Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3

Biochemistry

Volumn 42, Issue 33, 2003, Pages 9989-10000

  Zhang, Da Wei ^a,b   Gu, Hong Mei ^b   Vasa, Monika ^a   Muredda, Mario ^a,b   Cole, Susan P C ^a,b   Deeley, Roger G ^a,b  

^a QUEEN S UNIVERSITY   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; DRUG PRODUCTS; HYDROGEN BONDS; MUTAGENESIS; PROTEINS; SUBSTRATES;

BILE SALTS;

AMINO ACIDS;

AMINO ACID; BILE SALT; ESTRADIOL 17 GLUCURONIDE; ETOPOSIDE; LEUKOTRIENE C4; MEMBRANE PROTEIN; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 3; PEPTIDOLEUKOTRIENE; TAUROCHOLIC ACID;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; DRUG TRANSPORT; EMBRYO; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE MUTATION; HUMAN; HUMAN CELL; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CELL DIVISION; CELL LINE; CELL MEMBRANE; DNA PRIMERS; DRUG RESISTANCE, MULTIPLE; ENZYME INHIBITORS; ESTRADIOL; ETOPOSIDE; HUMANS; HYDROGEN BONDING; KINETICS; LEUKOTRIENE C4; METHOTREXATE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; P-GLYCOPROTEINS; POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TAUROCHOLIC ACID; TRANSFECTION;

EID: 0042473136     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034462b     Document Type: Article

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