메뉴 건너뛰기




Volumn 34, Issue 1, 1996, Pages 37-46

Dominant TCR α-chain clonotypes and interferon-γ are expressed in the pancreas of patients with recent-onset insulin-dependent diabetes mellitus

Author keywords

insulin dependent diabetes mellitus; interferon ; interleukin 4; pancreas; T cell receptor

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 0030250176     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(96)01328-9     Document Type: Article
Times cited : (31)

References (46)
  • 1
    • 0021357468 scopus 로고
    • β-Cell damage in diabetic insulitis: Are we approaching a solution?
    • [1] Bottazzo GF (1984) β-Cell damage in diabetic insulitis: are we approaching a solution? Diabetologia 26, 241-249.
    • (1984) Diabetologia , vol.26 , pp. 241-249
    • Bottazzo, G.F.1
  • 2
    • 0022617990 scopus 로고
    • Type 1 diabetes mellitus: A chronic autoimmune disease
    • [2] Eisenbarth, G.S. (1986) Type 1 diabetes mellitus: a chronic autoimmune disease. N. Engl. J. Med. 314, 1360-1368.
    • (1986) N. Engl. J. Med. , vol.314 , pp. 1360-1368
    • Eisenbarth, G.S.1
  • 4
    • 0022475906 scopus 로고
    • The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: A 25-year review of deaths in patients under 20 years of age in the UK
    • [4] Foulis, A.K., Liddle, C.N., Farquharson, M.A., Richmond, J.A. and Weir, R.S. (1986) The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the UK. Diabetologia 29, 267-274.
    • (1986) Diabetologia , vol.29 , pp. 267-274
    • Foulis, A.K.1    Liddle, C.N.2    Farquharson, M.A.3    Richmond, J.A.4    Weir, R.S.5
  • 5
    • 0027361654 scopus 로고
    • Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus
    • [5] Itoh, N., Hanafusa, T., Miyazaki, A., et al. (1993) Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus. J. Clin. Invest. 92, 2313-2322.
    • (1993) J. Clin. Invest. , vol.92 , pp. 2313-2322
    • Itoh, N.1    Hanafusa, T.2    Miyazaki, A.3
  • 6
    • 0023252262 scopus 로고
    • HLA-DQ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
    • [6] Todd, J.A., Bell, J.I. and McDevitt, H.O. (1987) HLA-DQ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329, 599-604.
    • (1987) Nature , vol.329 , pp. 599-604
    • Todd, J.A.1    Bell, J.I.2    McDevitt, H.O.3
  • 7
    • 0024467188 scopus 로고
    • Aspartic acid at position 57 of dqβ chain does not protect against Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects
    • [7] Yamagata, K., Nakajima, H., Hanafusa, T., et al. (1989) Aspartic acid at position 57 of DQβ chain does not protect against Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects. Diabetologia 32, 762-764.
    • (1989) Diabetologia , vol.32 , pp. 762-764
    • Yamagata, K.1    Nakajima, H.2    Hanafusa, T.3
  • 8
    • 0025921292 scopus 로고
    • HLA-DQA1*1 contributes to resistance and A1*3 confers susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects
    • [8] Yamagata, K., Hanafusa, T., Nakajima, H., et al. (1991) HLA-DQA1*1 contributes to resistance and A1*3 confers susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects. Diabetologia 34, 133-136.
    • (1991) Diabetologia , vol.34 , pp. 133-136
    • Yamagata, K.1    Hanafusa, T.2    Nakajima, H.3
  • 9
    • 0027406406 scopus 로고
    • Selection for T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis
    • [9] Oksenberg, J.R., Panzara, M.A., Begovich, A.B., et al, (1993) Selection for T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 362, 68-70.
    • (1993) Nature , vol.362 , pp. 68-70
    • Oksenberg, J.R.1    Panzara, M.A.2    Begovich, A.B.3
  • 10
    • 0025022560 scopus 로고
    • Examination of islets in the pancreas biopsy specimens from newly diagnosed Type 1 (insulin-dependent) diabetic patients
    • [10] Hanafusa, T., Miyazaki, A., Miyagawa, J., et al. (1990) Examination of islets in the pancreas biopsy specimens from newly diagnosed Type 1 (insulin-dependent) diabetic patients. Diabetologia 33, 105-111.
    • (1990) Diabetologia , vol.33 , pp. 105-111
    • Hanafusa, T.1    Miyazaki, A.2    Miyagawa, J.3
  • 11
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • [11] Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 13
    • 0025779157 scopus 로고
    • Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease
    • [13] Davies, T.F., Martin, A., Concepcion, E.S., Graves, P., Cohen, L. and Ben-Nun, A. (1991) Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease, N. Engl. J. Med. 325, 238-244.
    • (1991) N. Engl. J. Med. , vol.325 , pp. 238-244
    • Davies, T.F.1    Martin, A.2    Concepcion, E.S.3    Graves, P.4    Cohen, L.5    Ben-Nun, A.6
  • 14
    • 0026604656 scopus 로고
    • Evidence for selective accumulation of intrathyroidal T lymphocytes in human autoimmune thyroid disease based on T cell receptor V gene usage
    • [14] Davies, T.F., Martin, A., Concepcion, E.S., et al. (1992) Evidence for selective accumulation of intrathyroidal T lymphocytes in human autoimmune thyroid disease based on T cell receptor V gene usage. J. Clin. Invest. 89. 157-162.
    • (1992) J. Clin. Invest. , vol.89 , pp. 157-162
    • Davies, T.F.1    Martin, A.2    Concepcion, E.S.3
  • 16
    • 0023019719 scopus 로고
    • Diversity and structure of human T-cell receptor β-chain variable region genes
    • [16] Concannon, P., Pickering, L.A., Kung, P. and Hood, L. (1986) Diversity and structure of human T-cell receptor β-chain variable region genes. Proc. Natl. Acad. Sci. USA 83, 6598-6602.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 6598-6602
    • Concannon, P.1    Pickering, L.A.2    Kung, P.3    Hood, L.4
  • 17
    • 0019971912 scopus 로고
    • Structure of the human immune interferon gene
    • [17] Gray, P.W. and Goeddel, D.V. (1982) Structure of the human immune interferon gene. Nature 298, 859-863.
    • (1982) Nature , vol.298 , pp. 859-863
    • Gray, P.W.1    Goeddel, D.V.2
  • 18
    • 0021907183 scopus 로고
    • Molecular cloning of the complementary DNA for human tumor necrosis factor
    • [18] Wang, A.M., Creasey, A.A., Ladner, M.B., et al. (1985) Molecular cloning of the complementary DNA for human tumor necrosis factor. Science 228, 149-154.
    • (1985) Science , vol.228 , pp. 149-154
    • Wang, A.M.1    Creasey, A.A.2    Ladner, M.B.3
  • 19
    • 0042927891 scopus 로고
    • Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell and T-cell stimulating activities
    • [19] Yokota, T., Otsuka, T., Mosmann, T., et al. (1986) Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell and T-cell stimulating activities. Proc. Natl. Acad. Sci. USA 83, 5894-5898.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 5894-5898
    • Yokota, T.1    Otsuka, T.2    Mosmann, T.3
  • 20
    • 0022499547 scopus 로고
    • Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
    • [20] Hirano, T., Yasukawa, K., Harada, H., et al. (1986) Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324, 73-76.
    • (1986) Nature , vol.324 , pp. 73-76
    • Hirano, T.1    Yasukawa, K.2    Harada, H.3
  • 21
    • 2642648459 scopus 로고
    • The outline structure of the T-cell αβ receptor
    • [21] Chothia, C., Boswell, D.R. and Lesk, A.M. (1988) The outline structure of the T-cell αβ receptor. EMBO J. 7, 3745-3755.
    • (1988) EMBO J. , vol.7 , pp. 3745-3755
    • Chothia, C.1    Boswell, D.R.2    Lesk, A.M.3
  • 22
    • 0023720148 scopus 로고
    • T-cell antigen receptor genes and T-cell recognition
    • [22] Davis, M.M. and Bjorkman, P.J. (1988) T-cell antigen receptor genes and T-cell recognition. Nature 334, 395-402.
