Cytokine expression in unstimulated PBMC of children with type 1 diabetes and subjects positive for diabetes-associated autoantibodies

Scandinavian Journal of Immunology

Volumn 53, Issue 5, 2001, Pages 510-513

  Halminen, M ^a,b   Simell, O ^a,c   Knip, M ^a,d   Ilonen, J ^a,c  

^a JDFI Centre for Diabetes Prevention in Finland   (Finland)

^b Departments of Virology   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL STIMULATION; CHILD; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETES MELLITUS; FEMALE; FLUOROMETRY; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA HYBRIDIZATION; TH2 CELL;

AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; CYTOKINES; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; INFANT; INTERFERON TYPE II; INTERLEUKIN-4; LEUKOCYTES, MONONUCLEAR; MALE; RNA, MESSENGER; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035041401     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2001.00904.x     Document Type: Article

References (24)

1. Autoimmunity and the highway to diabetes
2. Insulin-dependent diabetes mellitus as an autoimmune disease
3. Insulin-dependent diabetes mellitus as a beta-cell targeted disease of immunoregulation
4. Increased circulating Ia-antigen-bearing T cells in type I diabetes mellitus
5. Immune activation and T cell subset abnormalities in circulation of patients with recently diagnosed type I diabetes mellitus
6. Abnormalities within CD4 and CD8 T lymphocytes subsets in type 1 (insulin-dependent) diabetes
7. Insulin-dependent diabetes mellitus
8. Insulitis in type I (insulin-dependent) diabetes mellitus in man: Macrophages, lymphocytes, and interferon-γ containing cells
9. Interferon expression in the pancreases of patients with type I diabetes
10. IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice
11. Oral tolerance: Immune mechanisms and treatment of autoimmune diseases
12. Transforming growth factor-beta (TGF-β)
13. Regulation of immune responses by TGFβ
14. T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin-12 and interferon-gamma and is inhibited by transforming growth factor-beta
15. Cytokines in sera from insulin-dependent diabetic patients at diagnosis
16. Transforming growth factor β1 (TGFβ1) mRNA correlates with magnetic resonance imaging disease activity in multiple sclerosis patients
17. Cytokine profile in coeliac disease
18. Simultaneous detection of IFN-γ and IL-4 mRNAs using RT-PCR and time-resolved fluorometry
19. Characterization of cytokine gene expression in CD4+ and CD8+ T cells after activation with phorbol myristate acetate and phytohaemagglutinin
20. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
21. Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes
22. Functional diversity of helper T lymphocytes
23. A novel population of B7-1 + T cells producing intracellular IL-4 is decreased in patients with multiple sclerosis
24. A new type of CD4+ suppressor T cell completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice