991;256-259.
9. Espersen G.T., Mathiesen O., Grunnet N., Jensen S., Ditzel J. Cytokine plasma levels and lymphocyte subsets in patients with newly diagnosed insulin-dependent (Type 1) diabetes mellitus before and following initial insulin treatment. APMIS. 101:1993;703-706.
10. Toms G.C., Baker P., Boucher B.J. The production of immunoreactive α- and γ interferon by circulating mononuclear cells in Type 1 diabetes. Diabetic Med. 8:1991;547-550.
11. Berman M.A., Sandborg C.I., Wang Z., Imfeld K.L., Zaldivar F., Dadufalza V., Buckingham B.A. Decreased IL-4 production in new onset Type I insulin-dependent diabetes mellitus. J. Immunol. 157:1996;4690-4696.
12. Wilson S.B., Kent S.C., Patton K.T., Orban T., Jackson R.A., Exley M., Porcelli S., Schatz D.A., Atkinson M.A., Balk S.P., Strominger G.L., Hafler D.A. Extreme Th1 bias of invariant Vα24JαO T cells in Type 1 diabetes. Nature. 391:1998;177-181.
13. Barcena A., Toribio M.L., Gutierrez-Ramos J.C., Kroemer G., Martinez A.C. Interplay between IL-2 and IL-4 in human thymocyte differentiation: antagonism or agonism. Int. Immunol. 3:1991;419-425.
14. Martinez O.M., Gibbons R.S., Garovoy M.R., Aronson F.R. IL-4 inhibits IL-2 receptor expression and IL-2 dependent proliferation of human T cells. J. Immunol. 144:1990;2211-2215.
15. Spits H., Yessel H., Takebe Y., Arai N., Yokota T., Lee F., Arai K., Banchereau J., DeVries J.E. Recombinant interleukin 4 promotes the growth of human T cells. J. Immunol. 139:1987;1142-1147.
16. National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 28:1979;1039-1059.
17. Dixon, W.J. 1990, BMDP Statistical Software, University of California Press, California.
18. Rapoport M.J., Jaramillo A., Zipris D., Lazarus A.H., Serreze D.V., Leiter E.H., Cyopick P., Danska J.S., Delovitch T.L. Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in non-obese diabetic mice. J. Exp. Med. 178:1993;87-99.
19. Rapoport M.J., Weiss L., Mor A., Bistritzer T., Ramot Y., Slavin S. Prevention of autoimmune diabetes by linomide in NOD mice is associated with up-regulation of the T cell receptor mediated activation of p21ras. J. Immunol. 157:1996;4721-4725.
20. Zipris D., Lazarus A.H., Crow A.R., Haddzija M., Delovitch T.I. Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune non-obese diabetic mice. Evidence for thymic T cell anergy that correlates with the onset of insulitis. J. Immunol. 146:1991;3763-3771.
21. De Maria R., Todaro M., Stassi G., Di-Blasi F., Giordano M., Galluzzo A., Giordano C. Defective T cell receptor/CD3 complex signaling in human Type I diabetes. Eur. J. Immunol. 24:1994;999-1002.
22. Faustman D., Li X.P., Lin H.Y., Fu Y.E., Eisenbarth G., Avruch J., Guo J. Linkage of faulty major histocompatibility complex class I to autoimmune diabetes. Science. 254:1991;1756-1761.
23. Shimada A., Charlton B., Taylor-Edwards C., Fathman C.G. B cell destruction may be a late consequence of the autoimmune process in non-obese diabetic mice. Diabetes. 45:1996;1063-1067.
24. Pennline K.J., Roque-Gaffney E., Monahan M. Recombinant human IL-10 prevents the onset of diabetes in the non-obese diabetic mouse. Clin. Immunol. Immunopathol. 71:1994;169-175.
25. Shehadeh N.N., LaRosa F., Lafferty K.J. Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J. Autoimmunity. 6:1993;291-300.
26. Elias D., Meilin A., Abllamunitz V., Birk O.S., Carmi P., Konen-Waisman S., Cohen I.R. Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and down-regulates autoimmunity to various B cell antigens. Diabetes. 46:1997;758-764.
27. Cameron M.J., Arreaza G.A., Zucker P., Chensue S.W., Strieter R.M., Chakrabarti S., Delovitch T.L. IL-4 prevents insulitis and insulin-dependent diabetes mellitus in non-obese diabetic mice by potentiation of regulatory T helper-2 cell function. J. Immunol. 159:1997;4686-4692.