    • (1988) Nature , vol.334 , pp. 395-402
    • Davis, M.M.1    Bjorkman, P.J.2
  • 23
    • 0026658604 scopus 로고
    • Variability in T cell receptor Vβ gene usage in human peripheral blood lymphocytes: Studies of identical twins, siblings, and insulin-dependent diabetes mellitus patients
    • [23] Malhotra, Y., Spielman, R. and Concannon, P. (1992) Variability in T cell receptor Vβ gene usage in human peripheral blood lymphocytes: Studies of identical twins, siblings, and insulin-dependent diabetes mellitus patients. J. Immunol. 149, 1802-1808.
    • (1992) J. Immunol. , vol.149 , pp. 1802-1808
    • Malhotra, Y.1    Spielman, R.2    Concannon, P.3
  • 24
    • 0025775862 scopus 로고
    • Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors
    • [24] Candeias, S., Katz, J., Benoist, C., Mathis, D. and Haskins, K. (1991) Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors. Proc. Natl. Acad. Sci. USA 88, 6167-6170.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 6167-6170
    • Candeias, S.1    Katz, J.2    Benoist, C.3    Mathis, D.4    Haskins, K.5
  • 25
    • 0025731505 scopus 로고
    • T cell receptor V gene usage of islet β cell-reactive T cells is not restricted in non-obese diabetic mice
    • [25] Nakano, N., Kikutani, H., Nishimoto, H. and Kishimoto, T. (1991) T cell receptor V gene usage of islet β cell-reactive T cells is not restricted in non-obese diabetic mice. J. Exp. Med. 173, 1091-1097
    • (1991) J. Exp. Med. , vol.173 , pp. 1091-1097
    • Nakano, N.1    Kikutani, H.2    Nishimoto, H.3    Kishimoto, T.4
  • 26
    • 0025354968 scopus 로고
    • Limited heterogeneity of rearranged T-cell receptor vα transcripts in brains of multiple sclerosis patients
    • [26] Oksenberg, J.R., Stuart, S., Begovich, A.B., et al. (1990) Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients. Nature 345, 344-346.
    • (1990) Nature , vol.345 , pp. 344-346
    • Oksenberg, J.R.1    Stuart, S.2    Begovich, A.B.3
  • 27
    • 0026575039 scopus 로고
    • Characterization of T-cell receptor αβ repertoire in synovial tissue from different temporal phases of rheumatoid arthritis
    • [27] Bucht, A., Oksenberg, J.R., Lindblad, S., Gronberg, A., Steinman, L. and Klareskog, L. (1992) Characterization of T-cell receptor αβ repertoire in synovial tissue from different temporal phases of rheumatoid arthritis. Scand. J. Immunol. 35, 159-165.
    • (1992) Scand. J. Immunol. , vol.35 , pp. 159-165
    • Bucht, A.1    Oksenberg, J.R.2    Lindblad, S.3    Gronberg, A.4    Steinman, L.5    Klareskog, L.6
  • 28
    • 0027272073 scopus 로고
    • Analysis of T cell receptor repertoire of muscle-infiltrating T lymphocytes in polymyositis
    • [28] Mantegazza, R., Andreetta, F., Bernasconi, P., et al. (1993) Analysis of T cell receptor repertoire of muscle-infiltrating T lymphocytes in polymyositis. J. Clin. Invest. 91, 2880-2886.
    • (1993) J. Clin. Invest. , vol.91 , pp. 2880-2886
    • Mantegazza, R.1    Andreetta, F.2    Bernasconi, P.3
  • 29
    • 0023753713 scopus 로고
    • Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention
    • [29] Acha-Orbea, H., Mitchell, D.J., Timmermann, L., et al. (1988) Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54, 263-273.
    • (1988) Cell , vol.54 , pp. 263-273
    • Acha-Orbea, H.1    Mitchell, D.J.2    Timmermann, L.3
  • 30
    • 0023751365 scopus 로고
    • Restricted use of T cell receptor V gene in murine autoimmune encephalomyelitis raises possibilities for antibody therapy
    • [30] Urban, J.L., Kumar, V., Kono, D.H., et al. (1988) Restricted use of T cell receptor V gene in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell 54, 577-592.
    • (1988) Cell , vol.54 , pp. 577-592
    • Urban, J.L.1    Kumar, V.2    Kono, D.H.3
  • 31
    • 0025283333 scopus 로고
    • The presumptive CDR3 regions of both T cell receptor α and β chains determine T cell specificity for myoglobin peptides
    • [31] Danska, J.S., Livingstone, A.M., Paragas, V., Ishihara, T. and Fathman, C.G. (1990) The presumptive CDR3 regions of both T cell receptor α and β chains determine T cell specificity for myoglobin peptides. J. Exp. Med. 172, 27-33.
    • (1990) J. Exp. Med. , vol.172 , pp. 27-33
    • Danska, J.S.1    Livingstone, A.M.2    Paragas, V.3    Ishihara, T.4    Fathman, C.G.5
  • 32
    • 0023879045 scopus 로고
    • Selection of amino acid sequences in the beta chain of the T cell antigen receptor
    • [32] Hedrick, S.M., Engel, I., McElligott, D.L., et al. (1988) Selection of amino acid sequences in the beta chain of the T cell antigen receptor. Science 239, 1541-1544.
    • (1988) Science , vol.239 , pp. 1541-1544
    • Hedrick, S.M.1    Engel, I.2    McElligott, D.L.3
  • 34
    • 0023008736 scopus 로고
    • Predominant use of a Vα gene segment in mouse T-cell receptors for cytochrome C
    • [34] Winoto, A., Urban, J.L., Lan, N.C., Govcrman, J., Hood, L. and Hansburg, D. (1986) Predominant use of a Vα gene segment in mouse T-cell receptors for cytochrome C. Nature 324, 679-682.
    • (1986) Nature , vol.324 , pp. 679-682
    • Winoto, A.1    Urban, J.L.2    Lan, N.C.3    Govcrman, J.4    Hood, L.5    Hansburg, D.6
  • 35
    • 0023789209 scopus 로고
    • The T cell receptor Vα3 gene segment is associated with reactivity to p-azobenzenearsonate
    • [35] Tan, K.N., Datlof, B.M., Gilmore, J.A., et al. (1988) The T cell receptor Vα3 gene segment is associated with reactivity to p-azobenzenearsonate. Cell 54, 247-261.
    • (1988) Cell , vol.54 , pp. 247-261
    • Tan, K.N.1    Datlof, B.M.2    Gilmore, J.A.3
  • 36
    • 0025251609 scopus 로고
    • Restricted V-segment usage in T-cell receptors from cytotoxic T lymphocytes specific for a major epitope of lymphocytic choriomeningitis virus
    • [36] Yanagi, Y., Maegawa, R., Cook, T., Kanagawa, O. and Oldstone, M.B.A. (1990) Restricted V-segment usage in T-cell receptors from cytotoxic T lymphocytes specific for a major epitope of lymphocytic choriomeningitis virus. J. Virol. 64, 5919-5926.
    • (1990) J. Virol. , vol.64 , pp. 5919-5926
    • Yanagi, Y.1    Maegawa, R.2    Cook, T.3    Kanagawa, O.4    Oldstone, M.B.A.5
  • 38
    • 0027378612 scopus 로고
    • Following a diabetogenic T cell from genesis through pathogenesis
    • [38] Katz, J.D., Wang, B., Haskins, K., Benoist, C. and Mathis, D. (1993) Following a diabetogenic T cell from genesis through pathogenesis. Cell 74, 1089-1100.
    • (1993) Cell , vol.74 , pp. 1089-1100
    • Katz, J.D.1    Wang, B.2    Haskins, K.3    Benoist, C.4    Mathis, D.5
  • 39
    • 0028574073 scopus 로고
    • HLA-DQ-restricted, islet-specific T-cell clones of a Type I diabetic patient: T-cell receptor sequence similarities to insulitis-inducing T-cells of nonobese diabetic mice
    • [39] Durinovic-Bello, J., Steinle, A., Ziegler, A.G. and Schendel, D.J. (1994) HLA-DQ-restricted, islet-specific T-cell clones of a Type I diabetic patient: T-cell receptor sequence similarities to insulitis-inducing T-cells of nonobese diabetic mice. Diabetes 43, 1318-1325.
    • (1994) Diabetes , vol.43 , pp. 1318-1325
    • Durinovic-Bello, J.1    Steinle, A.2    Ziegler, A.G.3    Schendel, D.J.4
  • 40
    • 0025791952 scopus 로고
    • T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: Implications for T cell allelic exclusion and antigen-specific repertoire
    • [40] Casanova, J.L., Romero, P., Widmann, C., Kourilsky, P. and Maryanski, J.L. (1991) T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire. J. Exp. Med. 174, 1371-1383.
    • (1991) J. Exp. Med. , vol.174 , pp. 1371-1383
    • Casanova, J.L.1    Romero, P.2    Widmann, C.3    Kourilsky, P.4    Maryanski, J.L.5
  • 41
    • 0026521299 scopus 로고
    • Preferential Vβ gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin-derived peptide: Evidence for a dominant role of a germline-encoded V region in antigen/major histocompatibility complex recognition
    • [41] Boitel, B., Ermonval, M., Panina-Bordignon, P., Mariuzza, R.A., Lanzavecchia, A. and Acuto, O. (1992) Preferential Vβ gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin-derived peptide: evidence for a dominant role of a germline-encoded V region in antigen/major histocompatibility complex recognition. J. Exp. Med. 175, 765-777
    • (1992) J. Exp. Med. , vol.175 , pp. 765-777
    • Boitel, B.1    Ermonval, M.2    Panina-Bordignon, P.3    Mariuzza, R.A.4    Lanzavecchia, A.5    Acuto, O.6
  • 42
    • 0028226301 scopus 로고
    • Skewed T-cell receptor usage junctional and heterogeneity among isletitis αβ and βδ T-cells in human IDDM
    • [42] Santamaria, P., Lewis, C., Jessurun, J., Sutherland, D.E.R. and Barbosa, J.J. (1994) Skewed T-cell receptor usage junctional and heterogeneity among isletitis αβ and βδ T-cells in human IDDM. Diabetes 43, 599-606.
    • (1994) Diabetes , vol.43 , pp. 599-606
    • Santamaria, P.1    Lewis, C.2    Jessurun, J.3    Sutherland, D.E.R.4    Barbosa, J.J.5
  • 43
    • 0027959188 scopus 로고
    • Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology
    • [43] Conrad, B., Weidmann, E., Trucco, G., et al. (1994) Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology. Nature 371, 351-355.
    • (1994) Nature , vol.371 , pp. 351-355
    • Conrad, B.1    Weidmann, E.2    Trucco, G.3
  • 44
    • 0026469344 scopus 로고
    • Human TH1 and TH2 subsets: Regulation of differentiation and role in protection and immunopathology
    • [44] Romagnani, S. (1992) Human TH1 and TH2 subsets: regulation of differentiation and role in protection and immunopathology, Int. Arch. Allergy Immunol. 98, 279-285
    • (1992) Int. Arch. Allergy Immunol. , vol.98 , pp. 279-285
    • Romagnani, S.1
  • 45
    • 0028354067 scopus 로고
    • Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM
    • [45] Rabinovitch, A. (1994) Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Diabetes 43, 613-621
    • (1994) Diabetes , vol.43 , pp. 613-621
    • Rabinovitch, A.1
  • 46
    • 0022502819 scopus 로고
    • Sequence and repertoire of human T cell receptor α chain variable region genes in mature T lymphocytes
    • [46] Yoshikai, Y., Kimura, N., Toyonaga, B. and Mak, T.W. (1986) Sequence and repertoire of human T cell receptor α chain variable region genes in mature T lymphocytes. J. Exp. Med. 164, 90-103.
    • (1986) J. Exp. Med. , vol.164 , pp. 90-103
    • Yoshikai, Y.1    Kimura, N.2    Toyonaga, B.3    Mak, T.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.